专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明授权

US08269043B2 Bicyclic aryl sphingosine 1-phosphate analogs 有权
标题翻译：双环芳基鞘氨醇1-磷酸类似物
公开(公告)号：US08269043B2
公开(公告)日：2012-09-18
申请号：US12588883
申请日：2009-10-30
申请人： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
发明人： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC分类号： C07C211/00 , C09B11/02 , A61K31/66
CPC分类号： A61K31/135 , A61K31/27 , C07C205/26 , C07C205/50 , C07C217/52 , C07C217/60 , C07C229/32 , C07C271/16 , C07D263/38 , C07F9/091 , C07F9/093 , C07F9/653 , C07F9/65744
摘要： Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
摘要翻译：提供了在一种或多种S1P受体上具有激动剂活性的化合物。化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。

42. 发明授权

US08013018B2 Aminoindane derivative or salt thereof 有权
标题翻译：氨基茚满衍生物或其盐
公开(公告)号：US08013018B2
公开(公告)日：2011-09-06
申请号：US12305254
申请日：2007-07-17
申请人： Satoshi Hayashibe , Shingo Yamasaki , Kazushi Watanabe , Nobuyuki Shiraishi , Daisuke Suzuki , Hiroaki Hoshii , Junya Ohmori , Takatoshi Kanayama
发明人： Satoshi Hayashibe , Shingo Yamasaki , Kazushi Watanabe , Nobuyuki Shiraishi , Daisuke Suzuki , Hiroaki Hoshii , Junya Ohmori , Takatoshi Kanayama
IPC分类号： A01N37/12 , A01N37/44 , A01N33/18 , A01N33/24 , A61K31/24 , A61K31/04
CPC分类号： C07C211/42 , C07C215/42 , C07C215/44 , C07C217/52 , C07C235/40 , C07C255/58 , C07C2602/08 , C07D209/40 , C07D221/16 , C07D295/12 , C07D307/82 , C07D333/78
摘要： Provided is a compound that is an NMDA receptor antagonist having a broader safety margin, and is useful as an agent for treating or preventing Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, or pain.A novel compound or a salt thereof, which is characterized in that it has an amino group and R1 (lower alkyl, cycloalkyl, -lower alkylene-aryl, aryl which may be substituted, and the like) on carbon atoms of indane, cyclopenta[b]thiophene, cyclopenta[b]furan, cyclopenta[b]pyridine, or cyclopenta[c]pyridine ring, or 2,3 -dihydro-1-benzofuran, 2,3-dihydro-1-benzothiophene, indoline ring, or the like, and has R2 and R3 (the same or different, each lower alkyl or aryl) on carbon atoms beside them, and an NMDA receptor antagonist comprising the same as an active component.
摘要翻译：提供了具有更宽安全裕度的NMDA受体拮抗剂的化合物，可用作治疗或预防阿尔茨海默病，脑血管性痴呆，帕金森病，缺血性中风或疼痛的药剂。一种新型化合物或其盐，其特征在于其具有在茚满的环戊二烯基的碳原子上具有氨基和可以被取代的R 1（低级烷基，环烷基， - 低级亚烷基 - 芳基，芳基等） b]噻吩，环戊二烯并[b]呋喃，环戊二烯并[b]吡啶或环戊并[c]吡啶环，或2,3-二氢-1-苯并呋喃，2,3-二氢-1-苯并噻吩，二氢吲哚环，或并且在它们旁边的碳原子上具有R2和R3（相同或不同，各个低级烷基或芳基），以及包含与活性组分相同的NMDA受体拮抗剂。

43. 发明申请

US20110144390A1 Method for Producing O-Alkylated Aminoalcohols 有权
标题翻译：生产O-烷基化氨基醇的方法
公开(公告)号：US20110144390A1
公开(公告)日：2011-06-16
申请号：US12158517
申请日：2006-12-11
申请人： Wolfgang Siegel , Gerd Haderlein , Tobias Stab
发明人： Wolfgang Siegel , Gerd Haderlein , Tobias Stab
IPC分类号： C07C213/06
CPC分类号： C07C213/06 , C07C2601/14 , C07C217/52
摘要： A process for preparing O-alkylated amino alcohols by reacting N-unsubstituted or N-monosubstituted amino alkoxide salts with alkyl halides, the amino alkoxide salts being formed by means of alkali metal or alkaline earth metal hydroxides.
摘要翻译：通过使N-未取代或N-单取代的氨基醇盐与烷基卤化物反应制备O-烷基化氨基醇的方法，所述氨基醇盐通过碱金属或碱土金属氢氧化物形成。

44. 发明申请

US20110124912A1 MONOETHERIFIED DIOLS OF DIAMONDOIDS 审中-公开
标题翻译：单一的DIAMONDOID DIOLS
公开(公告)号：US20110124912A1
公开(公告)日：2011-05-26
申请号：US12996399
申请日：2009-06-02
申请人： Peter R. Schreiner , Hartmut Schwertfeger
发明人： Peter R. Schreiner , Hartmut Schwertfeger
IPC分类号： C07C227/02 , C07C43/196 , C07C41/09 , C07C231/06 , C07C213/02
CPC分类号： C07C41/09 , C07C43/196 , C07C215/44 , C07C217/52 , C07C229/50 , C07C233/23 , C07C2603/90 , Y02P20/55
摘要： The invention at hand describes functionalized diols of diamondoids, in which one of the two hydroxy groups is masked by a protective group, as well as methods for producing these functionalized diols. The protective group is a group —CHR1R2, wherein R1 and R2 stand for alkyl groups and the protective group comprises at least one halogen atom. The monoethers of the diamondoid diols according to the present invention are produced by reacting the diamondoid diol with a halogenated alcohol CHOHR1R2 in the presence of a catalyst acid.The monoetherified diols allow for the targeted production of derivatives of diamondoids, for example, of the corresponding aminoalcohols and aminocarboxylic acids. For that purpose, the diamondoid monoether is reacted in a first step with a halogen nitrile in a Ritter reaction to the corresponding monoether amide. From this monoether amide, the corresponding aminoalcohol can be produced by reacting the protective group —CHR1R2 first with trifluoroacetic acid to the alkanoyloxy group and by subsequently obtaining the aminoalcohol by reaction with thiourea, ethanol and glacial acetic acid.The aminoalcohol can be reacted with a sulfuric acid/formic acid or oleum/formic acid to the corresponding aminocarboxylic acid.The amino, hydroxy and carboxylic groups of the diamondoids can be converted into many other functional groups.
摘要翻译：本发明描述了金刚石的官能化二醇，其中两个羟基中的一个被保护基掩蔽，以及制备这些官能化二醇的方法。保护基是基团-CHR1R2，其中R1和R2代表烷基，保护基包括至少一个卤素原子。根据本发明的金刚石二醇的单醚通过在催化剂酸的存在下使类金刚石二醇与卤代醇CHOHR1R2反应来制备。单醚化的二醇允许目标生成类金刚石衍生物，例如相应的氨基醇和氨基羧酸。为此，金刚石单醚在第一步中与Ritter反应中的卤素腈与相应的单醚酰胺反应。从该单醚酰胺可以通过使保护基-CHR1R2与三氟乙酸首先与烷酰氧基反应，随后通过与硫脲，乙醇和冰醋酸反应得到氨基醇来制备相应的氨基醇。氨基醇可以与硫酸/甲酸或发烟硫酸/甲酸反应至相应的氨基羧酸。金刚石的氨基，羟基和羧基可以转化为许多其他官能团。

45. 发明申请

US20100249374A1 DIPHENYLMETHANE COMPOUND 有权
标题翻译：二苯基甲烷化合物
公开(公告)号：US20100249374A1
公开(公告)日：2010-09-30
申请号：US12749980
申请日：2010-03-30
申请人： Daisuke TAKAHASHI
发明人： Daisuke TAKAHASHI
IPC分类号： C07K1/06 , C07C43/23 , C07C217/58 , C07C217/64
CPC分类号： C07C43/23 , C07C43/2055 , C07C217/52 , C07C217/58 , C07C2601/14 , C07K1/06 , C07K1/062 , C07K1/066 , C07K5/1021
摘要： Compounds having a diphenylmethane skeleton are superior in broad utility and stability, and are useful as a protecting reagent (anchor) of amino acid and/or peptide in the liquid phase synthesis and the like of a peptide having a C-terminal etc., which are of a carboxamide(-CONHR)-type, and in organic synthetic reaction methods (particularly peptide liquid phase synthetic methods), and may be contained in a kit for peptide liquid phase synthesis.
摘要翻译：具有二苯基甲烷骨架的化合物的广泛用途和稳定性优异，可用作具有C末端等的肽的液相合成等中的氨基酸和/或肽的保护试剂（锚）具有羧酰胺（-CONHR）型，有机合成反应方法（特别是肽液相合成方法），可以包含在用于肽液相合成的试剂盒中。

46. 发明申请

US20090186916A1 AMINOINDANE DERIVATIVE OR SALT THEREOF 有权
标题翻译：氨基衍生物或其盐
公开(公告)号：US20090186916A1
公开(公告)日：2009-07-23
申请号：US12305254
申请日：2007-07-17
申请人： Satoshi Hayashibe , Shingo Yamasaki , Kazushi Watanabe , Nobuyuki Shiraishi , Daisuke Suzuki , Hiroaki Hoshii , Junya Ohmori , Takatoshi Kanayama
发明人： Satoshi Hayashibe , Shingo Yamasaki , Kazushi Watanabe , Nobuyuki Shiraishi , Daisuke Suzuki , Hiroaki Hoshii , Junya Ohmori , Takatoshi Kanayama
IPC分类号： A61K31/135 , C07C211/38 , C07D333/78 , C07D307/93 , C07D221/04 , A61K31/381 , A61K31/343 , A61K31/44 , A61P25/00
CPC分类号： C07C211/42 , C07C215/42 , C07C215/44 , C07C217/52 , C07C235/40 , C07C255/58 , C07C2602/08 , C07D209/40 , C07D221/16 , C07D295/12 , C07D307/82 , C07D333/78
摘要： Provided is a compound that is an NMDA receptor antagonist having a broader safety margin, and is useful as an agent for treating or preventing Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, or pain.A novel compound or a salt thereof, which is characterized in that it has an amino group and R1 (lower alkyl, cycloalkyl, -lower alkylene-aryl, aryl which may be substituted, and the like) on carbon atoms of indane, cyclopenta[b]thiophene, cyclopenta[b]furan, cyclopenta[b]pyridine, or cyclopenta[c]pyridine ring, or 2,3-dihydrdo-1-benzofuran, 2,3-dihydrdo-1-benzothiophene, indoline ring, or the like, and has R2 and R3 (the same or different, each lower alkyl or aryl) on carbon atoms beside them, and an NMDA receptor antagonist comprising the same as an active component.
摘要翻译：提供了具有更宽安全裕度的NMDA受体拮抗剂的化合物，可用作治疗或预防阿尔茨海默病，脑血管性痴呆，帕金森病，缺血性中风或疼痛的药剂。一种新型化合物或其盐，其特征在于其具有在茚满的环戊二烯基的碳原子上具有氨基和可以被取代的R 1（低级烷基，环烷基， - 低级亚烷基 - 芳基，芳基等） b]噻吩，环戊二烯并[b]呋喃，环戊二烯并[b]吡啶或环戊二烯并[c]吡啶环，或2,3-二氢-1-苯并呋喃，2,3-二氢-1-苯并噻吩，二氢吲哚环或并且在它们旁边的碳原子上具有R2和R3（相同或不同，各个低级烷基或芳基），以及包含与活性组分相同的NMDA受体拮抗剂。

47. 发明授权

US07420003B2 Compounds and a novel process for their preparation 失效
标题翻译：化合物及其制备方法
公开(公告)号：US07420003B2
公开(公告)日：2008-09-02
申请号：US10855783
申请日：2004-05-28
申请人： Keith Fagnou , Mark Lautens
发明人： Keith Fagnou , Mark Lautens
IPC分类号： C07C43/18 , A61K31/075
CPC分类号： C07D295/096 , C07B2200/07 , C07C41/01 , C07C43/196 , C07C43/23 , C07C43/253 , C07C45/71 , C07C49/84 , C07C67/24 , C07C69/013 , C07C69/732 , C07C205/38 , C07C215/44 , C07C217/52 , C07C255/54 , C07C271/24 , C07C311/20 , C07C2602/10 , C07D209/08 , C07D215/06 , C07D217/04 , C07D295/135 , C07F7/081 , C07F7/1804 , C07C69/16 , C07C69/78 , C07C69/08 , C07C69/54 , C07C69/38
摘要： The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a catalyst and in the presence of a phosphine ligand. The compounds synthesized may be used in pharmaceutical preparations for the treatment of a variety of diseases and conditions.
摘要翻译：本发明涉及制备含有水合萘环结构的对映体富集化合物的方法。该方法包括使用铑作为催化剂和在膦配体的存在下，使异丁苯并苯并异戊二烯与亲核试剂反应。合成的化合物可用于治疗各种疾病和病症的药物制剂中。

48. 发明授权

US07211694B2 Substituted 4-aminocyclohexanols 有权
标题翻译：取代的4-氨基环己醇
公开(公告)号：US07211694B2
公开(公告)日：2007-05-01
申请号：US10947551
申请日：2004-09-23
申请人： Bernd Sundermann , Hagen-Heinrich Hennies , Werner Englberger , Babette-Yvonne Koegel
发明人： Bernd Sundermann , Hagen-Heinrich Hennies , Werner Englberger , Babette-Yvonne Koegel
IPC分类号： C07C211/38 , C07D277/62 , C07D209/04 , C07D333/56 , C07D333/72 , C07D317/72 , C07D307/94
CPC分类号： C07C217/52 , C07C2601/14 , C07D209/18 , C07D333/20
摘要： Substituted 4-aminocyclohexanols, processes for their preparation, pharmaceutical compositions comprising these compounds and to the use of substituted 4-aminocyclohexanols in the preparation of pharmaceutical compositions for the treatment of various indications, especially pain as well as the treatment of these indications.
摘要翻译：取代的4-氨基环己醇，其制备方法，包含这些化合物的药物组合物以及在制备用于治疗各种适应症，特别是疼痛以及治疗这些适应症的药物组合物中的取代的4-氨基环己醇的用途。

49. 发明申请

US20070004718A1 Ion channel modulating compounds and uses thereof 审中-公开
公开(公告)号：US20070004718A1
公开(公告)日：2007-01-04
申请号：US11450921
申请日：2006-06-09
申请人： Allen Bain , Gregory Beatch , Cindy Longley , Bertrand Plouvier , Tao Sheng , Michael Walker , Richard Wall , Sandro Yong , Jeff Zhu , Alexander Zolotoy
发明人： Allen Bain , Gregory Beatch , Cindy Longley , Bertrand Plouvier , Tao Sheng , Michael Walker , Richard Wall , Sandro Yong , Jeff Zhu , Alexander Zolotoy
IPC分类号： A61K31/5375 , A61K31/495 , A61K31/445 , A61K31/405 , A61K31/4015 , A61K31/138
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.

50. 发明授权

US06953792B2 Cyclohexyl derivatives and their use as therapeutic agents 失效
标题翻译：环己基衍生物及其作为治疗剂的用途
公开(公告)号：US06953792B2
公开(公告)日：2005-10-11
申请号：US10276129
申请日：2001-05-16
申请人： Jose Luis Castro Pineiro , Kevin Dinnell , Jason Matthew Elliot , Gregory John Hollingworth , Duncan Edward Shaw , Christopher John Swain , Lihu Yang
发明人： Jose Luis Castro Pineiro , Kevin Dinnell , Jason Matthew Elliot , Gregory John Hollingworth , Duncan Edward Shaw , Christopher John Swain , Lihu Yang
IPC分类号： C07D295/04 , A61K31/075 , A61K31/12 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/215 , A61K31/341 , A61K31/357 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/4164 , A61K31/4196 , A61K31/4355 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4453 , A61K31/451 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P1/08 , A61P25/04 , A61P25/06 , A61P25/22 , A61P25/24 , A61P29/00 , A61P43/00 , C07C43/178 , C07C45/29 , C07C49/497 , C07C49/517 , C07C49/697 , C07C49/747 , C07C49/753 , C07C69/757 , C07C69/767 , C07C217/48 , C07C217/52 , C07C229/22 , C07C233/23 , C07C233/31 , C07C233/32 , C07C233/58 , C07C233/59 , C07C235/40 , C07C235/80 , C07C235/82 , C07C237/04 , C07C237/08 , C07C237/24 , C07D207/06 , C07D207/16 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/74 , C07D213/38 , C07D217/04 , C07D233/90 , C07D241/08 , C07D257/04 , C07D265/30 , C07D275/04 , C07D277/28 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/192 , C07D295/205 , C07D307/52 , C07D317/72 , C07D333/20 , C07D401/04 , C07D401/06 , C07D413/04 , C07D417/12 , C07D487/08 , C07D491/20 , C07D295/16
CPC分类号： C07D295/185 , C07B2200/09 , C07C45/29 , C07C49/697 , C07C49/747 , C07C49/753 , C07C217/52 , C07C233/23 , C07C233/31 , C07C233/58 , C07C233/59 , C07C235/40 , C07C235/82 , C07C237/04 , C07C237/24 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D211/48 , C07D211/58 , C07D213/38 , C07D241/08 , C07D295/096 , C07D295/15 , C07D295/155 , C07D295/192 , C07D295/205 , C07D401/06 , C07C47/228
摘要： The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R?17, R18, R19, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
摘要翻译：本发明涉及式（I）的化合物：其中环A为苯基或吡啶环; X代表选自（a），（b），（c），（d），（e），（f），（g），（h），（i），（j），（k），（1）和R 1，R 2，R 3，R 4，R R 5，R 6，R 7，R 13，R 14，R 14， R 16，R 16，R 17，R 18，R 19，R 21a， SUP>和R 21b如本文所定义。该化合物特别用于治疗或预防抑郁，焦虑，疼痛，炎症，偏头痛，呕吐或带状疱疹后神经痛。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式