专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

US20040096463A1 Novel vaccine 审中-公开
标题翻译：新型疫苗
公开(公告)号：US20040096463A1
公开(公告)日：2004-05-20
申请号：US10469087
申请日：2004-01-07
发明人： Nathalie Garcon , Moncef Mohamed Slaoui , Christian Van Hoecke
IPC分类号： A61K039/145
CPC分类号： A61K39/145 , A61K9/0021 , A61K2039/54 , C12N7/00 , C12N2760/16134 , C12N2760/16163
摘要： The invention relates to the use of an influenza antigen preparation obtainable by the following process, in the manufacture of an intradermal flu vaccine: (i) harvesting of virus-containing material from a culture; (ii) clarification of the harvested material to remove non-virus material; (iii) concentration of the harvested virus; (iv) a further step to separate whole virus from non-virus material; (v) splitting of the whole virus using a suitable splitting agent for instance a detergent such as sodim deoxycholate in a density gradient centrifugation step; (vi) filtration to remove undesired materials; wherein the steps are performed in that outer but not necessarily consecutively.
摘要翻译：本发明涉及通过以下方法可获得的流感抗原制备物在制造皮内流感疫苗中的用途：（i）从培养物中收获含病毒材料; （ii）澄清收获的材料以清除非病毒材料; （iii）收获的病毒的浓度; （iv）将全病毒与非病毒材料分离的进一步步骤; （v）在密度梯度离心步骤中使用合适的分裂剂例如洗涤剂如Sodim脱氧胆酸酯裂解整个病毒; （vi）过滤以除去不想要的物质; 其中所述步骤以外部但不一定连续地执行。

42. 发明授权

US6093564A Methods and compositions for the selective modification of nucleic acids 失效
标题翻译：用于选择性修饰核酸的方法和组合物
公开(公告)号：US6093564A
公开(公告)日：2000-07-25
申请号：US5606
申请日：1998-01-12
申请人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
IPC分类号： C12N7/04 , A61K31/396 , A61K38/00 , A61K39/00 , A61K39/12 , A61L2/00 , A61P31/00 , A61P31/12 , A61P43/00 , C07D203/02 , C07D203/12 , C12N7/06 , C12N7/00
CPC分类号： C12N7/00 , A61L2/0082 , A61L2/0088 , C12N2740/16063 , C12N2760/16163 , C12N2760/20263 , C12N2770/32363 , C12N2770/32463 , C12N2795/10163
摘要： Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: ##STR1## where each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, and R.sub.8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, and R.sub.8 cannot all be H; R.sub.5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 1 and 10, inclusive are disclosed.
摘要翻译：用于选择性修饰生物组合物中核酸分子的方法和组合物，包括使组合物与具有下式的灭活剂接触：其中R1，R2，R3，R4，R6，R7和R8各自独立地为H或单价含有1至4个碳原子的烃部分（包括端值），条件是R1，R2，R3，R4，R6，R7和R8不能全部为H; R5是含有2至4个碳原子的二价烃部分，包括端值; X是药学上可接受的抗衡离子; n为1〜10的整数，包括端值。

43. 发明授权

US06048537A Method for preparing an influenza virus, antigens obtained and applications thereof 失效
标题翻译：制备流感病毒的方法，获得的抗原及其应用
公开(公告)号：US06048537A
公开(公告)日：2000-04-11
申请号：US793373
申请日：1997-05-27
申请人： Jean Michel Violay , Guy Court , Catherine Gerdil , Herve Chalumeau , Patric McVerry
发明人： Jean Michel Violay , Guy Court , Catherine Gerdil , Herve Chalumeau , Patric McVerry
IPC分类号： C12N7/00 , A61K39/145 , A61K49/00 , A61P31/16 , C12N7/06 , A61K35/145 , C12N7/02
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K2039/5252 , C12N2760/16134 , C12N2760/16163
摘要： Method for preparing purified influenza antigens from a fluid containing influenza virus, comprising the steps of concentration, purification, fragmentation and, where appropriate, inactivation, characterized in that:A. either the purification step entails several ultracentrifugation steps separated by a filtration step,B. or the fragmentation step is performed on the live virus in the presence of an amphiphilic nonionic detergent, followed by a removal of undesirable substances by filtration, retaining all of the viral constituents,or these two steps are carried out in any order.
摘要翻译： PCT No.PCT / FR95 / 00727 Sec。 371日期：1997年5月27日 102（e）日期1997年5月27日PCT提交1995年6月6日PCT公布。出版物WO96 / 05294 日本1996年2月22日从含有流感病毒的流体制备纯化流感抗原的方法，包括浓缩，纯化，断裂和适当的灭活步骤，其特征在于：A.纯化步骤需要几个超速离心步骤，过滤步骤B.或在两亲性非离子洗涤剂存在下对活病毒进行断裂步骤，然后通过过滤除去不期望的物质，保留所有病毒成分，或者这两个步骤在任何订单。

44. 发明授权

US3847737A Inactivation of myxoviruses and method of preparing a vaccine therefrom 失效
标题翻译： MYXOVIRUSES灭活及其制备方法
公开(公告)号：US3847737A
公开(公告)日：1974-11-12
申请号：US73600668
申请日：1968-06-11
申请人： KANAREK A
发明人： KANAREK A
IPC分类号： A61K39/12 , A61K39/145 , A61K39/165 , C12K7/00 , C12K5/00
CPC分类号： A61K39/165 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/55505 , C12N7/00 , C12N2760/16163 , C12N2760/16263 , C12N2760/18434 , C12N2760/18463 , C12N2760/18863
摘要： A method for inactivating myxoviruses without significant loss of antigenic activity, which comprises contacting the myxoviruses in an aqueous suspension at a pH between 6 and 8 in the presence of at least about 0.05 percent w/v of a surface active agent selected from the class of polyoxyethylene ester of partial oleic acid, polyoxyethylene ester of lauric acid, polyoxyethylene ester of palmitic acid, and polyoxyethylene ester of stearic acid, with an organic solvent selected from the class consisting of chlorinated lower hydrocarbon having from 2 to 5 carbon atoms and chlorinated and fluorinated lower hydrocarbon having from 2 to 5 carbon atoms, the solvent being liquid at room temperature.
摘要翻译：一种用于灭活粘液病毒而不显着损失抗原活性的方法，其包括在至少约0.05％w / v的表面活性剂存在下，使pH6-6之间的粘液病毒接触粘液病毒，所述表面活性剂选自部分油酸的聚氧乙烯酯，月桂酸的聚氧乙烯酯，棕榈酸的聚氧乙烯酯和硬脂酸的聚氧乙烯酯与选自具有2至5个碳原子的氯化低级烃和氯化和氟化的有机溶剂具有2至5个碳原子的低级烃，溶剂在室温下为液体。

45. 发明授权

US3436461A Use of alkylguanidine salts as virucides 失效
标题翻译：使用阿奇霉素盐作为毒素
公开(公告)号：US3436461A
公开(公告)日：1969-04-01
申请号：US3436461D
申请日：1968-01-17
申请人： AMERICAN CYANAMID CO
发明人： SCOTTI FRANK
IPC分类号： C07C279/04 , C12N7/06 , A61K27/00
CPC分类号： C12N7/00 , C07C279/04 , C12N2760/16163

46. 发明授权

US11844832B2 Inorganic polyatomic oxyanions for protecting against antigenic damage during pathogen inactivation for vaccine production 有权
公开(公告)号：US11844832B2
公开(公告)日：2023-12-19
申请号：US16994500
申请日：2020-08-14
申请人： Najít Technologies, Inc.
发明人： Ian J. Amanna , Elizabeth A. Poore
IPC分类号： A61K39/12 , C12N7/00 , A61P31/14 , A61K39/145 , A61K39/02 , A61K33/40 , A61P31/16 , A61K39/112 , A61K39/275 , A61K39/00
CPC分类号： A61K39/145 , A61K33/40 , A61K39/02 , A61K39/0283 , A61K39/105 , A61K39/12 , A61K39/275 , A61P31/14 , A61P31/16 , C12N7/00 , A61K2039/521 , A61K2039/5252 , C12N2760/16131 , C12N2760/16134 , C12N2760/16163 , C12N2760/16171 , C12N2770/24134 , C12N2770/24163 , C12N2770/24171 , C12N2770/36134 , C12N2770/36163 , C12N2770/36171 , Y02A50/30
摘要： Provided are methods for rapidly inactivating a pathogen, or for producing a vaccine composition containing an inactivated noninfectious pathogen having retained antigenicity and/or immunogenicity, comprising exposing the pathogen to a chemical inactivating agent (e.g., one or more chemical oxidizing, alkylating or crosslinking agents) in the presence of inorganic polyatomic oxyanions in an amount and for a time sufficient to render the pathogen noninfectious while enhancing retention of pathogen antigenicity and/or immunogenicity relative to that retained by contacting the pathogen with the chemical inactivating agent alone. The methods are broadly applicable to pathogens having RNA or DNA genomes (e.g., including viruses, bacteria, fungi, and parasites). Also provided are vaccine compositions (medicaments) containing a pathogen inactivated by exposure to an inactivating agent in the presence of elevated concentrations of inorganic polyatomic oxyanions, and methods for eliciting an immune response in a subject by administering the vaccine compositions.

47. 发明公开

US20230175017A1 RECOMBINANT HVT VECTORS EXPRESSING MULTIPLE ANTIGENS OF AVIAN PATHOGENS AND USES THEREOF 审中-公开
公开(公告)号：US20230175017A1
公开(公告)日：2023-06-08
申请号：US17812732
申请日：2022-07-15
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH
发明人： Michel Bublot , Teshome Mebatsion , Joyce Pritchard , Perry Linz , Aemro Kassa
IPC分类号： C12N15/869 , A61K39/12 , A61K39/155 , A61K39/245 , A61K39/295 , C07K14/03 , C07K14/08 , C12N7/00
CPC分类号： C12N15/869 , A61K39/12 , A61K39/155 , A61K39/245 , A61K39/295 , C07K14/03 , C07K14/08 , C12N7/00 , C12N2760/16163 , C12N2710/16363 , C12N2760/18163 , C12N2710/16334 , C12N2710/16343 , C12N2720/10034 , C12N2760/18134 , C12N2830/20 , C12N2830/50 , C12N2840/203 , C12N2710/16311
摘要： The invention relates to a bonding and forming device for an inner box of a paper box and surface paper. The bonding and forming device comprises a stand, a lifting platform, a paper box inner support member, a flanging pressing plate, an ejector pin, a left hairbrush, a right hairbrush, a first pushing part, a front hairbrush, a rear hairbrush and a second pushing part and also comprises a driving device, a first control device a second control device, a third control device, a fourth control device and a fifth control device, wherein the driving device is used for driving the ejector pin to rise or fall; the first control device is used for controlling the paper box inner support member to rise or fall; the second control device is used for controlling the left hairbrush and the right hairbrush to stretch; the third control device is used for controlling the first pushing part to stretch; the fourth control device is used for controlling the front hairbrush and the rear hairbrush to stretch; the fifth control device is used for controlling the second pushing part to stretch; an inhibiting device is arranged between the first control device and the driving device; and the paper box inner support member and the flanging pressing plate are respectively provided with a through hole for the ejector pin to pass through. By adopting the technical scheme, according to the bonding and forming device for the inner box of the paper box and the surface paper, provided by the invention, the inner box and other surfaces of the surface paper can be automatically bonded to be formed after a bottom plate of the inner box and the bottom surface of the surface paper are bonded. The degree of automation is high and the production efficiency is high.

48. 发明申请

US20180245053A1 VIRAL VACCINES AND METHODS OF FORMING THE SAME 审中-公开
公开(公告)号：US20180245053A1
公开(公告)日：2018-08-30
申请号：US15906685
申请日：2018-02-27
申请人： NDSU Research Foundation
发明人： Sheela RAMAMOORTHY
IPC分类号： C12N7/00 , A61K39/145 , A61K39/215
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K39/215 , A61K2039/5252 , A61K2039/543 , A61P31/14 , A61P31/16 , C12N2760/16134 , C12N2760/16163 , C12N2770/20034 , C12N2770/20063 , C12N2770/24134
摘要： Provided herein is a method for producing an inactivated virus including a) heating the virus to a temperature sufficient to disrupt the virus membrane; b) exposing the virus of step (a) to an RNA degrading enzyme; and c) cooling the virus to a temperature sufficient to reestablish the integrity of the virus membrane. Also provided herein is a vaccine produced using the instant method.

49. 发明申请

US20180086694A1 DISINFECTING COMPOSITIONS HAVING IMPROVED ANTIMICROBIAL EFFICACY 审中-公开
公开(公告)号：US20180086694A1
公开(公告)日：2018-03-29
申请号：US15712666
申请日：2017-09-22
申请人： Michael Lisle Howell , Zsolt Istvan Hertelendy , Joseph Paul Thomas
发明人： Michael Lisle Howell , Zsolt Istvan Hertelendy , Joseph Paul Thomas
IPC分类号： C07C229/16 , A61K31/132 , A61K31/045 , A01N31/08 , A61L2/00
CPC分类号： C07C229/16 , A01N27/00 , A01N31/08 , A01N31/16 , A61K31/045 , A61K31/047 , A61K31/05 , A61K31/132 , A61K31/198 , A61L2/0088 , A61L2/18 , C12N1/20 , C12N2760/16163 , Y02A50/473 , Y02A50/481 , A01N25/30 , A01N31/02 , A01N37/44 , A61K2300/00
摘要： Disinfecting compositions effective against multiple bacterial, fungal or viral organisms are described herein. Personal or consumer care products as well as clinical disinfectant products including the disinfecting compositions are also described.

50. 发明申请

US20180050058A1 NUCLEIC ACID APTAMER SPECIFICALLY BINDING TO AVIAN INFLUENZA VIRUS SUBTYPE H5 AND METHOD OF DETECTING AVIAN IFLUENZA VIRUS SUBTYPE H5 USING THE SAME 审中-公开
公开(公告)号：US20180050058A1
公开(公告)日：2018-02-22
申请号：US15679610
申请日：2017-08-17
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人： Byoung-Chan KIM , Sang-Kyung KIM , Seok LEE , Chang-Seon SONG , Sang-Won LEE , Un-Jung Kim
IPC分类号： A61K31/7088 , C12N15/115
CPC分类号： A61K31/7088 , C07K14/005 , C12N15/115 , C12N2310/16 , C12N2310/3517 , C12N2760/10162 , C12N2760/16163
摘要： This invention relates to a nucleic acid aptamer specifically binding to avian influenza virus subtype H5 and a method of detecting avian influenza virus subtype H5 using the same, and more particularly to a method of detecting avian influenza virus subtype H5, which is able to rapidly check the presence and concentration of avian influenza virus subtype H5 using a nucleic acid aptamer specifically binding to hemagglutinin, which is a surface protein of avian influenza virus subtype H5.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式