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41. 发明申请

US20090208514A1 METHOD OF DIAGNOSING ESOPHAGEAL CANCER 失效
标题翻译：诊断食管癌的方法
公开(公告)号：US20090208514A1
公开(公告)日：2009-08-20
申请号：US11913170
申请日：2006-07-26
申请人： Yusuke Nakamura , Yataro Daigo , Shuichi Nakatsuru
发明人： Yusuke Nakamura , Yataro Daigo , Shuichi Nakatsuru
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/53 , C40B40/06 , A61K31/7052 , A61K39/00 , C12N5/00 , A61K35/12 , A61P35/00 , C07H21/02 , C07K16/00
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , Y10T436/25
摘要： In order to identify the molecules involved in esophageal carcinogenesis and those to be useful for diagnostic markers as well as targets for new drugs and immunotherapy, a cDNA microarray representing 32,256 genes was constructed to analyze the expression profiles of 19 esophageal squamous-cell carcinomas (ESCCS) purified by laser-capture microdissection. A detailed genome-wide database for sets of genes that are significantly up- or down-regulated in esophageal cancer is disclosed herein. These genes find use in the development of therapeutic drugs or immunotherapy as well as tumor markers. Additionally, genes associated with lymph-node metastasis and post-surgery recurrence are disclosed herein. Among the candidate molecular target genes, a Homo sapiens epithelial cell transforming sequence 2 oncogene (ECT2) and a cell division cycle 45, S. cerevisiae, homolog-like (CDC45L) are further characterized. Treatment of ESCC cells with small interfering RNAs (siRNAs) of ECT2 or CDC45L suppressed growth of the cancer cells. Thus, the data herein provide valuable information for identifying diagnostic systems and therapeutic target molecules for esophageal cancer. Furthermore, the present inventors have identified DKK1 as a potential biomarker for diagnosis of cancer such as lung and esophageal cancers as well as prediction of the poor prognosis of the patients with these diseases. DKK1 was specifically over-expressed in most lung and esophageal cancer tissues the present inventors examined, and was elevated in the sera of a large proportion of patients with these tumors. DKK1, combined with other tumor markers, could significantly improve the sensitivity of cancer diagnosis. Moreover, this molecule is also a likely candidate for development of therapeutic approaches such as antibody therapy.
摘要翻译：为了鉴定涉及食管癌发生的分子以及可用于诊断标志物以及新药和免疫治疗靶标的分子，构建了代表32,256个基因的cDNA微阵列，分析19例食管鳞状细胞癌（ESCCS）的表达谱）通过激光捕获显微切割纯化。本文公开了在食管癌中显着上调或下调的基因组的详细全基因组数据库。这些基因可用于治疗药物或免疫治疗以及肿瘤标志物的开发。此外，本文公开了与淋巴结转移和手术后复发相关的基因。在候选分子靶基因中，进一步表征了人类上皮细胞转化序列2致癌基因（ECT2）和细胞分裂周期45，酿酒酵母，同系物样（CDC45L）。用ECT2或CDC45L的小干扰RNA（siRNA）处理ESCC细胞抑制癌细胞的生长。因此，本文的数据提供了用于鉴定诊断系统和用于食管癌的治疗靶分子的有价值的信息。此外，本发明人鉴定了DKK1作为肺癌，食管癌等癌症诊断用潜在生物标志物，并预测了这些疾病患者的预后差。本发明人检查的大多数肺癌和食管癌组织中DKK1被特异性过度表达，并且在大量患有这些肿瘤的患者的血清中升高。 DKK1与其他肿瘤标志物结合可显着提高癌症诊断的敏感性。此外，该分子也是开发抗体治疗等治疗方法的可能候选者。

42. 发明申请

US20090202576A1 PEPTIDE VACCINES FOR LUNG CANCERS EXPRESSING TTK, URLC10 OR KOC1 POLYPEPTIDES 有权
标题翻译：用于表达TTK，URLC10或KOC1多肽的肺癌患者的抗生素疫苗
公开(公告)号：US20090202576A1
公开(公告)日：2009-08-13
申请号：US11816616
申请日：2006-02-25
申请人： Hideaki Tahara , Takuya Tsunoda , Yusuke Nakamura , Yataro Daigo , Shuichi Nakatsuru
发明人： Hideaki Tahara , Takuya Tsunoda , Yusuke Nakamura , Yataro Daigo , Shuichi Nakatsuru
IPC分类号： A61K39/00 , C12N9/12 , C12N5/06 , C12N15/87
CPC分类号： C12N9/1211 , C12Q1/6886
摘要： The present invention provides peptides comprising the amino acid sequence of SEQ ID NO: 8, 67, 89, as well as peptides comprising the above-mentioned amino acid sequences in which 1, 2, or several amino acids are substituted, deleted, or added, and having cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing tumors comprising these peptides. The peptides of the present invention can also be used as vaccines.
摘要翻译：本发明提供了包含SEQ ID NO：8,67,89的氨基酸序列的肽以及包含上述氨基酸序列的肽，其中1,2或几个氨基酸被取代，缺失或添加，并具有细胞毒性T细胞诱导性。本发明还提供了用于治疗或预防包含这些肽的肿瘤的药物。本发明的肽也可以用作疫苗。

43. 发明申请

US20090142344A1 BREAST CANCER RELATED GENE ZNFN3A1 有权
标题翻译：乳腺癌相关基因ZNFN3A1
公开(公告)号：US20090142344A1
公开(公告)日：2009-06-04
申请号：US11817303
申请日：2006-02-09
申请人： Yusuke Nakamura , Yoichi Furukawa , Shuichi Nakatsuru
发明人： Yusuke Nakamura , Yoichi Furukawa , Shuichi Nakatsuru
IPC分类号： A61K39/395 , C12Q1/68 , C12Q1/02 , G01N33/53 , A61K31/7088
CPC分类号： C12Q1/6897 , C07K14/4748 , C12N9/1007 , C12N15/1137 , C12N2310/14 , C12Q1/48 , C12Q1/6886 , C12Q2600/136 , G01N33/573 , G01N33/57415 , G01N2333/91011 , G01N2500/00
摘要： Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. Also described are methods of treating and preventing breast cancer and breast cancer metastasis as well as methods of assessing the prognosis of a breast cancer subject and the efficacy of a breast cancer therapy. In one embodiment, the diagnostic method involves determining the expression level of ZNFN3A1, a gene whose expression is markedly elevated in breast cancers, that therefore can be used to discriminate between BRC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of BRC, methods of treating BRC and method for vaccinating a subject against BRC.
摘要翻译：本文描述了用于检测和诊断乳腺癌（BRC）的客观方法。还描述了治疗和预防乳腺癌和乳腺癌转移的方法以及评估乳腺癌受试者的预后和乳腺癌治疗的功效的方法。在一个实施方案中，诊断方法包括确定在乳腺癌中表达显着升高的基因的ZNFN3A1的表达水平，因此可以用于区分BRC细胞和正常细胞。本发明还提供筛选用于治疗BRC的治疗剂的方法，治疗BRC的方法和用BRC接种受试者的方法。

44. 发明申请

US20090012032A1 GENES AND POLYPEPTIDES RELATING TO HUMAN COLON CANCERS 有权
标题翻译：与人类癌症相关的基因和多肽
公开(公告)号：US20090012032A1
公开(公告)日：2009-01-08
申请号：US12180204
申请日：2008-07-25
申请人： Yusuke Nakamura , Yoichi Furukawa , Hideaki Tahara , Takuya Tsunoda
发明人： Yusuke Nakamura , Yoichi Furukawa , Hideaki Tahara , Takuya Tsunoda
IPC分类号： A61K31/7088 , C12N15/11 , C12N15/00 , A61P31/00 , C12N5/06 , C12P21/04
CPC分类号： C07K14/47 , C07K14/4748
摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
摘要翻译：本申请提供了在结肠直肠癌中表达显着升高的新型人基因RNF43，以及与相应的非癌组织相比，胃癌中其表达显着升高的CXADRL1和GCUD1。由该基因编码的基因和多肽可用于例如细胞增殖性疾病的诊断，以及用于开发针对该疾病的药物的靶分子。

45. 发明申请

US20080280293A1 Method of Examining Inflammatory Disease and Method of Screening Remedy for Imflammatory Disease 失效
标题翻译：检查炎症疾病的方法和筛查炎症性疾病的方法
公开(公告)号：US20080280293A1
公开(公告)日：2008-11-13
申请号：US11795016
申请日：2006-01-11
申请人： Toshihiro Tanaka , Koichi Ozaki , Aritoshi Iida , Masatsugu Hori , Yusuke Nakamura
发明人： Toshihiro Tanaka , Koichi Ozaki , Aritoshi Iida , Masatsugu Hori , Yusuke Nakamura
IPC分类号： C12Q1/68 , C07H21/04 , G01N33/566
CPC分类号： C12Q1/6883 , C12Q2600/156 , G01N33/566 , G01N33/6893 , G01N2333/705 , G01N2800/32 , G01N2800/324
摘要： A gene polymorphism on a Toll-like receptor gene is analyzed and an inflammatory disease is examined based on the results of the analysis. A remedy for an inflammatory disease is screened by selecting a substance capable of altering the interaction between Toll-like receptor and galectin-2.
摘要翻译：分析Toll样受体基因的基因多态性，并根据分析结果检测炎性疾病。通过选择能够改变Toll样受体和半乳凝素-2的相互作用的物质来筛选炎性疾病的治疗方法。

46. 发明申请

US20080241960A1 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 失效
标题翻译：胰岛素样生长因子结合蛋白
公开(公告)号：US20080241960A1
公开(公告)日：2008-10-02
申请号：US12013293
申请日：2008-01-11
申请人： Kazuya Yamano , Susumu Sekine , Mitsuo Satoh , Toshio Ota , Akiko Furuya , Kenji Shibata , Yuki Kobayashi , Miho Takebayashi , Yusuke Nakamura , Sumio Sugano
发明人： Kazuya Yamano , Susumu Sekine , Mitsuo Satoh , Toshio Ota , Akiko Furuya , Kenji Shibata , Yuki Kobayashi , Miho Takebayashi , Yusuke Nakamura , Sumio Sugano
IPC分类号： G01N33/566 , C07K16/18
CPC分类号： C07K16/26 , A61K38/00 , A61K2039/505 , C07K14/4743 , C07K16/18 , C07K2317/34
摘要： Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.
摘要翻译：使用本发明的蛋白质，编码蛋白质的DNA和识别蛋白质的抗体，与本发明的新型胰岛素样生长因子结合蛋白相关的疾病的检测方法以及诊断试剂，预防剂和治疗剂可以提供与本发明的蛋白质相关的疾病的药剂。

47. 发明申请

US20080063640A1 Pin-Prc Transition Genes 审中-公开
标题翻译： Pin-Prc转换基因
公开(公告)号：US20080063640A1
公开(公告)日：2008-03-13
申请号：US10598296
申请日：2005-02-04
申请人： Yusuke Nakamura , Hidewaki Nakagawa , Shuichi Nakatsuru
发明人： Yusuke Nakamura , Hidewaki Nakagawa , Shuichi Nakatsuru
IPC分类号： A61K31/70 , A61K39/00 , A61K39/395 , A61P13/08 , C12Q1/68 , C40B30/04 , C40B30/06 , C40B40/08
CPC分类号： C12Q1/6886 , A61K39/0011 , C12Q2600/136 , G01N33/57434 , G01N2500/10
摘要： Objective methods for diagnosing a predisposition to developing prostate cancer (PRC) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of PRC-associated gene that discriminate between PRC and PIN. The present invention further provides methods of screening for therapeutic agents useful in the treatment of PRC, methods of treating PRC.
摘要翻译：本文描述了诊断发展中的前列腺癌（PRC）倾向的客观方法。在一个实施方案中，诊断方法涉及确定区分PRC和PIN的PRC相关基因的表达水平。本发明还提供筛选用于治疗PRC的治疗剂的方法，以及治疗PRC的方法。

48. 发明授权

US07332301B2 Insulin-like growth factor binding protein 失效
标题翻译：胰岛素样生长因子结合蛋白
公开(公告)号：US07332301B2
公开(公告)日：2008-02-19
申请号：US11396430
申请日：2006-03-30
申请人： Kazuya Yamano , Susumu Sekine , Mitsuo Satoh , Toshio Ota , Akiko Furuya , Kenji Shibata , Yuki Kobayashi , Miho Takebayashi , Yusuke Nakamura , Sumio Sugano
发明人： Kazuya Yamano , Susumu Sekine , Mitsuo Satoh , Toshio Ota , Akiko Furuya , Kenji Shibata , Yuki Kobayashi , Miho Takebayashi , Yusuke Nakamura , Sumio Sugano
IPC分类号： C12P21/06 , C07H17/00 , C07K14/00
CPC分类号： C07K16/26 , A61K38/00 , A61K2039/505 , C07K14/4743 , C07K16/18 , C07K2317/34
摘要： Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.
摘要翻译：使用本发明的蛋白质，编码蛋白质的DNA和识别蛋白质的抗体，与本发明的新型胰岛素样生长因子结合蛋白相关的疾病的检测方法以及诊断试剂，预防剂和治疗剂可以提供与本发明的蛋白质相关的疾病的药剂。

49. 发明申请

US20070092519A1 Method for diagnosing chronic myeloid leukemia 审中-公开
标题翻译：诊断慢性骨髓性白血病的方法
公开(公告)号：US20070092519A1
公开(公告)日：2007-04-26
申请号：US10529833
申请日：2003-08-12
申请人： Yusuke Nakamura , Toyomasa Katagiri
发明人： Yusuke Nakamura , Toyomasa Katagiri
IPC分类号： A61K39/395 , C12Q1/68 , C12M3/00 , A61K48/00
CPC分类号： C12Q1/6883 , A61K39/0011 , C07K14/47 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57426 , G01N2500/04
摘要： Objective methods for detecting and diagnosing Chronic myeloid leukemia (CML) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of CML-associated gene that discriminate between CML and normal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of CML, methods of treating CML and method of vaccinating a subject against CML.
摘要翻译：本文描述了用于检测和诊断慢性骨髓性白血病（CML）的客观方法。在一个实施方案中，诊断方法涉及确定区分CML和正常细胞的CML相关基因的表达水平。本发明进一步提供筛选用于治疗CML的治疗剂，CML治疗方法以及针对CML接种受试者的方法。

50. 发明申请

US20060240419A1 Method of detecting gene polymorphism 审中-公开
标题翻译：检测基因多态性的方法
公开(公告)号：US20060240419A1
公开(公告)日：2006-10-26
申请号：US10514780
申请日：2003-05-16
申请人： Yusuke Nakamura , Akihiro Sekine , Aritoshi Lida , Susumu Saito
发明人： Yusuke Nakamura , Akihiro Sekine , Aritoshi Lida , Susumu Saito
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6858 , C12Q1/6827
摘要： A method for detecting a genetic polymorphism(s), comprising creating oligonucleotide probes and/or oligonucleotide primers so that the probes and/or primers contain a polymorphic site(s) present in a gene encoding a receptor or a sequence complementary thereto or so that the polymorphic site(s) is/are contained in the amplified fragment when at least one of said gene encoding the receptor and said sequence complementary thereto is amplified; and detecting at least one genetic polymorphism in a gene of a subject encoding the receptor using the resultant oligonucleotide probes and/or oligonucleotide primers.
摘要翻译：一种用于检测遗传多态性的方法，包括产生寡核苷酸探针和/或寡核苷酸引物，使得探针和/或引物含有存在于编码受体或与其互补的序列的基因中的多态性位点，或使得当编码受体的所述基因和与其互补的所述序列的至少一个被扩增时，所述多态性位点被包含在扩增的片段中; 并使用得到的寡核苷酸探针和/或寡核苷酸引物检测编码受体的受试者的基因中的至少一个遗传多态性。

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