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41. 发明申请

US20160038530A1 Nutritional Supplement to Complement Cancer Therapy 审中-公开
标题翻译：补充癌症治疗的营养补充
公开(公告)号：US20160038530A1
公开(公告)日：2016-02-11
申请号：US14454548
申请日：2014-08-07
申请人： Kevin Engholdt
发明人： Kevin Engholdt
IPC分类号： A61K31/737 , A61K31/015 , A61K31/375 , A61K31/593 , A61K31/355 , A61K33/10 , A61K31/525 , A61K31/455 , A61K31/675 , A61K31/519 , A61K31/714 , A61K31/197 , A61K31/716 , A61K31/51
CPC分类号： A61K31/737 , A61K31/015 , A61K31/197 , A61K31/355 , A61K31/375 , A61K31/455 , A61K31/51 , A61K31/519 , A61K31/525 , A61K31/593 , A61K31/675 , A61K31/714 , A61K31/716 , A61K33/10 , A61K2300/00
摘要： A nutritional or dietary supplement composition that strengthens and promotes health through the prevention, stabilization, reversal and/or treatment of cancers, chemotherapy, and/or radiation therapy related complications. The nutritional or dietary supplement composition may likewise reduce the risk and/or prevalence of cancerous cells in addition to providing complement to cancer related therapies. The essential ingredients of the nutritional or dietary supplement composition are vitamin A, vitamin B6, vitamin B12, vitamin C, vitamin D3, vitamin E, calcium, thiamin, riboflavin, niacin, folic acid, pantothenic acid, fucoidan (extract from seaweed species such as, but not limited to; laminaria japonica and undaria pinnatifida), beta-glucans (extract from mushroom species such as, but not limited to; ganoderma lucidum and grifola frondosa), and antioxidants (from vegetable, fruit, or herb such as, but not limited to; acai berry (Euterpe oleracea), sumac, cloves, and sorghum). The essential ingredients are preferably provided in a capsule or tablet form suitable for oral ingestion. Preferably the composition is taken in the form of 3 tablets taken once daily.
摘要翻译：通过预防，稳定，逆转和/或治疗癌症，化疗和/或放射治疗相关并发症来增强和促进健康的营养或膳食补充剂组合物。除了提供癌症相关疗法的补充之外，营养或膳食补充剂组合物同样可以降低癌细胞的风险和/或流行。营养或膳食补充剂组合物的基本成分是维生素A，维生素B6，维生素B12，维生素C，维生素D3，维生素E，钙，硫胺素，核黄素，烟酸，叶酸，泛酸，岩藻依聚糖 β-葡聚糖（来自蘑菇物种的提取物，例如但不限于灵芝和冰片三叶草）以及抗氧化剂（来自植物，水果或草本植物，例如，但不限于：aria粳和und ida属）但不限于：acai berry（Euterpe oleracea），sumac，丁香和高粱）。基本成分优选以适合于口服摄取的胶囊或片剂形式提供。优选地，组合物以3片每片一次的形式取出。

42. 发明申请

US20160015762A1 Antiviral supplement compositions and methods of use 审中-公开
标题翻译：抗病毒补充剂组合物和使用方法
公开(公告)号：US20160015762A1
公开(公告)日：2016-01-21
申请号：US14333645
申请日：2014-07-17
申请人： Jonathan Shelley Nimitz
发明人： Jonathan Shelley Nimitz
IPC分类号： A61K36/25 , A61K33/30 , A61K36/19 , A61K36/481 , A61K45/06 , A61K36/23 , A61K36/539 , A61K31/716 , A61K36/63 , A61K36/185 , A61K36/315
CPC分类号： A61K45/06 , A61K31/716 , A61K33/30 , A61K36/185 , A61K36/254 , A61K2300/00
摘要： The present invention relates to the field of dietary supplements, and in particular to antiviral compositions and methods of use. Compositions are described involving various combinations of Andrographis, Astragalus, Eleuthero, Isatis, Lomatium, Pelargonium, Sambucus, Scute, and/or Zinc, optionally with additional components. These combinations of supplements synergistically reduce both severity and duration of viral infections, including in particular colds and influenza, as well as providing additional benefits.
摘要翻译：本发明涉及膳食补充剂领域，特别涉及抗病毒组合物和使用方法。描述了包括穿心莲，黄芪，埃柳塞罗，茜素，茉莉，天竺葵，接骨木蛋白，Scute和/或锌的各种组合的组合物，任选地含有另外的组分。这些补充剂的组合协同地减少病毒感染的严重性和持续时间，特别是感冒和流感，以及提供额外的益处。

43. 发明授权

US09211304B2 Therapy-enhancing glucan 有权
标题翻译：治疗增强型葡聚糖
公开(公告)号：US09211304B2
公开(公告)日：2015-12-15
申请号：US13760307
申请日：2013-02-06
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , Biotec Pharmacon ASA
发明人： Nai-Kong V. Cheung , Rolf Einar Engstad
IPC分类号： A61K31/716 , C08B37/00 , A61K31/715 , A61K31/739 , A61K39/39 , A61K39/395 , A61K39/44 , A61K47/36 , A61K39/00
CPC分类号： A61K39/39 , A61K31/715 , A61K31/716 , A61K31/739 , A61K39/39541 , A61K39/39558 , A61K39/44 , A61K47/36 , A61K2039/55583 , C08B37/0024 , A61K2300/00
摘要： This invention provides a method for introducing substances into cells comprising contacting a composition comprising orally administered beta-glucan with said cells. This invention also provides a method for introducing substances into a subject comprising administering to the subject an effective amount of the above compositions. The substance which could be delivered orally includes but is not limited to peptides, proteins, RNAs, DNAs, chemotherapeutic agents, biologically active agents, plasmids, and other small molecules and compounds. Finally, this invention provides a composition comprising orally administered beta-glucan capable of enhancing efficacy of IgM and different uses of the said composition.
摘要翻译：本发明提供了将物质引入细胞的方法，包括使包含口服β-葡聚糖的组合物与所述细胞接触。本发明还提供了将物质引入受试者的方法，包括向受试者施用有效量的上述组合物。可以口服递送的物质包括但不限于肽，蛋白质，RNA，DNA，化学治疗剂，生物活性剂，质粒和其他小分子和化合物。最后，本发明提供一种组合物，其包含能够增强IgM的功效和所述组合物的不同用途的口服β-葡聚糖。

44. 发明授权

US09206217B2 Nucleoside phosphoramidates 有权
标题翻译：核苷氨基磷酸酯
公开(公告)号：US09206217B2
公开(公告)日：2015-12-08
申请号：US13732725
申请日：2013-01-02
申请人： GILEAD PHARMASSET LLC
发明人： Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Suguna Rachakonda , Hai-Ren Zhang , Byoung-Kwon Chun , Peiyuan Wang
IPC分类号： C07H19/00 , C07H19/10 , A61K31/7072 , A61K45/00 , C07F9/24 , A61K31/716 , C07H17/02 , C07F9/6558
CPC分类号： C07H19/10 , A61K31/7072 , A61K31/716 , A61K45/00 , C07F9/24 , C07F9/242 , C07F9/65586 , C07H1/00 , C07H17/02 , Y02A50/463 , Y02P20/55
摘要： Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.
摘要翻译：本文公开了核苷氨基磷酸酯及其作为治疗病毒性疾病的药剂的用途。这些化合物是RNA依赖性5 RNA病毒复制的抑制剂，可用作HCV NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和用于治疗哺乳动物的丙型肝炎感染。

45. 发明申请

US20150290261A1 METHODS OF USE FOR PROBIOTICS AND PREBIOTICS 审中-公开
标题翻译：用于预防和预防的方法
公开(公告)号：US20150290261A1
公开(公告)日：2015-10-15
申请号：US14503930
申请日：2014-10-01
申请人： Mead Johnson Nutrition Company
发明人： Maciej Chichlowski , Brian Berg , Colin Rudolph , Robert J. McMahon , Rosaline Waworuntu
IPC分类号： A61K35/747 , A23L1/308 , A23L1/29 , A23L1/30 , A61K31/716 , A61K31/702
CPC分类号： A61K35/747 , A23L33/10 , A23L33/135 , A23L33/26 , A23L33/40 , A23V2002/00 , A23Y2220/73 , A61K31/702 , A61K31/716 , A61K2035/115 , C12N1/20
摘要： The present disclosure relates to method(s) for reducing the risk of visceral pain hypersensitivity, modulating the gut-brain axis, or reducing the local inflammatory response in a subject. The method(s) include providing a nutritional composition that includes Lactobacillus rhamnosus GG (LGG), galacto-oligosaccharide(s) (GOS) and polydextrose (PDX) to the subject. The combination of LGG, GOS, and PDX may exhibit additive or synergistic beneficial health effects when consumed. The nutritional compositions herein are suitable for administration to children and infants.
摘要翻译：本公开涉及减少内脏痛过敏风险，调节肠 - 脑轴线或减少受试者局部炎症反应的方法。该方法包括向受试者提供包括鼠李糖乳杆菌GG（LGG），低聚半乳糖（GOS）和聚右旋糖（PDX））的营养组合物。当消费时，LGG，GOS和PDX的组合可能表现出增加的或协同的有益的健康影响。本发明的营养组合物适用于给予儿童和婴儿。

46. 发明申请

US20150290260A1 METHODS OF USE FOR PROBIOTICS AND PREBIOTICS 审中-公开
公开(公告)号：US20150290260A1
公开(公告)日：2015-10-15
申请号：US14249548
申请日：2014-04-10
申请人： Mead Johnson Nutrition Company
发明人： Maciej Chichlowski , Brian Berg , Colin Rudolph , Robert J. McMahon , Rosaline Waworuntu
IPC分类号： A61K35/747 , A23L1/308 , A23L1/29 , A23L1/30 , A61K31/702 , A61K31/716
CPC分类号： A61K35/747 , A23L33/12 , A23L33/135 , A23L33/15 , A23L33/16 , A23L33/21 , A23L33/26 , A23L33/40 , A23V2002/00 , A23Y2220/73 , A61K31/202 , A61K31/702 , A61K31/716 , A61K2035/115 , A23V2200/31 , A23V2200/3204 , A23V2250/1592 , A23V2250/1862 , A23V2250/1868 , A23V2250/28 , A23V2250/5034 , A23V2250/54248
摘要： The present disclosure relates to method(s) for reducing the risk of visceral pain hypersensitivity, modulating the gut-brain axis, or reducing the local inflammatory response in a subject. The method(s) include providing a nutritional composition that includes Lactobacillus rhamnosus GG (LGG), galacto-oligosaccharide(s) (GOS) and polydextrose (PDX) to the subject. The combination of LGG, GOS, and PDX may exhibit additive or synergistic beneficial health effects when consumed. The nutritional compositions herein are suitable for administration to children and infants.

47. 发明申请

US20150267234A1 BRANCHED ALPHA-GLUCAN, ALPHA-GLUCOSYLTRANSFERASE WHICH FORMS THE GLUCAN, THEIR PREPARATION AND USES 有权
标题翻译：分支的ALPHA-GLUCAN，ALPHA-GLUCOSYLTRANSFERASE，其形成葡萄糖，其制备和用途
公开(公告)号：US20150267234A1
公开(公告)日：2015-09-24
申请号：US14734607
申请日：2015-06-09
申请人： Hayashibara Co., Ltd
发明人： Hikaru Watanabe , Takuo Yamamoto , Tomoyuki Nishimoto , Keji Tsusaki , Kazuyuki Oku , Hiroto Chaen , Shigeharu Fukuda
IPC分类号： C12P19/04 , C12P19/18
CPC分类号： A23L33/21 , A21D2/18 , A23C9/1307 , A23C9/1544 , A23L2/39 , A23L9/20 , A23L11/05 , A23L29/35 , A23L33/10 , A23L33/18 , A23V2002/00 , A61K8/73 , A61K8/732 , A61K9/06 , A61K9/20 , A61K31/716 , A61K31/718 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0009 , C12N9/1051 , C12P19/04 , C12P19/18 , C12R1/06 , C12R1/09 , Y02P20/52 , A23V2250/5118 , A23V2200/3262 , A23V2200/328
摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
摘要翻译：本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。本发明通过提供由葡萄糖分子构成并以甲基化分析为特征的支链α-葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）部分甲基化的2,3,6-三甲基-1,4,5-三乙酰 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰 - 葡糖醇的总含量为60％以上葡萄糖醇乙酸酯; （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链α-葡聚糖的新型α-葡糖基转移酶，其制备方法及其用途。

48. 发明申请

US20150258162A9 COMPOSITION FOR COSMETIC, PHARMACEUTICAL AND DIETARY APPLICATIONS 有权
标题翻译：化妆品，药物和饮食应用的组成
公开(公告)号：US20150258162A9
公开(公告)日：2015-09-17
申请号：US14141560
申请日：2013-12-27
申请人： LIPOID GmbH
发明人： Herbert Rebmann
IPC分类号： A61K36/886 , A61K31/685 , A61K8/97 , A61K31/522 , A61K8/55 , A61K36/82 , A61K36/185 , A61K36/77 , A61K31/716 , A61K8/73
CPC分类号： A61K8/73 , A23L3/44 , A23L33/105 , A23V2002/00 , A61K8/553 , A61K8/60 , A61K8/97 , A61K9/06 , A61K9/127 , A61K9/19 , A61K31/522 , A61K31/685 , A61K31/716 , A61K36/16 , A61K36/185 , A61K36/23 , A61K36/258 , A61K36/31 , A61K36/45 , A61K36/48 , A61K36/63 , A61K36/77 , A61K36/82 , A61K36/886 , A61Q19/00 , A61K2300/00 , A23V2250/21 , A23V2250/5114 , A23V2250/032
摘要： A composition including 0.5-40 weight % vegetable extract, 30-90 weight % sugar and 0.5-30 weight % phospholipid for cosmetic, pharmaceutical or dietary uses.
摘要翻译：包含0.5-40重量％植物提取物，30-90重量％糖和0.5-30重量％磷脂用于化妆品，药物或膳食用途的组合物。

49. 发明申请

US20150258131A1 Peyer's Patch Activator 有权
标题翻译：派伊的补丁激活器
公开(公告)号：US20150258131A1
公开(公告)日：2015-09-17
申请号：US14432315
申请日：2013-09-18
申请人： Mitsui Sugar Co., Ltd. , The Kitakaso Institute
发明人： Haruki Yamada , Hiroaki Kiyohara , Kazuhiko Otoguro , Aki Ishiyama , Masato Iwatsuki , Satoshi Omura , Masami Mizu , Toshikazu Kawai , Jun Kashimura , Kenji Koge
IPC分类号： A61K31/716 , A23K1/16 , A61K36/899 , A23L1/30 , A61K31/4706 , A61K31/357
CPC分类号： A61K31/716 , A23K20/163 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/137 , A61K31/357 , A61K31/4706 , A61K31/4709 , A61K31/49 , A61K31/505 , A61K31/635 , A61K36/899 , C08B37/0003 , C08B37/006 , C08L5/00 , Y02A50/411 , A61K2300/00
摘要： The present invention provides a Peyer's patch activator containing a polysaccharide obtained from sugar cane as an active ingredient, wherein the polysaccharide contains α-glucan as a main component and has a peak molecular weight within a range of 720,000 to 1,080,000, with a proportion of glucose in all component sugars being 80% or more, and proportions of nonreducing terminal glucose and α-1,6-linked glucose being 20 to 30% and 15 to 25%, respectively.
摘要翻译：本发明提供了含有从甘蔗获得的多糖作为活性成分的派耶尔贴剂激活剂，其中多糖含有α-葡聚糖作为主要成分，峰分子量在72万至108万之间，葡萄糖的比例在所有组分糖中均为80％以上，非还原性末端葡萄糖和α-1,6-连接葡萄糖的比例分别为20〜30％和15〜25％。

50. 发明授权

US09114129B2 Augmentation of titer for vaccination in animals 有权
标题翻译：增加动物疫苗接种滴度
公开(公告)号：US09114129B2
公开(公告)日：2015-08-25
申请号：US14447327
申请日：2014-07-30
申请人： OmniGen Research, L.L.C.
发明人： Neil E. Forsberg , Steven B. Puntenney
IPC分类号： A61K39/00 , A61K39/02 , A61K39/385 , A61K39/39 , A61K31/715 , A61K31/716 , A61K31/736 , A61K35/02 , A61K38/47 , A23K1/16 , A23K1/00
CPC分类号： A61K39/39 , A23K10/16 , A23K20/147 , A61K31/715 , A61K31/716 , A61K31/736 , A61K35/02 , A61K38/47 , A61K39/02 , Y02A50/463 , A61K2300/00
摘要： The disclosure relates to a composition added to animal feed used in combination with a vaccine to enhance the effectiveness of the vaccine. Amongst other effects, the composition raises the titer of antibodies to the vaccine.
摘要翻译：本公开涉及添加到动物饲料中的组合物，其与疫苗组合以增强疫苗的有效性。除了其他效果之外，组合物还提高了疫苗的抗体滴度。

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