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41. 发明申请

US20060111311A1 5-nitro-nucleoside compounds for treating viral infections 失效
标题翻译：用于治疗病毒感染的5-硝基 - 核苷化合物
公开(公告)号：US20060111311A1
公开(公告)日：2006-05-25
申请号：US11280984
申请日：2005-11-15
申请人： Jesse Keicher , Christopher Roberts , Natalia Dyatkina
发明人： Jesse Keicher , Christopher Roberts , Natalia Dyatkina
IPC分类号： A61K31/7076 , C07H19/22
CPC分类号： A61K31/7076 , A61K38/21 , C07H19/14 , C07H19/22 , A61K2300/00
摘要： Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.
摘要翻译：公开了用于治疗由黄病毒科家族病毒（例如丙型肝炎病毒）引起的病毒感染的化合物，组合物和方法。

42. 发明申请

US20050215511A1 Nucleoside compounds for treating viral infections 失效
公开(公告)号：US20050215511A1
公开(公告)日：2005-09-29
申请号：US10971477
申请日：2004-10-21
申请人： Christopher Roberts , Jesse Keicher , Natalia Dyatkina
发明人： Christopher Roberts , Jesse Keicher , Natalia Dyatkina
IPC分类号： C07H19/14 , A61K31/7076 , C07H19/22
CPC分类号： C07H19/14 , A61K31/7076
摘要： Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.

43. 发明授权

US06855500B2 Fluorescence-based genotyping 失效
标题翻译：基于荧光的基因分型
公开(公告)号：US06855500B2
公开(公告)日：2005-02-15
申请号：US10107748
申请日：2002-03-26
申请人： Jia Liu Wolfe , Tomohiko Kawate , Charles R. Allerson , Vincent P. Stanton, Jr.
发明人： Jia Liu Wolfe , Tomohiko Kawate , Charles R. Allerson , Vincent P. Stanton, Jr.
IPC分类号： C07H19/10 , C07H19/14 , C07H19/20 , C07H21/00 , C12N9/12 , C12N15/11 , C12P19/34 , C12Q1/68
CPC分类号： C07H19/10 , C07H19/14 , C07H19/20 , C07H21/00 , C12N9/1252 , C12N15/11 , C12P19/34 , C12Q1/6827 , C12Q1/6872 , C12Q2565/627 , C12Q2525/101 , C12Q2523/107
摘要： The present invention relates to a method for genotyping a diploid organism to detect single nucleotide polymorphisms (SNPs) using modified nucleotides or nucleotide residues substituted with fluorescent groups.
摘要翻译：本发明涉及使用修饰的核苷酸或被荧光基团取代的核苷酸残基来检测二核生物体以检测单核苷酸多态性（SNP）的方法。

44. 发明授权

US06653462B2 Nucleotide compounds including a rigid linker 有权
标题翻译：包括刚性接头的核苷酸化合物
公开(公告)号：US06653462B2
公开(公告)日：2003-11-25
申请号：US10085561
申请日：2002-02-26
申请人： Shaheer H. Khan , Barnett B. Rosenblum , Weiguo Zhen , Steven M. Menchen
发明人： Shaheer H. Khan , Barnett B. Rosenblum , Weiguo Zhen , Steven M. Menchen
IPC分类号： C07H2100
CPC分类号： C07H21/00 , C07H19/04 , C07H19/06 , C07H19/14 , C07H19/16 , C07H19/20 , C12Q1/6869 , C12Q2525/186 , C12Q2525/117 , C12Q2525/113
摘要： A nucleoside/tide compound having the structure: NUC-L-S-LB/LG is described wherein NUC is a nucleoside/tide having a nucleobase portion B, L is a rigid linkage, S is a spacer; and LB/LG is a member of a linkage pair or a label. NUC is attached to L through B such that when B is a purine, L is attached to the 8-position of the purine, when B is 7-deazapurine, L is attached to the 7-position of the 7-deazapurine, and when B is pyrimidine, L is attached to the 5-position of the pyrimidine. In an important aspect of the invention, L has the structure: wherein each of n, o and p are integers ranging from 0 to 3, and the sum of n, o and p is at least 2, and each of W, X, Y and Z is selected from the group consisting of carbon and nitrogen. The invention further includes polynucleotide compounds comprising the nucleoside/tide, and primer extension methods utilizing the nucleoside/tide, particularly when used in combination with certain mutant polymerase enzymes.
摘要翻译：描述了具有以下结构的核苷/潮汐化合物：其中NUC是具有核碱基部分B的核苷/潮汐，L是刚性键，S是间隔基; 而LB / LG是连锁对或标签的成员。 N与B连接，B为嘌呤时，L为嘌呤8位时，B为7-脱氮嘌呤时，L为7-脱氮嘌呤的7-位， B是嘧啶，L连接到嘧啶的5位上。在本发明的一个重要方面，L具有以下结构：其中n，o和p各自为0至3的整数，n，o和p之和至少为2，W，X， Y和Z选自碳和氮。本发明还包括包含核苷/潮汐的多核苷酸化合物，以及利用核苷/潮汐的引物延伸方法，特别是当与某些突变型聚合酶组合使用时。

45. 发明授权

US06582923B2 Method for analyzing polynucleotides 有权
标题翻译：多核苷酸分析方法
公开(公告)号：US06582923B2
公开(公告)日：2003-06-24
申请号：US10104818
申请日：2002-03-22
申请人： Vincent P. Stanton, Jr. , Jia Liu Wolfe , Tomohiko Kawate , Gregory L. Verdine
发明人： Vincent P. Stanton, Jr. , Jia Liu Wolfe , Tomohiko Kawate , Gregory L. Verdine
IPC分类号： C12Q168
CPC分类号： C07H19/10 , C07H19/14 , C07H19/20 , C07H21/00 , C12N9/1252 , C12N15/11 , C12P19/34 , C12Q1/6827 , C12Q1/6872 , C12Q2565/627 , C12Q2525/101 , C12Q2523/107
摘要： The present invention relates to a method of synthesizing a polynucleotide with incorporation of a modified nucleotide.
摘要翻译：本发明涉及合成多核苷酸并掺入经修饰的核苷酸的方法。

46. 发明授权

US06500650B1 Method for identifying polymorphisms 有权
标题翻译：识别多态性的方法
公开(公告)号：US06500650B1
公开(公告)日：2002-12-31
申请号：US09655104
申请日：2000-09-05
申请人： Vince P. Stanton, Jr. , Jia Liu Wolfe , Tomohiko Kawate , Gregory L. Verdine , Jeffrey Olson
发明人： Vince P. Stanton, Jr. , Jia Liu Wolfe , Tomohiko Kawate , Gregory L. Verdine , Jeffrey Olson
IPC分类号： C12Q168
CPC分类号： C12Q1/6858 , C07H19/10 , C07H19/14 , C07H19/20 , C07H21/00 , C12N9/1252 , C12N15/11 , C12P19/34 , C12Q1/6827 , C12Q1/683 , C12Q1/6872 , C12Q2525/117 , C12Q2523/107 , C12Q2527/107 , C12Q2565/627 , C12Q2525/101
摘要： The present invention relates to methods for the detection of polymorphism in polynucleotides by using hybridization of fragments of segments of a polynucleotide suspected of containing a polymorphism with an oligonucleotide having a sequence complementary to a fragment identifying the polymorphism and subsequent detection of incorporated labels in the oligonucleotide-fragment duplex.
摘要翻译：本发明涉及通过使用疑似含有多态性的多核苷酸的片段的片段与具有与鉴定多态性的片段互补的序列的寡核苷酸杂交并随后检测寡核苷酸中的并入标记的方法来检测多核苷酸中的多态性的方法碎片双工。

47. 发明授权

US06495677B1 Nucleoside compounds 有权
标题翻译：核苷化合物
公开(公告)号：US06495677B1
公开(公告)日：2002-12-17
申请号：US09594410
申请日：2000-06-16
申请人： Kanda S. Ramasamy , Guangyi Wang , Johnson Lau
发明人： Kanda S. Ramasamy , Guangyi Wang , Johnson Lau
IPC分类号： C07H1904
CPC分类号： C07H19/14 , A61K31/70 , C07H19/052 , C07H19/056
摘要： Nucleosides, novel nucleoside analog compounds and their novel prodrug forms are disclosed. The novel compounds, prodrugs, or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat an infection, an infestation, a neoplasm, or an autoimmune disease. The novel compounds may also be used to modulate aspects of the immune system, including modulation of Type 1 and Type 2 activity.
摘要翻译：公开了核苷，新型核苷类似物化合物及其新型前体药物形式。其新颖化合物，前体药物或其药学上可接受的酯或盐可用于药物组合物中，并且此类组合物可用于治疗感染，感染，肿瘤或自身免疫性疾病。新化合物也可用于调节免疫系统的方面，包括调节1型和2型活性。

48. 发明授权

US06479651B1 Modified oligonucleotides, their preparation and their use 有权
标题翻译：修饰的寡核苷酸，其制备及其用途
公开(公告)号：US06479651B1
公开(公告)日：2002-11-12
申请号：US09643233
申请日：2000-08-22
申请人： Frank Seela , Horst Thomas
发明人： Frank Seela , Horst Thomas
IPC分类号： C12Q168
CPC分类号： C07H19/10 , C07H19/044 , C07H19/14 , C07H21/00
摘要： Modified oligonucleotides which possess at least one substituted 7-deazapurine base form more stable hybridization complexes with nucleic acids than unsubstituted analogs. They are useful as inhibitors of gene expression, as probes for detecting nucleic acids, as aids in molecular biology and as pharmaceuticals or diagnostic agents. Processes for preparing them are provided.
摘要翻译：具有至少一个取代的7-脱氮嘌呤碱基的修饰的寡核苷酸与核酸形成比未取代的类似物更稳定的杂交复合物。它们可用作基因表达的抑制剂，作为用于检测核酸的探针，作为分子生物学的辅助物质以及药物或诊断剂。提供了制备方法。

49. 发明授权

US06455508B1 Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides 有权
标题翻译：用蒂拉唑和吡咯并嘧啶核糖核苷治疗疾病的方法
公开(公告)号：US06455508B1
公开(公告)日：2002-09-24
申请号：US09595365
申请日：2000-10-05
申请人： Kanda S. Ramasamy , Robert Tam
发明人： Kanda S. Ramasamy , Robert Tam
IPC分类号： A61K3170
CPC分类号： A61K31/70 , A61K31/7056 , A61K38/20 , A61K38/21 , A61K45/06 , C07H19/056 , C07H19/14 , A61K2300/00
摘要： Novel heterocyclic aromatic compounds are disclosed. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat an infection, an infestation, a neoplasm, or an autoimmune disease. The novel compounds may also be used to modulate aspects of the immune system, including modulation of Type 1 and Type 2 activity.
摘要翻译：公开了新的杂环芳族化合物。新化合物或其药学上可接受的酯或其盐可以用于药物组合物中，并且这些组合物可用于治疗感染，感染，肿瘤或自身免疫性疾病。新化合物也可用于调节免疫系统的方面，包括调节1型和2型活性。

50. 发明授权

US06440705B1 Method for analyzing polynucleotides 有权
公开(公告)号：US06440705B1
公开(公告)日：2002-08-27
申请号：US09394457
申请日：1999-09-10
申请人： Vincent P. Stanton, Jr. , Jia Liu Wolfe , Tomohiko Kawate , Gregory L. Verdine
发明人： Vincent P. Stanton, Jr. , Jia Liu Wolfe , Tomohiko Kawate , Gregory L. Verdine
IPC分类号： C12P1934
CPC分类号： C07H19/10 , C07H19/14 , C07H19/20 , C07H21/00 , C12N9/1252 , C12N15/11 , C12P19/34 , C12Q1/6827 , C12Q1/6872 , C12Q2565/627 , C12Q2525/101 , C12Q2523/107
摘要： The present invention relates to methods for the analysis of polynucleotides including detection of variance in nucleotide sequence without the need for full sequence determination, full sequence determination of a polynucleotide, genotyping of DNA and labeling a polynucleotide fragment during the process of cleaving it into fragments.

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