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41. 发明授权

US08598373B2 Halichondrin B analogs 有权
标题翻译： Halichondrin B类似物
公开(公告)号：US08598373B2
公开(公告)日：2013-12-03
申请号：US12936056
申请日：2009-04-03
申请人： Yongbo Hu
发明人： Yongbo Hu
IPC分类号： C07D321/00
CPC分类号： C07D493/22 , C07B2200/13
摘要： The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediates.
摘要翻译：本发明包括具有药物活性的软骨素B类似物; 在一些情况下，其结晶形式，并且在一些情况下，具有作为合成中间体的进一步实用性的软绵绵蛋白B类似物。

42. 发明申请

US20130150314A1 TRIOXACARCINS AND USES THEREOF 有权
标题翻译：三氧化二砷及其用途
公开(公告)号：US20130150314A1
公开(公告)日：2013-06-13
申请号：US13636263
申请日：2011-03-22
申请人： Andrew G. Myers , Nicholas E. Hill , Jakub Svenda , Robert T. Yu , Daniel J. Smaltz , Thomas Magauer
发明人： Andrew G. Myers , Nicholas E. Hill , Jakub Svenda , Robert T. Yu , Daniel J. Smaltz , Thomas Magauer
IPC分类号： C07H17/04
CPC分类号： C07H17/04 , C07D493/22 , C07H15/24 , C07H15/26
摘要： The present invention relates to trioxacarcin compounds of the formula: (I) or pharmaceutically acceptable forms thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8, and R9 are as defined herein. The present invention also provides processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; and methods of use and treatment.
摘要翻译：本发明涉及式（I）的三恶草酮化合物或其药学上可接受的形式; 其中R1，R2，R3，R4，R5，R6，R7，R8和R9如本文所定义。本发明还提供了制备这些化合物及其中间体的方法; 包含这些化合物的药物组合物; 以及使用和治疗方法。

43. 发明申请

US20120225936A1 METHOD FOR PRODUCING TRIPTOLIDE 有权
标题翻译：三磷酸盐生产方法
公开(公告)号：US20120225936A1
公开(公告)日：2012-09-06
申请号：US13508068
申请日：2010-11-05
申请人： Nicolas Steward , Nadine Chomarat , Ngoc Thien N'Guyen
发明人： Nicolas Steward , Nadine Chomarat , Ngoc Thien N'Guyen
IPC分类号： A61K31/34 , A61P17/06 , C07D493/22 , A61P29/00 , C12P17/16 , C12N5/04
CPC分类号： A61K36/37 , A61K8/4973 , A61K8/97 , A61K31/365 , A61Q19/00 , C07D493/22 , C12P5/00 , C12P17/18 , C12P17/181
摘要： The invention relates to a method for producing triptolide from a suspension cell culture of Tripterygium sp., to a triptolide-enriched extract obtainable by means of extraction from the culture medium of an in vitro culture of dedifferentiated cells of the species Tripterygium, and to the therapeutic applications of said extract.
摘要翻译：本发明涉及一种从雷公藤的悬浮细胞培养物中制备雷公藤内酯的方法，该方法是通过从培养基中提取物种雷公藤的去分化细胞的体外培养而获得的富含雷公藤内酯的提取物，所述提取物的治疗应用。

44. 发明授权

US08222022B2 Tri-functionalized cryptophane biosensors 有权
标题翻译：三官能化的cryptophane生物传感器
公开(公告)号：US08222022B2
公开(公告)日：2012-07-17
申请号：US12498858
申请日：2009-07-07
申请人： Ivan Dmochowski , Aru P. Hill , Qian Wei , Jennifer M. Chambers
发明人： Ivan Dmochowski , Aru P. Hill , Qian Wei , Jennifer M. Chambers
IPC分类号： C12M3/00
CPC分类号： C07D493/22 , C07D493/18 , G01N33/54373
摘要： This invention relates to biosensors with improved solubility and affinity to a noble element. Specifically, the invention relates to methods and systems for the detection of target entities using the signal observed in a noble element complexed to the biosensor.
摘要翻译：本发明涉及具有改善对贵金属元素的溶解性和亲和性的生物传感器。具体地，本发明涉及使用在与生物传感器复合的贵族元素中观察到的信号来检测目标实体的方法和系统。

45. 发明申请

US20120095242A1 INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS 有权
标题翻译：用于合成黑曲霉B类似物的中间体和方法
公开(公告)号：US20120095242A1
公开(公告)日：2012-04-19
申请号：US13334516
申请日：2011-12-22
申请人： Charles Chase , Atsushi Endo , Francis G. Fang , Jing Li
发明人： Charles Chase , Atsushi Endo , Francis G. Fang , Jing Li
IPC分类号： C07D493/06 , C07D493/20 , C07D493/04 , C07D493/22
CPC分类号： C07D493/20 , C07D307/20 , C07D307/26 , C07D307/28 , C07D307/33 , C07D309/16 , C07D405/06 , C07D405/14 , C07D493/04 , C07D493/08 , C07D493/18 , C07D493/22 , Y02P20/55
摘要： Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.
摘要翻译：描述了合成有用于合成软组蛋白B类似物的中间体的方法。

46. 发明授权

US08153767B2 Antibody against aflatoxins, support using the antibody, method of immunologically detecting aflatoxins and method of concentrating and purifying aflatoxins 有权
标题翻译：抗黄曲霉毒素抗体，使用抗体的支持，免疫学检测黄曲霉毒素的方法和浓缩和纯化黄曲霉毒素的方法
公开(公告)号：US08153767B2
公开(公告)日：2012-04-10
申请号：US12515263
申请日：2007-11-13
申请人： Mikiko Uchigashima , Shiro Miyake , Hiroshi Yamashita
发明人： Mikiko Uchigashima , Shiro Miyake , Hiroshi Yamashita
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： G01N33/56961 , C07D493/14 , C07D493/22 , C07K16/14 , C07K16/44 , Y10S530/809
摘要： It is intended to detect, concentrate and purify aflatoxins of all types which are possibly contained in a sample such as a food. It is also intended to detect the total amount or the individual amounts thereof at a high sensitivity. By using aflatoxin B2 or its derivative as a hapten compound, an antibody, which shows the same reactivity to individual aflatoxin analogs and is highly tolerant to organic solvents, is obtained. Then, a detection/concentration/purification means and an immunological detection means with the use of the above antibody are constructed. The detection means thus constructed achieves a high sensitivity and excellent quantification properties.
摘要翻译：旨在检测，浓缩和纯化可能包含在诸如食物的样品中的所有类型的黄曲霉毒素。也用于以高灵敏度检测总量或其个体量。通过使用黄曲霉毒素B2或其衍生物作为半抗原化合物，获得对个体黄曲霉毒素类似物具有相同反应性并且对有机溶剂高度耐受的抗体。然后，构建使用上述抗体的检测/浓缩/纯化方法和免疫检测手段。这样构成的检测装置具有高灵敏度和极好的定量特性。

47. 发明授权

US08134017B1 Compound and use thereof 有权
标题翻译：化合物及其用途
公开(公告)号：US08134017B1
公开(公告)日：2012-03-13
申请号：US12958504
申请日：2010-12-02
申请人： Shinichiro Kamino , Shuichi Enomoto
发明人： Shinichiro Kamino , Shuichi Enomoto
IPC分类号： C07D491/22 , C07D493/04 , C07D493/22 , A61K31/35
CPC分类号： C07D493/04 , C07D491/22 , C07D493/22 , Y10S436/80
摘要： A compound represented by the following formula (1) or (2):
摘要翻译：由下式（1）或（2）表示的化合物：

48. 发明申请

US20120034216A1 SPIROKETALS 有权
公开(公告)号：US20120034216A1
公开(公告)日：2012-02-09
申请号：US13208210
申请日：2011-08-11
申请人： Paul Warren Reddell , Victoria Anne Gordon
发明人： Paul Warren Reddell , Victoria Anne Gordon
IPC分类号： A61K31/366 , A61P33/00 , A61P33/02 , A61P35/00 , A61P29/00 , A61P33/04 , A61P33/06 , A61P37/00 , A61P35/02 , A61K31/661 , A61K31/704 , A61K31/665 , A61K31/4375 , A61K31/513 , A61K31/5395 , A61K39/395 , A61K31/506 , A61P31/04
CPC分类号： C07D493/20 , A61K31/366 , A61K45/06 , C07D493/22
摘要： The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative disorders and anti inflammatory disorders. The spiroketal compounds are also useful as immunosuppressive agents, and also in methods of controlling pests.
摘要翻译：本发明涉及可用于治疗或预防原生动物感染，寄生虫感染，细菌感染，细胞增殖性疾病和抗炎症病症的方法中的螺缩酮化合物。螺缩酮化合物也可用作免疫抑制剂，也可用于防治害虫的方法。

49. 发明申请

US20110076293A1 TRIPTOLIDE DERIVATIVES FOR MODULATION OF APOPTOSIS AND IMMUNOSUPPRESSION 审中-公开
标题翻译：用于调节疫苗和免疫抑制的三嵌段衍生物
公开(公告)号：US20110076293A1
公开(公告)日：2011-03-31
申请号：US12961367
申请日：2010-12-06
申请人： Dongcheng Dai , John H. Musser , Edwin S. Lennox
发明人： Dongcheng Dai , John H. Musser , Edwin S. Lennox
IPC分类号： A61K31/365 , A61P35/00 , A61P35/02 , A61P37/06 , A61P3/10 , A61P7/06 , A61P25/00 , A61P17/06 , A61P19/02 , A61P37/08 , A61P9/10 , A61P11/06
CPC分类号： A61K31/365 , C07D493/22
摘要： Variously substituted carbonate and carbamate derivatives of triptolide compounds have good aqueous solubility and convert to biologically active compounds in vivo, at a rate which can be modulated by varying the substitution on the prodrug. The prodrugs are useful as immunosuppressive, anti-inflammatory and anticancer agents.
摘要翻译：雷公藤内酯化合物的各种取代的碳酸酯和氨基甲酸酯衍生物具有良好的水溶性，并以可以通过改变前药上的取代来调节的速率在体内转化为生物活性化合物。前药可用作免疫抑制，抗炎和抗癌剂。

50. 发明申请

US20110071305A1 PRODUCTION OF 5-MEMBERED AND 6-MEMBERED CYCLIC ESTERS OF POLYOLS 有权
标题翻译：制备多组分5份和6份环状酯
公开(公告)号：US20110071305A1
公开(公告)日：2011-03-24
申请号：US12993143
申请日：2009-05-28
申请人： Stephen Howard , Alexandra Sanborn
发明人： Stephen Howard , Alexandra Sanborn
IPC分类号： C07D493/04
CPC分类号： C07D493/04 , C07D493/22 , Y02P20/582
摘要： Described herein are improved methods for the preparation of 5- and 6-membered cyclic mono and diesters of sugar alcohols and anhydrosugar alcohols by reaction with an organic acid RCOOH over a solid acidic substrate. The process is adaptable to a continuous process for simultaneously making and separating the cyclic esters from the sugar alcohols and anhydrosugar alcohols under mild conditions using the solid acid substrate as both the catalyst and a chromatographic bed for separation. The reactions are performed at mild temperatures of 700 C to 1000 C and the formation of the cyclic esters is nearly quantitative. Also described is a method for making 5- and 6-membered cyclic mono and diesters of sugar alcohols and anhydrosugar alcohols using microwave irradiation in the presence of the organic acid.
摘要翻译：本文描述了通过在固体酸性底物上与有机酸RCOOH反应来制备糖醇和脱水糖醇的5-和6-元环状单酯和二酯的改进方法。该方法适用于在温和条件下使用固体酸底物作为催化剂和用于分离的色谱床同时制备和分离环状酯与糖醇和脱水糖醇的连续方法。反应在700℃至1000℃的温和温度下进行，环酯的形成几乎是定量的。还描述了在有机酸存在下使用微波辐射制备糖醇和脱水糖醇的5-和6-元环状单酯和二酯的方法。

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