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41. 发明授权

US09403911B2 Compositions and methods for detection and treatment of cancer 有权
标题翻译：用于癌症检测和治疗的组合物和方法
公开(公告)号：US09403911B2
公开(公告)日：2016-08-02
申请号：US14122171
申请日：2012-06-06
申请人： Surinder K. Batra , Maneesh Jain , Moorthy P. Ponnusamy
发明人： Surinder K. Batra , Maneesh Jain , Moorthy P. Ponnusamy
IPC分类号： C07K16/30 , G01N33/574 , A61K49/00
CPC分类号： C07K16/3092 , A61K49/00 , G01N33/574 , G01N33/57411 , G01N33/57438 , G01N33/57446 , G01N33/57449 , G01N2333/4725 , G01N2400/02
摘要： Novel antibodies for the detection and/or treatment of a cancer (e.g., a pancreatic cancer or an ovarian cancer) are provided. In certain embodiments the antibodies bind a region of the MUC4 protein that does not comprise the central tandem repeat (TR) domain of MUC4. Certain antibodies bind to the MUC4 peptide fragment MUC4-α-N-Ter and/or to the MUC4 peptide fragment MUC4-α-C-Ter. Chimeric constructs comprising such antibodies are also provided.
摘要翻译：提供了用于检测和/或治疗癌症（例如胰腺癌或卵巢癌）的新型抗体。在某些实施方案中，抗体结合不包含MUC4的中心串联重复（TR）结构域的MUC4蛋白的区域。某些抗体结合MUC4肽片段MUC4-α-N-Ter和/或与MUC4肽片段MUC4-α-C-Ter结合。还提供了包含此类抗体的嵌合构建体。

42. 发明申请

US20160207962A1 ELECTRON SPIN LABELED ICE BINDING COMPOUNDS USED FOR CARRYING PARAMAGNETIC CENTERS FOR DYNAMIC NUCLEAR POLARIZATION 审中-公开
标题翻译：用于携带用于动态核极化的参考中心的电子旋转标签冰结合化合物
公开(公告)号：US20160207962A1
公开(公告)日：2016-07-21
申请号：US15014978
申请日：2016-02-03
申请人： The Trustees of California State University
发明人： Yong Ba , Yougang Mao
IPC分类号： C07K14/00 , C09K3/18
CPC分类号： C07K14/00 , A61K49/00 , A61K49/14 , C07K14/46
摘要： Spin labeled ice binding compounds (IBCs) including ice binding proteins (IBPs), also called antifreeze proteins (AFPs) and their analogs are exploited to carry the paramagnetic centers for dynamic nuclear polarization (DNP), for enhancing nuclear magnetic resonance (NMR) signal intensities. Use of spin labeled IBCs to perform DNP exploits the IBCs' ability to homogeneously distribute the paramagnetic centers in frozen water solution at low temperature, leading to high DNP efficiency. Other advantages of using spin labeled IBCs include: (1) ability to cryo-protect biological samples; (2) the relative positions and orientations of the spin labeling groups in an IBC may also be cryo-preserved; (3) positions and orientations of spin labeling groups to an IBC can be selected with great freedom and without technical barrier to making multiple spin labels in an IBC; and (4) water solubilities of spin labeled IBCs are potentially high, enabling use of a solvent that is primarily water for DNP at low temperatures.
摘要翻译：包含冰结合蛋白（IBC）的自旋标记的冰结合化合物（IBC）也被称为防冻蛋白（AFP）及其类似物，用于携带动态核极化（DNP）的顺磁中心，用于增强核磁共振（NMR）信号强度使用自旋标记的IBC来执行DNP利用IBC在低温下均匀分布冷冻水溶液中顺磁中心的能力，导致高的DNP效率。使用自旋标记的IBC的其他优点包括：（1）冷冻保护生物样品的能力; （2）IBC中自旋标记组的相对位置和取向也可以被低温保存; （3）自由标记组对IBC的位置和取向可以自由选择，并且在IBC中制备多个自旋标记的技术障碍可以选择; 和（4）自旋标记的IBC的水溶性可能很高，使得能够在低温下使用主要用于DNP的水。

43. 发明申请

US20160193349A1 FUCOIDAN NANOGELS AND METHODS OF THEIR USE AND MANUFACTURE 有权
公开(公告)号：US20160193349A1
公开(公告)日：2016-07-07
申请号：US15069311
申请日：2016-03-14
申请人： Memorial Sloan Kettering Cancer Center
发明人： Daniel A. Heller , Yosef Shamay
IPC分类号： A61K47/48 , A61K9/06 , A61K31/4412 , A61K31/337 , A61K31/704 , A61K51/06
CPC分类号： A61K47/61 , A61K9/0019 , A61K9/06 , A61K9/5146 , A61K9/5161 , A61K9/5169 , A61K31/337 , A61K31/4412 , A61K31/704 , A61K31/737 , A61K41/0038 , A61K47/585 , A61K47/60 , A61K47/64 , A61K47/643 , A61K47/6935 , A61K47/6939 , A61K49/00 , A61K51/065
摘要： Described herein are polymeric drug-carrying nanogels that are capable of targeting to P-selectin for the treatment of cancer and other diseases and conditions associated with P-selectin. Furthermore, in certain embodiments, the nanogels presented here offer a drug release mechanism based on acidic pH in the microenvironment of a tumor, thereby providing improved treatment targeting capability and allowing use of lower drug doses, thereby reducing toxicity.

44. 发明授权

US09382346B2 Gold nanoparticle conjugates and uses thereof 有权
公开(公告)号：US09382346B2
公开(公告)日：2016-07-05
申请号：US14867165
申请日：2015-09-28
申请人： Colorado School of Mines
发明人： Stephen G. Boyes , Misty D. Rowe , Jay Hotchkiss
IPC分类号： A61K9/16 , C08F8/42 , A61K49/18 , B82Y5/00 , C07F5/00 , A61K49/00 , A61K49/12 , C08F122/36 , A61K47/48 , A61B5/055
CPC分类号： C08F8/42 , A61B5/055 , A61K47/58 , A61K49/00 , A61K49/0054 , A61K49/12 , A61K49/1818 , A61K49/1854 , B82Y5/00 , C07B2200/11 , C07F5/003 , C08F122/36
摘要： The disclosure generally relates to formation of polymers grafted to or polymerized from the surface of gold nanoparticles. The polymers are functionalized to include therapeutic agents and/or targeting agents at their surface, thereby allowing both therapeutic and targeting compounds to be directed to specific cells in a patient.

45. 发明授权

US09375492B2 Mixture of liquid-crystal compounds, system of three liquid-crystal mixtures and their use 有权
公开(公告)号：US09375492B2
公开(公告)日：2016-06-28
申请号：US14038491
申请日：2013-09-26
申请人： BRASTER SA
发明人： Jacek Bernard Stephien , Henryk Jaremek , Grzegorz Franciszek Pielak
IPC分类号： C09K19/26 , G01K11/16 , C09K19/54 , A61B5/01 , A61K49/00 , C09K19/36
CPC分类号： A61K49/00 , C09K19/26 , C09K19/36 , G01K11/165
摘要： Three organic compounds mixtures of liquid-crystal properties, which when mixed together in a precisely determined weight ratio, may show an ability to form thermo-optically active mesophases of established, narrow range thermooptical transitions separation, every 0.5° C., in the temperature range: from 31.8° C. to 32.8° C., from 32.8° C. to 33.8° C., and from 33.8° C. to 34.8° C. and system including these mixtures. The use of these mixtures and the system containing the above mentioned mixtures for colorimetric detection of temperature differentiation on the surface of biological objects in a narrow range of temperatures.

46. 发明申请

US20160144061A1 Compositions and Imaging Methods Comprising Detectably Labeled Phosphatidylethanolamine-Binding Peptides 审中-公开
公开(公告)号：US20160144061A1
公开(公告)日：2016-05-26
申请号：US15015585
申请日：2016-02-04
申请人： Board of Regents, The University of Texas System
发明人： Philip E. Thorpe , Jin He
IPC分类号： A61K51/08 , A61K51/02 , C07K7/64
CPC分类号： A61K51/088 , A61K39/395 , A61K39/39558 , A61K47/62 , A61K47/6811 , A61K47/6835 , A61K47/6849 , A61K49/00 , A61K49/14 , A61K51/025 , A61K51/08 , A61K2039/505 , C07K2/00 , C07K7/64 , C07K16/18 , C07K16/2836 , C07K16/44 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , A61K2300/00
摘要： Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.

47. 发明申请

US20160130319A1 HIGH-STABILITY T-CELL RECEPTOR AND PREPARATION METHOD AND APPLICATION THEREOF 审中-公开
标题翻译：高稳定性T细胞受体及其制备方法及应用
公开(公告)号：US20160130319A1
公开(公告)日：2016-05-12
申请号：US14901344
申请日：2014-06-25
申请人： Yi LI , GUANGZHOU XIANGXUE PHARMACEUTICAL CO. LTD
发明人： Yi Li
IPC分类号： C07K14/725 , A61K38/17 , C07K16/28 , A61K47/48 , A61K49/00
CPC分类号： C07K14/7051 , A61K38/00 , A61K38/1774 , A61K47/6425 , A61K49/00 , C07K16/2809 , C07K2317/76 , C07K2319/30
摘要： The present invention provides a high-stability T cell receptor. The T cell receptor has mutations in its hydrophobic core domain causing the enhancement of stability thereof. The present invention additionally provides a preparation method and an application of the T-cell receptor.
摘要翻译：本发明提供高稳定性T细胞受体。 T细胞受体在其疏水核心结构域中具有突变，导致其稳定性的提高。本发明另外提供了T细胞受体的制备方法和应用。

48. 发明申请

US20160130235A1 CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING 有权
公开(公告)号：US20160130235A1
公开(公告)日：2016-05-12
申请号：US14845320
申请日：2015-09-04
申请人： Lantheus Medical Imaging, Inc.
发明人： David S. Casebier , Simon P. Robinson , Ajay Purohit , Heike S. Radeke , Michael T. Azure , Douglas D. Dischino
IPC分类号： C07D237/16 , A61K51/04 , A61K49/00
CPC分类号： C07D237/16 , A61K49/00 , A61K49/0002 , A61K49/0052 , A61K49/10 , A61K49/22 , A61K51/04 , A61K51/0421 , A61K51/0453 , A61K51/0459 , C07B59/002
摘要： The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.

49. 发明申请

US20160101195A1 DIAGNOSTIC KIT 有权
标题翻译：诊断包
公开(公告)号：US20160101195A1
公开(公告)日：2016-04-14
申请号：US14972127
申请日：2015-12-17
申请人： RESPIRATORIUS AB
发明人： Martin JOHANSSON
IPC分类号： A61K49/00
CPC分类号： A61K49/00 , A61K51/0455 , C07B59/002 , C07D471/04
摘要： Compounds and a method for imaging myocardial perfusion, including administering to a patient a compound linked to an imaging moiety, wherein the compound binds MC-1, and scanning the patient using diagnostic imaging. Kits including the compound or precursor compounds linked or not linked to an imaging moiety are also described.
摘要翻译：化合物和用于成像心肌灌注的方法，包括向患者施用与成像部分连接的化合物，其中所述化合物结合MC-1，并使用诊断成像扫描患者。还描述了包括与成像部分连接或未连接的化合物或前体化合物的试剂盒。

50. 发明申请

US20160096893A1 ANTI-HER2 ANTIBODIES AND IMMUNOCONJUGATES 审中-公开
标题翻译：抗HER2抗体和免疫球蛋白
公开(公告)号：US20160096893A1
公开(公告)日：2016-04-07
申请号：US14851001
申请日：2015-09-11
申请人： Genentech, Inc.
发明人： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC分类号： C07K16/28 , A61K39/395 , G01N33/574 , A61K47/48
CPC分类号： C07K16/32 , A61K31/5517 , A61K31/675 , A61K31/704 , A61K39/3955 , A61K47/68 , A61K47/6809 , A61K47/6849 , A61K47/6855 , A61K47/6863 , A61K49/00 , C07K16/2863 , C07K16/3015 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , G01N33/57415 , G01N33/57446 , G01N33/57492 , G01N2333/82
摘要： The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
摘要翻译：本发明提供抗HER2抗体和免疫缀合物及其使用方法。

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