专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

US20170071912A1 Polyamide Compound and Pharmaceutical Composition for Treating Mitochondrial Genetic Diseases 审中-公开
标题翻译：用于治疗线粒体遗传病的聚酰胺化合物和药物组合物
公开(公告)号：US20170071912A1
公开(公告)日：2017-03-16
申请号：US15357335
申请日：2016-11-21
申请人： Takamitsu YANO
发明人： Takamitsu YANO
IPC分类号： A61K31/4178
CPC分类号： A61K31/4178 , A61K31/785 , A61K31/787 , A61K47/595 , C07D403/14 , C08G73/0611 , C08G73/0616 , C12N15/1062 , C12Q2600/178
摘要： The object of the present invention is to provide a fundamental therapy to mitochondrial genetic diseases caused by mutation of the mitochondrial (mt)DNA, and a pharmaceutical composition used for the same.The object can be solved by a polyamide compound binding to a target double-stranded mtDNA comprising A/T pair consisting of first A of the following sense-stranded DNA and the corresponding T, A/T pair consisting of 8th A of the following sense-stranded DNA and the corresponding T, G/C pair consisting of 9th G of the following sense-stranded DNA and the corresponding C, G/C pair consisting of 14th G of the following sense-stranded DNA and the corresponding C, T/A pair consisting of 15th T of the following sense-stranded DNA and the corresponding A, or the like, in the double-stranded DNA consisting of the sense-stranded DNA having base sequence of 5′-ATGGCAGAGCCCGGTAATCGCATAA-3′ (SEQ ID NO: 1) and the antisense-stranded DNA having base sequence of 5′-TTATGCGATTACCGGGCTCTGCCAT-3′ (SEQ ID NO: 2).
摘要翻译：该目的可以通过结合到包含由以下正义链DNA的第一个A组成的A / T对的对象双链mtDNA的聚酰胺化合物和由以下意义的第8位组成的对应的T，A / T对并且相应的T，G / C对由以下正义链DNA的第9G组成的相应的C，G / C对由以下正义链DNA的第14位和对应的C，T / 由具有5'-ATGGCAGAGCCCGGTAATCGCATAA-3'（SEQ ID NO：3）的碱基序列的有义链DNA组成的双链DNA中的由第15位以下的正义链和相应的A等构成的对：1）和具有5'-TTATGCGATTACCGGGCTCTGCCAT-3'（SEQ ID NO：2）的碱基序列的反义链DNA。

42. 发明授权

US09592280B2 Compositions and kits for enzymatic debridement and methods of using the same 有权
标题翻译：用于酶清创的组合物和试剂盒及其使用方法
公开(公告)号：US09592280B2
公开(公告)日：2017-03-14
申请号：US14511912
申请日：2014-10-10
申请人： ROCHAL INDUSTRIES, LLP
发明人： Joseph Charles Salamone , Kelly Xiaoyu Chen Leung , Ann Beal Salamone , Katelyn Elizabeth Reilly
IPC分类号： A61K38/54 , A61K31/155 , A61K31/785 , A61K38/47 , A61K45/06 , A61L26/00 , A61L15/38 , A61L15/44
CPC分类号： A61K38/54 , A61K31/155 , A61K31/785 , A61K38/47 , A61K45/06 , A61L15/38 , A61L15/44 , A61L26/0047 , A61L26/0066 , A61L2300/206 , A61L2300/254 , A61L2300/402 , A61L2300/404 , A61L2300/45 , C12Y302/01001 , C12Y302/01002 , C12Y302/01003 , C12Y304/22032 , C12Y304/24007 , A61K2300/00
摘要： A debridement enzyme for necrotic tissue is described that is not dependent upon proteolytic enzymatic activity but instead utilizes the amylase family of enzymes. The amylases (α-, β-, γ-amylase) are noted for the cleavage of the α-glycosidic bonds of polysaccharides, yielding lower molecular weight carbohydrate/sugar fragments. It has now been found that α-amylase is effective in the debridement of devitalized tissue.
摘要翻译：描述了坏死组织的清创酶，其不依赖于蛋白水解酶活性，而是利用酶的淀粉酶家族。注意到淀粉酶（α-，β-，γ-淀粉酶）用于多糖的α-糖苷键的切割，产生较低分子量的碳水化合物/糖片段。现在已经发现α-淀粉酶在清除失活的组织中是有效的。

43. 发明授权

US09585911B2 Sachet formulation for amine polymers 有权
标题翻译：胺聚合物的香囊配方
公开(公告)号：US09585911B2
公开(公告)日：2017-03-07
申请号：US14750459
申请日：2015-06-25
申请人： Genzyme Corporation
发明人： Hitesh R. Bhagat , Jeffrey M. Goldberg
IPC分类号： A61K9/14 , A61K31/787 , A61K9/00 , A61K31/00 , A61K31/785 , A61K9/16 , A61K8/81 , A61K8/898 , A61K47/34 , A61K47/36
CPC分类号： A61K31/787 , A61K8/8105 , A61K8/817 , A61K8/898 , A61K9/0053 , A61K9/0056 , A61K9/0095 , A61K9/1652 , A61K31/00 , A61K31/785 , A61K47/34 , A61K47/36
摘要： A powder formulation comprises a pharmaceutically acceptable anionic stabilizer and an aliphatic amine polymer or a pharmaceutically acceptable salt thereof mixed with the anionic stabilizer. The powder formulation is conveniently packaged in a container, such as a sachet. A method of treating a subject with hyperphosphotemia with the powder formulation is also disclosed.
摘要翻译：粉末制剂包含与阴离子稳定剂混合的药学上可接受的阴离子稳定剂和脂族胺聚合物或其药学上可接受的盐。粉末制剂方便地包装在容器中，例如小袋。还公开了用粉末制剂治疗患有高光合速率的受试者的方法。

44. 发明授权

US09585909B2 Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof 有权
标题翻译：聚合物共轭的MetAP2抑制剂及其治疗方法
公开(公告)号：US09585909B2
公开(公告)日：2017-03-07
申请号：US15065412
申请日：2016-03-09
申请人： SynDevRx, Inc.
发明人： John S. Petersen
IPC分类号： A61K31/785 , A61K47/48 , C07D303/18 , C07D405/14 , C07D407/04 , C07D473/34 , C07K7/06 , C08F220/58 , A61K31/336
CPC分类号： A61K31/785 , A61K31/336 , A61K47/58 , C07D303/18 , C07D405/14 , C07D407/04 , C07D473/34 , C07K7/06 , C08F220/58
摘要： One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.
摘要翻译：本发明的一个方面提供了聚合物缀合的MetAP2抑制剂。虽然不受任何特定理论的约束，但是认为通过本文所述的接头偶联MetAP2抑制性核提供对母体小分子具有优异功效的化合物和优异的药代动力学特征。在本发明的一个方面，缀合有共轭的MetAP2抑制剂可用于治疗疾病的方法，包括向有需要的受试者施用治疗有效量的聚合物缀合的MetAP2抑制剂。

45. 发明授权

US09566299B2 Oral pharmaceutical composition of aliphatic amine polymer or salts thereof 有权
标题翻译：脂族胺聚合物或其盐的口服药物组合物
公开(公告)号：US09566299B2
公开(公告)日：2017-02-14
申请号：US14766327
申请日：2014-02-05
申请人： WOCKHARDT LIMITED
发明人： Girish Kumar Jain , Venkataramana Naidu , Abdul Rehman Khan , Amar Agarwal , Srikanth Pattipati
IPC分类号： A61K9/28 , A61K31/785
CPC分类号： A61K31/785 , A61K9/282 , A61K9/2866 , A61K9/2893
摘要： The present invention relates to an oral pharmaceutical composition of aliphatic amine polymer or salts thereof comprising mixture of water and organic solvent(s) and/or less than of about 10% of plasticizing agent in the coating composition. In particular, present invention relates to a coated pharmaceutical composition of aliphatic amine polymer or salt thereof which comprises mixture of water and organic solvent(s) and less than of about 10% of plasticizing agent in coating. The invention also includes process of preparing such composition.
摘要翻译：本发明涉及在涂料组合物中包含水和有机溶剂和/或少于约10％增塑剂的混合物的脂族胺聚合物或其盐的口服药物组合物。特别地，本发明涉及一种脂质胺聚合物或其盐的包衣药物组合物，其包含水和有机溶剂的混合物，并且在涂层中包含小于约10％的增塑剂。本发明还包括制备这种组合物的方法。

46. 发明授权

US09555056B2 Aliphatic amine polymer salts for tableting 有权
标题翻译：用于压片的脂族胺聚合物盐
公开(公告)号：US09555056B2
公开(公告)日：2017-01-31
申请号：US14326877
申请日：2014-07-09
申请人： Genzyme Corporation
发明人： Hitesh R. Bhagat , Jeffrey M. Goldberg , Abizer I. Harianawala , Louis Brenner
IPC分类号： A61K9/20 , A61K31/785 , A61K31/13 , A61K47/02 , A61K47/34
CPC分类号： A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2866 , A61K31/13 , A61K31/785 , A61K47/02 , A61K47/34
摘要： The tablets, compositions and methods of the present invention, comprising a carbonate salt of an aliphatic amine polymer and s monovalent anion can prevent or ameliorate acidosis, in particular acidosis in patients with renal disease. The tablets and compositions of the present invention maintain a disintegration time of no greater than 30 minutes at 37° C. and at pH of at least 1 for a period of at least ten weeks at 60° C. Furthermore, the tablets are stable for extended periods of time without the need for specialized storage conditions.
摘要翻译：包含脂族胺聚合物和单价阴离子的碳酸盐的本发明的片剂，组合物和方法可以预防或改善酸中毒，特别是肾病患者的酸中毒。本发明的片剂和组合物在60℃下在37℃和至少1℃的pH下保持不超过30分钟至少10周的崩解时间。此外，片剂对于延长的时间段，而不需要专门的储存条件。

47. 发明申请

US20160361352A1 Treatment of Multiple Sclerosis With Combination of Laquinimod and Glatiramer Acetate 审中-公开
标题翻译：治疗多发性硬化症联合拉喹莫德和格拉美拉醋酸盐
公开(公告)号：US20160361352A1
公开(公告)日：2016-12-15
申请号：US15148074
申请日：2016-05-06
申请人： Yossi Gilgun , Nora Tarcic
发明人： Yossi Gilgun , Nora Tarcic
IPC分类号： A61K31/785 , A61K31/4704 , A61K45/06 , A61K9/08 , A61J1/05 , A61K9/48 , A61K9/20 , A61K9/28 , A61K47/16 , A61J1/03 , A61K9/00 , A61K47/26
CPC分类号： A61K31/785 , A61J1/035 , A61J1/05 , A61K9/0019 , A61K9/0043 , A61K9/0053 , A61K9/0073 , A61K9/08 , A61K9/20 , A61K9/2866 , A61K9/48 , A61K31/47 , A61K31/4704 , A61K31/765 , A61K38/02 , A61K45/06 , A61K47/16 , A61K47/26 , A61K2300/00
摘要： This invention provides a method of treating a patient afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering to the patient laquinimod as an add-on therapy to or in combination with glatiramer acetate. This invention also provides a package and a pharmaceutical composition comprising laquinimod and glatiramer acetate for treating a patient afflicted with multiple sclerosis or presenting a clinically isolated syndrome. This invention also provides laquinimod for use as an add-on therapy or in combination with glatiramer acetate in treating a patient afflicted with multiple sclerosis or presenting a clinically isolated syndrome. This invention further provides use of laquinimod and glatiramer acetate in the preparation of a combination for treating a patient afflicted with multiple sclerosis or presenting a clinically isolated syndrome.
摘要翻译：本发明提供一种治疗患有多发性硬化症或出现临床分离综合征的患者的方法，其包括向患者施用作为对醋酸格拉默或其与醋酸格拉默组合的附加疗法的拉喹莫德。本发明还提供一种包含药物组合物，其包含拉喹莫德和醋酸格拉司他，用于治疗患有多发性硬化症或出现临床分离综合征的患者。本发明还提供用作附加疗法或与醋酸格拉默组合治疗患有多发性硬化症或出现临床分离综合征的患者的拉喹莫德。本发明还提供了拉喹莫德和格拉默姆醋酸酯在制备用于治疗患有多发性硬化症或呈现临床分离的综合征的患者的组合的用途。

48. 发明授权

US09504755B2 Multi-arm polymeric alkanoate conjugates 有权
公开(公告)号：US09504755B2
公开(公告)日：2016-11-29
申请号：US14948976
申请日：2015-11-23
申请人： Nektar Therapeutics
发明人： Antoni Kozlowski , Samuel P. McManus , Jennifer Riggs-Sauthier , Xiaoming Shen , Wen Zhang
IPC分类号： C07D471/00 , A61K47/48 , A61K38/00 , A61K31/785 , C08G79/08 , A61K31/337 , A61K31/4745
CPC分类号： A61K31/337 , A61K31/4745 , A61K31/785 , A61K38/00 , A61K47/60 , C08G65/3328 , C08G65/33344 , C08G79/08
摘要： Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.

49. 发明申请

US20160324883A1 CATIONIC POLYMERS AS CO-DRUGS FOR CHEMOTHERAPEUTIC AGENTS 有权
标题翻译：阳离子聚合物作为化学治疗剂的药物
公开(公告)号：US20160324883A1
公开(公告)日：2016-11-10
申请号：US15146451
申请日：2016-05-04
申请人： Research Foundation of the City University of New York
发明人： Debra Auguste , Daxing Liu
IPC分类号： A61K31/704 , A61K31/198 , A61K38/17 , A61K31/132
CPC分类号： A61K31/704 , A61K31/506 , A61K31/513 , A61K31/7068 , A61K31/785 , A61K38/1706 , A61K45/06 , A61K47/34 , A61K2300/00
摘要： A method for treating a biological cell is disclosed. The method administers a mixture of a chemotherapeutic drug and a co-drug that facilitates delivery of the chemotherapeutic drug to the nucleus of the cell. Examples of co-drugs include cationic polymers, cationic lipids and cationic proteins. Cationic polymers include a polyethyleneimine (PEI), polylysine, a polybetaaminoester (PBAE), an ε-polylysine (EPL) including ε-poly-L-lysine (e-PLL), a polyarginine peptide, chitosan, a polyamidoamine dendrimer (PAMAM). Cationic lipids include 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP). Cationic proteins include protamine.
摘要翻译：公开了一种治疗生物细胞的方法。该方法施用化学治疗药物和辅助药物的混合物，其有助于将化疗药物递送至细胞核。助药的实例包括阳离子聚合物，阳离子脂质和阳离子蛋白。阳离子聚合物包括聚乙烯亚胺（PEI），聚赖氨酸，聚β-氨基酯（PBAE），包含ε-聚-L-赖氨酸（e-PLL），聚精氨酸肽，壳聚糖，聚酰胺胺树枝状聚合物（PAMAM）的ε-聚赖氨酸（EPL）。阳离子脂质包括1,2-二油酰-3-三甲基铵 - 丙烷（DOTAP）。阳离子蛋白质包括鱼精蛋白。

50. 再颁专利

USRE46190E1 High-molecular weight conjugate of steroids 有权
标题翻译：类固醇的高分子量缀合物
公开(公告)号：USRE46190E1
公开(公告)日：2016-11-01
申请号：US14594748
申请日：2015-01-12
申请人： Nippon Kayaku Kabushiki Kaisha
发明人： Masayuki Kitagawa , Toshitaka Murata
IPC分类号： A61K47/48 , A61K31/785
CPC分类号： A61K31/785 , A61K47/60 , A61K47/645
摘要： Enzymes in the body vary among different species, and also vary among individuals of the same species. Thus, it has been demanded to develop a novel steroid-containing pharmaceutical preparation which can release a drug in a manner independent of the enzymes present in the body, and which is expected to have an efficacious therapeutic effect.Disclosed is a high-molecular weight conjugate of a steroid, comprising a structure in which a carboxylic acid group of a polymer having a polyethylene glycol moiety and a succinic acid monoamide moiety having two or more succinic acid monoamide units is ester-bonded to a hydroxy group in the steroid.
摘要翻译：公开了类固醇的高分子量缀合物，其包含其中具有聚乙二醇部分的聚合物的羧酸基团和具有两个或多个琥珀酸单酰胺单元的琥珀酸单酰胺部分与羟基酯键合的结构在类固醇组。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式