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41. 发明授权

US07393445B2 Ion exchanger 有权
标题翻译：离子交换器
公开(公告)号：US07393445B2
公开(公告)日：2008-07-01
申请号：US11299586
申请日：2005-12-12
申请人： Hiroshi Inoue , Koji Yamanaka , Makio Tamura , Shusaku Yoshida , Hideo Nakamura
发明人： Hiroshi Inoue , Koji Yamanaka , Makio Tamura , Shusaku Yoshida , Hideo Nakamura
IPC分类号： B01D61/48
CPC分类号： B01J47/08 , B01D61/48 , B01J20/28033 , B01J20/28054 , B01J20/28069 , B01J20/28083 , B01J20/28085 , B01J20/28092 , B01J39/26 , B01J41/20 , B01J47/014 , B01J2220/52 , C02F1/42 , C02F1/469
摘要： A porous ion exchanger includes an open cell structure including interconnected macropores and mesopores whose average diameter is in a range of 1 to 1000 μm existing on walls of the macropores. Moreover, a total pore volume is in a range of 1 to 50 ml/g, ion exchange groups are uniformly distributed, and an ion exchange capacity is not less than 0.5 mg equivalent/g of dry porous ion exchanger. The porous ion exchanger can be used as an ion exchanger filled into a deionization module of an electrodeionization water purification device, solid acid catalyst, adsorbent, and filler for chromatography.
摘要翻译：多孔离子交换器包括开孔结构，其包含互连的大孔和介孔，其平均直径在大孔壁上存在1〜1000μm的范围。此外，总孔体积在1〜50ml / g的范围内，离子交换基团均匀分布，离子交换容量不小于0.5mg当量/ g干式多孔离子交换剂。多孔离子交换剂可用作填充在电去离子水净化装置，固体酸催化剂，吸附剂和色谱填料的去离子模块中的离子交换剂。

42. 发明授权

US07208093B2 Chromatographic two-layer particles 有权
标题翻译：色谱双层颗粒
公开(公告)号：US07208093B2
公开(公告)日：2007-04-24
申请号：US10526088
申请日：2003-08-18
申请人： Hans Berg , Philippe Busson , Mats Carlsson
发明人： Hans Berg , Philippe Busson , Mats Carlsson
IPC分类号： B01D15/08
CPC分类号： B01D15/363 , B01D15/1807 , B01J20/285 , B01J20/286 , B01J20/3285 , B01J20/3293 , B01J39/26 , B01J41/20
摘要： The present invention is a method of producing a chromatographic separation matrix, wherein porous polymeric particles comprised of two layers with different properties are prepared in a two-phase system by (a) providing porous polymeric particles with reactive groups on their surfaces; (b) washing said particles with a first solvent and draining the particles to enclose a first phase; (c) wetting the outer layer of the particles by adding a second solvent, which is essentially insoluble in the first solvent; (d) reacting the reactive groups in the outer layer by adding a reagent, which is essentially non-reactive in the first solvent; and (e) coupling of chromatographic binding groups to the reactive groups in the inner layer. The invention also encompasses a porous polymer particle suitable for use as a chromatographic separation matrix and a process of separation, wherein a matrix according to the invention is used.
摘要翻译：本发明是一种制备色谱分离基质的方法，其中通过（a）在其表面上提供具有反应性基团的多孔聚合物颗粒，在两相体系中制备由具有不同性质的两层组成的多孔聚合物颗粒。（b）用第一溶剂洗涤所述颗粒并排出颗粒以包围第一相; （c）通过加入基本不溶于第一溶剂的第二溶剂润湿颗粒外层; （d）通过添加在第一溶剂中基本上不反应的试剂使外层中的反应性基团反应; 和（e）色谱结合基团与内层中的反应性基团的偶合。本发明还包括适合用作色谱分离基质的多孔聚合物颗粒和分离方法，其中使用根据本发明的基质。

43. 发明授权

US07183544B2 Bi-functional polymer chip 有权
标题翻译：双功能聚合物芯片
公开(公告)号：US07183544B2
公开(公告)日：2007-02-27
申请号：US11014225
申请日：2004-12-17
申请人： Egisto Boschetti , Luc Bourgeois
发明人： Egisto Boschetti , Luc Bourgeois
IPC分类号： H02J49/00 , C12Q1/68
CPC分类号： B01J39/26 , B01D15/361 , B01J20/3204 , B01J20/3208 , B01J20/3217 , B01J20/3219 , B01J20/3221 , B01J20/3257 , B01J20/3272 , B01J20/3274 , B01J20/3289 , B01J41/20 , B01J47/016 , B01J2220/54 , G01N33/54393 , G01N33/6851
摘要： In relation to a chromatographic chip, for protein separation, a polymer surface is provided that has a first polymer layer, attached to a support surface, which can be anionic or cationic. To the first layer is attached a second polymer layer, characterized by an opposite charge.
摘要翻译：关于色谱芯片，对于蛋白质分离，提供聚合物表面，其具有连接到支撑表面的第一聚合物层，其可以是阴离子或阳离子的。第一层附着有第二聚合物层，其特征在于相反的电荷。

44. 发明申请

US20070039891A1 Separation of proteins based on isoelectric point using solid-phase buffers 审中-公开
标题翻译：使用固相缓冲液分离基于等电点的蛋白质
公开(公告)号：US20070039891A1
公开(公告)日：2007-02-22
申请号：US11493923
申请日：2006-07-27
申请人： Egisto Boschetti , Pier Righetti , Pierre Girot , Frederic Fortis
发明人： Egisto Boschetti , Pier Righetti , Pierre Girot , Frederic Fortis
IPC分类号： B01D15/08
CPC分类号： B01D15/362 , B01D15/1871 , B01D15/36 , B01D15/363 , B01J20/28033 , B01J39/26 , B01J41/20 , B01J47/018 , B01J2220/603 , B01J2220/82 , C07K1/18 , G01N30/461
摘要： Proteins can be separated from mixtures, based on their pI values, through the use of a series of chromatographic materials, each comprising a solid buffer and an ion exchange resin. Each solid buffer generates a stable pH, such that passing proteins possess a net charge and can be separated by means of an appropriate ion exchanger. In this fashion, proteins from complex biological fluids can be separated for identification and study.
摘要翻译：通过使用一系列色谱材料，每种包含固体缓冲液和离子交换树脂，蛋白质可以基于其pI值与混合物分离。每个固体缓冲液产生稳定的pH，使得通过的蛋白质具有净电荷并且可以通过合适的离子交换剂分离。以这种方式，可以分离来自复杂生物流体的蛋白质进行鉴定和研究。

45. 发明授权

US07132049B2 Negatively charged membrane 有权
标题翻译：负电荷膜
公开(公告)号：US07132049B2
公开(公告)日：2006-11-07
申请号：US11037356
申请日：2005-01-19
申请人： Chung-Jen Hou , Peter Konstantin , Yujing Yang
发明人： Chung-Jen Hou , Peter Konstantin , Yujing Yang
IPC分类号： B01D39/00 , B01D63/00 , B01D11/00 , C02F1/44
CPC分类号： B01D67/0088 , B01D15/362 , B01D61/00 , B01D61/007 , B01D61/14 , B01D67/0009 , B01D71/08 , B01D71/40 , B01D2323/12 , B01D2323/30 , B01D2325/14 , B01D2325/36 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/267 , B01J20/28035 , B01J20/2804 , B01J20/28078 , B01J20/2808 , B01J20/286 , B01J20/3208 , B01J20/3212 , B01J20/327 , B01J20/3274 , B01J20/3282 , B01J39/20 , B01J39/26 , B01J47/12 , B01J2220/44 , B01J2220/54 , C07K1/34 , Y10T436/143333
摘要： The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.
摘要翻译：本发明在某些实施方案中提供了一种带负电荷的微多孔膜，其包含多孔基底和具有固定负电荷的交联涂层。交联涂层可以例如由含有阴离子基团的不饱和单体，N-（羟甲基） - 和/或N-（烷氧基甲基） - 丙烯酰胺，亲水性不饱和单体和引发剂的聚合组合物制备。在一些实施方案中，本发明进一步提供了一种带负电荷的微多孔膜，其包含多孔基材和由聚合组合物制备的交联涂层，所述聚合组合物包含具有阴离子基团的不饱和单体，N-（羟甲基） - 或N-（烷氧基甲基） - 丙烯酰胺，多糖和引发剂。本发明的膜适用于离子交换色谱法，例如分离和纯化带正电荷的物质如蛋白质。

46. 发明申请

US20060246285A1 Process for the production of cellulosic moulded bodies 审中-公开
标题翻译：纤维素成形体的制造方法
公开(公告)号：US20060246285A1
公开(公告)日：2006-11-02
申请号：US11368102
申请日：2006-03-03
申请人： Josef Schmidtbauer , Harald Schobesberger
发明人： Josef Schmidtbauer , Harald Schobesberger
IPC分类号： D01F2/02 , D03D15/00 , D01F2/00 , D01F6/04 , D04B21/00 , D04H13/00 , D02G3/00 , F16J15/20
CPC分类号： B01J20/28016 , B01J20/28004 , B01J20/28038 , B01J20/28042 , B01J39/22 , B01J39/26 , B01J41/16 , B01J41/20 , B01J47/12 , B01J47/127 , C02F2001/422 , C02F2001/425 , D01F2/10 , Y10T428/2913 , Y10T428/2915 , Y10T442/30 , Y10T442/40 , Y10T442/60
摘要： The invention relates to a method for producing cellulose moulded bodies according to the viscose method, the bodies containing a material with ion-exchanging characteristics, which is added to the spinning dope and/or to a precursor thereof. The inventive method is characterized in that the material is added in the form of a dispersion of particles with a maximum grain size of 20 μm or less.
摘要翻译：本发明涉及一种根据粘胶法生产纤维素成型体的方法，该方法包括添加到纺丝原液和/或其前体中的具有离子交换特性的物质。本发明的方法的特征在于，该材料以最大粒径为20μm或更小的颗粒分散体的形式加入。

47. 发明申请

US20060228737A1 Method of isolating a nucleic acid using a material containing an amino group and a carboxyl group and positively charged at a first PH and a solid material for nucleic acid isolation used for the method 有权
标题翻译：使用含有氨基和羧基并在第一PH带正电的材料和用于该方法的核酸分离的固体材料分离核酸的方法
公开(公告)号：US20060228737A1
公开(公告)日：2006-10-12
申请号：US11401794
申请日：2006-04-11
申请人： Kyu-youn Hwang , Chang-eun Yoo
发明人： Kyu-youn Hwang , Chang-eun Yoo
IPC分类号： C12Q1/68 , C07H21/00 , C07C237/20 , C07C237/18
CPC分类号： C12N15/1006 , B01D15/362 , B01J20/3204 , B01J20/3208 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J20/3285 , B01J20/3289 , B01J39/26
摘要： Provided are a method of isolating a nucleic acid from a sample and a solid material for isolating the nucleic acid which can be used for the above method. The method includes contacting the sample with a bifunctional material containing an amino group and a carboxyl group at a first pH to bind the nucleic acid to the bifunctional material, the bifunctional material being positively charged at the first pH; and releasing the nucleic acid at a second pH which is higher than the first pH.
摘要翻译：提供分离来自样品的核酸和用于分离可用于上述方法的核酸的固体材料的方法。该方法包括使样品与含有氨基和羧基的双官能材料在第一pH下接触，以将核酸与双功能材料结合，双功能材料在第一pH下带正电荷; 并且在高于第一pH的第二pH下释放核酸。

48. 发明申请

US20060084765A1 Crosslinked (meth)acrylamide particles, process for their production and their use 有权
标题翻译：交联的（甲基）丙烯酰胺颗粒，其生产和使用的过程
公开(公告)号：US20060084765A1
公开(公告)日：2006-04-20
申请号：US11247157
申请日：2005-10-12
申请人： Kazuaki Muranaka , Maho Yamanaka , Kosuke Araki
发明人： Kazuaki Muranaka , Maho Yamanaka , Kosuke Araki
IPC分类号： C08F20/56
CPC分类号： B01J39/26 , B01J20/261 , B01J20/267 , B01J20/28004 , B01J20/285 , B01J41/20 , B01J43/00 , B01J2220/54 , C08F8/00 , C08F220/58
摘要： Crosslinked (meth)acrylamide particles in the form of substantially spherical fine particles having particle sizes of from 1 to 1000 μm made of a polymer of a N-alkoxymethyl(meth)acrylamide and a polyfunctional unsaturated monomer copolymerizable with the N-alkoxymethyl(meth)acrylamide, wherein the structural units derived from the N-alkoxymethyl(meth)acrylamide are crosslinked by a crosslink having a structure represented by the formula 1 (wherein X is hydrogen or a methyl group, and each of R8 and R9 is another structural unit derived from the N-alkoxymethyl(meth)acrylamide and bonded to the nitrogen atom in another structural unit derived from the N-alkoxymethyl(meth)acrylamide monomer via a methylene group).
摘要翻译：交联的（甲基）丙烯酰胺颗粒，其形式为粒径为1-1000μm的基本上为球形的细颗粒，其由N-烷氧基甲基（甲基）丙烯酰胺的聚合物和可与N-烷氧基甲基（甲基）丙烯酸烷基酯共聚的多官能不饱和单体制成，丙烯酰胺，其中衍生自N-甲氧基甲基（甲基）丙烯酰胺的结构单元通过具有由式1表示的结构的交联（其中X是氢或甲基，并且R SUB 8 >和R 9是来自N-烷氧基甲基（甲基）丙烯酰胺的另一结构单元，并且通过亚甲基与N-烷氧基甲基（甲基）丙烯酰胺单体衍生的另一结构单元中的氮原子键合）。

49. 发明申请

US20060021939A1 Porous materials for solid phase extraction and chromatography and processes for preparation and use thereof 有权
标题翻译：用于固相萃取和色谱的多孔材料及其制备和使用方法
公开(公告)号：US20060021939A1
公开(公告)日：2006-02-02
申请号：US10782397
申请日：2004-02-18
申请人： Claude Mallet , John O'Gara , Darryl Brousmiche
发明人： Claude Mallet , John O'Gara , Darryl Brousmiche
IPC分类号： B01D15/08
CPC分类号： B01J20/26 , B01J20/261 , B01J20/264 , B01J20/28042 , B01J20/285 , B01J20/3285 , B01J39/20 , B01J39/26 , B01J41/20 , B01J2220/54 , B01J2220/58 , B01J2220/62 , B01J2220/66 , B01J2220/82 , C08F8/24 , C08F8/32 , C08F8/36 , C08F2800/20 , G01N30/02 , B01D15/361 , C08F212/36
摘要： Embodiments of the present invention are directed to porous materials for use in solid phase extractions and chromatography. The materials feature at least one hydrophobic component, at least one hydrophilic component and at least one ion-exchange functional group. The materials exhibit superior wetting and ion-exchange performance.
摘要翻译：本发明的实施方案涉及用于固相萃取和色谱法的多孔材料。该材料具有至少一种疏水组分，至少一种亲水性组分和至少一种离子交换官能团。该材料表现出优异的润湿和离子交换性能。

50. 发明申请

US20050274662A1 Disposable monolithic column 有权
标题翻译：一次性整体柱
公开(公告)号：US20050274662A1
公开(公告)日：2005-12-15
申请号：US11200773
申请日：2005-08-10
申请人： Shaofeng Xie
发明人： Shaofeng Xie
IPC分类号： B01D15/08 , B01J20/28 , B01J20/285 , B01J39/26 , B01J41/20 , G01N30/52 , G01N30/60
CPC分类号： B01J20/285 , B01D15/20 , B01D15/206 , B01J8/0005 , B01J19/0013 , B01J19/18 , B01J20/261 , B01J20/28042 , B01J20/28052 , B01J20/283 , B01J39/26 , B01J41/20 , B01J2219/00162 , B01J2220/54 , B01J2220/58 , B01J2220/82 , G01N30/52 , G01N30/54 , G01N30/56 , G01N30/6091 , G01N2030/525 , G01N2030/528 , G01N2030/567 , Y10T29/49604 , G01N2030/522 , G01N30/30
摘要： Permeable polymeric monolithic materials are prepared in a plastic column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized by the application of heat from an external source starting at a low temperature such as 40 degrees centigrade, depending on the mixture and size of the column, and continuing at a higher temperature, such as 60 degrees centigrade. The temperature at the start of the polymerization is low enough so as not to cause exothermal run-away conditions and to avoid high heat of reaction that would prevent a substantially constant temperature across the cross-section of the column. The higher temperature is used after sufficient monomer depletion has occurred and steric interference has increased so the polymerization reaction is sufficiently slow to avoid heat of reaction generation high enough to cause significant reduction in the homogeneousness of the pore sizes.
摘要翻译：在塑料柱套管中制备可渗透的聚合物整体材料。在一个实施方案中，可透过的聚合物整体材料通过根据柱的混合物和尺寸从外部源起始于低温（例如40℃）进行聚合，并在较高温度下继续进行，例如 60摄氏度。聚合开始时的温度足够低，从而不会引起放热的脱离条件，并避免高度的反应热，从而阻止整个塔的截面上的基本恒定的温度。在发生足够的单体消耗并且空间干扰增加之后使用较高的温度，因此聚合反应足够慢，以避免足够高的反应产生热，导致孔径的均匀性显着降低。

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