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41. 发明授权

US09556234B2 Template-fixed peptidomimetics 有权
标题翻译：模板固定肽模拟物
公开(公告)号：US09556234B2
公开(公告)日：2017-01-31
申请号：US14555796
申请日：2014-11-28
申请人： Universitaet Zuerich , POLYPHOR LTD.
发明人： Daniel Obrecht , Frank Gombert , Steven J. Demarco , Christian Ludin , Jan Wim Vrijbloed , Kerstin Moehle , John-Anthony Robinson , Reshmi Mukherjee , Heiko Henze , Barbara Romagnoli
IPC分类号： C07K7/56 , C07K7/64 , A61K38/12
CPC分类号： C07K7/56 , A61K38/00 , A61K38/12 , C07K7/64
摘要： The template-fixed B-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.
摘要翻译：模板固定的B发夹肽模拟物Cyclo（-Tyr-His-X-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro），Cys4 和Gys11及其药学上可接受的盐，其中X为Ala或Tyr，具有CXCR4拮抗性质，可用于癌症介导或由CXCR4受体活性产生的地方。

42. 发明申请

US20140187471A1 TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY 有权
标题翻译：具有抗微生物活性的模板固定肽
公开(公告)号：US20140187471A1
公开(公告)日：2014-07-03
申请号：US14175160
申请日：2014-02-07
申请人： Steven J. DEMARCO , Wim Vrijbloed , Ricardo Dias , John Anthony Robinson , Nityakalyani Srinivas , Frank Gombert , Daniel Obrecht
发明人： Steven J. DEMARCO , Wim Vrijbloed , Ricardo Dias , John Anthony Robinson , Nityakalyani Srinivas , Frank Gombert , Daniel Obrecht
IPC分类号： C07K7/64 , A01N43/36 , C07K1/10
CPC分类号： C07K7/64 , A01N43/36 , A61K38/00 , C07K1/10 , C07K7/06 , C07K7/08 , C07K14/001
摘要： Template-fixed β-hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 12 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections.These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.
摘要翻译：模板固定和通用的肽模拟物，其中Z是12个α-氨基酸残基的模板固定链，取决于它们在链中的位置（从N-末端氨基酸开始计数）是Gly，或Pro，或某些类型，其作为上述式中的其余符号在说明书和权利要求书中及其盐中定义，具有选择性抑制绿脓假单胞菌等微生物生长或杀死微生物的性质。它们可以用作食品，化妆品，药物或其他含营养材料的消毒剂，或用作治疗或预防感染的药物。这些和平滑肽模拟物可以通过基于混合固相和溶液相合成策略的方法制造。

43. 发明授权

US08765775B2 Anti-angiogenic compounds 失效
标题翻译：抗血管生成化合物
公开(公告)号：US08765775B2
公开(公告)日：2014-07-01
申请号：US12863724
申请日：2009-01-23
申请人： Danzhi Huang , Peter Kolb , Karine Lafleur , Cristina Nevado , Amedeo Caflisch
发明人： Danzhi Huang , Peter Kolb , Karine Lafleur , Cristina Nevado , Amedeo Caflisch
IPC分类号： A61K31/522 , C07D473/04 , C07D473/06
CPC分类号： C07D473/06 , A61K31/522 , C07D473/04 , C07D487/14
摘要： The invention relates to compounds of formula 1, tautomers and salts thereof, wherein R1, R2, R3, R4, and R5 have the meanings indicated in the specification. These compounds are receptor tyrosine kinase EphB4 inhibitors useful for the treatment of angiogenesis dependent cancers and intraocular neovascular syndromes. The invention further relates to a method termed ALTA (anchor-based library tailoring) of selecting compounds from a large compound library for screening as EphB4 inhibitors by computational procedures.
摘要翻译：本发明涉及式1化合物，其互变异构体及其盐，其中R 1，R 2，R 3，R 4和R 5具有说明书中所示的含义。这些化合物是可用于治疗血管生成依赖性癌症和眼内新生血管综合征的受体酪氨酸激酶EphB4抑制剂。本发明还涉及一种称为ALTA（基于锚的文库定制）的方法，从大型化合物文库中选择化合物，通过计算程序筛选为EphB4抑制剂。

44. 发明申请

US20130203612A1 METHOD FOR ASSAYING SEPSIS IN HUMANS 有权
标题翻译：人体测量方法
公开(公告)号：US20130203612A1
公开(公告)日：2013-08-08
申请号：US13853514
申请日：2013-03-29
申请人： Rolf Graf , Daniel Bimmler , Marius Keel
发明人： Rolf Graf , Daniel Bimmler , Marius Keel
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2333/474 , G01N2800/26
摘要： The present invention relates to a reliable method of prediction of sepsis in humans after a trauma, wherein the level of pancreatic stone protein/regenerating protein (PSP/reg) is determined in serum, and a high level is indicative of the development of sepsis at early stages of the disease. Furthermore a method of determination of PSP/reg levels in serum is described.
摘要翻译：本发明涉及一种在创伤后预测人类败血症的可靠方法，其中在血清中测定胰蛋白/再生蛋白（PSP / reg）的水平，高水平表明败血症发展为疾病的早期阶段。此外，描述了测定血清中PSP / reg水平的方法。

45. 发明授权

US07912811B2 Computer-based system and computer program product for collaborative editing of documents 有权
标题翻译：基于计算机的系统和计算机程序产品，用于文档的协同编辑
公开(公告)号：US07912811B2
公开(公告)日：2011-03-22
申请号：US11596798
申请日：2005-05-17
申请人： Thomas B. Hodel-Widmer
发明人： Thomas B. Hodel-Widmer
IPC分类号： G06F17/20 , G06F17/24
CPC分类号： G06Q10/10 , G06F17/24
摘要： A computer-based system for collaborative editing of documents has a computer-based control module and computerized workstations. The system has a database connected to the control module that stores a document in the database as linked character objects. Each character object represents one particular character of the document, includes a unique object identifier, and represents a type of the particular character. The character object represents the particular character being linked to a first character object representing a character preceding directly the particular character in the document and to a second character object representing a character following directly the particular character in the document. The control module receives and processes editing commands. The system has a propagation module for transmitting propagation messages to the workstations participating in the collaborative editing of the document, propagation messages including the character objects inserted or deleted in the database.
摘要翻译：用于文档协同编辑的基于计算机的系统具有基于计算机的控制模块和计算机化的工作站。该系统具有连接到控制模块的数据库，该数据库将文档作为链接的字符对象存储在数据库中。每个字符对象表示文档的一个特定字符，包括唯一的对象标识符，并且表示特定字符的类型。字符对象表示链接到表示直接在文档中的特定字符之前的字符的第一字符对象的特定字符以及表示文档中的特定字符之后的字符的第二字符对象。控制模块接收并处理编辑命令。该系统具有传播模块，用于向参与协作编辑文档的工作站传输传播消息，包括在数据库中插入或删除的字符对象的传播消息。

46. 发明公开

US20240201303A1 METHOD OF ESTIMATING MOTION OF AN OBJECT AND/OR MAGNETIC FIELD OFFSETS DURING AN MRI SCAN 审中-公开
公开(公告)号：US20240201303A1
公开(公告)日：2024-06-20
申请号：US18557980
申请日：2022-04-30
申请人： EIDGENOESSISCHE TECHNISCHE HOCHSCHULE (ETH) , UNIVERSITAET ZUERICH
发明人： Thomas ULRICH , Klaas PRUESSMANN
IPC分类号： G01R33/565 , G01R33/54
CPC分类号： G01R33/56563 , G01R33/543 , G01R33/56509
摘要： In a method of estimating motion of an object and/or magnetic field offsets in a region surrounding the object during a magnetic resonance (MR) imaging scan of the object, superimposed magnetic fields and radiofrequency fields are generated according to an MR sequence for forming images, the MR sequence comprising a train of sequence modules, each sequence module comprising a radiofrequency (RF) excitation segment and an image encoding gradient segment, the MR sequence further comprising a plurality of navigator gradient segments. The navigator signal is acquired along a trajectory in k-space and expressed as a discrete time series comprising a predefined number of complex-valued signal datapoints. The navigator signal acquired in a first sequence module is used to calculate a transformation matrix which relates rotation angles and translational shifts and/or changes of the magnetic field to corresponding changes in navigator signal in a first order approximation. The navigator signal acquired in a subsequent sequence module is used to estimate object motion in terms of a translational displacement and a rotational displacement of the object and/or magnetic field offsets in terms of a scalar field variation and a vectorial field variation between the first sequence module and the subsequent sequence module by solving a corresponding linear least-squares estimation problem.

47. 发明授权

US11421001B2 Template-fixed peptidomimetics 有权
公开(公告)号：US11421001B2
公开(公告)日：2022-08-23
申请号：US17013111
申请日：2020-09-04
申请人： UNIVERSITAET ZUERICH , POLYPHOR LTD.
发明人： Daniel Obrecht , Frank Gombert , Steven J. Demarco , Christian Ludin , Jan Wim Vrijbloed , Kerstin Moehle , John-Anthony Robinson , Reshmi Mukherjee , Heiko Henze , Barbara Romagnoli
IPC分类号： C07K7/56 , A61K38/12 , C07K7/64 , A61K38/00
摘要： The template-fixed β-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.

48. 发明申请

US20210166112A1 METHOD FOR NEURAL NETWORK AND APPARATUS PERFORMING SAME METHOD 有权
公开(公告)号：US20210166112A1
公开(公告)日：2021-06-03
申请号：US17171551
申请日：2021-02-09
申请人： SAMSUNG ELECTRONICS CO., LTD. , UNIVERSITAET ZUERICH
发明人： Jun Haeng LEE , Daniel Neil , Shih-Chii Liu , Tobi Delbruck
IPC分类号： G06N3/063 , G06N3/04
摘要： A method for operating an artificial neuron and an apparatus for performing the method are provided. The artificial neuron may calculate a change amount of an activation based on an input signal received via an input synapse, determine whether an event occurs in response to the calculated change amount of the activation, and transmit, to an output synapse, an output signal that corresponds to the event in response to an occurrence of the event.

49. 发明申请

US20190100558A1 TEMPLATE-FIXED PEPTIDOMIMETICS 审中-公开
公开(公告)号：US20190100558A1
公开(公告)日：2019-04-04
申请号：US16190459
申请日：2018-11-14
申请人： UNIVERSITAET ZUERICH , POLYPHOR LTD.
发明人： Daniel OBRECHT , Frank GOMBERT , Steven J. DEMARCO , Christian LUDIN , Jan Wim VBIJBLOED , Kerstin MOEHLE , John-Anthony ROBINSON , Reshmi MUKHERJEE , Heiko HENZE , Barbara ROMAGNOLI
IPC分类号： C07K7/56 , A61K38/12 , C07K7/64 , A61K38/00
摘要： The template-fixed β-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gysll, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity

50. 发明授权

US10213297B2 Controlling tissue engineered heart valve geometry by using predefined inserts during culture 有权
公开(公告)号：US10213297B2
公开(公告)日：2019-02-26
申请号：US15024857
申请日：2014-09-24
申请人： Technische Universiteit Eindhoven , Universitaet Zuerich
发明人： Bart Sanders , Sandra Vossen-Loerakker , Anita Driessen-Mol , Simon Philipp Hoerstrup , Franciscus Petrus Thomas Baaijens
IPC分类号： A61F2/00 , A61F2/24 , C12M1/00 , C12M1/12 , C12M3/00
摘要： Various inserts, called shapers and spacers, are provided for controlling tissue engineered heart valve (TEHV) leaflet geometry during culture. These inserts will prevent TEHV leaflet retraction during culture, be able to control the leaflet geometry during culture, enable culturing TEHV leaflets with a larger coaptation area, control the height of the coaptation area, maintain TEHV leaflet curvatures, and/or enable possibilities to culture TEHV leaflets in open configuration.

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