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41. 发明授权

US08636894B2 Electrochemical determination of factor XA inhibitors 有权
标题翻译：因子XA抑制剂的电化学测定
公开(公告)号：US08636894B2
公开(公告)日：2014-01-28
申请号：US12432490
申请日：2009-04-29
申请人： Liesel Doerge , Margarete Galm , Carina Horn
发明人： Liesel Doerge , Margarete Galm , Carina Horn
IPC分类号： G01N27/26
CPC分类号： G01N27/26 , C12Q1/005 , C12Q1/56 , G01N33/86
摘要： Methods and devices for determining factor Xa inhibitors, in particular heparins and fractionated or low-molecular-weight heparins, as well as direct factor Xa inhibitors in blood samples. The methods include contacting a blood sample with a detection reagent that contains at least one thrombin substrate having a peptide residue that can be cleaved by thrombin and is amidically bound via the carboxyl end to an electrogenic substance, and with a known amount of factor X reagent and an activator reagent which induces the conversion of factor X into factor Xa. Subsequently, in a second step, the amount or activity of the electrogenic substance that is cleaved from the thrombin substrate by the factor Xa-mediated thrombin activation and/or the time course thereof is determined as the measurement signal using electrochemical methods. In a third step, the amount of the factor Xa inhibitor in the sample of the blood to be analyzed or a measured quantity that correlates therewith, in particular a clotting time that correlates therewith, is determined on the basis of this measurement signal.
摘要翻译：用于确定因子Xa抑制剂，特别是肝素和分级或低分子量肝素的方法和装置，以及血液样品中的直接因子Xa抑制剂。所述方法包括使血液样品与含有至少一个凝血酶底物的检测试剂接触，所述凝血酶底物具有可被凝血酶切割的肽残基，并且经由羧基末端与电生物质酰胺结合，并且使用已知量的因子X试剂和诱导因子X转化成因子Xa的活化剂。随后，在第二步骤中，通过因子Xa介导的凝血酶活化和/或其时间过程将从凝血酶底物切割的电生物质的量或活性确定为使用电化学方法的测量信号。在第三步骤中，基于该测量信号确定要分析的血液样品中的因子Xa抑制剂的量或与其相关的测量量，特别是与其相关的凝血时间。

42. 发明申请

US20120241335A1 SIMPLIFIED STORAGE OF INTEGRATED SYSTEMS 有权
标题翻译：简化的集成系统存储
公开(公告)号：US20120241335A1
公开(公告)日：2012-09-27
申请号：US13400267
申请日：2012-02-20
申请人： Carina Horn , Christian Freitag , Hans-Peter Haar , Heino Eikmeier
发明人： Carina Horn , Christian Freitag , Hans-Peter Haar , Heino Eikmeier
IPC分类号： B65D79/00
CPC分类号： G01N27/3272 , G01N33/48757 , G01N33/48764 , G01N33/48778
摘要： Storage containers for storing at least one diagnostic test element including an enzyme and a stabilized coenzyme are disclosed. In addition, diagnostic products which include diagnostic test elements including an enzyme and a stabilized coenzyme, as well as analytical measuring devices which include such storage containers or diagnostic products, are also disclosed. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving test elements which include an enzyme and a stabilized coenzyme.
摘要翻译：公开了用于存储至少一种包括酶和稳定化辅酶的诊断测试元件的储存容器。此外，还公开了包括酶和稳定化辅酶的诊断测试元件以及包括这种储存容器或诊断产品的分析测量装置的诊断产品。其他方面包括但不限于独特的方法，技术，产品，系统和涉及包括酶和稳定化辅酶的测试元件的设备。

43. 发明申请

US20120045843A1 TEST ELEMENT FOR DETERMINING A BODY FLUID AND MEASUREMENT METHOD 失效
标题翻译：用于确定体液和测量方法的测试单元
公开(公告)号：US20120045843A1
公开(公告)日：2012-02-23
申请号：US13224751
申请日：2011-09-02
申请人： Hans-Peter Haar , Carina Horn
发明人： Hans-Peter Haar , Carina Horn
IPC分类号： G01N21/64 , G01N21/75 , G01N33/66
CPC分类号： G01N33/66 , G01N21/6408 , G01N21/77 , G01N21/78 , G01N21/8483 , G01N33/525 , G01N2021/7786 , Y10T436/144444
摘要： A test element for determining a body fluid, in particular for determining the blood glucose level, comprises a detection region which is charged with a reagent sensitive to the body fluid. A function element is arranged in and/or adjacent to the detection region for detecting at least one status parameter for the detection region, wherein said functional element can be evaluated by means of a status measurement. A method for measuring the test element is also disclosed.
摘要翻译：用于确定体液的测试元件，特别是用于确定血液葡萄糖水平的测试元件包括带有对体液敏感的试剂的检测区域。功能元件布置在检测区域和/或邻近检测区域中，用于检测用于检测区域的至少一个状态参数，其中可以通过状态测量来评估功能元件。还公开了一种用于测量测试元件的方法。

44. 发明申请

US20100144042A1 AUTOMATIC DIFFERENTIATION OF A SAMPLE SOLUTION AND A CONTROL SOLUTION 审中-公开
标题翻译：一个样品溶液的自动分辨和一个控制解决方案
公开(公告)号：US20100144042A1
公开(公告)日：2010-06-10
申请号：US12705792
申请日：2010-02-15
申请人： Guenter Frey , Carina Horn , Otto Gaa , Hans Kintzig , Hans-Ruediger Murawski
发明人： Guenter Frey , Carina Horn , Otto Gaa , Hans Kintzig , Hans-Ruediger Murawski
IPC分类号： G01N33/48
CPC分类号： G01N33/96 , Y10T436/10 , Y10T436/104165 , Y10T436/104998 , Y10T436/106664 , Y10T436/25
摘要： The invention concerns a method for automatically differentiating between a sample liquid and a control liquid especially within the context of analytical measuring systems, wherein the presence of a special property of the control liquid and/or at least two criteria are used for the differentiation. In addition the invention concerns appropriate control liquids that are suitable for the new method.
摘要翻译：本发明涉及一种用于自动区分样品液体和对照液体的方法，特别是在分析测量系统的上下文中，其中存在控制液体的特殊性质和/或至少两个标准用于鉴别。此外，本发明涉及适用于新方法的合适的对照液体。

45. 发明授权

US07378255B2 Fluorimetric determination of analytes by an intramolecular quencher-fluorophore conjugate 有权
标题翻译：通过分子内猝灭剂 - 荧光团缀合物进行荧光测定分析物
公开(公告)号：US07378255B2
公开(公告)日：2008-05-27
申请号：US10766457
申请日：2004-01-28
申请人： Carina Horn , Hans-Peter Josel , Jürgen Spinke , Rupert Herrmann , Dieter Heindl
发明人： Carina Horn , Hans-Peter Josel , Jürgen Spinke , Rupert Herrmann , Dieter Heindl
IPC分类号： C12Q1/26
CPC分类号： G01N21/6428 , G01N2021/6432 , Y10S436/80 , Y10S436/904
摘要： A method and reagent for detecting an analyte by a redox reaction and a fluorimetric determination, is disclosed. The method comprises contacting a sample containing the analyte with a detection reagent which contains a compound of the general formula Q-F as a fluorimetric redox indicator, wherein Q is a quencher group and F is a fluorophore group.
摘要翻译：公开了一种用于通过氧化还原反应和荧光测定来检测分析物的方法和试剂。该方法包括将含有分析物的样品与含有通式Q-F化合物的检测试剂接触，作为荧光氧化还原指示剂，其中Q为猝灭剂基团，F为荧光团。

46. 发明授权

US08580949B2 Enzymatic synthesis of carba-NAD 有权
标题翻译：碳酰化酶的酶合成
公开(公告)号：US08580949B2
公开(公告)日：2013-11-12
申请号：US13358146
申请日：2012-01-25
申请人： Hartmut Duefel , Dieter Heindl , Carina Horn , Thomas Meier , Rainer Schmuck
发明人： Hartmut Duefel , Dieter Heindl , Carina Horn , Thomas Meier , Rainer Schmuck
IPC分类号： C07H19/207
CPC分类号： C07H19/207 , C12P19/32
摘要： The disclosure concerns the enzymatic synthesis of stable analogues of nicotinamide adenine dinucleotide NAD/NADH and nicotinamide adenine dinucleotide phosphate NADP/NADPH, the so-called “carba-NADs”, i.e. analogues of NAD/NADH or NADP/NADPH, respectively, comprising a carbacyclic sugar instead of ribose.
摘要翻译：本公开内容涉及烟酰胺腺嘌呤二核苷酸NAD / NADH和烟酰胺腺嘌呤二核苷酸磷酸NADP / NADPH的稳定类似物的酶合成，即所谓的“carba-NAD”，即NAD / NADH或NADP / NADPH的类似物，分别包含碳环糖代替核糖。

47. 发明申请

US20130052674A1 DETECTING THE DECOMPOSITION OF ENZYMES IN A TEST ELEMENT BY MEANS OF CONTROLLED RELEASE OF A PROTECTED ANALYTE 审中-公开
标题翻译：通过受保护分析仪的控制释放检测测试单元中酶的分解
公开(公告)号：US20130052674A1
公开(公告)日：2013-02-28
申请号：US13524199
申请日：2012-06-15
申请人： Carina Horn , Dieter Heindl , Hans-Peter Haar , Nelli Steinke
发明人： Carina Horn , Dieter Heindl , Hans-Peter Haar , Nelli Steinke
IPC分类号： C12Q1/32 , G01N21/77 , C12Q1/54
CPC分类号： C12Q1/54
摘要： In one form, a diagnostic element for determining at least one analyte is provided. In a further form, an analytical measuring device includes the diagnostic element. Still, other forms are related to methods for the determination of an analyte, correcting a signal generated by an analyte, and/or checking the detection optics of an analytical measuring device using the diagnostic element. Another form is related to a system for the controlled release of a reagent and the use of such a system as a circuit element. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving diagnostic elements.
摘要翻译：在一种形式中，提供了用于确定至少一种分析物的诊断元件。在另一种形式中，分析测量装置包括诊断元件。仍然，其它形式涉及用于确定分析物的方法，校正由分析物产生的信号和/或使用诊断元件检查分析测量装置的检测光学元件。另一种形式涉及用于控制释放试剂的系统以及使用诸如电路元件的系统。其他方面包括但不限于涉及诊断元件的独特方法，技术，产品，系统和设备。

48. 发明授权

US08338118B2 Fluorescence spectropscopy in absorbing media 有权
标题翻译：吸收介质中的荧光分光光度法
公开(公告)号：US08338118B2
公开(公告)日：2012-12-25
申请号：US12368286
申请日：2009-02-09
申请人： Wolfgang Petrich , Claudia Gaessler-Dietsche , Carina Horn , Kari Hebestreit , Jean-Michel Asfour , Klemens Bardelang , Gerrit Kocherscheidt
发明人： Wolfgang Petrich , Claudia Gaessler-Dietsche , Carina Horn , Kari Hebestreit , Jean-Michel Asfour , Klemens Bardelang , Gerrit Kocherscheidt
IPC分类号： C12Q1/54
CPC分类号： C12Q1/008 , C12Q1/26 , C12Q1/32 , C12Q1/54 , G01N33/52 , G01N33/66 , Y10T436/144444
摘要： The invention relates to processes and devices for detecting an analyte in a sample by fluorescence measurement of a fluorophore, wherein the detection medium which contains a fluorophore or a precursor of the fluorophore is admixed with an absorber whose absorbance spectrum superimposes the fluorescence excitation range of the fluorophore. The system consisting of the fluorophore and the absorber, which is produced in the detection medium, has an altered effective fluorescence excitation range with an altered fluorescence excitation maximum. Illumination with fluorescence excitation light can take place within the range of this altered excitation maximum. The measured signal obtained from determining fluorescence emission exhibits only low dependence on the wavelength of the excitation light.
摘要翻译：本发明涉及通过荧光团的荧光测定来检测样品中分析物的方法和装置，其中将含有荧光团或荧光团前体的检测介质与吸收光谱与吸收光谱的荧光激发范围相加荧光团。由荧光团和在检测介质中产生的吸收体组成的系统具有改变的有效荧光激发范围，具有改变的荧光激发最大值。荧光激发光的照明可以在这种改变的激发最大值的范围内进行。从确定荧光发射获得的测量信号仅显示对激发光的波长的低依赖性。

49. 发明授权

US07670846B2 Automatic differentiation of a sample solution and a control solution 失效
标题翻译：样品溶液和对照溶液的自动鉴别
公开(公告)号：US07670846B2
公开(公告)日：2010-03-02
申请号：US10518968
申请日：2003-06-24
申请人： Guenter Frey , Carina Horn , Otto Gaa , Hans Kintzig , Hans-Ruediger Murawski
发明人： Guenter Frey , Carina Horn , Otto Gaa , Hans Kintzig , Hans-Ruediger Murawski
IPC分类号： G01N21/17 , G01N21/27
CPC分类号： G01N33/96 , Y10T436/10 , Y10T436/104165 , Y10T436/104998 , Y10T436/106664 , Y10T436/25
摘要： The invention concerns a method for automatically differentiating between a sample liquid and a control liquid especially within the context of analytical measuring systems, wherein the presence of a special property of the control liquid and/or at least two criteria are used for the differentiation. In addition the invention concerns appropriate control liquids that are suitable for the new method.
摘要翻译：本发明涉及一种用于自动区分样品液体和对照液体的方法，特别是在分析测量系统的上下文中，其中存在控制液体的特殊性质和/或至少两个标准用于鉴别。此外，本发明涉及适用于新方法的合适的对照液体。

50. 发明申请

US20090236238A1 Electrochemical Determination of Factor XA Inhibitors 有权
标题翻译：电化学测定因子XA抑制剂
公开(公告)号：US20090236238A1
公开(公告)日：2009-09-24
申请号：US12432490
申请日：2009-04-29
申请人： Liesel Doerge , Margarete Galm , Carina Horn
发明人： Liesel Doerge , Margarete Galm , Carina Horn
IPC分类号： G01N27/26
CPC分类号： G01N27/26 , C12Q1/005 , C12Q1/56 , G01N33/86
摘要： Methods and devices for determining factor Xa inhibitors, in particular heparins and fractionated or low-molecular-weight heparins, as well as direct factor Xa inhibitors in blood samples. The methods include contacting a blood sample with a detection reagent that contains at least one thrombin substrate having a peptide residue that can be cleaved by thrombin and is amidically bound via the carboxyl end to an electrogenic substance, and with a known amount of factor X reagent and an activator reagent which induces the conversion of factor X into factor Xa. Subsequently, in a second step, the amount or activity of the electrogenic substance that is cleaved from the thrombin substrate by the factor Xa-mediated thrombin activation and/or the time course thereof is determined as the measurement signal using electrochemical methods. In a third step, the amount of the factor Xa inhibitor in the sample of the blood to be analyzed or a measured quantity that correlates therewith, in particular a clotting time that correlates therewith, is determined on the basis of this measurement signal.
摘要翻译：用于确定因子Xa抑制剂，特别是肝素和分级或低分子量肝素的方法和装置，以及血液样品中的直接因子Xa抑制剂。所述方法包括使血液样品与含有至少一个凝血酶底物的检测试剂接触，所述凝血酶底物具有可被凝血酶切割的肽残基，并且经由羧基末端与电生物质酰胺结合，并且使用已知量的因子X试剂和诱导因子X转化成因子Xa的活化剂。随后，在第二步骤中，通过因子Xa介导的凝血酶活化和/或其时间过程将从凝血酶底物切割的电生物质的量或活性确定为使用电化学方法的测量信号。在第三步骤中，基于该测量信号确定要分析的血液样品中的因子Xa抑制剂的量或与其相关的测量量，特别是与其相关的凝血时间。

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