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41. 发明授权

US07494490B2 Apparatus and method for reconstructing a ligament 失效
标题翻译：用于重建韧带的装置和方法
公开(公告)号：US07494490B2
公开(公告)日：2009-02-24
申请号：US10964590
申请日：2004-10-13
申请人： Daniel F. Justin
发明人： Daniel F. Justin
IPC分类号： A61B17/58
CPC分类号： A61F2/0805 , A61B17/1714 , A61B17/1735 , A61B17/8875 , A61B2017/564 , A61F2/0811 , A61F2002/0852 , A61F2002/0882
摘要： Apparatus and method is disclosed for securing a graft ligament in a bone tunnel. A method is disclosed comprising the steps of forming a first bone tunnel and a second bone tunnel being transverse to, and intersecting one another; positioning a closed loop of a flexible member within the first bone tunnel and a portion of the second bone tunnel such that the closed loop extends out of the first bone tunnel and the second bone tunnel, parting the closed loop outside the second bone tunnel so as to create a first free end and a second free end, and passing the second free end through the opposite end of second bone tunnel, and positioning the graft ligament over a portion of the flexible member extending out of the first opening; and pulling the flexible member so as to draw the graft ligament into the first bone tunnel.
摘要翻译：公开了用于将移植韧带固定在骨隧道中的装置和方法。公开了一种方法，其包括以下步骤：形成横向于并相互交叉的第一骨隧道和第二骨隧道; 将柔性构件的闭环定位在所述第一骨隧道内以及所述第二骨隧道的一部分中，使得所述闭合环从所述第一骨隧道和所述第二骨隧道延伸出来，将所述闭合环分开在所述第二骨隧道外部，以便以产生第一自由端和第二自由端，并使第二自由端穿过第二骨隧道的相对端，并将移植物韧带定位在延伸出第一开口的柔性构件的一部分上; 并拉动柔性构件以将移植韧带拉入第一骨隧道。

42. 发明申请

US20080181954A1 Chondrocyte Therapeutic Delivery Stystem 有权
标题翻译：软骨细胞治疗递送系统
公开(公告)号：US20080181954A1
公开(公告)日：2008-07-31
申请号：US11463708
申请日：2006-08-10
申请人： Francois Binette , Brooks J. Story
发明人： Francois Binette , Brooks J. Story
IPC分类号： A61K9/00 , A61K48/00 , A61P37/00 , A61P7/00
CPC分类号： C12N5/0655 , A61K35/12 , C12N2510/00 , C12N2533/74 , C12N2533/76
摘要： Methods and compositions for producing therapeutic agents using chondrocytes are provided. The genetically engineered chondrocytes can be used to express the therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.
摘要翻译：提供了使用软骨细胞产生治疗剂的方法和组合物。基因工程软骨细胞可用于在受试者中表达治疗剂，包括在通常与软骨细胞相关的环境中以及通常不与软骨细胞相关的环境中。

43. 发明申请

US20080147063A1 CANNULATED SUTURE ANCHOR 有权
公开(公告)号：US20080147063A1
公开(公告)日：2008-06-19
申请号：US11555545
申请日：2006-11-01
申请人： Nathan Cauldwell , Jonathan Howe , Eugene Wolf
发明人： Nathan Cauldwell , Jonathan Howe , Eugene Wolf
IPC分类号： A61B17/56
CPC分类号： A61B17/0401 , A61B17/0487 , A61B17/06166 , A61B17/888 , A61B2017/0403 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0427 , A61B2017/044 , A61B2017/0445 , A61B2017/0454 , A61B2017/0458 , A61B2017/0459 , A61B2017/0496 , A61B2017/0619
摘要： Methods and devices are provided for anchoring suture to bone. In one exemplary embodiment, a cannulated suture anchor is provided and it includes a suture-engaging member formed therein and configured to receive a suture therearound such that trailing ends of the suture can extend through the suture anchor. The present invention also provides exemplary sutures and drivers that can be used with the various methods and devices disclosed herein, or with other methods and devices known in the art.
摘要翻译：提供了将缝合线锚定到骨头上的方法和装置。在一个示例性实施例中，提供了一种插管缝合锚，并且其包括形成在其中的缝合线接合构件，并且构造成在其周围接收缝合线，使得缝合线的后端可延伸穿过缝合线锚。本发明还提供可以与本文公开的各种方法和装置一起使用的示例性缝线和驱动器，或与本领域已知的其它方法和装置一起使用。

44. 发明申请

US20070233189A1 WEDGE SHAPED SUTURE ANCHOR AND METHOD OF IMPLANTATION 审中-公开
标题翻译：楔形锚固锚和植入方法
公开(公告)号：US20070233189A1
公开(公告)日：2007-10-04
申请号：US11762556
申请日：2007-06-13
申请人： Jack Pedlick , Thu Le , John DiGiovanni , Dennis Jamiolkowski , Mark Suseck
发明人： Jack Pedlick , Thu Le , John DiGiovanni , Dennis Jamiolkowski , Mark Suseck
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/0482 , A61B90/92 , A61B2017/00424 , A61B2017/00455 , A61B2017/00862 , A61B2017/0409 , A61B2017/0414 , A61B2017/0458 , A61B2017/06057 , A61B2017/06142 , A61B2090/037 , A61B2090/3937 , Y10S606/916
摘要： A suture anchor is described which in one form may be easily fabricated from extruded material by angular cuts and bore holes which provide an offset pulling force to the suture. In an alternate and preferred embodiment the suture anchor is injection molded having an annular displaced corner and abutment wall which act to seat the suture anchor firmly within a bore hole. Novel application means are also disclosed which hold the suture anchor on a frangible shaft for insertion and upon completion of the insertion permit fracture of the frangible portion and removal of the instrument. In another form of the invention, the suture anchor comprises a substantially wedge-shaped body having a smaller distal end and a larger proximal end, means thereon for retaining a suture, and means thereon for releasable connection to an inserter shaft; a boundary surface and a plow surface of the body intersecting to form a biting edge at the proximal end of the body; and the boundary surface and an abutment surface of the body intersecting to form a cam surface at the proximal end of the body; and the biting edge being adapted to be in engagement with a first wall portion of a bore in a bone and the cam surface being adapted to be in engagement with a second wall portion of the bore opposed to the first wall portion; wherein tension on the inserter shaft is operable to move the cam portion along the bore second wall portion and rotate the body in the bore such that the biting edge bites into the bore first wall portion to lock the body in the bore.
摘要翻译：描述了一种缝合锚，其以一种形式可以通过角切口和钻孔轻松地由挤压材料制造，所述角切口和钻孔向缝合线提供偏移拉力。在替代和优选实施例中，缝合锚固件被注塑成型，其具有环形移位的角部和邻接壁，其用于将缝合锚固件牢固地安置在钻孔内。还公开了新颖的施加装置，其将缝合锚定件保持在易断裂的轴上用于插入，并且在完成易碎部分的插入允许断裂和器械的移除之后。在本发明的另一形式中，缝合锚固件包括具有较小远端和较大近端的基本楔形体，用于保持缝合线的装置及其上的装置用于可释放地连接到插入器轴; 主体的边界表面和犁面相交，以在主体的近端形成咬合边缘; 并且所述主体的边界表面和邻接表面相交以在所述主体的近端处形成凸轮表面; 并且所述咬合边缘适于与骨中的孔的第一壁部分接合，并且所述凸轮表面适于与所述孔的与所述第一壁部相对的第二壁部分接合; 其中所述插入器轴上的张力可操作以沿着所述孔第二壁部分移动所述凸轮部分并且使所述主体在所述孔中旋转，使得所述咬合边缘咬入所述孔第一壁部分中以将所述主体锁定在所述孔中。

45. 发明申请

US20070185505A1 Suture grasping device 失效
标题翻译：缝合抓取装置
公开(公告)号：US20070185505A1
公开(公告)日：2007-08-09
申请号：US11699199
申请日：2007-01-29
申请人： Rickey Hart
发明人： Rickey Hart
IPC分类号： A61B17/04
CPC分类号： A61B17/0469 , A61B17/0483 , A61B17/0485 , A61B17/221 , A61B17/30 , A61B18/14 , A61B2017/00349 , A61B2017/0046 , A61B2017/2215 , A61B2017/2929
摘要： A device for snaring cord-like objects is provided. The device comprises a hollow shaft having a pointed distal end, a rod having a pair of wires attached to its distal end, the wires being spring biased away from one another, and activation means. The rod and wires are located in the lumen of the shaft in reciprocally movable relationship therewith. The activation means is attached to the proximal ends of the shaft and the rod so as to allow the controlled movement of the rod and wires relative to the shaft. One of the wire-like elements defines a hook-shaped configuration at its distal end. The device allows the wire-like elements to be selectively located within the distal end of the shaft or in a configuration wherein the wire-like elements extend outwardly from the distal end of the shaft in flaring relationship to one another.
摘要翻译：提供了用于卷绕线状物体的装置。该装置包括具有尖端远端的中空轴，具有连接到其远端的一对线的杆，所述线被彼此偏离的弹簧偏压和激活装置。杆和线位于轴的内腔中，与其相互可移动的关系。激活装置附接到轴和杆的近端，以允许杆和线相对于轴的受控运动。线状元件中的一个在其远端限定了钩状构造。该装置允许线状元件选择性地位于轴的远端内，或者以这样的构型，其中线状元件从轴的远端向外延伸，彼此以扩张关系。

46. 发明授权

US07232455B2 Wedge shaped suture anchor and method of implantation 有权
标题翻译：楔形缝合锚和植入方法
公开(公告)号：US07232455B2
公开(公告)日：2007-06-19
申请号：US10854016
申请日：2004-05-26
申请人： Jack S. Pedlick , Thu Anh Le , John DiGiovanni , Dennis D. Jamiolkowski , Mark J. Suseck
发明人： Jack S. Pedlick , Thu Anh Le , John DiGiovanni , Dennis D. Jamiolkowski , Mark J. Suseck
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/0482 , A61B90/92 , A61B2017/00424 , A61B2017/00455 , A61B2017/00862 , A61B2017/0409 , A61B2017/0414 , A61B2017/0458 , A61B2017/06057 , A61B2017/06142 , A61B2090/037 , A61B2090/3937 , Y10S606/916
摘要： A suture anchor is described which in one form may be easily fabricated from extruded material by angular cuts and bore holes which provide an offset pulling force to the suture. In an alternate and preferred embodiment the suture anchor is injection molded having an annular displaced corner and abutment wall which act to seat the suture anchor firmly within a bore hole. Novel application means are also disclosed which hold the suture anchor on a frangible shaft for insertion and upon completion of the insertion permit fracture of the frangible portion and removal of the instrument. In another form of the invention, the suture anchor comprises a substantially wedge-shaped body having a smaller distal end and a larger proximal end, means thereon for retaining a suture, and means thereon for releasable connection to an inserter shaft; a boundary surface and a plow surface of the body intersecting to form a biting edge at the proximal end of the body; and the boundary surface and an abutment surface of the body intersecting to form a cam surface at the proximal end of the body; and the biting edge being adapted to be in engagement with a first wall portion of a bore in a bone and the cam surface being adapted to be in engagement with a second wall portion of the bore opposed to the first wall portion; wherein tension on the inserter shaft is operable to move the cam portion along the bore second wall portion and rotate the body in the bore such that the biting edge bites into the bore first wall portion to lock the body in the bore.
摘要翻译：描述了一种缝合锚，其以一种形式可以通过角切口和钻孔轻松地由挤压材料制造，所述角切口和钻孔向缝合线提供偏移拉力。在替代和优选实施例中，缝合锚固件被注塑成型，其具有环形移位的角部和邻接壁，其用于将缝合锚固件牢固地安置在钻孔内。还公开了新颖的施加装置，其将缝合锚定件保持在易断裂的轴上用于插入，并且在完成易碎部分的插入允许断裂和器械的移除之后。在本发明的另一形式中，缝合锚固件包括具有较小远端和较大近端的基本楔形体，用于保持缝合线的装置及其上的装置用于可释放地连接到插入器轴; 主体的边界表面和犁面相交，以在主体的近端形成咬合边缘; 并且所述主体的边界表面和邻接表面相交以在所述主体的近端处形成凸轮表面; 并且所述咬合边缘适于与骨中的孔的第一壁部分接合，并且所述凸轮表面适于与所述孔的与所述第一壁部相对的第二壁部分接合; 其中所述插入器轴上的张力可操作以沿着所述孔第二壁部分移动所述凸轮部分并且使所述主体在所述孔中旋转，使得所述咬合边缘咬入所述孔第一壁部分中以将所述主体锁定在所述孔中。

47. 发明申请

US20070031470A1 NONWOVEN TISSUE SCAFFOLD 有权
标题翻译：非金属组织SCAFFOLD
公开(公告)号：US20070031470A1
公开(公告)日：2007-02-08
申请号：US11427477
申请日：2006-06-29
申请人： Stephanie Kladakis , Joseph Hammer , Shetty Dhanuraj , Sridevi Dhanaraj , Mark Timmer
发明人： Stephanie Kladakis , Joseph Hammer , Shetty Dhanuraj , Sridevi Dhanaraj , Mark Timmer
IPC分类号： A61F2/00
CPC分类号： A61L27/56 , A61F2/30756 , A61F2/3872 , A61F2002/30766 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/06 , C08L67/04
摘要： A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.
摘要翻译：公开了一种生物相容性半月板修复装置。所述组织修复装置包括适于与弯液面中的缺陷接触的支架，所述支架包括高密度干法铺设的非织造聚合物材料和生物相容性泡沫。支架提供增加的缝线拉拔强度。

48. 发明申请

US20060292131A1 Chondrocyte Therapeutic Delivery System 有权
标题翻译：软骨细胞治疗递送系统
公开(公告)号：US20060292131A1
公开(公告)日：2006-12-28
申请号：US11463714
申请日：2006-08-10
申请人： Francois Binette , Brooks Story
发明人： Francois Binette , Brooks Story
IPC分类号： A61K48/00 , C12N5/08
CPC分类号： C12N5/0655 , A61K35/12 , C12N2510/00 , C12N2533/74 , C12N2533/76
摘要： Methods and compositions for producing therapeutic agents using chondrocytes are provided. The genetically engineered chondrocytes can be used to express the therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.
摘要翻译：提供了使用软骨细胞产生治疗剂的方法和组合物。基因工程软骨细胞可用于在受试者中表达治疗剂，包括在通常与软骨细胞相关的环境中以及通常不与软骨细胞相关的环境中。

49. 发明申请

US20130317437A1 HIP OBTURATOR AND METHOD FOR ATRAUMATIC HIP ACCESS 有权
标题翻译：髋关节置换器和ATRAUMATIC HIP访问方法
公开(公告)号：US20130317437A1
公开(公告)日：2013-11-28
申请号：US13480509
申请日：2012-05-25
申请人： Benjamin Cleveland , Bethany F. Grant , Jeffery Tolonen
发明人： Benjamin Cleveland , Bethany F. Grant , Jeffery Tolonen
IPC分类号： A61B17/34
CPC分类号： A61B17/3211 , A61B1/317 , A61B17/1666 , A61B17/1746 , A61B17/320016 , A61B17/32053 , A61B17/3209 , A61B17/3423 , A61B17/3496 , A61B2017/22038 , A61B2017/32113 , A61B2017/3454
摘要： An obturator provides access to a joint through a capsule surrounding the joint. A distal end of the obturator has a first distal location with a first width dimension and a second distal location with a second width dimension, wherein the second distal location is proximal to the first distal location and the second width dimension greater than the first width dimension. A retractable blade can extend from the obturator to be exposed between the first distal location and the second distal location.
摘要翻译：闭孔器通过围绕关节的胶囊提供对关节的通路。闭孔器的远端具有第一宽度尺寸的第一远端位置和具有第二宽度尺寸的第二远端位置，其中第二远侧位置靠近第一远侧位置，第二宽度尺寸大于第一宽度尺寸。可伸缩刀片可以从闭塞器延伸以暴露在第一远侧位置和第二远端位置之间。

50. 发明申请

US20130296896A1 Systems, Devices, and Methods for Securing Tissue using a Suture Having One or More Protrusions 有权
标题翻译：使用具有一个或多个突起的缝合线来固定组织的系统，装置和方法
公开(公告)号：US20130296896A1
公开(公告)日：2013-11-07
申请号：US13465362
申请日：2012-05-07
申请人： Mehmet Sengun
发明人： Mehmet Sengun
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/06166 , A61B2017/0403 , A61B2017/0414 , A61B2017/0475 , A61B2017/0496 , A61B2017/06176 , A61B2017/06185
摘要： Systems, devices, and methods are provided for securing soft tissue to bone. One exemplary embodiment of a surgical repair construct includes an anchor, a filament having a snare on one end and a collapsible loop on another end, and a suture having a plurality of stationary protrusions. The suture is configured to be coupled to detached tissue and have its ends passed through an opening in the snare. The snare can be collapsed around the suture so at least one of the protrusions is proximal of the collapsed snare. The anchor can be disposed in bone and the filament coupled thereto. Accordingly, collapsing the snare around the suture couples the tissue to bone, and applying tension to a tensioning limb of the filament can collapse the loop to incrementally tighten and secure the tissue to bone. Other exemplary systems, devices, and methods for use with tissue repair are also provided.
摘要翻译：提供系统，装置和方法来将软组织固定到骨骼上。手术修复构造的一个示例性实施例包括锚固体，在一端具有圈套的细丝和在另一端上的可折叠环，以及具有多个固定突起的缝合线。缝合线被配置成联接到脱离的组织并且其端部穿过网圈中的开口。该圈套可以围绕缝合线折叠，使得突起中的至少一个位于收缩的圈套的近侧。锚固件可以设置在骨头中，并且灯丝联接到其上。因此，围绕缝合线塌陷圈套将组织耦合到骨骼，并且向细丝的张紧肢部施加张力可以使环圈折叠以递增地紧固并将组织固定到骨骼上。还提供了用于组织修复的其它示例性系统，装置和方法。

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