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41. 发明申请

US20110217754A1 KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (R)-3-HYDROXYTHIOLANE 有权
标题翻译：用于生产（R）-3-羟基甲硅烷氧基的酮交酯聚合物
公开(公告)号：US20110217754A1
公开(公告)日：2011-09-08
申请号：US13110789
申请日：2011-05-18
申请人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Rama Voladri , James LaLonde , Gjalt W. Huisman
发明人： Jack Liang , Stephane J. Jenne , Emily Mundorff , Rama Voladri , James LaLonde , Gjalt W. Huisman
IPC分类号： C12N9/02 , C12N15/53 , C12N15/63 , C12N1/21
CPC分类号： C12P17/00 , C12N9/0006 , C12P17/167 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成手性化合物的方法。

42. 发明申请

US20100248227A1 DRUG-PHOSPHORYLATING ENZYME 有权
标题翻译：药物 - 磷酸酶
公开(公告)号：US20100248227A1
公开(公告)日：2010-09-30
申请号：US12376434
申请日：2007-08-03
申请人： Futoshi Nara , Kiyoaki Yonesu , Kazuishi Kubota
发明人： Futoshi Nara , Kiyoaki Yonesu , Kazuishi Kubota
IPC分类号： C12Q1/68 , G01N33/573 , C12P7/62
CPC分类号： C12Q1/485 , C12N9/1205 , C12P17/00 , G01N2500/00
摘要： The objects of the present invention are: elucidation of an enzyme that phosphorylates in vivo a compound such as (2R)-2-amino-2-methyl-4-[5-(5-phenylpentanoyl)thiophen-2-yl]butan-1-ol and provision of a method of phosphorylating the aforementioned compound; provision of a method of screening for a substance phosphorylated by the aforementioned enzyme; provision of a method of determining the ability of a subject to phosphorylate a test compound.Provision of a method of phosphorylating the aforementioned compound using a human fructosamine-3-kinase-related protein and/or fructosamine-3-kinase, and a method of determining the ability of a subject to phosphorylate a test compound.
摘要翻译：本发明的目的是：阐明在体内磷酸化化合物如（2R）-2-氨基-2-甲基-4- [5-（5-苯基戊酰基）噻吩-2-基]丁-1-醇的化合物的酶，提供磷酸化上述化合物的方法; 提供筛选由上述酶磷酸化的物质的方法; 提供确定受试者磷酸化测试化合物的能力的方法。提供使用人果糖胺-3-激酶相关蛋白和/或果糖胺-3-激酶磷酸化上述化合物的方法，以及确定受试者磷酸化试验化合物的能力的方法。

43. 发明申请

US20100173369A1 KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE 有权
标题翻译：用于制备3-亚氨基-3-羟基丙酰胺的3-氨基-3-羟基丙酰胺的高聚糖多糖
公开(公告)号：US20100173369A1
公开(公告)日：2010-07-08
申请号：US12549293
申请日：2009-08-27
申请人： Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
发明人： Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
IPC分类号： C12P13/00 , C12N9/04 , C07H21/04 , C12N15/63 , C12N1/21
CPC分类号： C12P17/00 , C12N9/0006 , C12P13/001 , C12Y101/01164 , C12Y101/01184
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。优化工程化的酮还原酶多肽，用于催化N-甲基-3-酮-3-（2-噻吩基）-1-丙胺向（S）-N-甲基-3-羟基-3-（2-噻吩基） -1-丙胺。

44. 发明申请

US20100151534A1 KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE 有权
标题翻译：用于生产3-亚氨基-3-羟基丙酰胺的3-氨基-3-羟基丙酰胺的热解聚醚多糖
公开(公告)号：US20100151534A1
公开(公告)日：2010-06-17
申请号：US12549154
申请日：2009-08-27
申请人： Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
发明人： Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
IPC分类号： C12N9/02 , C12N15/53 , C12N15/70 , C12N1/21 , C12P13/00
CPC分类号： C12N9/0006 , C12P13/001 , C12P17/00 , C12P41/002
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N,N-dimethyl-3-keto-3-(2-thienyl)-1-ketopropanamine to (S)—N,N-dimethyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
摘要翻译：本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。优化了工程化酮还原酶多肽，用于催化N，N-二甲基-3-酮-3-（2-噻吩基）-1-酮基丙胺转化为（S）-N，N-二甲基-3-羟基-3-（ 2-噻吩基）-1-丙胺。

45. 发明申请

US20090328258A1 Radiosynthesis as an Alternative Energy Utilization Process in Melanized Organisms and Uses Thereof 有权
标题翻译：作为替代能源利用过程的放射合成在黑色生物及其用途
公开(公告)号：US20090328258A1
公开(公告)日：2009-12-31
申请号：US12225990
申请日：2007-04-02
申请人： Ekaterina Dadachova , Ruth Bryan , Arturo Casadevall
发明人： Ekaterina Dadachova , Ruth Bryan , Arturo Casadevall
IPC分类号： A01H5/00 , A62D3/02 , C12N1/20 , C12N1/14 , C12N13/00 , C07D417/14
CPC分类号： C12N13/00 , C12P17/00
摘要： This present invention provides methods of enhancing the growth of a microorganism or plant by increasing its melanin content and exposing it to radiation, and methods of using melanized microorganisms to contain or exclude radiation.
摘要翻译：本发明提供通过增加其黑色素含量并将其暴露于辐射来增强微生物或植物的生长的方法，以及使用黑化微生物来包含或排除辐射的方法。

46. 发明授权

US07323573B2 Production of polyketides 有权
标题翻译：聚酮化合物的生产
公开(公告)号：US07323573B2
公开(公告)日：2008-01-29
申请号：US11200525
申请日：2005-08-08
申请人： Robert L. Arslanian
发明人： Robert L. Arslanian
IPC分类号： C07D277/30
CPC分类号： C07D405/06 , C07D313/00 , C07D413/06 , C07D417/06 , C07D491/04 , C12N1/20 , C12N9/00 , C12N15/52 , C12N15/74 , C12P17/00 , C12P17/16 , C12P17/167 , C12P17/181 , C12R1/01
摘要： Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.
摘要翻译：重组粘球菌宿主细胞可用于产生聚酮化合物，包括可从发酵液中纯化并结晶的埃坡霉素和埃坡霉素类似物。

47. 发明申请

US20040248118A1 Method for producing l-amino acids 审中-公开
标题翻译： 1-氨基酸的生产方法
公开(公告)号：US20040248118A1
公开(公告)日：2004-12-09
申请号：US10481793
申请日：2003-12-23
发明人： Hirobumi Aoki , Harumi Kamachi
IPC分类号： C12Q001/68 , C12P013/22
CPC分类号： C12P13/04 , C12P13/222 , C12P13/225 , C12P13/227 , C12P17/00
摘要： A method for producing an optically active amino acid, which comprises adding ammonia to an acrylic acid derivative by action of a plant enzyme and obtaining the corresponding optically active amino acid. The method for producing an L-amino acid, which comprises, in the presence of ammonia, allowing phenylalanine ammonia-lyase derived from a plant to act on an acrylic acid derivative, which may have an aromatic ring group that may have various substituents and comprise a hetero atom.
摘要翻译：一种光学活性氨基酸的制造方法，其包括通过植物酶的作用将氨加入到丙烯酸衍生物中，得到相应的光学活性氨基酸。 L-氨基酸的制备方法，其包括在氨存在下使来自植物的苯丙氨酸氨裂解酶作用于丙烯酸衍生物上，所述丙烯酸衍生物可具有可具有各种取代基的芳族环基团并且包含杂原子。

48. 发明申请

US20040086983A1 Method for producing a heterocyclic compound and an aromatic carboxylic acid having one or more hydroxyl groups, and modified aromatic ring dioxygenase 审中-公开
标题翻译：具有一个以上羟基的杂环化合物和芳香族羧酸的制造方法以及改性芳香环双加氧酶
公开(公告)号：US20040086983A1
公开(公告)日：2004-05-06
申请号：US09950822
申请日：2001-09-13
发明人： Norihiko Misawa , Kazutoshi Shindo , Hiroshi Okazaki , Kensuke Furukawa , Sueharu Horinouchi
IPC分类号： C12P017/10 , C12P017/12
CPC分类号： C12N9/0069 , C12P7/22 , C12P17/00
摘要： An objective of the present invention is to provide a method of producing hydroxylated heterocyclic compounds and hydroxylated aromatic carboxylic acids by bioengineering technique, and modified enzymes which can be used for this method. A method of producing hydroxylated heterocyclic compounds or hydroxylated aromatic carboxylic acids comprises reacting an aromatic ring dioxygenase with heterocyclic compounds or aromatic carboxylic acids to hydroxylate these compounds. An enzyme according to the present invention is an aromatic ring dioxygenase comprising an null-subunit consisting of the amino acid sequence of SEQ ID NO: 2, which is modified according to the null-subunit of the biphenyl dioxygenase derived from the strain Burkholderia cepacia LB400, a null-subunit consisting of the amino acid sequence of SEQ ID NO: 4, and a ferredoxin consisting of the amino acid sequence of SEQ ID NO: 6, and a ferredoxin reductase consisting of the amino acid sequence of SEQ ID NO: 8.
摘要翻译：本发明的目的是提供通过生物工程技术生产羟基化杂环化合物和羟基化芳族羧酸的方法，以及可用于该方法的改性酶。生成羟基化杂环化合物或羟基化芳族羧酸的方法包括使芳环双加氧酶与杂环化合物或芳族羧酸反应，使这些化合物羟化。根据本发明的酶是包含由SEQ ID NO：2的氨基酸序列组成的α-亚基的芳环双加氧酶，其根据源自洋葱伯克霍尔德菌LB400的联苯双加氧酶的α-亚基进行修饰，由SEQ ID NO：4的氨基酸序列组成的β亚基和由SEQ ID NO：6的氨基酸序列组成的铁氧还蛋白，以及由SEQ ID NO：8的氨基酸序列组成的铁氧还蛋白还原酶。

49. 发明授权

US06723745B2 Amino alcohol derivatives 失效
标题翻译：氨基醇衍生物
公开(公告)号：US06723745B2
公开(公告)日：2004-04-20
申请号：US10337702
申请日：2003-01-07
申请人： Takahide Nishi , Toshiyasu Takemoto , Takaichi Shimozato , Futoshi Nara
发明人： Takahide Nishi , Toshiyasu Takemoto , Takaichi Shimozato , Futoshi Nara
IPC分类号： A61K3138
CPC分类号： C12P13/001 , A61K31/381 , C07C271/16 , C07D333/20 , C07D333/22 , C07D333/32 , C07F7/1804 , C12P13/002 , C12P13/008 , C12P13/02 , C12P17/00 , Y02P20/55
摘要： Compounds of formula (I) which exhibit excellent immune suppression activity, pharmacologically acceptable salts thereof esters thereof or other derivatives: wherein R1 and R2 are a hydrogen atom, an amino protecting group; R3 is a hydrogen atom, a hydroxy protecting group; R4 is a lower alkyl group; n is an integer from 1 to 6; X is an ethylene group; Y is a C1-C10 alkylene group, a C1-C10 aklene group substituted with 1 to 3 substituents selected from substituent group a and b; R5 is an aryl group; R6 and R7 are a hydrogen atom, a group selected from substituent group a; with the proviso when R5 is a hydrogen atom, Y is not a single bond or a straight chain C1-C10 akylene group.
摘要翻译：表现出优异的免疫抑制活性的式（I）化合物，其药理学上可接受的盐或其衍生物：其中R 1和R 2为氢原子，氨基保护基; R 3是氢原子，羟基保护基; R 4是低级烷基; n是1至6的整数; X是亚乙基; Y是C1-C10亚烷基，被1〜3个选自取代基组a和b的取代基取代的C1-C10亚烷基; R 5是芳基; R 6和R 7是氢原子，选自取代基a的基团; 条件是当R 5为氢原子时，Y不是单键或直链C1-C10亚烷基。

50. 发明申请

US20030073205A1 Production of polyketides 有权
标题翻译：聚酮化合物的生产
公开(公告)号：US20030073205A1
公开(公告)日：2003-04-17
申请号：US09957483
申请日：2001-09-19
发明人： Robert L. Arslanian , Gary Ashley , Scott Frykman , Bryan Julien , Leonard Katz , Chaitan Khosla , Janice Lau , Peter J. Licari , Rika Regentin , Daniel Santi , Li Tang
IPC分类号： C12P017/00 , C12P017/02 , C07D417/02 , C07D47/02
CPC分类号： C07D405/06 , C07D313/00 , C07D413/06 , C07D417/06 , C07D491/04 , C12N1/20 , C12N9/00 , C12N15/52 , C12N15/74 , C12P17/00 , C12P17/16 , C12P17/167 , C12P17/181 , C12R1/01
摘要： Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.
摘要翻译：重组粘球菌宿主细胞可用于产生聚酮化合物，包括可从发酵液中纯化并结晶的埃坡霉素和埃坡霉素类似物。

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