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41. 发明申请

US20080166817A1 Apparatus and Method for Polymer Characterization 有权
标题翻译：聚合物表征的装置和方法
公开(公告)号：US20080166817A1
公开(公告)日：2008-07-10
申请号：US11794417
申请日：2006-01-19
申请人： David T. Gillespie , Colin Li Pi Shan , Lonnie G. Hazlitt , Alexander W. Degroot , Peter B. Arnoudse , Charles Allen Williams
发明人： David T. Gillespie , Colin Li Pi Shan , Lonnie G. Hazlitt , Alexander W. Degroot , Peter B. Arnoudse , Charles Allen Williams
IPC分类号： G01N21/47 , G01N30/02
CPC分类号： G01N30/468 , G01N25/147 , G01N30/463 , G01N30/54 , G01N33/442 , G01N2030/008 , G01N2030/3007
摘要： Apparatus for GPC/TREF and TREF/GPC characterization of a polymer sample. The apparatus provides for the automated and integrated use of multiple TREF columns and a GPC system employing a multiple flow through detectors. In addition, a method for TREF/GPC characterization of a polymer sample by GPC analysis of TREF fractions at increasing TREF elution temperatures from multiple TREF columns operated in a coordinated and synchronized temperature cycle for increased sample throughput. Also, a method for GPC/TREF characterization of a polymer sample by GPC fractionation followed by TREF fractionation of the GPC fractionations.
摘要翻译：用于GPC / TREF和TREF / GPC表征聚合物样品的装置。该装置提供了多个TREF柱的自动化和集成使用以及采用多个流过检测器的GPC系统。此外，通过在增加TREF洗脱温度的TREF洗脱温度下，通过GPC分析TREF级分，通过在协同和同步的温度循环中操作以提高样品通量的多个TREF柱来对聚合物样品进行TREF / GPC表征的方法。此外，通过GPC分级随后进行GPC分馏的TREF分馏，GPC / TREF表征聚合物样品的方法。

42. 发明申请

US20070295664A1 Focusing a sample on an analytical column 审中-公开
标题翻译：将样品聚焦在分析柱上
公开(公告)号：US20070295664A1
公开(公告)日：2007-12-27
申请号：US11820445
申请日：2007-06-19
申请人： Bernd Glatz , Karsten Kraiczek
发明人： Bernd Glatz , Karsten Kraiczek
IPC分类号： B01D15/08
CPC分类号： G01N30/462 , G01N30/463 , G01N30/465 , G01N30/468 , G01N2030/347
摘要： A focusing unit for a fluidic system adapted for processing a mobile phase containing a fluidic sample, the fluidic system having a first processing element and a second processing element each for interacting with the mobile phase, wherein the mobile phase is to be conducted through the first and second processing elements, wherein the focusing unit is adapted for being coupled to an inlet of the second processing element and is adapted for modifying an elution strength of the mobile phase in order to spatially focus at least a portion of the fluidic sample in a region close to the inlet of the second processing element.
摘要翻译：一种用于流体系统的聚焦单元，适用于处理含有流体样品的流动相，所述流体系统具有第一处理元件和第二处理元件，每个处理元件和第二处理元件各自与流动相相互作用，其中流动相通过第一和第二处理元件，其中所述聚焦单元适于耦合到所述第二处理元件的入口，并且适于改变所述流动相的洗脱强度，以便将所述流体样品的至少一部分空间聚焦在区域靠近第二处理元件的入口。

43. 发明申请

US20070214866A1 Two valves switching modulator for comprehensive two-dimensional gas chromatography 有权
标题翻译：两个阀门开关调制器，用于全面的二维气相色谱
公开(公告)号：US20070214866A1
公开(公告)日：2007-09-20
申请号：US11716325
申请日：2007-03-09
申请人： Frank C. Wang
发明人： Frank C. Wang
IPC分类号： G01N30/04
CPC分类号： G01N30/465 , G01N30/04 , G01N30/20 , G01N30/38 , G01N30/463 , G01N30/6034 , G01N2030/385
摘要： The present invention is an improvement to two-dimensional comprehensive gas chromatography. The improvement is a two-valve switching modulator connecting two different type of separation columns. The advantages of current invention are (1) a simple system can be built by readily available parts; (2) no specific materials required (other than electricity) to operate the system, especially, do not need any type of coolant; (3) can be build on any GC as an externally added on unit; (4) The first and the second dimensional column flow are independently controlled, it is easier to design the experiment; and (5) it is cost effective, the cost of building this system is inexpensive than other type of modulation.
摘要翻译：本发明是二维综合气相色谱的改进。改进是连接两种不同类型的分离柱的双阀开关调制器。本发明的优点是（1）可以通过易于使用的部件构建简单的系统; （2）无需特殊材料（电力除外）操作系统，特别是不需要任何类型的冷却液; （3）可以作为外部添加在单元上的任何GC上构建; （4）第一和第二维柱流独立控制，设计实验更容易; 和（5）它是成本有效的，构建该系统的成本比其他类型的调制便宜。

44. 发明申请

US20070074766A1 System and method for controlling fluid flow 有权
标题翻译：控制流体流动的系统和方法
公开(公告)号：US20070074766A1
公开(公告)日：2007-04-05
申请号：US11240421
申请日：2005-09-30
申请人： Matthew Klee , Michael Thompson , James McCurry , Paul Dryden
发明人： Matthew Klee , Michael Thompson , James McCurry , Paul Dryden
IPC分类号： G05D7/06
CPC分类号： G05D7/0676 , G01N30/32 , G01N30/463 , Y10T137/7761
摘要： A system for controlling fluid flow comprises a first fluid conduit having a length, an inner diameter, an input pressure and an output pressure, and a second fluid conduit having a length, an inner diameter, an input pressure and an output pressure where the output pressure of the first fluid conduit is the input pressure of the second fluid conduit. The system also comprises a pressure sensor configured to determine the output pressure of the first fluid conduit, and a controller configured to control the output pressure of the first fluid conduit, thereby establishing a desired fluid flow through the second fluid conduit based on the length of the second fluid conduit, the inner diameter of the second fluid conduit, the temperature of the second fluid conduit and the type of fluid flowing in the second fluid conduit.
摘要翻译：用于控制流体流动的系统包括具有长度，内径，输入压力和输出压力的第一流体导管和具有长度，内径，输入压力和输出压力的第二流体导管，其中输出第一流体导管的压力是第二流体导管的输入压力。该系统还包括被配置为确定第一流体导管的输出压力的压力传感器，以及被配置为控制第一流体导管的输出压力的控制器，从而基于第一流体导管的长度来建立通过第二流体导管的期望流体流第二流体导管，第二流体导管的内径，第二流体导管的温度和在第二流体导管中流动的流体的类型。

45. 发明申请

US20070042414A1 Retentate chromatography and protein chip arrays with applications in biology and medicine 审中-公开
标题翻译：保留色谱和蛋白质芯片阵列在生物学和医学应用
公开(公告)号：US20070042414A1
公开(公告)日：2007-02-22
申请号：US11509278
申请日：2006-08-23
申请人： T. Hutchens , Tai-Tung Yip
发明人： T. Hutchens , Tai-Tung Yip
IPC分类号： C40B30/06 , C40B40/08 , C40B50/06
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
摘要翻译：本发明提供了用于分析样品中分析物的滞留层析方法。所述方法包括在多种不同的选择性条件下将分析物吸附到底物上，并通过解吸光谱法检测保留在底物上的分析物。这些方法在生物学和医学中是有用的，包括临床诊断和药物发现。

46. 发明申请

US20070039375A1 Multidimensional gas chromatography apparatus and analyte transfer procedure using a multiple-cool strand interface 有权
标题翻译：多维气相色谱仪和使用多重冷链的界面的分析物转移程序
公开(公告)号：US20070039375A1
公开(公告)日：2007-02-22
申请号：US11582919
申请日：2006-10-17
申请人： Alain Chaintreau , Frederic Begnaud
发明人： Alain Chaintreau , Frederic Begnaud
IPC分类号： G01N30/06 , G01N1/40
CPC分类号： G01N30/463 , G01N30/465 , G01N2030/123
摘要： The invention provides a MDGC apparatus that includes a cryotrapping apparatus capable of cooling at least twice a portion of a chemical sample and provided with a detector device disposed upstream of the cryotrap and allowing identification of the portion of the chemical sample to control the residence time of the latter in the cryotrapping apparatus.
摘要翻译：本发明提供了一种MDGC装置，其包括能够冷却至少两次化学样品的至少两倍的微量滴定装置，并且设置有设置在该低温滚筒上游的检测器装置，并允许鉴定化学样品的一部分以控制化学样品的停留时间后者在cryotapping设备中。

47. 发明授权

US07160734B2 Retentate chromatography and protein chip arrays with applications in biology 有权
标题翻译：保留色谱和蛋白质芯片阵列与生物学应用
公开(公告)号：US07160734B2
公开(公告)日：2007-01-09
申请号：US10150587
申请日：2002-05-17
申请人： T. William Hutchens , Tai-Tung Yip
发明人： T. William Hutchens , Tai-Tung Yip
IPC分类号： G01N33/543
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
摘要翻译：本发明提供了用于分析样品中分析物的滞留层析方法。所述方法包括在多种不同的选择性条件下将分析物吸附到底物上，并通过解吸光谱法检测保留在底物上的分析物。这些方法在生物学和医学中是有用的，包括临床诊断和药物发现。

48. 发明申请

US20060266218A1 Device for positioning and holding a length of gas chromatographic column 失效
公开(公告)号：US20060266218A1
公开(公告)日：2006-11-30
申请号：US11435279
申请日：2006-05-17
申请人： Giacinto Zilioli , Daniela Cavagnino , Tiziano Bosaglia
发明人： Giacinto Zilioli , Daniela Cavagnino , Tiziano Bosaglia
IPC分类号： B01D53/02
CPC分类号： G01N30/6047 , G01N30/463 , G01N30/465 , G01N2030/122 , G01N2030/623
摘要： The invention relates to a device for positioning and holding one or more chromatographic column lengths being subjected to one or more jets of fluid to change the temperature, especially in a modulator for GC×GC. The device comprises one or more V-shaped seats in which the column is housed, and pushed within the groove.

49. 发明授权

US07107818B2 Method and device for comprehensive two-dimensional gas chromatography 有权
标题翻译：全面二维气相色谱法的方法和装置
公开(公告)号：US07107818B2
公开(公告)日：2006-09-19
申请号：US10466812
申请日：2003-02-04
申请人： Giacinto Zilioli , Jan Beens
发明人： Giacinto Zilioli , Jan Beens
IPC分类号： G01N30/02 , B01D53/02
CPC分类号： G01N30/463 , G01N30/30 , G01N2030/025 , G01N2030/122 , G01N2030/623
摘要： A method for detecting substances or mixtures of substances within a sample in an apparatus for comprehensive two-dimensional gas-chromatographic analysis according to the present invention, comprising the steps of: subjecting the sample to a first separation within a first capillary column; modulating in time the effluents from the first column by means of the subdivision into adjacent fractions of the effluents from the first column and subsequently sending each fraction into a second capillary column, the modulation of the effluents being periodic with a first modulation frequency f1 of the sample; separating each of the fractions in the aforesaid second capillary column; and detecting, at the end of the second capillary column, the effluents by means of periodic sampling by discrete time points at a second frequency f2. The method moreover envisages the step of generating the first frequency f1 of modulation and the second frequency f2 of sampling in such a way that sampling by discrete points downstream of the second column will be in phase with the modulation of the effluents from the first column.
摘要翻译：一种用于检测根据本发明的用于全面的二维气相色谱分析的装置中的物质或物质混合物的方法，包括以下步骤：使样品在第一毛细管柱内进行第一次分离; 通过将第一列的排出物排入邻近的来自第一列的流出物的馏分，并随后将每个馏分送入第二毛细管柱，调节流出物的第一调制频率f _{1 样品; 分离上述第二毛细管柱中的每个级分; 以及在所述第二毛细管柱的末端，通过在第二频率f 2 2处的离散时间点进行周期性采样来检测所述流出物。该方法还设想以下述方式产生调制的第一频率f 1 1和采样的第二频率f 2 2的步骤，即以第二柱将与来自第一列的流出物的调制同步。}

50. 发明授权

US07041208B2 Microfluidic devices and methods for two-dimensional separations 失效
标题翻译：用于二维分离的微流体装置和方法
公开(公告)号：US07041208B2
公开(公告)日：2006-05-09
申请号：US10317148
申请日：2002-12-11
申请人： Sau Lan Tang Staats
发明人： Sau Lan Tang Staats
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N30/92 , B01L3/502707 , B01L3/502753 , B01L2200/0689 , B01L2200/12 , B01L2300/0822 , B01L2300/0874 , B01L2300/0887 , B01L2400/0421 , B01L2400/0487 , B01L2400/086 , C07K1/24 , C07K1/285 , G01N27/44773 , G01N30/6026 , G01N30/6095 , G01N30/90 , G01N30/463
摘要： A microfluidic device includes first and second substrates and a microfluidic cavity formed in one of the first and second substrates. The microfluidic cavity has a width (W) and a depth (D), wherein the other of the first and second substrates encloses the microfluidic cavity and a width (W) to depth (D) ratio is at least 100 with the depth (D) being from about 10 μm to about 150 μm. The device also includes a plurality of ports formed in the other of the first and second substrates to permit access to the microfluidic cavity and a third substrate disposed on the second substrate and including microchannels formed therein. The microchannels are formed so that a plurality of ports formed in the second substrate for sample selection and sample output communicate therewith.
摘要翻译：微流体装置包括第一和第二基底和形成在第一和第二基底之一中的微流体腔。微流体空腔具有宽度（W）和深度（D），其中第一和第二基板中的另一个包围微流体空腔，宽度（W）至深度（D）的比率至少为100，深度（D ）为约10um至约150mum。该装置还包括形成在第一和第二基板中的另一个中的多个端口，以允许访问微流体空腔，以及设置在第二基板上并包括形成在其中的微通道的第三基板。微通道形成为使得形成在第二基板中的用于样品选择和样品输出的多个端口与其通信。

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