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41. 发明申请

US20150066106A1 Flexible Circuit Electrode Array Embedded in a Cured Body 有权
标题翻译：嵌入固化体的柔性电路电极阵列
公开(公告)号：US20150066106A1
公开(公告)日：2015-03-05
申请号：US14532982
申请日：2014-11-04
申请人： Second Sight Medical Products, Inc.
发明人： Robert J. Greenberg , Matthew J. McMahon , Jordan Matthew Neysmith , James S. Little , Neil Hamilton Talbot , Kelly H. McClure , Brian V. Mech
IPC分类号： A61N1/36 , A61N1/05 , A61N1/372
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/37223 , H05K1/028 , H05K1/0281 , H05K1/118 , H05K3/0014 , H05K3/28 , H05K2201/0133 , H05K2201/09018 , H05K2201/09145 , H05K2201/09909 , H05K2201/2009 , H05K2203/1105 , H05K2203/1476 , H05K2203/302 , Y10T29/49158
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, and cortical stimulation, and many related purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. It is advantageous that the array edges not contact tissue.
摘要翻译：聚合物材料可用作神经刺激的电极阵列体。它们特别有用于视网膜刺激以产生人造视觉，耳蜗刺激以产生人造听觉和皮质刺激以及许多相关目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。阵列边缘不接触组织是有利的。

42. 发明授权

US08954157B2 Implantable package to facilitate inspection 有权
标题翻译：可植入包装方便检查
公开(公告)号：US08954157B2
公开(公告)日：2015-02-10
申请号：US14179252
申请日：2014-02-12
申请人： Second Sight Medical Products, Inc.
发明人： Boozarjomehr Faraji , Kevin Jun Ha , Neil Hamilton Talbot , James Singleton Little , Robert J Greenberg
IPC分类号： A61N1/00 , A61N1/05 , A61N1/375 , G01N29/00 , A61N1/36 , G01N29/26
CPC分类号： A61N1/0543 , A61N1/0526 , A61N1/36046 , A61N1/375 , G01N29/00 , G01N29/26
摘要： The present invention is a non-destructive method of inspecting a bond, particularly a braze bond, in a hermetic package. The invention involves a unique hermetic package design adapted for ultrasonic inspection and a method of inspecting the package. This package and non-destructive inspection process are particularly useful in implantable neural stimulators such as visual prostheses.
摘要翻译：本发明是一种在密封包装中检查粘合剂，特别是钎焊粘合剂的非破坏性方法。本发明涉及适用于超声波检查的独特的密封包装设计和检查包装的方法。该包装和非破坏性检查过程在可植入的神经刺激器如视觉假体中特别有用。

43. 发明授权

US08954156B2 Methods and apparatuses for configuring artificial retina devices 有权
标题翻译：用于配置人造视网膜装置的方法和装置
公开(公告)号：US08954156B2
公开(公告)日：2015-02-10
申请号：US13282421
申请日：2011-10-26
申请人： Long-Sheng Fan
发明人： Long-Sheng Fan
IPC分类号： A61N1/00 , A61F2/14 , A61F2/16 , A61N1/05
CPC分类号： A61F2/14 , A61N1/0543
摘要： Methods and apparatuses for configuring an implantable device to interface with retina cells are described. The device may comprise an array of pixel units capable of stimulating the retina cells are described. The pixel units may operate in a mode of operation selected from a plurality of modes including a normal mode and a calibration mode. A control circuitry of the device may be configured to switch the mode of operation for the pixel units. In one embodiment, the pixel units may be configured to receive light for stimulating the retina cells during the normal mode to enable perception of the light. During the calibration mode, the pixel units may be configured to adjust amount of stimulation to the retina cells.
摘要翻译：描述了用于配置可植入装置以与视网膜细胞接触的方法和装置。该装置可以包括能够刺激视网膜细胞的像素单元的阵列。像素单元可以在从包括正常模式和校准模式的多种模式中选择的操作模式中操作。设备的控制电路可以被配置为切换像素单元的操作模式。在一个实施例中，像素单元可以被配置为在正常模式期间接收用于刺激视网膜细胞的光，以使得能够感知光。在校准模式期间，像素单元可以被配置为调整对视网膜细胞的刺激量。

44. 发明授权

US08942822B2 Visual apparatus and visual method 有权
标题翻译：视觉设备和视觉方法
公开(公告)号：US08942822B2
公开(公告)日：2015-01-27
申请号：US14061788
申请日：2013-10-24
申请人： Sony Corporation
发明人： Akira Arafune
IPC分类号： A61N1/00 , A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046
摘要： A visual apparatus includes at least one set of probes and a signal generation unit. The at least one set of probes includes a plurality of probes. The signal generation unit is configured to generate a stimulation pattern signal corresponding to information on color, and to input, to at least a part of an area ranging from a retina to a visual nerve, a plurality of pattern signals as the generated stimulation pattern signal via the plurality of probes in the at least one set of probes.
摘要翻译：视觉装置包括至少一组探测器和信号发生单元。所述至少一组探针包括多个探针。信号生成单元被配置为生成与颜色信息相对应的刺激图形信号，并且输入到从视网膜到视神经的范围的区域的至少一部分，多个图案信号作为生成的刺激图案信号通过所述至少一组探针中的多个探针。

45. 发明申请

US20150025608A1 LUBRICIOUS, BIOCOMPATIBLE HYDROPHILIC THERMOSET COATING USING INTERPENETRATING HYDROGEL NETWORKS 审中-公开
标题翻译：润滑油，生物易燃水热油漆涂料使用互连氢化网络
公开(公告)号：US20150025608A1
公开(公告)日：2015-01-22
申请号：US14329123
申请日：2014-07-11
申请人： Cardiac Pacemakers, Inc.
发明人： Joseph T. Delaney, JR. , Jeannette C. Polkinghorne , Adegbola O. Adenusi , David R. Wulfman , Kasyap Seethamraju
IPC分类号： H01B7/04 , D01D5/00 , H01B13/32 , A61N1/05 , H01B13/16
CPC分类号： D01D5/0023 , A61N1/05 , A61N1/0534 , A61N1/0541 , A61N1/0543 , A61N1/0551 , A61N1/056 , D01D5/0007
摘要： A medical electrical lead includes an insulative lead body extending from a distal region to a proximal region and a conductor disposed within the insulative lead body and extending from the proximal region to the distal region. An electrode is disposed on the insulative lead body and is in electrical contact with the conductor. The medical electrical lead also includes a cross-linked hydrophilic polymer coating disposed over at least a portion of the electrode. The cross-linked hydrophilic polymer coating includes a fibrous matrix comprising a plurality of discrete fibers and pores formed between at least a portion of the fibers and a hydrophilic polyethylene glycol-containing hydrogel network disposed within the pores of the fibrous matrix.
摘要翻译：医用电线包括从远端区域延伸到近端区域的绝缘引线体和设置在绝缘引线主体内并从近端区域延伸到远端区域的导体。电极设置在绝缘引线体上并与导体电接触。医用电引线还包括设置在电极的至少一部分上的交联的亲水聚合物涂层。交联的亲水性聚合物涂层包括纤维基质，其包含多个离散的纤维和形成在纤维的至少一部分之间的孔和设置在纤维基质的孔内的亲水性含聚乙二醇的水凝胶网络。

46. 发明授权

US08918186B2 Device with flexible multilayer system for contacting or electrostimulation of living tissue cells or nerves 有权
标题翻译：具有用于接触或电刺激活组织细胞或神经的柔性多层系统的装置
公开(公告)号：US08918186B2
公开(公告)日：2014-12-23
申请号：US12280123
申请日：2007-01-26
申请人： Hans-Jürgen Tiedtke
发明人： Hans-Jürgen Tiedtke
IPC分类号： A61N1/05 , A61N1/40
CPC分类号： A61N1/05 , A61N1/0541 , A61N1/0543 , A61N1/40
摘要： The object,—to create a printed circuit board for an implant having improved properties in connection with the electrical contacting via the contact points of the conductor tracks on the printed circuit board,—is achieved, according to the present invention, by means of a device for contacting and/or electrostimulation of living tissue cells or nerves with having a printed circuit board having with at least one contact point for electrical contacting, the printed circuit board encompassing comprising a flexible multilayer system with at least one conductor track. In accordance with the invention, the contact points for the conductor track in the multilayer system are galvanically reinforced. To this end, a galvanically reinforced layer is grown onto the already preprocessed contact point, for example by means of a galvanic process. By virtue of the application of one or more additional material layers onto the contact points of the conductor tracks, these latter are mechanically more stably anchored in the printed circuit board in mechanically more stable manner and hence become more reliable in their function.
摘要翻译：本发明的目的是为了通过印刷电路板上的导体轨迹的接触点，创建一种具有改进的性质与电接触的性质的印刷电路板，根据本发明，通过用于接触和/或电刺激活组织细胞或神经的装置，其具有具有至少一个用于电接触的接触点的印刷电路板，所述印刷电路板包括具有至少一个导体轨道的柔性多层系统。根据本发明，多层系统中的导体轨迹的接触点是电流增强的。为此，将电加强层生长到已经预处理的接触点上，例如通过电镀工艺。由于在导体轨道的接触点上施加一个或多个附加材料层，这些后者以机械上更稳定的方式机械地更稳定地锚定在印刷电路板中，因此在其功能上变得更可靠。

47. 发明授权

US08903495B2 Flexible circuit electrode array embedded in a cured body 有权
标题翻译：柔性电路电极阵列嵌入固化体
公开(公告)号：US08903495B2
公开(公告)日：2014-12-02
申请号：US13923277
申请日：2013-06-20
申请人： Second Sight Medical Products, Inc.
发明人： Robert J Greenberg , Matthew J McMahon , Jordan Matthew Neysmith , James S Little , Neil Hamilton Talbot , Kelly H McClure , Brian V Mech
IPC分类号： A61N1/05 , H05K1/02 , H05K3/00 , A61N1/36 , H05K1/11 , H05K3/28
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/37223 , H05K1/028 , H05K1/0281 , H05K1/118 , H05K3/0014 , H05K3/28 , H05K2201/0133 , H05K2201/09018 , H05K2201/09145 , H05K2201/09909 , H05K2201/2009 , H05K2203/1105 , H05K2203/1476 , H05K2203/302 , Y10T29/49158
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, and cortical stimulation, and many related purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. It is advantageous that the array edges not contact tissue.
摘要翻译：聚合物材料可用作神经刺激的电极阵列体。它们特别有用于视网膜刺激以产生人造视觉，耳蜗刺激以产生人造听觉和皮质刺激以及许多相关目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。阵列边缘不接触组织是有利的。

48. 发明申请

US20140350639A1 Method and Apparatus for Predicting and Controlling the Percepts Induced by a Visual Prosthesis 有权
标题翻译：用于预测和控制由视觉假体引起的感知的方法和装置
公开(公告)号：US20140350639A1
公开(公告)日：2014-11-27
申请号：US14456714
申请日：2014-08-11
申请人： Second Sight Medical Products, Inc.
发明人： Devyani Nanduri , Ione Fine , Robert J. Greenberg , Jessy D. Dorn
IPC分类号： A61N1/36
CPC分类号： A61N1/0543 , A61N1/0526 , A61N1/36046 , A61N1/375 , G01N29/00 , G01N29/26
摘要： Here we present the first model that quantitatively predicts the apparent spatial position and shape of percepts elicited by retinal electrical stimulation in humans based on the known anatomy of the retina. This model successfully predicts both the shape of percepts elicited by single electrode stimulation and the shape and relative positions of percepts elicited by multiple electrode stimulation. Model fits to behavioral data show that sensitivity to electrical stimulation is not confined to the axon initial segment, but does fall off rapidly with the distance between stimulation and the initial segment. Using the model, it is possible to compensate, preferably with a look up table, to match percepts to a desired image.
摘要翻译：在这里，我们提出了第一个定量预测视网膜电刺激引起的视觉空间位置和形状的模型，基于视网膜的已知解剖结构。该模型成功地预测了由单电极刺激引起的感知形状以及由多电极刺激引起的感知的形状和相对位置。模型符合行为数据表明，对电刺激的敏感性不限于轴突初始段，而是随刺激与初始段之间的距离迅速下降。使用该模型，可以优选地使用查找表来补偿所需图像的感知。

49. 发明授权

US08892211B2 System and method for selective retinal stimulation 有权
标题翻译：选择性视网膜刺激的系统和方法
公开(公告)号：US08892211B2
公开(公告)日：2014-11-18
申请号：US12789063
申请日：2010-05-27
申请人： Warren M. Grill , Matthew A. Schiefer
发明人： Warren M. Grill , Matthew A. Schiefer
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/36046 , A61N1/0543
摘要： A method for electrically stimulating a retina of an eye to induce visual perception includes placing an electrode adjacent a retinal ganglion cell (RGC) layer and selectively applying a biphasic asymmetrical waveform (BAW) to a portion of the axon. The BAW includes a pre-pulse phase and a stimulation-pulse phase. The pre-pulse phase has a first polarity, a first amplitude, and a first duration. The first amplitude and the first duration together define a pre-pulse charge having a first magnitude. The stimulation-pulse phase has a second polarity opposite the first polarity, a second amplitude, and a second duration less than the first duration. The second amplitude and the second duration together define a stimulation charge having a second magnitude. Application of the pre-pulse phase and the stimulation-pulse phase effects a change in excitability of the at least one ganglion cell and induces visual perception, respectively.
摘要翻译：用于电刺激眼睛的视网膜以诱导视觉感知的方法包括将电极放置在视网膜神经节细胞（RGC）层附近并选择性地将两相不对称波形（BAW）应用于轴突的一部分。 BAW包括预脉冲相位和刺激脉冲相位。预脉冲相位具有第一极性，第一幅度和第一持续时间。第一幅度和第一持续时间一起限定具有第一幅度的预脉冲电荷。刺激脉冲相位具有与第一极性相反的第二极性，第二幅度和小于第一持续时间的第二持续时间。第二幅度和第二持续时间一起限定具有第二幅度的刺激电荷。预脉冲相位和刺激脉冲相位的应用分别影响至少一个神经节细胞的兴奋性变化并分别诱导视觉感知。

50. 发明授权

US08880165B2 Biocompatible bonding method and electronics package suitable for implantation 有权
标题翻译：生物相容性接合方法和电子封装适合植入
公开(公告)号：US08880165B2
公开(公告)日：2014-11-04
申请号：US13009769
申请日：2011-01-19
申请人： Robert J. Greenberg , Neil Talbot , Jerry Ok , Jordan Neysmith , Dao Min Zhou
发明人： Robert J. Greenberg , Neil Talbot , Jerry Ok , Jordan Neysmith , Dao Min Zhou
IPC分类号： A61N1/00 , A61N1/36 , A61N1/05 , A61N1/375 , H01L23/498 , H05K3/36 , H05K1/03 , H05K3/46 , H05K3/32 , H05K3/42 , H01L21/56 , H05K3/40
CPC分类号： A61N1/3758 , A61N1/0543 , A61N1/36046 , A61N1/375 , H01L21/563 , H01L23/49827 , H01L23/49838 , H01L23/4985 , H01L24/81 , H01L2224/0557 , H01L2224/05571 , H01L2224/05573 , H01L2224/13169 , H01L2224/13178 , H01L2224/16225 , H01L2224/16227 , H01L2224/32225 , H01L2224/73204 , H01L2224/81469 , H01L2224/81478 , H01L2224/81815 , H01L2924/00014 , H01L2924/01019 , H01L2924/01046 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/14 , H01L2924/1461 , H05K1/028 , H05K1/0306 , H05K1/09 , H05K1/111 , H05K1/113 , H05K1/115 , H05K1/189 , H05K3/10 , H05K3/188 , H05K3/305 , H05K3/321 , H05K3/328 , H05K3/3436 , H05K3/361 , H05K3/4015 , H05K3/4038 , H05K3/4084 , H05K3/423 , H05K3/4644 , H05K3/4652 , H05K3/4691 , H05K13/0469 , H05K2201/09127 , H05K2201/1028 , H05K2201/10287 , H05K2201/10295 , H05K2201/10977 , H05K2203/05 , H05K2203/06 , H05K2203/0733 , H05K2203/09 , H05K2203/107 , H05K2203/1446 , H01L2924/00 , H01L2224/05599
摘要： The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package, that is suitable for implantation in living tissue, such as for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.
摘要翻译：本发明涉及一种将气密密封的电子封装结合到电极或柔性电路的方法以及所得到的电子封装，其适于植入生物组织，例如用于视网膜或皮质电极阵列，以使视力恢复对某些无意识的个人。电气密封的电子封装通过电镀生物相容性材料（例如铂或金）直接结合到柔性电路或电极上，有效地形成电镀铆钉形连接，其将柔性电路连接到电子封装。所得到的电子装置是生物相容的并且适合长期植入生物体组织。

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