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41. 发明授权

US4824955A Selenium oxy chloride-pyridine or bipyridine complexes 失效
标题翻译：氯氧化硒 - 吡啶或联吡啶配合物
公开(公告)号：US4824955A
公开(公告)日：1989-04-25
申请号：US928551
申请日：1986-11-10
申请人： Hisao Ekimoto , Masanobu Suzuki , Takao Izawa , Katsutoshi Takahashi , Tokuji Nakatani , Akio Fujii
发明人： Hisao Ekimoto , Masanobu Suzuki , Takao Izawa , Katsutoshi Takahashi , Tokuji Nakatani , Akio Fujii
IPC分类号： C07D207/20 , C07D213/06 , C07D213/22 , C07D213/61 , C07D213/64 , C07D213/68 , C07D213/73 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D213/89 , C07D215/06 , C07D215/18 , C07D215/22 , C07D215/233 , C07D215/24 , C07D217/02 , C07D233/68 , C07D235/06 , C07D235/08 , C07D471/04 , C07D473/08 , C07D473/10 , C07D473/12 , C07D521/00 , C07F9/11 , C07D401/04 , C07D213/65
CPC分类号： C07D213/06 , C07D207/20 , C07D213/22 , C07D213/61 , C07D213/64 , C07D213/68 , C07D213/73 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D213/89 , C07D215/06 , C07D215/18 , C07D215/233 , C07D215/24 , C07D217/02 , C07D231/12 , C07D233/56 , C07D233/68 , C07D235/06 , C07D235/08 , C07D249/08 , C07D471/04 , C07D473/08 , C07D473/10 , C07D473/12 , C07F9/11
摘要： This invention relates to the novel selenium compounds which are useful as an antineoplastic agent. The compounds are represented by the general formula (I):Se(O).sub.a (R).sub.b (X).sub.c (A).sub.n (Y).sub.m (I)wherein R, X, A and Y represent the groups specified below, a represents a number of 0 or 1, b represents a number of 0, 1 or 2, and (1) when a is 0 and b is also 0, c is 4, n is 1 or 2 and m is 0, (2) when a is 1 and b is 0, c is 2, n is 1 or 2 and m is 0 or 1, and (3) when b is 1 or 2, c, n and m are all 0;(i) when b is 2, R represents (1) a C.sub.4-10 alkoxy group substituted with a halogen atom, (2) a lower alkoxyl group substituted with a halogen atom and a phenyl group, or (3) a cycloalkyloxy group substituted with a halogen atom, and (ii) when b is 1, R represents a group represented by the formula ##STR1## (wherein R.sub.0 is a C.sub.2-6 alkyl group); X represents a halogen atom;A represents a compound represented by the formula ##STR2## (wherein R.sub.1 and R.sub.2 may be the same or different and represent a hydrogen atom, a hydroxyl group, a lower alkyl group, a halogen atom, a phenyl group, a cyano group, a lower alkoxycarbonly group, a phenoxycarbonyl group, an amino group (to which a lower alkyl, lower alkylaminocarbonyl, lower halogenoalkylaminocarbonyl or lower alkoxycarbonyl group may be bonded), a benzoyl group, a loweralkoxyl group, a carbamyl group or an allyloxycarbonyl group; R.sub.7 represents a hydrogen atom, a lower alkyl group or a group represented by the formula ##STR3## (wherein R.sub.9 represents an amino group or a lowr alkoxyl group); Y represents H.sub.2 O.
摘要翻译：本发明涉及可用作抗肿瘤剂的新型硒化合物。这些化合物由通式（I）表示：Se（O）a（R）b（X）c（A）n（Y）m（I）其中R，X，A和Y表示下面规定的基团， a表示0或1的数，b表示0,1或2的数，以及（1）当a为0且b为0时，c为4，n为1或2，m为0，（2））当a为1且b为0时，c为2，n为1或2，m为0或1，（3）当b为1或2时，c，n和m均为0; （i）当b为2时，R表示（1）被卤素原子取代的C 4-10烷氧基，（2）被卤素原子和苯基取代的低级烷氧基，或（3）环烷氧基取代和（ii）当b为1时，R表示由式“IMAGE”表示的基团（其中R 0为C 2-6烷基）; X表示卤原子; A表示由式“IMAGE”表示的化合物（其中R 1和R 2可以相同或不同，表示氢原子，羟基，低级烷基，卤原子，苯基，氰基，苯氧基羰基，氨基（可以键合有低级烷基，低级烷基氨基羰基，低级卤代烷基氨基羰基或低级烷氧基羰基），苯甲酰基，低级烷氧基，氨基甲酰基或烯丙氧基羰基; R7表示氢原子，低级烷基或下式表示的基团（其中R9表示氨基或低级烷氧基）; Y表示H 2 O。

42. 发明授权

US4476313A Pyrylium salts 失效
标题翻译：吡喃鎓盐
公开(公告)号：US4476313A
公开(公告)日：1984-10-09
申请号：US494392
申请日：1983-05-13
申请人： Kevin T. Potts
发明人： Kevin T. Potts
IPC分类号： C07D213/22 , C07D213/50 , C07D213/70 , C07D215/36 , C07D309/34 , C07D311/30 , C07D333/22 , C07D333/28 , C07D335/02 , C07D405/14 , C07D409/06 , C07D409/14
CPC分类号： C07D213/22 , C07C323/00 , C07D213/50 , C07D213/70 , C07D215/36 , C07D309/34 , C07D311/30 , C07D333/22 , C07D333/28 , C07D335/02 , C07D405/14 , C07D409/06 , C07D409/14
摘要： A method is disclosed for preparing pyrylium and thiapyrylium salts having the formula represented below (where X is O,S or Se): ##STR1## and where R.sup.1 and R.sup.2 represents a branched or unbranched alkyl radical having up to about 15 carbon atoms, an aromatic group having as substituents alkyl radicals with 1 to about 15 carbon atoms, alkoxy radicals having 1 to about 4 carbon atoms, substituted amino radicals have 1 to 2 carbon radicals containing 1 to about 4 carbon atoms, an heterocyclic group having as substitute alkyl radicals with 1 to about 15 carbon atoms, alkoxy radicals having 1 to about 4 carbon atoms and amino radicals having 1 or 2 carbon radicals containing 1 to about 4 carbons, thiophene radicals and furan radical containing a variety of substituents; R.sup.3 represents a thioalkyl radical having 1 to about 4 carbon atoms thiobenzyl, thioaryl and thiocycloalkyl, as well as thiohetaryl radicals such as thiohydridyl and related 5-and-membered systems; and Z.sup.- is an anionic function. The salts are prepared by condensing the methyl ketone with carbon disulfide in the presence of sodium hydride, treating the product with methyl iodide to form the .alpha.-oxoketenedithioacetal; condensing the .alpha.-oxoketenedithioacetal with another methyl ketone in the presence of two equivalents of potassium tert-butoxide to form a 1,5-enedione; and cyclizing the enedione with tetrafluoroboric acid.
摘要翻译：公开了一种制备具有下式（其中X为O，S或Se）的吡喃鎓和硫代吡喃鎓盐的方法：其中R 1和R 2表示具有至多约15个碳原子的支链或非支链烷基，作为具有1至约15个碳原子的取代基的烷基的芳族基团，具有1至约4个碳原子的烷氧基，取代的氨基具有1至2个含有1至约4个碳原子的碳基，具有作为替代烷基的杂环基具有1至约15个碳原子，具有1至约4个碳原子的烷氧基和具有1至约4个碳的1或2个碳基的氨基，包含各种取代基的噻吩基和呋喃基; R3表示具有1至约4个碳原子的硫代烷基硫代苄基，硫代芳基和硫代环烷基，以及硫代芳基如硫代氢化基和相关的5-元系体系; Z-是阴离子官能团。盐在氢化钠存在下将甲基酮与二硫化碳缩合制备，用甲基碘处理产物以形成α-酮酮二硫缩醛; 在二当量的叔丁醇钾存在下，将α-氧基酮二硫缩醛与另一种甲基酮缩合形成1,5-烯二酮; 并用四氟硼酸环化烯酮。

43. 发明授权

US4177349A Substituted 2,2'-bipyridyl compounds and process for preparing same 失效
标题翻译：取代的2,2'-联吡啶化合物及其制备方法
公开(公告)号：US4177349A
公开(公告)日：1979-12-04
申请号：US928396
申请日：1978-07-27
申请人： Charles K. McGill
发明人： Charles K. McGill
IPC分类号： C07D213/22 , C07D213/73
CPC分类号： C07D213/22 , C07D213/73
摘要： A process for preparing substituted 2,2'-bipyridyl compounds and several compounds so prepared, the process comprising the steps of first selecting a substituted pyridine of the formula defined herein, then mixing a stoichiometric excess of the substituted pyridine with an amount of sodamide, causing the resultant mixture to be at a temperature sufficiently high to cause substituted 2,2'-bipyridyl formation, and isolating the substituted 2,2'-bipyridyl thereby formed. The new substituted 2,2'-bipyridyl compounds are selected from the group consisting of 4,4'-di-(5-nonyl)-2,2'-bipyridyl; 4,4'-di-(3-pentyl)-2,2'-bipyridyl; 6,6'-di-(3-pentyl)-2,2'-bipyridyl; 6,6'-di-(5-nonyl)-2,2'-bipyridyl; 4,4'-di-(cyclohexylmethyl)-2,2'-bipyridyl; 5,5'-di-(5-nonyl)-2,2'-bipyridyl; 4,4'-di-(3-phenylpropyl)-2,2'-bipyridyl; 4,4'-di-(4-tetrahydropyranyl)-2,2'-bipyridyl; 4,4'-di-benzyl-2,2'-bipyridyl; 6,6'-di-isoamyl-2,2'-bipyridyl; and 4,4'-di-(t-butyl)-2,2'-bipyridyl.
摘要翻译：制备取代的2,2'-联吡啶化合物和如此制备的若干化合物的方法，该方法包括以下步骤：首先选择本文定义的式的取代吡啶，然后将化学计量过量的取代的吡啶与一定量的聚丁二酰胺混合，使得所得混合物的温度足够高以引起取代的2,2'-联吡啶形成，并分离由此形成的取代的2,2'-联吡啶。新的取代的2,2'-联吡啶化合物选自4,4'-二（5-壬基）-2,2'-联吡啶基; 4,4'-二（3-戊基）-2,2'-联吡啶; 6,6'-二（3-戊基）-2,2'-联吡啶; 6,6'-二（5-壬基）-2,2'-联吡啶; 4,4'-二（环己基甲基）-2,2'-联吡啶; 5,5'-二（5-壬基）-2,2'-联吡啶基; 4,4'-二（3-苯基丙基）-2,2'-联吡啶; 4,4'-二（4-四氢吡喃基）-2,2'-联吡啶; 4,4'-二苄基-2,2'-联吡啶; 6,6'-二 - 异戊基-2,2'-联吡啶; 和4,4'-二 - （叔丁基）-2,2'-联吡啶。

44. 发明授权

US4175195A Process for the production of substituted pyridine (A) 失效
标题翻译：制备取代吡啶（A）的方法
公开(公告)号：US4175195A
公开(公告)日：1979-11-20
申请号：US830984
申请日：1977-09-06
申请人： Helmut Beschke , Heinz Friedrich , Heribert Offermanns
发明人： Helmut Beschke , Heinz Friedrich , Heribert Offermanns
IPC分类号： C07D213/12 , C07D213/22 , C07D405/04 , C07D409/04
CPC分类号： C07D213/22 , C07D213/12
摘要： Pyridines substituted in the 2-position by an aromatic or heteroaromatic group are prepared by reacting an aliphatic aromatic or aliphatic heteroaromatic ketone with an aliphatic oxo compound having a carbon to carbon ethylenic double bond on the carbon atom adjacent to the oxo group and ammonia in the presence of a dehydrating and dehydrogenating catalyst at a temperature of about 250.degree. to 550.degree. C.
摘要翻译：通过芳族或杂芳族基团在2位上取代的吡啶通过使脂族芳族或脂族杂芳族酮与在与氧代基相邻的碳原子上具有碳 - 碳烯键式双键的脂族氧代化合物和氨在在约250℃至550℃的温度下存在脱水和脱氢催化剂。

45. 发明授权

US4052405A Manufacture of 1,1'-dialkyl-4,4'-bipyridylium salts 失效
标题翻译： 1,1'-二烷基-4,4'-二乙基铝盐的制备
公开(公告)号：US4052405A
公开(公告)日：1977-10-04
申请号：US357656
申请日：1973-05-07
申请人： John Reginald Case , Geoffrey James Moore
发明人： John Reginald Case , Geoffrey James Moore
IPC分类号： C07D213/22
CPC分类号： C07D213/22
摘要： A 1,1'-dialkyl-4,4'-bipyridylium salt is prepared from the corresponding 4,4'-bipyridyl using an alkylsulphate salt as the quaternizing agent.

46. 发明授权

US3970658A Nitrile process 失效
标题翻译：腈过程
公开(公告)号：US3970658A
公开(公告)日：1976-07-20
申请号：US577684
申请日：1975-05-15
申请人： Ellis K. Fields
发明人： Ellis K. Fields
IPC分类号： C07D213/06 , C07D213/127 , C07D213/22 , C07D213/84 , C07D333/08 , C07D333/10 , C07D333/38 , C07D213/57
CPC分类号： C07D213/06 , C07D213/22 , C07D213/84 , C07D333/08 , C07D333/10 , C07D333/38
摘要： A decarboxylation process for substituting cyano radicals for silver carboxylate radicals which comprises reacting the silver salts of carboxylic acids with silver cyanide under decarboxylation conditions of at least 320.degree.C.
摘要翻译：用于将氰基取代为羧酸羧酸酯基团的脱羧方法，其包括在至少320℃的脱羧条件下使羧酸的银盐与氰化银反应。

47. 发明授权

US3931137A Herbicidal compositions 失效
标题翻译：除草成分
公开(公告)号：US3931137A
公开(公告)日：1976-01-06
申请号：US472513
申请日：1974-05-22
申请人： Brian Graham White
发明人： Brian Graham White
IPC分类号： C07D213/22 , C07B21/00
CPC分类号： C07D213/22
摘要： A solid complex of a herbicidal bipyridylium salt in combination with urea or thiourea having the formula:X(A).sub.n (H.sub.2 O).sub.mWherein X represents the bipyridylium salt, A represents urea or thiourea, n is 1, 2 or 4, and m is 0 to 4, its preparation and use are disclosed.
摘要翻译：一种除草联吡啶鎓盐与具有下式的脲或硫脲的固体复合物：X（A）n（H 2 O）m WHEREIN X代表联吡啶鎓盐，A代表脲或硫脲，n是1,2或4，m 是0至4，其制备和使用被公开。

48. 发明授权

US3838157A Process for producing bipyridyls 失效
标题翻译：生产二氯乙烯的方法
公开(公告)号：US3838157A
公开(公告)日：1974-09-24
申请号：US17451971
申请日：1971-08-24
申请人： ICI LTD
发明人： BOWDEN R
IPC分类号： C07D213/22 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/51 , C07D213/56 , C07D31/42
CPC分类号： C07D213/22 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/51 , C07D213/56
摘要： THE INVENTION IS CONCERNED WITH A PROCESS OF PRODUCING BIPYRIDYLS BY OXIDIZING A SUBSTITUTED PYRIDINE WITH MOLECULAR OXYGEN IN THE VAPOR PHASE AT 250*C. TO 450*C.

49. 发明授权

US3824245A Manufacture of bipyridylium salts and related compounds 失效
标题翻译： BIPYRIDYLIUM SALTS及相关化合物的制造
公开(公告)号：US3824245A
公开(公告)日：1974-07-16
申请号：US27063472
申请日：1972-07-11
申请人： ICI LTD
发明人： CAREY J , COLCHESTER J , CAIRNS J
IPC分类号： C07D211/82 , C07D213/22 , C07D31/44
CPC分类号： C07D213/22 , C07D211/82
摘要： THERE IS PROVIDED A METHOD OF CONVERTING DISUBSTITUTED TETRAHYDROBIPYRIDYLS TO THE CORRESPONDING DIPYRIDINUM SALTBY TREATING THE TETRAHYDROPYRIDYL WITH A DEHYDROGENATING AGENT SUCH AS PLARNIUM METALS AND OXIDES TO CONVERT THE TETRAHYDROBIPYRIDYL TO THE CORRESPONDING DIHYDROBIPYRIDYL AND SUBSEQUENTLY OXIDIZING THE DIHYDROBIPYRIDYL TO THE CORRESPONDING SALT.

50. 发明授权

US3793335A Manufacture of 1,1'-disubstituted-4,4'-bipyridylium salts and related compounds 失效
标题翻译： 1,1'-取代-4,4'-二乙基铝盐及其相关化合物的制备
公开(公告)号：US3793335A
公开(公告)日：1974-02-19
申请号：US3793335D
申请日：1971-01-18
申请人： ICI LTD
发明人： BEACHAM J , CAREY J
IPC分类号： C07D213/22 , C07D31/42 , C07D31/44
CPC分类号： C07D213/22
摘要： A PROCESS FOR THE MANUFACTURE OF A 1,1''-DISUBSTITUTED-4, 4''-BIPYRIDYLIUM CATION RADICAL WHICH COMPRISES MIXING A SOLUTION OF A 1,1''-DISUBSTITUTED-1,1''-DIHYDRO-4,4''-BIPYRIDYL WITH A 1,1''-DISUBSTITUTED-4,4''-BIPHYDRYLIUM SALT TO FORM THE 1,1''-DISUBSTITUTED-4,4''-BIPYRIDYLIUM CATION RADICAL.

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