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41. 发明申请

US20140079661A1 NOVEL ADHESIVE COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：新型胶粘组合物及其用途
公开(公告)号：US20140079661A1
公开(公告)日：2014-03-20
申请号：US14009753
申请日：2012-04-03
申请人： José Miguel Martín Martínez , Manuel Martínez Paino , Luis Esteban Domínguez Arribas , Ana Villarreal Gómez
发明人： José Miguel Martín Martínez , Manuel Martínez Paino , Luis Esteban Domínguez Arribas , Ana Villarreal Gómez
IPC分类号： C09J4/00
CPC分类号： C09J4/00 , A61L24/0078 , A61L24/0089 , A61L24/06 , C08F222/00 , C08F222/32 , C09J135/04 , C08L35/04
摘要： It is provided new adhesive compositions comprising three components, compounds of formula (I), (II) and (III), namely, alkyl cyanoacrylates, alkyl carboxyacrylates and acrylates. It is also provided said compositions for use in medicine and veterinary, as bioadhesives.
摘要翻译：提供了包含三种组分，即式（I），（II）和（III）的化合物，即氰基丙烯酸烷基酯，丙烯酸烷基酯和丙烯酸酯的新的粘合剂组合物。还提供了用作医药和兽医的组合物作为生物粘合剂。

42. 发明授权

US08609746B2 Bone cement composition, bone cement composition kit and forming method of bone cement hardened material 有权
标题翻译：骨水泥组合物，骨水泥组合物试剂盒和骨水泥硬化材料的成型方法
公开(公告)号：US08609746B2
公开(公告)日：2013-12-17
申请号：US13203221
申请日：2010-02-23
申请人： Takashi Nakamura , Koji Goto , Takehiro Shibuya , Yoshimichi Ueda , Tokuo Suita , Masashi Imamura , Hiroaki Nishii
发明人： Takashi Nakamura , Koji Goto , Takehiro Shibuya , Yoshimichi Ueda , Tokuo Suita , Masashi Imamura , Hiroaki Nishii
IPC分类号： A61F2/28 , A61K6/083 , C08L33/12 , C08K3/22
CPC分类号： A61L24/0089 , A61L24/06 , A61L2430/02 , C08L33/06
摘要： A bone cement composition which contains large-diameter (meth)acrylate polymer particles having an average particle diameter of 10 to 60 μm, small-diameter (meth)acrylate polymer particles having an average particle diameter of 0.1 to 2.0 μm, a (meth)acrylate monomer and a polymerization initiator, wherein the content of the small-diameter (meth)acrylate polymer particles is 5 to 30% by mass based on the total mass of the small-diameter (meth)acrylate polymer particles and the large-diameter (meth)acrylate polymer particles, and a part or a whole of the small-diameter (meth)acrylate polymer particles are contained in the form of aggregates having an average particle diameter of 30 to 50 μm.
摘要翻译：一种骨水泥组合物，其含有平均粒径为10〜60μm的大直径（甲基）丙烯酸酯聚合物粒子，平均粒径为0.1〜2.0μm的小直径（甲基）丙烯酸酯聚合物粒子，（甲基）丙烯酸酯单体和聚合引发剂，其中小直径（甲基）丙烯酸酯聚合物颗粒的含量相对于小直径（甲基）丙烯酸酯聚合物颗粒和大直径（甲基）丙烯酸酯聚合物颗粒的总质量为5〜30质量％甲基）丙烯酸酯聚合物颗粒，一部分或全部小直径（甲基）丙烯酸酯聚合物颗粒以平均粒径为30至50微米的聚集体的形式包含。

43. 发明申请

US20130331898A1 Bioactive Bone Graft Substitutes 审中-公开
标题翻译：生物活性骨移植替代物
公开(公告)号：US20130331898A1
公开(公告)日：2013-12-12
申请号：US13493531
申请日：2012-06-11
申请人： Jevon Nyemscek , Vipin Kunjachan , Allison Adams
发明人： Jevon Nyemscek , Vipin Kunjachan , Allison Adams
IPC分类号： A61K33/42 , A61P19/00 , A61B17/88
CPC分类号： A61L27/54 , A61L24/0005 , A61L24/001 , A61L24/0015 , A61L24/0036 , A61L24/0089 , A61L27/3804 , A61L27/446 , A61L27/50 , A61L27/56 , A61L2300/412 , A61L2430/02 , C08L89/06
摘要： Provided are synthetic bone graft substitutes that include bioactive glass and a carrier. Synthetic bone graft substitutes may include bioactive glass, glycerol and polyethylene glycol. Also provided are bone graft substitutes that include collagen and bioactive glass particles. Example bone graft substitutes may include collagen and bioactive glass particles. Other example embodiments may include Type I Bovine Collagen, an angiogenic agent, such as hyaluronic acid, and bioactive glass. Further provided are methods that include administering the present bone graft substitutes to a mammal, e.g., by surgical insertion of the bone graft substitute into the mammal, either alone or in conjunction with one or more implant devices. Further provided are kits that include the present bone grafts.
摘要翻译：提供包括生物活性玻璃和载体的合成骨移植替代物。合成骨移植物替代物可以包括生物活性玻璃，甘油和聚乙二醇。还提供了包括胶原和生物活性玻璃颗粒的骨移植替代物。骨移植替代物可以包括胶原和生物活性玻璃颗粒。其它示例性实施方案可以包括I型牛胶原，血管生成剂，例如透明质酸和生物活性玻璃。还提供了方法，其包括将本发明的骨移植物替代物施用于哺乳动物，例如通过将骨移植物替代物手术插入到哺乳动物中，单独或与一个或多个植入装置结合。还提供了包括目前骨移植物的试剂盒。

44. 发明申请

US20130158158A1 Paste-Like Bone Cement 有权
标题翻译：糊状骨水泥
公开(公告)号：US20130158158A1
公开(公告)日：2013-06-20
申请号：US13715314
申请日：2012-12-14
申请人： Heraeus Medical GmbH
发明人： Sebastian Vogt
IPC分类号： A61L24/04
CPC分类号： A61L24/043 , A61K6/005 , A61K6/0073 , A61K6/083 , A61L24/001 , A61L24/0089 , A61L24/06 , A61L27/16 , A61L27/26 , A61L27/50 , A61L2430/02 , C08L33/08 , C08L33/10 , C08L33/14
摘要： The present invention relates to a kit comprising at least two pastes, A and B. Paste A contains at least one monomer for radical polymerisation; and at least one barbituric acid derivative as polymerisation initiator. Paste B contains at least one monomer for radical polymerisation; and at least one heavy metal compound as polymerisation accelerator that is selected from heavy metal salts and heavy metal complexes. Paste B contains less than 0.01% by weight, relative to the total weight of paste B, of a peroxide; at least one of the pastes A and B contains-at least one filling agent that is poorly soluble or insoluble in the monomer for radical polymerization in either paste A or B respectively; and at least one of the pastes A and B contains at least one inorganic halide salt.
摘要翻译：本发明涉及包含至少两种糊剂A和B的试剂盒。糊剂A含有至少一种用于自由基聚合的单体; 和至少一种巴比妥酸衍生物作为聚合引发剂。糊剂B含有至少一种用于自由基聚合的单体; 和至少一种重金属化合物作为选自重金属盐和重金属络合物的聚合促进剂。糊剂B相对于糊料B的总重量小于0.01重量％的过氧化物; 糊剂A和B中的至少一种含有至少一种难溶于或不溶于单体中的糊剂A或B中的自由基聚合的填充剂; 并且糊料A和B中的至少一种含有至少一种无机卤化物盐。

45. 发明授权

US08012501B2 Flexible bone composite 有权
标题翻译：柔性骨复合材料
公开(公告)号：US08012501B2
公开(公告)日：2011-09-06
申请号：US11148193
申请日：2005-06-09
申请人： Sean Kerr , James W. Dwyer
发明人： Sean Kerr , James W. Dwyer
IPC分类号： A61K33/42 , A61F2/00
CPC分类号： A61L27/50 , A61F2/28 , A61F2/30767 , A61F2002/2817 , A61F2002/30062 , A61F2002/30064 , A61F2002/30113 , A61F2002/30153 , A61F2002/30293 , A61F2002/30677 , A61F2002/30769 , A61F2002/30785 , A61F2002/30971 , A61F2210/0004 , A61F2230/0006 , A61F2230/0019 , A61F2230/0091 , A61F2310/00293 , A61F2310/00796 , A61L24/0089 , A61L27/46 , A61L2430/02
摘要： The present invention relates in general to implantable flexible bone composites, and method for preparing the same. The flexible bone composite includes at least one polymeric layer and at least one calcium-containing layer. The polymeric layer can be a polymeric layer including a synthetic polymer. The calcium-containing layer can include a calcium compound such as β-Ca3(PO4)2. The flexible bone composites of the invention are useful as bone void fillers and have improved handling characteristics.
摘要翻译：本发明一般涉及可植入的柔性骨组合物及其制备方法。柔性骨复合材料包括至少一个聚合物层和至少一个含钙层。聚合物层可以是包含合成聚合物的聚合物层。含钙层可以包括钙化合物，例如-Ca 3（PO 4）2。本发明的柔性骨复合材料可用作骨隙填料并且具有改进的处理特性。

46. 发明授权

US07951402B2 Drug delivery particle 有权
标题翻译：给药颗粒
公开(公告)号：US07951402B2
公开(公告)日：2011-05-31
申请号：US12235978
申请日：2008-09-23
申请人： Janel Lanphere , Erin McKenna , Wendy Naimark , Marcia Buiser , Stephan Mangin
发明人： Janel Lanphere , Erin McKenna , Wendy Naimark , Marcia Buiser , Stephan Mangin
IPC分类号： A61K9/14 , A61K9/50
CPC分类号： A61L24/02 , A61B18/18 , A61K9/14 , A61K9/1635 , A61K9/1652 , A61K49/0452 , A61K51/1244 , A61L24/0015 , A61L24/0036 , A61L24/0089 , A61L2300/102 , A61L2300/418 , A61L2300/606 , A61L2400/04 , A61L2430/36
摘要： A drug delivery particle including a reservoir region having primarily large pores and a metering region. The particle can be highly spherical.
摘要翻译：药物递送颗粒包括具有主要大孔的储存区域和计量区域。颗粒可以是高度球形的。

47. 发明授权

US07947759B2 Cement products and methods of making and using the same 有权
标题翻译：水泥制品及其制造和使用方法
公开(公告)号：US07947759B2
公开(公告)日：2011-05-24
申请号：US11500798
申请日：2006-08-08
申请人： Juchui Ray Lin , Edward S. Ahn , Hansen Yuan , Paul J. Mraz
发明人： Juchui Ray Lin , Edward S. Ahn , Hansen Yuan , Paul J. Mraz
IPC分类号： A61K6/08 , C08G59/68 , C09K3/00
CPC分类号： A61K6/087 , A61K6/083 , A61L24/0089 , A61L24/046 , C08L33/00 , C08L63/00 , C08L79/02
摘要： Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component comprising a polymerizable resin comprising ethylenic unsaturated double bond, a second component comprising a compound comprising more than one type of amine selected from the group consisting of primary amines, secondary amines, tertiary amines and quaternary amines, and, optionally, the cement product includes a bioactive component to promote bone formation.
摘要翻译：公开了水泥产品，使用水泥产品形成水泥的方法以及在矫形和牙科应用中使用水泥产品的方法。通常，所公开的水泥产品包括含有包含烯键式不饱和双键的可聚合树脂的第一组分，第二组分包含选自伯胺，仲胺，叔胺和季胺的多于一种类型的胺的化合物，并且任选地，水泥产品包括促进骨形成的生物活性成分。

48. 发明申请

US20100196514A1 CALCIUM SILICATE-BASED COMPOSITE CEMENT AND METHODS FOR THE PREPARATION 审中-公开
标题翻译：基于硅酸钙的复合水泥及其制备方法
公开(公告)号：US20100196514A1
公开(公告)日：2010-08-05
申请号：US12364278
申请日：2009-02-02
申请人： Shinn-Jyh Ding
发明人： Shinn-Jyh Ding
IPC分类号： A61K33/08 , A61P19/08
CPC分类号： A61L24/0021 , A61L24/0089 , A61L24/02 , A61L2430/02
摘要： The present invention provides a method for producing calcium silicate-based bone cement and a composition produced by the method. It further provides a novel composition for bone tissue repair.
摘要翻译：本发明提供一种生产基于硅酸钙的骨水泥的方法和通过该方法制备的组合物。它进一步提供了用于骨组织修复的新型组合物。

49. 发明申请

US20090131551A1 POLYFUNCTIONAL COMPOUNDS AND USES AS IMPLANT MATERIALS 审中-公开
标题翻译：多功能化合物和用作植入材料
公开(公告)号：US20090131551A1
公开(公告)日：2009-05-21
申请号：US12280929
申请日：2007-02-27
申请人： Dong Xie
发明人： Dong Xie
IPC分类号： A61K6/083 , C07C69/003 , A61Q11/00 , C07C229/04
CPC分类号： C07C69/63 , A61K6/0835 , A61L24/0089 , A61L24/02 , A61L27/446 , C08F299/00 , C08F2438/01 , C08L33/02 , C08F2222/104 , C08F220/20 , C08F2220/325 , C08F2222/1026
摘要： The synthesis and characterization of polymer core initiators are described herein. Polymer core initiators are used to prepare the polyfunctional prepolymers described herein, which may be optionally tethered. The polyfunctional prepolymers described herein are used to prepare cements, optionally with added co-monomers, for repairing and restoring tissues.
摘要翻译：本文描述了聚合物核心引发剂的合成和表征。聚合物核心引发剂用于制备本文所述的多官能预聚物，其可任选地连接。本文所述的多官能预聚物用于制备用于修复和恢复组织的水泥，任选地加入共聚单体。

50. 发明申请

US20090105144A1 ONE-COMPONENT BONE CEMENT PASTES AND METHODS FOR CURING THEM 有权
标题翻译：单组分骨水泥浆及其固化方法
公开(公告)号：US20090105144A1
公开(公告)日：2009-04-23
申请号：US12255224
申请日：2008-10-21
申请人： SEBASTIAN VOGT , HUBERT BUCHNER
发明人： SEBASTIAN VOGT , HUBERT BUCHNER
IPC分类号： A61L24/06 , A61K38/18
CPC分类号： A61L24/0094 , A61L24/0089 , A61L2430/02 , C08L33/10
摘要： One-component bone cement pastes, containing: AI at least one methacrylate monomer that is suited for radical polymerisation; AII at least one polymer that is soluble in AI; AIII at least one particulate polymer that is insoluble in AI and has a particle size of less than 500 μm; optionally AIV at least one initiator that can be activated, in particular at least one radical-forming initiator or at least one radical initiator that is soluble in AI and subject to thermal decomposition; optionally AV at least one electrically conductive radio-opaquer, in particular in the form of ferromagnetic particles; are well-suited, e.g., for producing paste-like two-component bone cements, for producing means for the fixation of total endoprostheses and revision endoprostheses, for producing selfcuring filling materials for vertebroplasty, kyphoplasty or femoral neck augmentation, or for producing local agent release systems, and, in the presence of component AV, can be heated through alternating magnetic fields of 500 Hz to 50 kHz or through induction until the decomposition of an initiator AIV commences. From this also results a method for the curing of pastes containing at least one initiator that can be activated, in particular at least one radical-forming initiator or at least one radical initiator that is subject to thermal decomposition; and at least electrically conductive particles, in particular ferromagnetic particles; whereby the paste is exposed to an alternating magnetic field with a frequency in the range of 500 Hz to 50 kHz, or whereby the paste is heated by induction until the decomposition of the initiator commences.
摘要翻译：单组分骨水泥膏，含有：至少一种适合自由基聚合的甲基丙烯酸单体; AII至少一种可溶于AI的聚合物; AIII至少一种不溶于AI且粒径小于500μm的颗粒状聚合物; 任选地AIV至少一个可以被活化的引发剂，特别是至少一种自由基形成引发剂或至少一种可溶于AI并经受热分解的自由基引发剂; 可选地AV至少一种导电性无光透明物，特别是铁磁性颗粒的形式; 适用于生产糊状双组分骨水泥，用于生产用于固定总内假体和修复内用假体的装置，用于生产用于椎体成形术，脊椎后凸成形术或股骨颈增大的自固化填充材料，或用于生产局部剂释放系统，并且在组分AV的存在下，可以通过500Hz至50kHz的交变磁场或通过感应加热直到引发剂AIV的分解开始。由此还可以得到含有至少一种可被活化的引发剂，特别是至少一种自由基形成引发剂或至少一种经受热分解的自由基引发剂的糊剂固化的方法。和至少导电颗粒，特别是铁磁颗粒; 由此将糊状物暴露于频率在500Hz至50kHz范围内的交变磁场，或者通过感应加热糊状物直到引发剂开始分解。

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