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41. 发明申请

US20050258570A1 Imprinting of supported and free-standing 3-D micro- or nano-structures 有权
标题翻译：支持和独立的3-D微结构或纳米结构的印刷
公开(公告)号：US20050258570A1
公开(公告)日：2005-11-24
申请号：US10852448
申请日：2004-05-24
申请人： Yen Kong , Hong Low , Stella Pang , Albert Yee
发明人： Yen Kong , Hong Low , Stella Pang , Albert Yee
IPC分类号： B28B11/08 , B29C59/02 , B81C1/00 , B81C99/00 , B82B3/00 , G03C5/00 , G03F7/00
CPC分类号： A61M25/00 , B27N3/08 , B28B3/06 , B81C99/0085 , B81C2201/034 , B81C2203/032 , B81C2203/038 , B82Y10/00 , B82Y40/00 , G03F7/0002 , Y10T428/24479 , Y10T428/254
摘要： The present invention is directed to micro- and nano-scale imprinting methods and the use of such methods to fabricate supported and/or free-standing 3-D micro- and/or nano-structures of polymeric, ceramic, and/or metallic materials. In some embodiments, a duo-mold approach is employed in the fabrication of these structures. In such methods, surface treatments are employed to impart differential surface energies to different molds and/or different parts of the mold(s). Such surface treatments permit the formation of three-dimensional (3-D) structures through imprinting and the transfer of such structures to a substrate. In some or other embodiments, such surface treatments and variation in glass transition temperature of the polymers used can facilitate separation of the 3-D structures from the molds to form free-standing micro- and/or nano-structures individually and/or in a film. In some or other embodiments, a “latch-on” assembly technique is utilized to form supported and/or free-standing stacked micro- and/or nano-structures that enable the assembly of polymers without a glass transition temperature and eliminate the heating required to assemble thermoplastic polymers.
摘要翻译：本发明涉及微尺度和纳米级压印方法，并且使用这种方法来制造聚合物，陶瓷和/或金属材料的负载和/或独立的3-D微观和/或纳米结构。在一些实施例中，在制造这些结构中采用双模方法。在这种方法中，使用表面处理以将不同的表面能赋予模具的不同模具和/或模具的不同部分。这种表面处理允许通过压印形成三维（3-D）结构并将这种结构转移到基底上。在一些或其它实施方案中，所使用的聚合物的这种表面处理和玻璃化转变温度的变化可促进3-D结构与模具的分离，以单独形成独立的和/或纳米结构，并且/ 电影。在一些或其它实施方案中，使用“闭锁”组装技术来形成支撑和/或独立堆叠的微结构和/或纳米结构，其能够组装聚合物而不具有玻璃化转变温度并消除所需的加热组装热塑性聚合物。

42. 发明申请

US20050230876A1 Manufacturing method of a microchemical chip made of a resin and a microchemical chip made of a resin by the method 有权
标题翻译：通过该方法由树脂制成的微化学芯片和由树脂制成的微化学芯片的制造方法
公开(公告)号：US20050230876A1
公开(公告)日：2005-10-20
申请号：US11103497
申请日：2005-04-12
申请人： Mitsuru Saito , Yoshiyuki Ikegami , Kenji Obara
发明人： Mitsuru Saito , Yoshiyuki Ikegami , Kenji Obara
IPC分类号： G01N37/00 , B29C33/00 , B29C33/38 , B29C33/42 , B29C39/02 , B29C41/02 , B29L31/00 , B81C1/00 , G03F7/00 , B29C33/40
CPC分类号： B29C39/26 , B01L3/502707 , B29C33/306 , B29C33/3842 , B29C33/424 , B29C39/006 , B29C45/2673 , B29C45/372 , B29K2033/08 , B29K2083/00 , B29L2031/756 , B81B2201/051 , B81B2201/058 , B81C99/0085 , B81C99/009
摘要： A manufacturing method of a microchemical chip made of a resin and having a micro channel, which comprises forming a photoresist film over the surface of one side of a metal support substratum, stacking a photomask for the formation of a channel pattern over the photoresist film, forming a minute-structure photoresist pattern over the metal support substratum by a photofabrication technology as a flat-sheet mold, disposing the flat-sheet mold or unit mold obtained by separating the flat-sheet mold on the bottom of a contour forming frame for resin molding, pouring a resin into the contour forming frame for resin molding and curing the resin to form a resin structure having a micro channel formed by the mold, and attaching the resin structure having a micro channel to a flat sheet to be a lid of the micro channel; and microchemical chips manufactured by this method.
摘要翻译：一种由树脂制成并具有微通道的微化学芯片的制造方法，包括在金属支撑基底的一侧的表面上形成光致抗蚀剂膜，在光致抗蚀剂膜上堆叠用于形成沟道图案的光掩模，通过作为平板模具的光加工技术在金属支撑基底上形成微小结构光致抗蚀剂图案，将通过将平板模具分离而获得的平板模具或单元模具设置在用于树脂的轮廓形成框架的底部上将树脂浇注到轮廓成形框架中以进行树脂模制和固化树脂，以形成具有由模具形成的微通道的树脂结构，并将具有微通道的树脂结构附着到平板上，以成为微通道和通过该方法制造的微量化学芯片。

43. 发明授权

US06948245B2 Gear and method of making the same 失效
标题翻译：齿轮和制作方法
公开(公告)号：US06948245B2
公开(公告)日：2005-09-27
申请号：US10149055
申请日：2000-12-04
申请人： Takashi Nishi
发明人： Takashi Nishi
IPC分类号： B23P15/14 , B81B1/00 , B81B5/00 , B81C1/00 , B81C99/00 , F16H55/17
CPC分类号： F16H55/22 , B23P15/14 , B81B2201/035 , B81C99/0085 , Y10T29/49462 , Y10T29/49467 , Y10T29/49469 , Y10T29/4948
摘要： In order that a worm 1 is rotated, a clearance (a region constituting a clearance portion between bearings and a worm gear) is formed (FIGS. 4(1) to (3)) in an upper surface of a base plate 3. A mold 12 for forming a lower half region of the worm therein is formed (FIG. 4(8)). A material 5 for the worm is deposited (FIG. 4(9)) to a height equal to that of a lower half region plus that of an upper half of the worm. An upper half of the worm is formed (FIGS. 4(10) to (12). Finally, the material 13 in the clearance between the base plate 3 and gear 1 is removed (FIG. 4(13)).
摘要翻译：为了使蜗杆1旋转，在基板3的上表面形成有间隙（构成轴承和蜗轮之间的间隙部的区域）（图4（1）〜（3））。形成用于形成蜗杆下半部分的模具12（图4（8））。将蠕虫的材料5（图4（9））沉积到等于下半部分加上蠕虫上半部的高度的高度。形成蜗杆的上半部（图4（10）〜（12）），最后移除基板3与齿轮1之间的间隙中的材料13（图4（13））。

44. 发明申请

US20050110180A1 Process for producing a tool insert for injection molding a microstructured part 有权
标题翻译：用于生产用于注射模塑微结构部件的工具刀片的方法
公开(公告)号：US20050110180A1
公开(公告)日：2005-05-26
申请号：US10720965
申请日：2003-11-24
申请人： Max Gmur , Thomas Fassler
发明人： Max Gmur , Thomas Fassler
IPC分类号： B01L3/00 , B23P15/00 , B29C33/00 , B29C33/38 , B29C45/26 , B29C45/37 , B81B1/00 , B81C1/00 , B81C99/00 , G03F7/00
CPC分类号： B23P15/007 , B01L3/5027 , B29C45/2628 , B29C45/2673 , B29C45/372 , B29L2031/756 , B81C99/0085 , B81C99/009
摘要： Process for producing a tool insert for injection molding a microstructured part fabricated of a synthetic material, a metal or a ceramic material and which comprises an arrangement of microchannels and which further comprises an arrangement of through-going orifices extending in a substantially perpendicular manner with respect to the outer surface of the part. The process comprises the following steps: (1) microstructuring the front side of a first wafer by means of plasma etching to form the arrangement of microchannels, which are formed on the front side of the wafer, (2) removing the etching mask from the front side of the first wafer, (3) microstructuring the rear side of the first wafer by means of plasma etching to form the arrangement of through-going orifices which extend in a substantially perpendicular manner with respect to the front side of the first wafer, (4) removing the etching mask from the rear side of the first wafer, (5) bonding the rear side of the first wafer to a carrier substrate to form a master, (6) electrochemically depositing a metal layer on the front side of the first wafer and in the through-going orifices which are present therein, wherein the deposited metal layer achieves a depth which is greater than the depth of the microchannels on the front side of the first wafer, and (7) separating the metal layer from the master, wherein the separated metal layer can be used as a tool insert for injection molding a part and has integrated in the metal layer piercing punches, each such punch having a shape and dimensions defined by the shape and dimensions of a corresponding one of the through-going orifices provided in the first wafer.
摘要翻译：用于制造用于注射模制由合成材料，金属或陶瓷材料制成的微结构部件的工具插入件的方法，其包括微通道的布置，并且还包括以基本上垂直的方式延伸的贯穿孔的布置，到零件的外表面。该方法包括以下步骤：（1）通过等离子体蚀刻对第一晶片的正面进行微结构以形成在晶片前侧形成的微通道的布置，（2）从蚀刻掩模（3）通过等离子体蚀刻对第一晶片的后侧进行微结构以形成相对于第一晶片的前侧以基本上垂直的方式延伸的贯通孔的布置，（4）从第一晶片的后侧去除蚀刻掩模，（5）将第一晶片的后侧粘合到载体基板上以形成母板，（6）在金属层的前侧电化学沉积金属层第一晶片和存在于其中的通孔中，其中沉积的金属层实现比第一晶片正面上的微通道的深度大的深度，以及（7）将金属层从主体，其中分离的金属层可以用作用于注射成型零件的工具插入件，并且已经集成在金属层穿孔冲头中，每个这样的冲头具有由相应的一个的相应的一个的形状和尺寸限定的形状和尺寸提供在第一晶片中的贯穿孔。

45. 发明申请

US20040266049A1 Micro device and process for producing it 失效
标题翻译：微型设备及其生产工艺
公开(公告)号：US20040266049A1
公开(公告)日：2004-12-30
申请号：US10631421
申请日：2003-07-30
发明人： Manfred Detterbeck , Stefan Lutter , Mathieu Burri , Theo Hartmann , Terunobu Akiyama
IPC分类号： H01L021/00
CPC分类号： G03F7/0035 , B81C99/0085 , G03F7/16
摘要： A micro device comprising a SU-8 photoresist layer adhered to a thin layer of, for example, silicon nitride, silicon oxide, metal, and diamond. The SU-8 layer is clamped on the thin layer by using an under-etching technique.
摘要翻译：一种微器件，包括粘附到例如氮化硅，氧化硅，金属和金刚石的薄层上的SU-8光致抗蚀剂层。通过使用底蚀刻技术将SU-8层夹在薄层上。

46. 发明授权

US06752942B2 Method of forming articles including waveguides via capillary micromolding and microtransfer molding 有权
标题翻译：通过毛细管微成型和微转移成型形成包括波导的制品的方法
公开(公告)号：US06752942B2
公开(公告)日：2004-06-22
申请号：US10016614
申请日：2001-10-30
申请人： Enoch Kim , Younan Xia , Milan Mrksich , Rebecca J. Jackman , Xiao-Mei Zhao , Stephen P. Smith , Mara G. Prentiss , George M. Whitesides , Christian Marzolin
发明人： Enoch Kim , Younan Xia , Milan Mrksich , Rebecca J. Jackman , Xiao-Mei Zhao , Stephen P. Smith , Mara G. Prentiss , George M. Whitesides , Christian Marzolin
IPC分类号： B29C4102
CPC分类号： B81C1/00206 , A61K47/6957 , B01J19/0046 , B01J2219/00382 , B01J2219/00416 , B01J2219/0043 , B01J2219/00466 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00713 , B29C31/04 , B29C33/42 , B29C37/0053 , B29C39/24 , B29C43/021 , B29C67/246 , B29D11/00346 , B29D11/00663 , B29K2105/0002 , B29L2011/0016 , B81B2201/0214 , B81C1/00031 , B81C99/0085 , B81C2201/034 , B82Y30/00 , C40B60/14 , G01N21/7703 , G01N2021/7776 , G02B6/138 , H05K3/0079 , H05K3/061
摘要： Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraries, etc. can be made. Differences in refractive index of waveguide and cladding can be created by subjecting the waveguide and cladding, made of identical prepolymeric material, to different polymerization or cross-linking conditions. Interferometers are defined by coupling arrays of waveguides, where coupling can be controlled by altering the difference in refractive index between cladding and waveguide at any desired location of the array. Alteration and refractive index can be created photochemically, chemically, or the like. Sensors also are disclosed, including biochemical sensors.
摘要翻译：化学或生物化学活性剂或其它物质通过提供具有轮廓表面的微胶体并在基底表面上形成结构的化学或生物化学活性剂或流体前体而在基底表面上图案化。化学或生物化学活性剂或流体前体也可以从敷料器中的凹陷转移到基底表面。衬底表面可以是平面的或非平面的。聚合物结构，无机陶瓷和盐等的流体前体可用于在表面形成图案化聚合物制品，无机盐和陶瓷，反应离子蚀刻掩模等。制品可以形成为包括横向尺寸小于约1毫米或更小的部分的图案。涂抹器的压痕图案可以用于将单独的，不同的化学或生物化学活性剂或流体前体转移到基底表面的分离的，分离的区域。可以制作波导阵列，组合化学或生物化学库等。可以通过将由相同的预聚物材料制成的波导和包层进行不同的聚合或交联条件来产生波导和包层的折射率差异。干涉仪通过耦合波导阵列来定义，其中可以通过改变阵列的任何所需位置处的包层和波导之间的折射率差来控制耦合。改变和折射率可以通过光化学，化学等方式产生。还公开了传感器，包括生化传感器。

47. 发明授权

US06256533B1 Apparatus and method for using an intracutaneous microneedle array 有权
标题翻译：使用皮内微针阵列的装置和方法
公开(公告)号：US06256533B1
公开(公告)日：2001-07-03
申请号：US09329025
申请日：1999-06-09
申请人： Vadim Vladimirovich Yuzhakov , Faiz Feisal Sherman , Grover David Owens , Vladimir Gartstein
发明人： Vadim Vladimirovich Yuzhakov , Faiz Feisal Sherman , Grover David Owens , Vladimir Gartstein
IPC分类号： A61N130
CPC分类号： B81C99/0085 , A61M5/1723 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , A61M2037/0061 , A61N1/30 , B81B2201/055
摘要： A microneedle array, constructed of silicon and silicon dioxide compounds or of a molded plastic material, is provided to penetrate the stratum corneum and epidermis layers of skin, but not into the dermis. The microneedles can be used to either dispense a liquid drug, or to sample a body fluid. The delivery of drugs and sampling of fluids can be performed by way of passive diffusion (time release), instantaneous injection, or iontophoresis. A complete closed-loop system can be manufactured including active elements, such as micro-machined pumps, as well as passive elements such as sensors. A “smart patch” can thereby be fabricated that samples body fluids, performs chemistry to decide on the appropriate drug dosage, and then administers the corresponding amount of drug. An electric field may be used to increase transdermal flow rate. Such a system can be made disposable, and can be used with medical devices to dispense drugs by iontophoretic/microneedle enhancement, to sample body fluids (while providing an iontophoretically/microneedle-enhanced body-fluid sensor), and as a closed-loop drug delivery system with fluid sampling feedback using a combination of the other two devices. As a drug dispensing system, the microneedle array includes electrodes that apply an electric potential to the skin between the electrode locations. One of the electrode assemblies is filled with an ionized drug, and the charged drug molecules move into the body due to the applied electric potential. As a body-fluid sampling system, the microneedle array also includes electrodes to assist in moving fluid from the body into a receiving chamber, and which further includes a bioelectrochemical sensor to measure the concentration of a particular substance.
摘要翻译：提供由硅和二氧化硅化合物或模制塑料材料构成的微针阵列以穿透角质层和皮肤表皮层，但不渗入真皮层。微针可以用于分配液体药物，或者对体液进行采样。可以通过被动扩散（时间释放），瞬时注射或离子电渗法进行药物的输送和液体取样。可以制造完整的闭环系统，包括有源元件，如微加工泵，以及诸如传感器的无源元件。因此，可以制造“智能贴片”，使样品体液进行化学以确定合适的药物剂量，然后施用相应量的药物。可以使用电场来增加透皮流速。这样的系统可以被制成一次性的，并且可以与医疗装置一起使用，通过离子电渗/微针增强来分配药物，以便体液（同时提供离子电渗/微型增强的体液传感器）和作为闭环药物交付系统采用流体采样反馈，使用其他两个设备的组合。作为药物分配系统，微针阵列包括在电极位置之间向皮肤施加电位的电极。电极组件中的一个填充有电离药物，并且带电药物分子由于施加的电位而进入体内。作为体液采样系统，微针阵列还包括有助于将流体从身体移动到接收室中的电极，并且还包括用于测量特定物质浓度的生物电化学传感器。

48. 发明授权

US06194066B1 Microscopic tube devices and method of manufacture 失效
标题翻译：显微镜管装置及其制造方法
公开(公告)号：US06194066B1
公开(公告)日：2001-02-27
申请号：US08229962
申请日：1994-04-15
申请人： Wesley P. Hoffman
发明人： Wesley P. Hoffman
IPC分类号： D02G300
CPC分类号： F28F7/02 , B81C99/0085 , B82Y30/00 , F15C3/002 , F15C5/00 , F28F2260/02 , H01H1/0036 , H01H29/00 , H01H2029/008 , Y10S366/03 , Y10T428/2918 , Y10T428/2975 , Y10T428/298
摘要： The invention comprises devices composed of at least one microscopic hollow tube having a wall of single or multiple layers with a thickness of at least one nanometer and a diameter of at least 5 nanometers. The tubes can be formed from a wide variety of materials, some of the preferred materials include metals, polymers, silica, carbon, carbides, nitrides and oxides. The inside of the tubes can be coated with a desired material such as a catalyst. The tubes further may act as devices upon which materials can be deposited which are not compatible with the fiber and further may have depressions or elevations therein that were imparted to the fibers upon which the tubes were formed. The wall layers may be porous for the purpose of removing the fiber therethrough. Further the hollow tubes can be used in a preform by themselves or serve the purpose of being used to form rods or filaments in the desired configuration after the tubes are removed.
摘要翻译：本发明包括由至少一个具有单层或多层的壁的至少一个微细中空管构成的装置，其厚度为至少一纳米，直径至少为5纳米。管可以由各种材料形成，一些优选的材料包括金属，聚合物，二氧化硅，碳，碳化物，氮化物和氧化物。管的内部可以涂覆有期望的材料，例如催化剂。管还可以用作可以沉积与纤维不相容的材料的装置，并且还可以在其中具有赋予形成管的纤维的凹陷或高度。为了通过其移除纤维，壁层可以是多孔的。此外，中空管可以自己使用在预成型件中，或者用于在管被移除之后用于在所需构造中形成杆或细丝的目的。

49. 发明授权

US5893974A Microfabricated capsules for immunological isolation of cell transplants 失效
标题翻译：用于免疫分离细胞移植的微型制剂胶囊
公开(公告)号：US5893974A
公开(公告)日：1999-04-13
申请号：US254330
申请日：1994-06-06
申请人： Christopher G. Keller , Mauro Ferrari
发明人： Christopher G. Keller , Mauro Ferrari
IPC分类号： A61F2/02 , A61K9/00 , A61K9/50 , A61K9/52 , B01D39/16 , B01D39/20 , B01D67/00 , B01D69/02 , B01D69/12 , B01D71/02 , B01J13/02 , B81B1/00 , B81C1/00 , C04B41/45 , C23C16/01 , G03F7/00 , B01D69/10
CPC分类号： B01D39/1692 , A61K9/0024 , A61K9/0097 , B01D39/20 , B01D67/0058 , B01D67/0062 , B01D67/0072 , B01D67/0083 , B01D69/02 , B01D69/12 , B01D71/02 , B01J13/02 , B81B1/002 , B81B1/004 , B81C1/00246 , B81C99/0085 , C04B41/4582 , C23C16/01 , G03F7/00 , G03F7/0015 , B01D2323/08 , B01D2325/04 , B81C2201/032 , B81C2203/0728 , Y10T428/249969
摘要： The present invention provides a capsule made of a biologically compatible material with sufficient mechanical strength to form a very thin membrane shell having at least a region with approximately uniformly sized and spaced holes or pores that are large enough to let a desired biologically active molecular product through, while blocking the passage of all larger immunological molecules. The present invention thus provides an immunological isolation of cell transplants contained therein. The present invention also provides a free standing thin film structure that may be used as a component of such a capsule and method for the fabrication of such component and capsules.
摘要翻译：本发明提供一种由具有足够的机械强度的生物相容性材料制成的胶囊，以形成非常薄的膜壳，其具有至少一个具有大致均匀尺寸和间隔开的孔或孔的区域，其足够大以使期望的生物活性分子产物通过，同时阻止所有较大免疫分子的通过。因此，本发明提供对其中包含的细胞移植的免疫学分离。本发明还提供可用作这种胶囊的组分的自立式薄膜结构和用于制造这种组分和胶囊的方法。

50. 发明公开

US20230286799A1 MANUFACTURING METHOD FOR 3D MICROELECTRODE 审中-公开
公开(公告)号：US20230286799A1
公开(公告)日：2023-09-14
申请号：US18019447
申请日：2021-09-23
申请人： HARBIN INSTITUTE OF TECHNOLOGY, SHENZHEN
发明人： Yonggang ZHU , Chaozhan CHEN , Huaying CHEN , Bin RAN , Bo LIU , Chuanwen LV
IPC分类号： B81C99/00
CPC分类号： B81C99/0085 , B81C2201/034 , B33Y80/00
摘要： Disclosed in the present disclosure is a manufacturing method for a 3D microelectrode. The manufacturing method includes the following steps: (1) manufacturing a 3D model of a 3D microelectrode; (2) pouring a flexible material into the 3D model, and performing demolding so as to form a flexible mold having a cavity, wherein the cavity of the flexible mold can be fitted to the 3D model; (3) performing silanization treatment on the flexible mold, then pouring a flexible material into the surface of the flexible mold having the cavity, and performing demolding so as to form a flexible 3D microelectrode substrate; and (4) manufacturing a conductive layer on the flexible 3D microelectrode substrate so as to form the 3D microelectrode. In the present disclosure, a 3D microelectrode having an ultrahigh microcolumn height can be manufactured by using a 3D printing technology and a two-time mold-reversing method.

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