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41. 发明授权

US5449736A Water soluble phosphorylated polysiloxanes 失效
标题翻译：水溶性磷酸化聚硅氧烷
公开(公告)号：US5449736A
公开(公告)日：1995-09-12
申请号：US93185
申请日：1993-07-16
申请人： Israel Cabasso , Shi Lin
发明人： Israel Cabasso , Shi Lin
IPC分类号： C07F9/40 , C07F9/655 , C08G77/395 , C07D319/06 , C07F7/18
CPC分类号： C07F9/65515 , C07F9/404 , C07F9/4056 , C07F9/6552 , C08G77/395
摘要： This invention relates to a novel family of phosphorylated polysiloxanes which are non-ionic and water soluble. When these polysiloxanes are dissolved in water, the resulting solutions exhibit low surface tensions. The invention also relates to phosphorylated polysiloxanes which are gels or hydrogels. The invention further contemplates methods of synthesizing the phosphorylated polysiloxanes.
摘要翻译：本发明涉及非离子和水溶性磷酸化聚硅氧烷的新型家族。当这些聚硅氧烷溶于水时，所得溶液表现出低的表面张力。本发明还涉及作为凝胶或水凝胶的磷酸化聚硅氧烷。本发明进一步考虑了合成磷酸化聚硅氧烷的方法。

42. 发明授权

US5447922A .alpha.-phosphonosulfinic squalene synthetase inhibitors 失效
标题翻译： α-膦酰亚磺酰角鲨烯合成酶抑制剂
公开(公告)号：US5447922A
公开(公告)日：1995-09-05
申请号：US295121
申请日：1994-08-24
申请人： R. Michael Lawrence , Scott A. Biller , Olga M. Fryszman
发明人： R. Michael Lawrence , Scott A. Biller , Olga M. Fryszman
IPC分类号： A61K31/66 , A61K31/67 , A61K31/675 , A61P3/06 , A61P9/10 , C07F9/32 , C07F9/34 , C07F9/38 , C07F9/40 , C07F9/572 , C07F9/58 , C07F9/60 , C07F9/655 , C07F9/6553
CPC分类号： C07F9/655345 , C07F9/3808 , C07F9/3826 , C07F9/383 , C07F9/3882 , C07F9/4006 , C07F9/4015 , C07F9/4018 , C07F9/4056 , C07F9/5728 , C07F9/582 , C07F9/60 , C07F9/65517
摘要： .alpha.-Phosphonosulfinate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These compounds have the formula ##STR1## wherein R.sup.2 is OR.sup.5 or R.sup.5a ; R.sup.3 and R.sup.5 are independently H, alkyl, arylalkyl, aryl or cycloalkyl; R.sup.5a is alkyl, arylalkyl or aryl; R.sup.4 is H or pharmaceutically acceptable cation;, Z is H, halogen, lower alkyl or lower alkenyl; and R.sup.1 is a lipophilic group which contains at least 7 carbons and is alkyl, alkenyl, alkynyl, mixed alkenyl-alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, cycloheteroalkyl, cycloheteroalkylalkyl; as further defined above; including pharmaceutically acceptable salts.
摘要翻译：提供α-磷酸亚磺酸盐化合物，其抑制酶角鲨烯合成酶，从而抑制胆固醇生物合成。这些化合物具有式“IMAGE”，其中R2是OR5或R5a; R3和R5独立地为H，烷基，芳烷基，芳基或环烷基; R5a是烷基，芳烷基或芳基; R4是H或药学上可接受的阳离子; Z是H，卤素，低级烷基或低级烯基; 并且R 1是含有至少7个碳原子并且是烷基，烯基，炔基，混合烯基 - 炔基，芳基，芳基烷基，环烷基，环烷基烷基，杂芳基，杂芳基烷基，环杂烷基，环杂烷基烷基的亲油基团。如上面进一步定义的; 包括药学上可接受的盐。

43. 发明授权

US5362916A Synthesis of mercaptaryl or hydroxyaryl enol ether alkali metal salts 失效
标题翻译：硫醇芳基或羟基芳基烯醇醚碱金属盐的合成
公开(公告)号：US5362916A
公开(公告)日：1994-11-08
申请号：US153791
申请日：1993-11-17
申请人： Brooks Edwards , Rouh-Rong Juo
发明人： Brooks Edwards , Rouh-Rong Juo
IPC分类号： C07C43/174 , C07C45/29 , C07C45/71 , C07C47/575 , C07D321/00 , C07F9/40 , C07F9/655 , C07F9/6561 , G01N21/76 , C07C49/167
CPC分类号： C07F9/6561 , C07C43/1747 , C07C45/292 , C07C45/71 , C07C47/575 , C07D321/00 , C07F9/4056 , C07F9/65512 , C07F9/65517 , C07F9/65522 , C07C2103/74
摘要： Hydroxyaryl enol ether alkali metal salts having the formula: ##STR1## in which T is a fused, substituted or unsubstituted polycycloalkylidene group, OR.sup.3 is an ether group Y is a light-emitting fluorophore-forming group which will be part of a luminescent substance formed by decomposition of a 1,2-dioxetane subsequently formed from the hydroxyaryl enol ether alkali metal salt, capable of absorbing energy to form an excited state from which it emits optically detectable energy to return to its ground state, and AM.sup.30 is an alkali metal cation, processes for the preparation of these intermediate salts, and their use as starting materials for acylation, phosphorylation and glycosylation reactions to give intermediates reactable to give stable, water-soluble chemiluminescent 1,2-dioketames, particularly ones that are enzymatically cleavable, are disclosed.
摘要翻译：具有下式的羟基芳基烯醇醚碱金属盐：其中T是稠合的，取代或未取代的多亚烷基，OR 3是醚基，Y是作为形成的发光物质的一部分的发光荧光团形成基团通过分解随后由羟基芳基烯醇醚碱金属盐形成的1,2-二氧杂环丁烷，其能够吸收能量以形成激发态，从其发射光学上可检测的能量以返回其基态，并且AM30是碱金属阳离子，这些中间体盐的制备方法，以及它们作为酰化，磷酸化和糖基化反应的起始原料的用途，得到可反应的中间体，得到稳定的水溶性化学发光1,2-二酮甲酮，特别是可酶切割的化合物。。

44. 发明授权

US5310503A Stilbene compound, intermediate for producing the stilbene compound, method of producing the stilbene compound, and liquid crystal composition containing the stilbene compound 失效
标题翻译：二苯乙烯化合物，二苯乙烯化合物的制造中间体，二苯乙烯化合物的制造方法以及含有该二苯乙烯化合物的液晶组合物
公开(公告)号：US5310503A
公开(公告)日：1994-05-10
申请号：US15433
申请日：1993-02-09
申请人： Masayuki Shoshi
发明人： Masayuki Shoshi
IPC分类号： C07C67/343 , C07C69/94 , C07F9/40 , C09K19/16 , C09K19/54 , C09K19/58 , C09K19/20 , C09K19/12
CPC分类号： C09K19/586 , C07C69/94 , C07F9/4056 , C09K19/16
摘要： An optically active stilbene compound of formula (I): ##STR1## wherein R is an alkoxy group with 20 or less carbon atoms; n is an integer of 1 or 2; and R* is an optically active group, a substituted benzylphosphonate compound of formula (II) serving as an intermediate for preparing the above active stilbene compound, ##STR2## wherein X represents ##STR3## R' is an alkyl group having 1 to 5 carbon atoms, or an unsubstituted or substituted aryl group; and R* is the same as in formula (I), a method of producing the optically active stilbene compound of formula (I), and a liquid crystal composition containing the optically active stilbene compound of formula (I) are disclosed.
摘要翻译：式（I）的光学活性二苯乙烯化合物：其中R是具有20个或更少碳原子的烷氧基; n为1或2的整数; 和R *是光学活性基团，用作制备上述活性二苯乙烯化合物的中间体的式（II）的取代苄基膦酸酯化合物，其中X表示R'是具有1个至5个碳原子，或未取代或取代的芳基; 和R *与式（I）中相同，公开了制备式（I）的光学活性二苯乙烯化合物的方法和含有式（I）的光学活性茋化合物的液晶组合物。

45. 发明授权

US5300687A Trifluoromethylbenzylphosphonates useful in treating osteoporosis 失效
标题翻译：可用于治疗骨质疏松症的三氟甲基苄基膦酸盐
公开(公告)号：US5300687A
公开(公告)日：1994-04-05
申请号：US732267
申请日：1991-07-18
申请人： Charles Schwender , Keith Demarest , David Wustrow
发明人： Charles Schwender , Keith Demarest , David Wustrow
IPC分类号： A61K31/66 , A61P3/00 , C07F9/38 , C07F9/40 , C07F9/6533 , C07F9/02 , C07D265/30 , C07D279/12 , C07F9/28
CPC分类号： C07F9/6533 , C07F9/3882 , C07F9/4056
摘要： Novel benzylphosphonate compounds of the general formula I: ##STR1## are disclosed as useful in treating bone wasting diseases including postmenopausal osteoporosis in increasing in mammals bone formation and bone mass.
摘要翻译：公开了通式I的新型苄基膦酸盐化合物：（*化学结构*）I可用于治疗哺乳动物骨形成和骨量增加中包括绝经后骨质疏松症的骨消耗疾病。

46. 发明授权

US5268246A Electrophotographic photoconductor with pyrene-ring-containing olefin compound for use in the same 失效
标题翻译：具有芘环的烯烃化合物的电子照相感光体用于其中
公开(公告)号：US5268246A
公开(公告)日：1993-12-07
申请号：US682324
申请日：1991-04-09
申请人： Tamotsu Aruga , Masaomi Sasaki , Tomoyuki Shimada , Hiroshi Adachi
发明人： Tamotsu Aruga , Masaomi Sasaki , Tomoyuki Shimada , Hiroshi Adachi
IPC分类号： C07C15/62 , C07C25/24 , C07D209/86 , C07F9/40 , G03G5/047
CPC分类号： C07C15/62 , C07C25/24 , C07D209/86 , C07F9/4056 , C07C2103/50
摘要： An electrophotographic photoconductor is composed of an electroconductive support and a photoconductive layer formed thereon comprising a novel pyrene-ring-containing olefin compound having formula [I]: ##STR1## wherein R.sup.1 and R.sup.2 each represent hydrogen or an alkyl group which may have a substituent; Y is an aliphatic hydrocarbon group which may have a substituent, a cyclic hydrocarbon group which may have a substituent, or an aromatic group which may have a substituent; n is an integer of 0 or 1, and m is an integer of 1 to 3, provided that when n is 0, m is 1, R.sup.1 is hydrogen, and Y is an aromatic group with a substituent ##STR2## R.sup.5 and R.sup.3 each represent hydrogen, and Y and R.sup.1 may be bonded to form a ring, a method of synthesizing the pyrene-ring-containing olefin compound and an intermediate therefor are disclosed.
摘要翻译：电子照相感光体由导电载体和形成在其上的光电导层组成，包含具有式[I]的新的含芘环的烯烃化合物：其中R 1和R 2各自表示氢或烷基，具有取代基; Y是可以具有取代基的脂族烃基，可以具有取代基的环状烃基或可以具有取代基的芳香族基; n为0或1的整数，m为1〜3的整数，条件是当n为0时，m为1，R 1为氢，Y为具有取代基的芳基，R 5和R 3为代表氢，Y和R 1可以键合形成环，公开了合成含芘环的烯烃化合物及其中间体的方法。

47. 发明授权

US5242908A Use of benzylphosphonic acid derivatives for the treatment of diseases caused by viruses 失效
标题翻译：用于治疗病毒引起的疾病的苯并恶唑酸衍生物的应用
公开(公告)号：US5242908A
公开(公告)日：1993-09-07
申请号：US648622
申请日：1991-02-01
申请人： Anuschirwan Peyman , Eugen Uhlmann , Karlheinz Budt , Jochen Knolle , Irvin Winkler , Matthias Helsberg
发明人： Anuschirwan Peyman , Eugen Uhlmann , Karlheinz Budt , Jochen Knolle , Irvin Winkler , Matthias Helsberg
IPC分类号： A61K31/66 , A61P31/12 , C07F9/38 , C07F9/40 , C07F9/6574
CPC分类号： C07F9/65742 , C07F9/3882 , C07F9/4056
摘要： The use of a compound of the formula I ##STR1## in which V is an alkyl group, fluorine, chlorine, bromine, or iodine, n is an integer from 1 to 5, W is an alkyl, alkenyl, alkynyl or alkoxy group, cyanide, nitro, carboxyl, hydrogen or a cycloalkyl, aryl, aralkyl or carboalkoxy group, R.sup.1 and R.sup.2 are an alkyl, alkenyl, alkynyl, cycloalkyl or halogenoalkyl group, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium or hydrogen, R.sup.1 and R.sup.2 together form a cyclic diester, R.sup.3 and R.sup.4 are an alkyl, alkenyl, alkynyl, carboalkoxy, cycloalkyl or alkoxy group, hydrogen, fluorine, chlorine, bromine or iodine and X, Y and Z are oxygen or sulfur, for the treatment of diseases caused by DNA viruses or RNA viruses is described.
摘要翻译：使用其中V为烷基，氟，氯，溴或碘的式I化合物I，其为1至5的整数，W为烷基，烯基，炔基或烷氧基，氰基，硝基，羧基，氢或环烷基，芳基，芳烷基或烷氧基，R1和R2是烷基，烯基，炔基，环烷基或卤代烷基，钠，钾，钙，镁，铝，锂，铵，或氢，R1和R2一起形成环状二酯，R3和R4是烷基，烯基，炔基，烷氧羰基，环烷基或烷氧基，氢，氟，氯，溴或碘，X，Y和Z是氧或硫，描述了用于治疗由DNA病毒或RNA病毒引起的疾病。

48. 发明授权

US5225584A Synthesis of stable water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor 失效
标题翻译：稳定的水溶性化学发光1,2-二氧杂环丁烷及其中间体的合成
公开(公告)号：US5225584A
公开(公告)日：1993-07-06
申请号：US680783
申请日：1991-04-03
申请人： Edwards Brooks , Juo Rhou-Rong
发明人： Edwards Brooks , Juo Rhou-Rong
IPC分类号： C07C43/174 , C07C45/29 , C07C45/71 , C07C47/575 , C07D321/00 , C07F9/40 , C07F9/655 , C07F9/6561
CPC分类号： C07F9/6561 , C07C43/1747 , C07C45/292 , C07C45/71 , C07C47/575 , C07D321/00 , C07F9/4056 , C07F9/65512 , C07F9/65517 , C07F9/65522 , C07C2103/74
摘要： A novel synthesis of compounds having the formula: ##STR1## wherein T is a stabilizing spiro-linked polycycloalkylidene group, R.sup.3 is a C.sub.1 -C.sub.20 alkyl, aralkyl or heteroatom containing group, Y is an aromatic fluorescent chromophore, and Z is a cleavable group which, when cleaved, induces decomposition of the dioxetane ring and emission of optically detectable light, is disclosed. A tertiary phosphorous acid alkyl ester of the formula:(R.sup.1 O).sub.3 Pwherein R.sup.1 is a lower alkyl group, is reacted with an aryl dialkyl acetal produced by reacting a corresponding aryl aldehyde with an alcohol of the formula:R.sup.3 OHwherein R.sup.3 is as defined above, to produce a 1-alkoxy-1-arylmethane phosphonate ester of the formula: ##STR2## reacting the phosphonate with base to produce a phosphonate-stabilized carbanion, reacting the carbanion with a ketone of the formula:T.dbd.Owherein T is as defined above, to produce an enol ether of the formula: ##STR3## then oxygenating the double bond in the enol ether to give the corresponding 1,2-dioxetane compound.
摘要翻译：具有下式的化合物的新合成：其中T是稳定螺环连接的多环亚烷基，R 3是C 1 -C 20烷基，含芳烷基或杂原子的基团，Y是芳族荧光发色团，Z是可裂解基团当其被切割时，引入二氧杂环丁烷环的分解和光学可检测光的发射。与其中R1是低级烷基的式（R1O）3P的叔亚磷酸烷基酯与芳基二烷基缩醛反应，该芳基二烷基缩醛通过使相应的芳基醛与下式的醇反应：其中R 3如上定义，以产生下式的1-烷氧基-1-芳基甲烷膦酸酯：将膦酸酯与碱反应以产生膦酸酯稳定的碳负离子，使碳负离子与下式的酮反应：T = O，其中T为以产生下式的烯醇醚：然后对烯醇醚中的双键进行氧化，得到相应的1,2-二氧杂环丁烷化合物。

49. 发明授权

US5171873A Process for the preparation of sterically hindered hydroxybenzylphosphonates 失效
标题翻译：制备异位羟基苯甲酰磷酸酯的方法
公开(公告)号：US5171873A
公开(公告)日：1992-12-15
申请号：US861704
申请日：1992-04-01
申请人： Thomas Kainmuller , Rudolf Maul
发明人： Thomas Kainmuller , Rudolf Maul
IPC分类号： B01J31/04 , C07B61/00 , C07F9/40
CPC分类号： C07F9/4056
摘要： A process for the preparation of hydroxybenzylphosphonates of forula ##STR1## by reacting Mannich base of formula ##STR2## with as trialkyl phosphite of formula ##STR3## wherein R.sub.1 and R.sub.2 are each independently of the other C.sub.1 -C.sub.12 alkyl or, when taken together form a piperidinyl or morpholinyl radical, and R.sub.5, R.sub.6 and R.sub.7 are each independently of one another C.sub.1 -C.sub.4 alkyl, which reaction is carried out in the presence of a carboxylic anhydride (IV).The compounds of formula I may suitably be used as processing stabilizers for plastics.
摘要翻译：通过使式（I）的曼尼希碱与式（III）的亚磷酸三烷基酯反应制备式（I）的羟基苄基膦酸盐的方法，其中R1和R2各自独立地为C1 -C 12烷基，或者当一起形成哌啶基或吗啉基时，R 5，R 6和R 7各自独立地为C 1 -C 4烷基，该反应在羧酸酐（IV）的存在下进行。式I化合物可适当地用作塑料的加工稳定剂。

50. 发明授权

US5157144A 2-(halomethyl)-alpha-(methoxyimino) benzeneacetic acid methyl ester 失效
标题翻译： 2-（卤代甲基）-α-（甲氧基亚氨基）苯乙酸甲酯
公开(公告)号：US5157144A
公开(公告)日：1992-10-20
申请号：US708289
申请日：1991-05-31
申请人： Vivienne M. Anthony , John M. Clough , Christopher R. A. Godfrey , Thomas E. Wiggens
发明人： Vivienne M. Anthony , John M. Clough , Christopher R. A. Godfrey , Thomas E. Wiggens
IPC分类号： A01N37/50 , A01N43/08 , A01N43/10 , A01N43/12 , A01N43/32 , A01N47/20 , C07C67/00 , C07C251/32 , C07C251/48 , C07C313/00 , C07C315/04 , C07C317/44 , C07C317/46 , C07C317/48 , C07C319/20 , C07C323/63 , C07D213/64 , C07D213/643 , C07D239/34 , C07D241/18 , C07D307/54 , C07D307/68 , C07D307/91 , C07D319/24 , C07D333/38 , C07D333/78 , C07F9/40
CPC分类号： C07D213/643 , A01N37/50 , A01N43/12 , A01N43/32 , A01N47/20 , C07D239/34 , C07D241/18 , C07D307/54 , C07D307/68 , C07D333/38 , C07F9/4056
摘要： Compounds of the formula (I): ##STR1## and stereoisomers thereof, wherein X is halogen, alkyl, cycloalkyl, aralkyl, aryloxyalkyl, alkenyl, alkynyl, aryl, amino, arylazo, heteroarylalkyl, heteroaryloxyalkyl, acylamino nitro, nitrile, trifluoromethyl, --OR.sup.1, SR.sup.1, --CO.sub.2 R.sup.2, --CONR.sup.3 R.sup.4, --COR.sup.5, --CR.sup.6 .dbd.NR.sup.7, --N.dbd.CR8R.sup.9, --SOR.sup.10 or --SO.sub.2 R.sup.11 ; W, Y and Z, which may be the same or different, are any of the atoms or groups listed for X above and, in addition, may be hydrogen atoms; or any two of the groups W, X, Y and Z, in adjacent positions on the phenyl ring, optionally join to form a fused ring, either aromatic or aliphatic, optionally containing one or more heteroatoms; R.sup.1 is alkyl, or cycloalkyl optionally containing a heteroatom in the cycloalkyl ring, alkenyl, acyl, aryl, heteroaryl, aralkyl or heteroarylalkyl; R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.8, R.sup.9, R.sup.10 and R.sup.11, which may be the same or different, are hydrogen or alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aralkyl, aryl or heteroaryl; and R.sup.7 is aryl, the alkyl, cycloalkyl, aralkyl, aryloxyalkyl, alkenyl, alkynyl, aryl, amino, arylazo, heteroarylalkyl, heteroaryloxyalkyl, acylamino, acyl, and heteroaryl being optionally substituted. The compounds are useful as fungicides and as plant growth regulators.
摘要翻译：式（I）化合物：其中X为卤素，烷基，环烷基，芳烷基，芳氧基烷基，烯基，炔基，芳基，氨基，芳基偶氮，杂芳基烷基，杂芳氧基烷基，酰氨基硝基，腈，三氟甲基，-OR1，SR1，-CO2R2，-CONR3R4，-COR5，-CR6 = NR7，-N = CR8R9，-SOR10或-SO2R11; W，Y和Z可以相同或不同，是上述X所列的任何原子或基团，另外也可以是氢原子; 或在苯环的相邻位置中的基团W，X，Y和Z中的任何两个，任选地连接形成任选含有一个或多个杂原子的芳族或脂族的稠环; R 1是任选地在环烷基环，烯基，酰基，芳基，杂芳基，芳烷基或杂芳基烷基中含有杂原子的烷基或环烷基; R 2，R 3，R 4，R 5，R 6，R 8，R 9，R 10和R 11可以相同或不同，为氢或烷基，环烷基，环烷基烷基，烯基，芳烷基，芳基或杂芳基; 并且R 7是任选取代的芳基，烷基，环烷基，芳烷基，芳氧基烷基，烯基，炔基，芳基，氨基，芳基偶氮，杂芳基烷基，杂芳氧基烷基，酰氨基，酰基和杂芳基。这些化合物可用作杀真菌剂和植物生长调节剂。

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