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41. 发明申请

US20100303890A1 COPOLYMERS SUITABLE FOR USE IN CORNEAL BANDAGES 审中-公开
标题翻译：适用于角钢带的共聚物
公开(公告)号：US20100303890A1
公开(公告)日：2010-12-02
申请号：US12444993
申请日：2007-10-12
申请人： Guilhem Tourniaire , Mark Bradley , Albert Liberski
发明人： Guilhem Tourniaire , Mark Bradley , Albert Liberski
IPC分类号： A61F2/14 , A61K35/44 , A61P27/02 , C08F226/00 , C08L33/08 , A61F13/00
CPC分类号： C08F220/34 , A61F15/00 , A61L27/34 , A61L27/3804 , A61L27/3839 , A61L2430/16 , C08F220/06 , C08F220/28 , C08L33/04
摘要： Disclosed is a polymer having an affinity for corneal cells such that it can be used as a substrate for the growth of corneal cells, and so is suitable for use in a corneal bandage, especially in the form of a contact lens in which at least the cornea contacting surface is composed of the polymer. The substrate with an affinity for corneal cells is a copolymer comprising units -(A)- and -(B)- in which the units A are derived from aminoalkyl (alkyl)acrylates and the units B are derived from aryloxy, alkoxy or hydroxyalkyl (alkyl)acrylates, and (alkyl)acrylic acids.
摘要翻译：公开了对角膜细胞具有亲和力的聚合物，使得其可以用作角膜细胞生长的底物，因此适用于角膜绷带，特别是以隐形眼镜的形式，其中至少角膜接触表面由聚合物组成。具有对角膜细胞亲和力的底物是包含单元 - （A） - 和 - （B））的共聚物，其中单元A衍生自氨基烷基（烷基）丙烯酸酯，并且单元B衍生自芳氧基，烷氧基或羟基烷基（烷基）丙烯酸酯和（烷基）丙烯酸。

42. 发明申请

US20100287638A1 NEURAL TUMOR STEM CELLS AND METHODS OF USE THEREOF 审中-公开
标题翻译：神经瘤肿瘤干细胞及其使用方法
公开(公告)号：US20100287638A1
公开(公告)日：2010-11-11
申请号：US12681036
申请日：2008-10-01
申请人： Peter B. Dirks , Austin Smith , Ian D.N. Clarke , Steve Pollard
发明人： Peter B. Dirks , Austin Smith , Ian D.N. Clarke , Steve Pollard
IPC分类号： C12Q1/02 , C12N5/09 , C40B30/06 , A01K67/00
CPC分类号： G01N33/5011 , A01K67/0271 , A01K2227/105 , A01K2267/0331 , C12N5/0695 , C12N2503/02 , C12N2533/52 , G01N33/5073
摘要： The present invention relates to the discovery that renewable stem cell lines can be derived from tumor cells and can be cultured in vitro. Accordingly, the invention provides neural tumor stem cell lines and cells from such cell lines. Because the cell lines retain characteristics of the tumors from which they are derived, the cells can be used in screening methods for identification of potential therapeutic agents and can be used to identify genetic markers which may be predictive for development of such tumors. Finally, such cells can be used to determine an appropriate therapeutic regimen for a patient suffering from a brain tumor. Cells from a patient's brain tumor can be cultured as described herein to create a cell line, and the relative effectiveness of a therapeutic agent against the cells can be tested to determine which agent or combination of agents is most effective in treating the patient's tumor.
摘要翻译：本发明涉及可再生干细胞系可以衍生自肿瘤细胞并且可以在体外培养的发现。因此，本发明提供了来自这些细胞系的神经肿瘤干细胞系和细胞。由于细胞系保留了衍生自其的肿瘤的特征，因此细胞可用于鉴定潜在治疗剂的筛选方法中，并可用于鉴定可能预测这些肿瘤发展的遗传标记。最后，这样的细胞可用于确定患有脑肿瘤的患者的适当的治疗方案。可以如本文所述培养来自患者脑肿瘤的细胞以产生细胞系，并且可以测试治疗剂对细胞的相对有效性，以确定哪种药剂或药剂组合在治疗患者的肿瘤中最有效。

43. 发明授权

US07790706B2 Treatment of inflammation with 5α reduced metabolites 有权
标题翻译：用5α治疗炎症代谢物降低
公开(公告)号：US07790706B2
公开(公告)日：2010-09-07
申请号：US11011977
申请日：2004-12-14
申请人： Brian Robert Walker , Ruth Andrew
发明人： Brian Robert Walker , Ruth Andrew
IPC分类号： A61K31/56 , A01N45/00
CPC分类号： A61K31/59 , A61K31/00 , A61K31/405 , A61K31/435 , A61K31/473 , A61K31/56 , A61K31/573
摘要： The present invention relates to the modulation of glucocorticoid metabolism. In particular the invention relates to the modulation of the functional activity of the glucocorticoid receptor by 5α reduced metabolic breakdown products of glucocorticoids.
摘要翻译：本发明涉及糖皮质激素代谢的调节。特别地，本发明涉及通过5α降低的糖皮质激素代谢分解产物调节糖皮质激素受体的功能活性。

44. 发明申请

US20100133636A1 SINGLE PHOTON DETECTOR AND ASSOCIATED METHODS FOR MAKING THE SAME 有权
标题翻译：单光子检测器及其相关方法
公开(公告)号：US20100133636A1
公开(公告)日：2010-06-03
申请号：US12327240
申请日：2008-12-03
申请人： Justin Richardson , Lindsay Grant , Marek Gersbach , Edoardo Charbon , Christiano Niclass , Robert Henderson
发明人： Justin Richardson , Lindsay Grant , Marek Gersbach , Edoardo Charbon , Christiano Niclass , Robert Henderson
IPC分类号： H01L31/00
CPC分类号： H01L31/107
摘要： A semiconductor device includes a semiconductor substrate, a photon avalanche detector in the semiconductor substrate. The photon avalanche detector includes an anode of a first conductivity type and a cathode of a second conductivity type. A guard ring is in the semiconductor substrate and at least partially surrounds the photon avalanche detector. A passivation layer of the first conductivity type is in contact with the guard ring to reduce an electric field at an edge of the photon avalanche detector.
摘要翻译：半导体器件包括半导体衬底，半导体衬底中的光子雪崩检测器。光子雪崩检测器包括第一导电类型的阳极和第二导电类型的阴极。保护环在半导体衬底中并且至少部分地围绕光子雪崩检测器。第一导电类型的钝化层与保护环接触以减少光子雪崩检测器边缘处的电场。

45. 发明申请

US20100122105A1 RECONFIGURABLE INSTRUCTION CELL ARRAY 审中-公开
标题翻译：可重构指令单元阵列
公开(公告)号：US20100122105A1
公开(公告)日：2010-05-13
申请号：US11919270
申请日：2006-04-28
申请人： Tughrul Arslan , Mark John Millward , Sami Khawam , Ioannis Nousias , Ying Yi
发明人： Tughrul Arslan , Mark John Millward , Sami Khawam , Ioannis Nousias , Ying Yi
IPC分类号： G06F9/30 , G06F1/04
CPC分类号： G06F17/5054 , G06F15/7867 , G06F17/5022 , Y02D10/12 , Y02D10/13
摘要： A reconfigurable processor architecture, compiler and method of program instruction execution provides reduced cost, short design time, low power consumption and high performance. The processor executes program instructions having datapaths of both dependent and independent program instructions. Simultaneous multithreading is also Interconnects Network supported. The processor has a reconfigurable core (1) with an interconnection network (4) and a heterogeneous array of instruction cells (2) each connected to the interconnection network (4). A decoding module (11) receives configuration instruction (10), each instruction encoding the mapping of one of the datapaths to a circuit of the instruction cells (2). The decoding module (11) decodes each configuration instruction (10) and configures the interconnection network (4) and instruction cells in order to map the datapath to the circuit of the instruction cells and execute the program instructions. A clock module (24) is reconfigurable each clock cycle by the configuration instruction (10). The compiler generates configuration instructions (10) for the processor by identifying the datapaths of both dependent and independent program instructions then mapping them as circuits of the instruction cells (2) using operation chaining.
摘要翻译：可编程处理器架构，编程器和程序指令执行方法可降低成本，缩短设计时间，降低功耗和高性能。处理器执行具有依赖和独立程序指令的数据通路的程序指令。同时多线程也是支持互连网络。处理器具有可互连网络（1）和可互连网络（4）的可重配置核心（1），每个连接到互连网络（4）的指令单元（2）的异构阵列。解码模块（11）接收配置指令（10），每个指令编码数据通路之一到指令单元（2）的电路的映射。解码模块（11）解码每个配置指令（10）并配置互连网络（4）和指令单元，以将数据路径映射到指令单元的电路并执行程序指令。时钟模块（24）可由配置指令（10）每个时钟周期重新配置。编译器通过识别依赖和独立程序指令的数据路径，然后将它们作为指令单元（2）的电路，使用操作链接来生成用于处理器的配置指令（10）。

46. 发明申请

US20090067115A1 Micro electromechanical capacitive switch 有权
标题翻译：微机电电容开关
公开(公告)号：US20090067115A1
公开(公告)日：2009-03-12
申请号：US12157828
申请日：2008-06-13
申请人： Tughrul Arslan , Anthony J. Walton , Nakul R. Haridas
发明人： Tughrul Arslan , Anthony J. Walton , Nakul R. Haridas
IPC分类号： H01G7/06
CPC分类号： H01G5/18 , H01H59/0009 , H01P1/127
摘要： A capacitive switch for microelectromechanical systems (MEMS) comprises a topmost metal plate which extends across a bridge structure formed by a polymer layer. The polymer layer comprises poly-monochoro-para-xylene (parylene-C). The space below the polymer layer contains the second plate on a substrate. Using parylene as the primary bridge material makes the bridge of the MEMS device very flexible and requires a relatively low actuation voltage to pull the bridge down and lower power is required to control the MEMS device.
摘要翻译：用于微机电系统（MEMS）的电容开关包括跨越由聚合物层形成的桥结构延伸的顶部金属板。聚合物层包含聚 - 对 - 对 - 二甲苯（对二甲苯-C）。聚合物层下面的空间包含基板上的第二板。使用聚对二甲苯作为主要桥梁材料使得MEMS器件的桥接非常灵活，并且需要相对较低的致动电压来拉低桥梁，并且需要较低的功率来控制MEMS器件。

47. 发明申请

US20080282870A1 Automated disc jockey 审中-公开
标题翻译：自动光盘骑师
公开(公告)号：US20080282870A1
公开(公告)日：2008-11-20
申请号：US12150967
申请日：2008-05-02
申请人： Raymond Carrick , George Anthony Bett
发明人： Raymond Carrick , George Anthony Bett
IPC分类号： G10H1/00
CPC分类号： G10H1/0041 , G06F16/40 , G06F16/639 , G06F16/68 , G10H2240/131
摘要： An automated disc jockey. It accesses a database that models multiple music tracks as linked data objects. Each music track model includes a music track data object identifying the music track and linked to a plurality of other data objects that parameterize metadata of the music track. Some of the other data objects are sharable data objects that may be linked from other music track data objects. Data objects and links defining a model of a first music track are extracted from the accessed database. Data objects and links that define a model of a second music track that is adjacent to and follows the first music track in a play-list are extracted from the accessed database. A sub-set of the extracted data objects and links, including interconnecting data objects and links that interconnect a first music track data object for the first music track and a second music track data object for the second music track via a shared data object that is shared between the model for the first music track and the model for the second music track, is selected. The interconnecting data objects and links are processed to manufacture disc jockey commentary that joins the first music track and the second music track.
摘要翻译：自动光盘骑师。它访问将多个音乐轨道建模为数据对象的数据库。每个音乐轨道模型包括识别音乐轨道并链接到参数化音乐轨道的元数据的多个其他数据对象的音轨数据对象。一些其他数据对象是可以从其他音轨数据对象链接的可共享数据对象。从被访问的数据库中提取定义第一音乐曲目的模型的数据对象和链接。从访问的数据库中提取定义与播放列表中的第一音乐轨道相邻并跟随其中的第二音轨的模型的数据对象和链接。所提取的数据对象和链接的子集，包括互连数据对象和链接，所述链接将第一音乐曲目的第一音乐曲目数据对象和第二音乐曲目的第二音轨数据对象经由共享数据对象相互连接，被选择在第一音乐轨道的模型和第二音乐轨道的模型之间共享。处理相互连接的数据对象和链接以制造加入第一音乐轨道和第二音乐轨道的唱片骑师评论。

48. 发明申请

US20080076671A1 Applications of Nucleic Acid Fragments 有权
标题翻译：核酸片段的应用
公开(公告)号：US20080076671A1
公开(公告)日：2008-03-27
申请号：US11666558
申请日：2005-10-31
申请人： Adrian Bird , Robert Illingworth , Helle Jorgensen
发明人： Adrian Bird , Robert Illingworth , Helle Jorgensen
IPC分类号： C40B30/04 , C07K14/00 , C12M1/00 , C40B40/08 , C40B50/06 , C12N1/08 , C12Q1/68
CPC分类号： C12N15/1093 , C12N15/1034 , C12Q1/6837 , G01N33/5308 , Y10S436/809 , C12Q2523/125 , C12Q2522/101
摘要： The present invention relates to a method of isolating fragments of nucleic acid according to the density of CpG dinucleotides and subsequent procedures for producing a library and/or an array or microarray of these fragments, as well as uses thereof.
摘要翻译：本发明涉及根据CpG二核苷酸的密度和随后的用于产生文库和/或这些片段的阵列或微阵列的程序以及其用途来分离核酸片段的方法。

49. 发明申请

US20080027594A1 Vehicle Guidance System 有权
标题翻译：车辆指导系统
公开(公告)号：US20080027594A1
公开(公告)日：2008-01-31
申请号：US11461277
申请日：2006-07-31
申请人： Michael Jump , Gareth D. Padfield , David N. Lee
发明人： Michael Jump , Gareth D. Padfield , David N. Lee
IPC分类号： G06F17/00 , G05D1/06
CPC分类号： G05D1/101
摘要： A vehicle guidance system comprising: a measurement system; a processor arranged to receive information from the measurement system and convert said information into at least one time-to-contact based parameter; and a control system arranged to receive the at least one time-to-contact based parameter from the processor and use the at least one time-to-contact based parameter to either automatically guide the vehicle or to provide vehicle guidance information to a pilot.
摘要翻译：一种车辆引导系统，包括：测量系统; 处理器，其布置成从测量系统接收信息并将所述信息转换成至少一个基于时间到接触的参数; 以及控制系统，其布置成从所述处理器接收所述至少一个基于时间接触的参数，并且使用所述至少一个基于时间接触的参数来自动引导所述车辆或向飞行员提供车辆引导信息。

50. 发明授权

US07256041B2 Isolation, selection and propagation of animal transgenic stem cells 失效
标题翻译：动物转基因干细胞的分离，选择和繁殖
公开(公告)号：US07256041B2
公开(公告)日：2007-08-14
申请号：US11084154
申请日：2005-03-21
申请人： Austin Gerard Smith , Peter Scott Mountford
发明人： Austin Gerard Smith , Peter Scott Mountford
IPC分类号： C12N15/85 , C12N15/63
CPC分类号： C12N15/907 , A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2227/105 , A01K2267/02 , A61K38/00 , C07K14/4702 , C07K14/52 , C07K14/70596 , C07K14/81 , C12N5/0623 , C12N9/12 , C12N15/85 , C12N15/8509 , C12N15/873 , C12N2506/02 , C12N2510/00 , C12N2830/00 , C12N2830/008 , C12N2830/42 , C12N2830/85 , C12N2840/203 , C12N2840/44
摘要： Animal stem cells are obtained and maintained by culturing cells containing, in the genome, a selectable marker. Differential expression of the selectable marker enables preferential survival and/or division of the desired stem cells compared to the non-stem cells.
摘要翻译：通过培养在基因组中含有选择性标记的细胞来获得和维持动物干细胞。与非干细胞相比，可选择标记的差异表达使得所需干细胞能够优先存活和/或分裂。

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