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41. 发明申请

US20160102069A1 ANTIOXIDANT HUMIC ACID DERIVATIVES AND METHODS OF PREPARATION AND USE 有权
标题翻译：抗氧化剂的酸酐衍生物及其制备和使用方法
公开(公告)号：US20160102069A1
公开(公告)日：2016-04-14
申请号：US14894616
申请日：2013-05-28
申请人： EMPIRE TECHNOLOGY DEVELOPMENT LLC
发明人： Georgius Abidal ADAM , Scott Andrew NEEDHAM
IPC分类号： C07D307/77 , C07C65/105 , C07D209/36 , C07D265/38
CPC分类号： C07D307/77 , A23L3/3463 , A23L3/3526 , A23L3/3544 , A61K8/368 , A61K8/49 , A61K8/492 , A61K8/4973 , A61K2800/28 , A61K2800/522 , A61Q1/04 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q1/14 , A61Q3/02 , A61Q5/006 , A61Q5/02 , A61Q5/06 , A61Q5/065 , A61Q5/12 , A61Q19/00 , A61Q19/001 , A61Q19/04 , A61Q19/08 , A61Q19/10 , C07C65/105 , C07D209/36 , C07D265/38 , C07D307/91 , C07D413/14 , C08K5/1535 , C08K5/3417 , C08K5/357
摘要： Disclosed are antioxidative, natural compounds, their salts, chelates and cleavage derivatives that exhibit a superior combination of properties. The compounds can be used for a variety of purposes, including stabilizing foods, cosmetics, beverages and nutritional supplement. The compounds can be prepared by substantially cleaving a humic acid of formula I to provide at least one antioxidant compounds of formula II, formula III, formula IV, formula V, formula VI, salts, or chelates thereof.
摘要翻译：公开了表现出优异的性能组合的抗氧化天然化合物，其盐，螯合物和裂解衍生物。该化合物可用于各种目的，包括稳定食品，化妆品，饮料和营养补充剂。可以通过基本上切割式I的腐殖酸来制备化合物，以提供至少一种式II，式III，式IV，式V，式VI的抗氧化剂化合物，其盐或螯合物。

42. 发明申请

US20150218128A1 Isatin Compounds, Compositions And Methods For Treatment Of Degenerative Diseases And Disorders 有权
标题翻译：靛红化合物，组合物和治疗退行性疾病和疾病的方法
公开(公告)号：US20150218128A1
公开(公告)日：2015-08-06
申请号：US14685962
申请日：2015-04-14
申请人： MUSC Foundation For Research Development
发明人： Craig C. Beeson , Christopher C. Lindsey , Yuri K. Peterson , Baerbel Rohrer
IPC分类号： C07D401/06 , C07D209/36
CPC分类号： C07D401/06 , C07D209/34 , C07D209/36 , C07D209/38 , C07D401/04 , C07D403/04 , C07D403/06
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
摘要翻译：本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。这些化合物和含有它们的药物组合物可用于治疗退行性疾病和病症。

43. 发明申请

US20140134105A1 HALOGENATED PHENOLS FOR DIAGNOSTICS, ANTIOXIDANT PROTECTION AND DRUG DELIVERY 审中-公开
标题翻译：用于诊断，抗氧化剂保护和药物输送的氢化酚
公开(公告)号：US20140134105A1
公开(公告)日：2014-05-15
申请号：US14156896
申请日：2014-01-16
申请人： Keith R. Latham
发明人： Keith R. Latham
IPC分类号： A61K49/00 , G01N33/52 , A61K51/04 , A61K49/04
CPC分类号： A61K47/48023 , A61K49/006 , A61K49/0438 , A61K51/0446 , C07C43/295 , C07C217/60 , C07C229/36 , C07C233/25 , C07C323/52 , C07D209/36 , C07D475/08 , C07D489/02 , C07D499/897 , C07J1/0022 , C07J5/0053 , G01N33/52 , Y10T436/145555
摘要： The present invention relates to a composition and method for the detection of a detectable product formed from a compound of the present invention in the body of an individual. The detectable product may include a halide or a benzenetriol-based or benzenetetrol-based product of a dehalogenation reaction in the presence of FROS. In many embodiments, an indigo-like product formed from an indigogenic compound of the present invention may also be a detectable product for diagnostic purposes. This indigo-like product may have a higher residence time in tissues where it is formed, thus providing a detectable product localized to sites of high FROS. An indigogenic compound containing one or more radioactive isotopes is further provided for therapeutic purposes.
摘要翻译：本发明涉及一种用于检测在个体内由本发明化合物形成的可检测产物的组合物和方法。可检测的产物可以包括在FROS存在下脱卤反应的卤化物或基于苯三醇或苯并四氢呋喃的产物。在许多实施方案中，由本发明的靛蓝化合物形成的靛蓝样产物也可以是用于诊断目的的可检测产物。这种靛蓝样产品可以在其形成的组织中具有更高的停留时间，从而提供定位于高FROS位点的可检测产物。进一步提供含有一种或多种放射性同位素的靛蓝化合物用于治疗目的。

44. 发明申请

US20120295946A1 Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof 失效
标题翻译：可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法
公开(公告)号：US20120295946A1
公开(公告)日：2012-11-22
申请号：US13559186
申请日：2012-07-26
申请人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
IPC分类号： A61K31/407 , A61P25/28
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译：本发明提供了向受试者施用化合物和方法，所述方法可以减少和产生APP，并且在广泛的剂量范围内是无毒的。本发明还提供了非氨基甲酸酯化合物和向受试者施用此类化合物的方法，所述方法可以减少APP生产并且在广泛剂量范围内不具有毒性。已经发现外消旋或对映体纯的非氨基甲酸酯化合物可用于减少和生产APP生产。

45. 发明申请

US20090131507A1 N-arylsulfonyl-3-aminoalkoxyindoles 有权
公开(公告)号：US20090131507A1
公开(公告)日：2009-05-21
申请号：US12349043
申请日：2009-01-06
申请人： Venkata Satya Nirogi Ramakrishna , Vikas Shreekrishna Shirsath , Rama Sastri Kambhampati , Venkata Satya Veerabhadra Vadlamudi Rao , Venkateswarlu Jasti
发明人： Venkata Satya Nirogi Ramakrishna , Vikas Shreekrishna Shirsath , Rama Sastri Kambhampati , Venkata Satya Veerabhadra Vadlamudi Rao , Venkateswarlu Jasti
IPC分类号： A61K31/404 , C07D209/36 , A61P3/04 , A61P25/28 , A61P25/18
CPC分类号： C07D209/36 , C07D209/08
摘要： N-arylsulfonyl-3-aminoalkoxyindoles indole compounds, radioisotopes, stereoisomers, geometric forms, N-oxides, polymorphs and pharmaceutically acceptable salts.

46. 发明申请

US20090131501A1 Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof 有权
标题翻译：可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法
公开(公告)号：US20090131501A1
公开(公告)日：2009-05-21
申请号：US12357115
申请日：2009-01-21
申请人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
发明人： Nigel H. Greig , Karen T.Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
IPC分类号： A61K31/407 , A61P25/28
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译：本发明提供了向受试者施用可以降低βAPP产生并且在广泛剂量范围内无毒性的化合物和方法。本发明还提供了非氨基甲酸酯化合物和向可以减少βAPP产生并且在广泛剂量范围内无毒性的受试者施用此类化合物的方法。已经发现外消旋或对映异构体纯的非氨基甲酸酯化合物可用于降低βAPP产生。

47. 发明授权

US07507835B2 N-arylsulfonyl-3-aminoalkoxyindoles 有权
标题翻译： N-芳基磺酰基-3-氨基烷氧基吲哚
公开(公告)号：US07507835B2
公开(公告)日：2009-03-24
申请号：US10536592
申请日：2003-11-25
申请人： Venkata Satya Nirogi Ramakrishna , Vikas Shreekrishna Shirsath , Rama Sastri Kambhampati , Venkata Satya Veerabhadra Vadlamudi Rao , Venkateswarlu Jasti
发明人： Venkata Satya Nirogi Ramakrishna , Vikas Shreekrishna Shirsath , Rama Sastri Kambhampati , Venkata Satya Veerabhadra Vadlamudi Rao , Venkateswarlu Jasti
IPC分类号： C07D209/36 , A61K51/04
CPC分类号： C07D209/36 , C07D209/08
摘要： N-arylsulfonyl-3-aminoalkoxyindoles indole compounds, radioisotopes, stereoisomers, geometric forms, N-oxides, polymorphs and pharmaceutically acceptable salts.
摘要翻译： N-芳基磺酰基-3-氨基烷氧基吲哚吲哚化合物，放射性同位素，立体异构体，几何形式，N-氧化物，多晶型物和药学上可接受的盐。

48. 发明授权

US07439359B2 Small molecule compositions for binding to hsp90 有权
标题翻译：用于结合hsp90的小分子组合物
公开(公告)号：US07439359B2
公开(公告)日：2008-10-21
申请号：US10415868
申请日：2001-11-01
申请人： Gabriela Chiosis , Neal Rosen
发明人： Gabriela Chiosis , Neal Rosen
IPC分类号： C07D473/40 , C07D473/30 , C07D473/34 , A61K31/52 , A61K31/522 , A61P35/00
CPC分类号： C07D473/00 , A61K31/52 , C07D209/36 , C07D473/34 , C07D473/40
摘要： Structural differences in binding pockets of members of the HSP90 family can be exploited to achieve differential degradation of kinases and other signaling proteins through the use of designed small molecules which interact with the N-terminal binding pocket with an affinity which is greater than ADP and different from the ansamycin antibiotics for at least one species of the HSP90 family. Moreover, these small molecules can be designed to be soluble in aqueous media, thus providing a further advantage over the use of ansamycin antibiotics. Pharmaceutical compositions can be formulated containing a pharmaceutically acceptable carrier and a molecule that includes a binding moiety which binds to the N-terminal pocket of at least one member of the HSP90 family of proteins. Such binding moieties were found to have antiproliferative activity against tumor cells which are dependent on proteins requiring chaperones of the HSP90 family for their function. Different chemical species have different activity, however, allowing the selection of, for example Her2 degradation without degradation of Raf kinase. Thus, the binding moieties possess an inherent targeting capacity. In addition, the small molecules can be linked to targeting moieties to provide targeting of the activity to specific classes of cells. Thus, the invention further provides a method for treatment of diseases, including cancers, by administration of these compositions. Dimeric forms of the binding moieties may also be employed.
摘要翻译：可以利用HSP90家族成员的结合口袋的结构差异，通过使用与N末端结合口袋相互作用的设计的小分子来实现激酶和其他信号传导蛋白质的差异降解，其亲和力大于ADP和不同对于至少一种HSP90家族的安莎霉素抗生素。此外，这些小分子可以被设计成可溶于含水介质，因此比使用安莎霉素抗生素提供了进一步的优点。药物组合物可以配制成含有药学上可接受的载体和分子，该分子包括与蛋白质的HSP90家族的至少一个成员的N-末端口袋结合的结合部分。发现这样的结合部分具有抗肿瘤细胞的抗增殖活性，其依赖于需要HSP90家族伴侣的功能的蛋白质。不同的化学物质具有不同的活性，然而，允许选择例如Her2降解而不降解Raf激酶。因此，结合部分具有固有的靶向能力。此外，小分子可以连接到靶向部分，以提供对特定细胞类别的活性的靶向。因此，本发明还提供了通过施用这些组合物来治疗疾病，包括癌症的方法。还可以使用结合部分的二聚体形式。

49. 发明申请

US20070155816A1 Indirubin derivatives having anticancer property against human cancer cell line 有权
标题翻译：对人癌细胞株具有抗癌性的靛玉红衍生物
公开(公告)号：US20070155816A1
公开(公告)日：2007-07-05
申请号：US10586780
申请日：2005-01-26
申请人： Yong-Chul Kim , Si Wouk Kim , Tae Kim , Sang Kook Lee , Jae Il Kim , Jung-Hoon Yoon , Sang-Gun Ahn , Myoung Moon
发明人： Yong-Chul Kim , Si Wouk Kim , Tae Kim , Sang Kook Lee , Jae Il Kim , Jung-Hoon Yoon , Sang-Gun Ahn , Myoung Moon
IPC分类号： A61K31/404 , C07D403/04
CPC分类号： A61K31/403 , C07D209/36 , C07D209/40
摘要： The present invention relates to an indirubin derivative having anticancer property by inhibiting cell proliferation as to human cancer cell line. More particularly, this invention provides the synthesis of indirubin derivative known as CDK(Cyclin-dependent kinase) inhibitor. Further, inhibition activity of proliferation as to human cancer cell line and apoptosis against induced-differentiation of said indirubin derivative are researched to develop a novel indirubin derivative having efficacious anticancer properties as to various human cell lines.
摘要翻译：本发明涉及通过抑制人癌细胞系的细胞增殖而具有抗癌性的靛玉红衍生物。更具体地，本发明提供称为CDK（细胞周期蛋白依赖性激酶）抑制剂的靛玉红衍生物的合成。此外，研究了对人癌细胞系增殖的抑制活性和对所述靛玉红衍生物的诱导分化的凋亡，以开发出对各种人细胞系具有有效抗癌特性的新的靛玉红衍生物。

50. 发明申请

US20060270729A1 Agents useful for reducing amylioid precursor protein and treating dementia and methods of use thereof 审中-公开
标题翻译：可用于还原淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法
公开(公告)号：US20060270729A1
公开(公告)日：2006-11-30
申请号：US11455959
申请日：2006-06-20
申请人： Nigel Greig , Karen Shaw , Qiang-Sheng Yu , Harold Holloway , Tada Utsuki , Timothy Soncrant , Donald Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
发明人： Nigel Greig , Karen Shaw , Qiang-Sheng Yu , Harold Holloway , Tada Utsuki , Timothy Soncrant , Donald Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane Davidson , Michael Sturgess
IPC分类号： A61K31/407 , A61K31/405 , A61K31/381 , A61K31/343
CPC分类号： C07D487/04 , A61K31/325 , A61K31/343 , A61K31/345 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/405 , A61K31/407 , C07D209/16 , C07D209/34 , C07D209/36 , C07D209/38 , C07D277/82 , C07D453/04 , C07D471/04 , C07D487/08 , C07D491/04 , C07D495/04
摘要： The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
摘要翻译：本发明提供了向受试者施用可以降低βAPP产生并且在广泛剂量范围内无毒性的化合物和方法。本发明还提供了非氨基甲酸酯化合物和向可以减少βAPP产生并且在广泛剂量范围内无毒性的受试者施用此类化合物的方法。已经发现外消旋或对映异构体纯的非氨基甲酸酯化合物可用于降低βAPP产生。

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