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41. 发明申请

US20040214259A1 Methods of sampling microbial communities and apparatus therefore 审中-公开
标题翻译：因此，微生物群落和装置的取样方法
公开(公告)号：US20040214259A1
公开(公告)日：2004-10-28
申请号：US10788432
申请日：2004-02-27
申请人： The University of Tennessee Research Foundation
发明人： Aaron D. Peacock , Greg A. Davis , David C. White
IPC分类号： C12Q001/18
CPC分类号： C12Q1/02
摘要： The subject invention provides an apparatus and methods for microbial sampling of solids, liquids, and gases, and in performing in situ microcosm or down-well subsurface solid phase sampler tests.
摘要翻译：本发明提供了一种用于固体，液体和气体的微生物取样以及在原位微观或井下地下固相取样器测试中进行微生物取样的装置和方法。

42. 发明授权

US09139546B2 Tri-aryl/heteroaromatic cannabinoids and use thereof 有权
标题翻译：三芳基/杂芳族大麻素及其用途
公开(公告)号：US09139546B2
公开(公告)日：2015-09-22
申请号：US13024643
申请日：2011-02-10
申请人： Bob M. Moore, II , Himanshu Bhattacharjee , Suni Mustafa
发明人： Bob M. Moore, II , Himanshu Bhattacharjee , Suni Mustafa
IPC分类号： C07D307/42 , C07D307/46
CPC分类号： C07D307/42 , C07D307/46
摘要： Cannabinoid derivatives according to formula (I) are disclosed wherein, X, Y, R1, R2, and W can have the definitions provided herein. Without limitation, use of such compounds, their salts or pro-drug, or compositions containing the compounds, salts, or pro-drug, to modify the activity of CB1 and CB2 receptors and treat conditions mediated by these receptors.
摘要翻译：公开了根据式（I）的大麻素衍生物，其中X，Y，R 1，R 2和W可具有本文提供的定义。不限于此，使用这些化合物，其盐或前药，或含有化合物，盐或前药的组合物来改变CB1和CB2受体的活性并治疗由这些受体介导的病症。

43. 发明申请

US20140107035A1 METHODS OF TREATING FIBROSING DISEASES BY INDUCTION OF IMMUNE TOLERANCE 审中-公开
标题翻译：通过诱导免疫耐受性治疗疾病的方法
公开(公告)号：US20140107035A1
公开(公告)日：2014-04-17
申请号：US14106038
申请日：2013-12-13
申请人： The University of Tennessee Research Foundation
发明人： Arnold E. Postlethwaite , Andrew H. Kang
IPC分类号： A61K38/39
CPC分类号： A61K38/39
摘要： The present invention has demonstrated for the first time that orally administered type I collagen (CI) induced tolerance to CI in patients suffering from systemic sclerosis (SSc) and ameliorated clinical manifestations of the disease. Accordingly, the present invention provides methods of treating a fibrosing disease by oral administration of a tissue protein, for example, collagen, derived from the tissue undergoing fibrosis.
摘要翻译：本发明首次证明口服I型胶原（CI）诱导患有系统性硬化症（SSc）的患者对CI的耐受性并改善了该疾病的临床表现。因此，本发明提供了通过口服给予经历纤维化的组织的组织蛋白例如胶原来治疗纤维化疾病的方法。

44. 发明授权

US08568763B2 Compositions and coatings for delivery of therapeutic agents 有权
标题翻译：用于递送治疗剂的组合物和涂层
公开(公告)号：US08568763B2
公开(公告)日：2013-10-29
申请号：US13484086
申请日：2012-05-30
申请人： Omran R. Abul-Khoudoud , Catherine Cagiannos , Waldemar G. DeRijk , Timothy C. Fabian , Lisa Kyle Jennings
发明人： Omran R. Abul-Khoudoud , Catherine Cagiannos , Waldemar G. DeRijk , Timothy C. Fabian , Lisa Kyle Jennings
IPC分类号： A61F13/00 , A61F2/06 , A61F2/00 , A61K9/14 , A61L33/00
CPC分类号： A61K31/436 , A61L27/16 , A61L27/34 , A61L27/54 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/404 , A61L2300/41 , A61L2300/416 , A61L2300/42 , C08L27/18 , C08L33/10
摘要： Water-soluble polymeric adhesive compositions and their use as delivery vehicles for carrying therapeutic agents on implantable devices, such as vascular grafts, are disclosed. Use of drug-coated vascular grafts is demonstrated for delivery of the therapeutic agents in vivo, thereby inhibiting restenosis or neointimal hyperplasia of the vascular graft and inhibiting infection at the vascular graft site. Methods of forming the adhesive and making the coated vascular grafts are also disclosed.
摘要翻译：公开了水溶性聚合物粘合剂组合物及其作为用于在可植入装置（例如血管移植物）上携带治疗剂的递送载体的用途。药物包被的血管移植物的使用被证明用于在体内递送治疗剂，从而抑制血管移植物的再狭窄或新内膜增生并抑制血管移植部位的感染。还公开了形成粘合剂并制备涂覆的血管移植物的方法。

45. 发明授权

US08431595B2 Furanopyridine cannabinoid compounds and related methods of use 失效
标题翻译：呋喃并吡啶大麻素化合物及相关使用方法
公开(公告)号：US08431595B2
公开(公告)日：2013-04-30
申请号：US12860733
申请日：2010-08-20
申请人： Bob M. Moore, II , Steven Gurley , Suni Mustafa
发明人： Bob M. Moore, II , Steven Gurley , Suni Mustafa
IPC分类号： A61K31/4355 , C07D471/06
CPC分类号： C07D491/04 , A61K31/4355
摘要： Furanopyridine cannabinoid analog compounds of the formula I are disclosed. The compounds are useful to modify the activity of CB1 and CB2 receptors and treat conditions mediated by these receptors.
摘要翻译：公开了式I的呋喃并吡啶大麻素类似物。该化合物可用于改变CB1和CB2受体的活性并治疗由这些受体介导的病症。

46. 发明申请

US20110295518A1 METHODS OF ASSOCIATING AN UNKNOWN BIOLOGICAL SPECIMEN WITH A FAMILY 有权
标题翻译：将未知生物样本与家族相关联的方法
公开(公告)号：US20110295518A1
公开(公告)日：2011-12-01
申请号：US13209278
申请日：2011-08-12
申请人： Ranajit Chakraborty , John Douglas Birdwell , Tse-Wei Wang , Dale V. Stansberry
发明人： Ranajit Chakraborty , John Douglas Birdwell , Tse-Wei Wang , Dale V. Stansberry
IPC分类号： G06F19/00
CPC分类号： G06F19/18
摘要： The present invention provides at least three methods of predicting whether an unknown biological specimen originates from a member of a particular family. These methods compare DNA profiles from unknown biological specimens to DNA profiles of more than one family member, which significantly increases the methods' identification ability. In particular, the invention describes combining at least a ranked first family member list and a ranked second family member list to create a combined ranked list and identifying the unknown biological specimen as one contained among a list of specimens having the highest combined rankings representing the candidates that are most likely related to the family. A second method encompasses comparing test DNA profiles from unknown biological specimens to a family pedigree comprising target DNA profiles obtained from multiple biological specimens of family members. This method also embodies using a modified Elston Stewart algorithm to determine a pedigree likelihood ratio to rank and identify the test profile of the unknown biological specimen most likely to be the missing person sought after by the corresponding family represented by the family pedigree. A third method encompasses construction of a database or directed graph of discovered or known relationships between biological specimens and comparison to a graph representing a family pedigree to identify portions of the database or directed graph that correspond to portions of the family pedigree, in order to rank or identify one or more unknown biological specimens as most likely related to one or more family pedigrees.
摘要翻译：本发明提供了至少三种预测未知生物样品是否源自特定家族成员的方法。这些方法将来自未知生物标本的DNA谱与多于一个家族成员的DNA谱进行了比较，从而显着提高了方法识别能力。特别地，本发明描述了将至少排列的第一家族成员列表和排名第二家庭成员列表组合以创建组合排名列表，并且将未知生物标本识别为包含表示候选者的具有最高组合排名的标本列表之一这很可能与家庭有关。第二种方法包括比较来自未知生物标本的测试DNA谱与家族谱系，其包括从家族成员的多个生物标本获得的靶DNA谱。该方法还体现了使用修改的埃尔斯顿斯图尔特算法来确定血统似然比以排列并鉴定最可能是由家族谱系所代表的相应家族所追求的失踪者的未知生物标本的测试轮廓。第三种方法包括构建生物标本之间已发现或已知关系的数据库或有向图，并与代表家族血统图的图表进行比较，以便识别对应于家族血统部分的数据库或有向图的部分，以便排列或识别一个或多个未知生物标本，其最可能与一个或多个家族谱系相关。

47. 发明授权

US07718765B2 Methods of treating fibrosing diseases by induction of immune tolerance 有权
标题翻译：通过诱导免疫耐受治疗纤维化疾病的方法
公开(公告)号：US07718765B2
公开(公告)日：2010-05-18
申请号：US11600525
申请日：2006-11-16
申请人： Arnold E. Postlethwaite , Andrew H. Kang
发明人： Arnold E. Postlethwaite , Andrew H. Kang
IPC分类号： C07K14/00 , A61K38/00
CPC分类号： A61K38/39
摘要： The present invention has demonstrated for the first time that orally administered type I collagen (CI) induced tolerance to CI in patients suffering from systemic sclerosis (SSc) and ameliorated clinical manifestations of the disease. Accordingly, the present invention provides methods of treating a fibrosing disease by oral administration of a tissue protein, for example, collagen, derived from the tissue undergoing fibrosis.
摘要翻译：本发明首次证明口服I型胶原（CI）诱导患有系统性硬化症（SSc）的患者对CI的耐受性并改善了该疾病的临床表现。因此，本发明提供了通过口服给予经历纤维化的组织的组织蛋白例如胶原来治疗纤维化疾病的方法。

48. 发明授权

US07704979B2 Materials and methods for the treatment or prevention of obesity 有权
标题翻译：用于治疗或预防肥胖症的材料和方法
公开(公告)号：US07704979B2
公开(公告)日：2010-04-27
申请号：US10017568
申请日：2001-12-14
申请人： Michael B. Zemel , Hang Shi
发明人： Michael B. Zemel , Hang Shi
IPC分类号： A01N45/00
CPC分类号： A61K31/59 , A23L33/16 , A23L33/30 , A61K31/00 , Y10S514/909
摘要： The subject invention provides methods of inducing the loss of adipose tissue by providing a diet high in calcium. In one aspect of the invention, the calcium is provided in the form of dairy products. In yet another aspect of the invention, calcium is provided in the form of a dietary supplement, such as calcium carbonate, of vitamin supplements. Methods of suppressing [Ca2+]i levels in individuals are also provided. The subject invention also provides methods of stimulating lipolysis, inhibiting lipogenesis, and increasing the expression of white adipose tissue uncoupling protein 2 (UPC2). The subject invention also provides methods of increasing the core temperature of an individual.
摘要翻译：本发明提供通过提供高钙饮食来诱导脂肪组织损失的方法。在本发明的一个方面，钙以乳制品的形式提供。在本发明的另一方面，钙以维生素补充剂的膳食补充剂如碳酸钙的形式提供。还提供了抑制个体中[Ca2 +] i水平的方法。本发明还提供了刺激脂肪分解，抑制脂肪生成和增加白色脂肪组织解偶联蛋白2（UPC2）的表达的方法。本发明还提供了增加个体的核心温度的方法。

49. 发明申请

US20080234293A1 Tri-aryl/heteroaromatic cannabinoids and use thereof 有权
标题翻译：三芳基/杂芳族大麻素及其用途
公开(公告)号：US20080234293A1
公开(公告)日：2008-09-25
申请号：US12074342
申请日：2008-03-03
申请人： Bob M. Moore , Himanshu Bhattacharjee , Charles R. Yates , Leslie Stuart
发明人： Bob M. Moore , Himanshu Bhattacharjee , Charles R. Yates , Leslie Stuart
IPC分类号： A61K31/505 , A61P29/00 , A61P35/00 , A61K31/381 , A61K31/12 , A61K31/44 , C07D263/30 , C07D231/10 , C07D333/04 , C07D261/06 , C07D239/02 , A61K31/40 , A61K31/415 , A61K31/421 , A61K31/42
CPC分类号： C07D307/42 , C07D307/46
摘要： Cannabinoid derivatives according to formula (I) are disclosed wherein, X, Y, R1, R2, and W can have the definitions provided herein. Without limitation, use of such compounds, their salts or pro-drug, or compositions containing the compounds, salts, or pro-drug, to modify the activity of CB1 and CB2 receptors and treat conditions mediated by these receptors.
摘要翻译：公开了根据式（I）的大麻素衍生物，其中X，Y，R 1，R 2和W可以具有本文提供的定义。不限于此，使用这些化合物，其盐或前药，或含有化合物，盐或前药的组合物来改变CB1和CB2受体的活性并治疗这些受体介导的病症。

50. 发明申请

US20080202398A1 Systems and methods for fluid dispensing 有权
公开(公告)号：US20080202398A1
公开(公告)日：2008-08-28
申请号：US12150772
申请日：2008-05-01
申请人： John B. Wilkerson , John H. Hancock , Fred H. Moody , Melvin A. Newman
发明人： John B. Wilkerson , John H. Hancock , Fred H. Moody , Melvin A. Newman
IPC分类号： A01C23/00
CPC分类号： A01C7/105 , A01C7/06 , A01C23/00 , Y10S111/90 , Y10S111/904
摘要： Systems and methods are disclosed for dispensing fluids. The systems can include a sensor operable to detect when an object passes a first location as the object moves to a second location. The systems can also include a fluid dispenser operable to dispense fluid at the second location. In addition, the systems can include a control unit in communication with the sensor and the fluid dispenser. The control unit can receive information from the sensor that the object has passed the first location and to control the fluid dispenser to dispense fluid at the second location at a predetermined time after the object passes the first location.

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