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41. 发明授权

US07177680B2 Field stimulation about a discontinuity of the myocardium to capture the heart at reduced pacing thresholds 失效
标题翻译：关于心肌不连续的场刺激，以降低的起搏阈值捕获心脏
公开(公告)号：US07177680B2
公开(公告)日：2007-02-13
申请号：US10403636
申请日：2003-03-31
申请人： Vinod Sharma , Xiaohong Zhou
发明人： Vinod Sharma , Xiaohong Zhou
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0573 , A61N1/0587
摘要： Improved pacing thresholds for capturing the heart are achieved by forming a discontinuity in the cardiac tissue of the heart chamber, disposing a pacing electrode at a distance less than a space constant of the cardiac tissue from the discontinuity in the cardiac tissue, and applying a stimulus of a first polarity at an energy insufficient to cause the directly stimulated tissue adjacent to the pacing electrode to propagate a depolarization wave through the cardiac tissue mass of the heart chamber but sufficient to induce a transmembrane potential change at the tissue adjacent to the discontinuity that results in a propagated wave front. Thus, pacing energy is advantageously reduced.
摘要翻译：通过在心脏室的心脏组织中形成不连续性来实现用于捕获心脏的改善的起搏阈值，将起搏电极设置在心脏组织的距离小于心脏组织的间隔常数的距离处，并施加刺激第一极性的能量不足以引起与起搏电极相邻的直接受刺激的组织通过心室的心脏组织块传播去极化波，但是足以在与不连续性相邻的组织处诱导跨膜电位变化，在传播的波前。因此，起搏能量有利地降低。

42. 发明授权

US06892094B2 Combined anti-tachycardia pacing (ATP) and high voltage therapy for treating ventricular arrhythmias 有权
标题翻译：联合抗心动过速起搏（ATP）和高压治疗治疗室性心律失常
公开(公告)号：US06892094B2
公开(公告)日：2005-05-10
申请号：US10137517
申请日：2002-04-30
申请人： Kevin T. Ousdigian , Vasant Padmanabhan , Paul J. DeGroot , Walter H. Olson , Vinod Sharma , Cameron J. Kaszas , Paul G. Krause
发明人： Kevin T. Ousdigian , Vasant Padmanabhan , Paul J. DeGroot , Walter H. Olson , Vinod Sharma , Cameron J. Kaszas , Paul G. Krause
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/3987
摘要： A system and method for treating an arrhythmia of the heart, involves delivery of anti-tachy pacing (ATP) pulses to the heart, possibly followed by the delivery of a high-voltage shock. ATP delivery is controlled such that the time delivery of any high-voltage shock is not affected by the prior delivery of the ATP pulses. System control may be accomplished using one or more programmable parameters, which may include a user-specified shock energy.
摘要翻译：用于治疗心脏心律失常的系统和方法涉及向心脏递送抗起搏起搏（ATP）脉冲，可能之后传递高压休克。控制ATP递送，使得任何高压休克的时间传递不受ATP脉冲的先前递送的影响。系统控制可以使用一个或多个可编程参数来实现，其可以包括用户指定的冲击能量。

43. 发明申请

US20050021089A1 Compositions and methods for treating cardiac dysfunction 审中-公开
标题翻译：治疗心脏功能障碍的组合物和方法
公开(公告)号：US20050021089A1
公开(公告)日：2005-01-27
申请号：US10626159
申请日：2003-07-24
申请人： Vinod Sharma
发明人： Vinod Sharma
IPC分类号： A61K48/00 , A61N1/362 , C07K14/705 , C12N5/077 , A61N1/00
CPC分类号： C12N5/0657 , A61K48/005 , A61K48/0075 , A61N1/362 , C07K14/705 , C12N2510/00 , C12N2799/025
摘要： Disclosed are methods and systems for restoring cardiac function or preventing cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of the conduction system of the heart. In one embodiment, the invention provides a method of genetically modifying the cells by delivering to the cells one or more coding sequences in a genetic construct capable of modifying the expression of or conductance of ion channels of the cells of the atrioventricular node cells to suppress conductance of impulses therethrough in combination with pacemaker treatment.
摘要翻译：公开了通过遗传修饰心脏传导系统来恢复心脏功能或预防心脏功能障碍的方法和系统，特别是心脏起搏功能障碍。在一个实施方案中，本发明提供了通过向细胞递送能够修饰房室结节细胞的细胞的离子通道的表达或导电以抑制电导的遗传构建体中的一个或多个编码序列来遗传修饰细胞的方法与心脏起搏器治疗相结合的脉冲。

44. 发明授权

US06836826B2 Multilevel cache system and method having a merged tag array to store tags for multiple data arrays 失效
标题翻译：多级缓存系统和方法具有合并的标记数组，用于存储多个数据数组的标签
公开(公告)号：US06836826B2
公开(公告)日：2004-12-28
申请号：US10600715
申请日：2003-06-23
申请人： Vinod Sharma
发明人： Vinod Sharma
IPC分类号： G06F1200
CPC分类号： G06F12/1027 , G06F12/0897
摘要： A multilevel cache system and method. A first data array and a second data array are coupled to a merged tag array. The merged tag array stores tags for both the first data array and second data array.
摘要翻译：多级缓存系统和方法。第一数据阵列和第二数据阵列耦合到合并标签阵列。合并的标签数组存储第一数据阵列和第二数据阵列的标签。

45. 发明授权

US06591341B1 Multilevel cache system and method having a merged tag array to store tags for multiple data arrays 有权
标题翻译：多级缓存系统和方法具有合并的标记数组，用于存储多个数据数组的标签
公开(公告)号：US06591341B1
公开(公告)日：2003-07-08
申请号：US09540754
申请日：2000-03-31
申请人： Vinod Sharma
发明人： Vinod Sharma
IPC分类号： G06F1200
CPC分类号： G06F12/1027 , G06F12/0897
摘要： A multilevel cache system and method. A first data array and a second data array are coupled to a merged tag array. The merged tag array stores tags for both the first data array and second data array.
摘要翻译：多级缓存系统和方法。第一数据阵列和第二数据阵列耦合到合并标签阵列。合并的标签数组存储第一数据阵列和第二数据阵列的标签。

46. 发明授权

US5559970A Crossbar switch for multi-processor, multi-memory system for resolving port and bank contention through the use of aligners, routers, and serializers 失效
标题翻译：用于多处理器，多存储器系统的交叉开关，用于通过使用对准器，路由器和串行器解析端口和组争用
公开(公告)号：US5559970A
公开(公告)日：1996-09-24
申请号：US237843
申请日：1994-05-04
申请人： Vinod Sharma
发明人： Vinod Sharma
IPC分类号： G06F13/14 , G06F15/16 , G06F15/167 , G06F15/173 , H04Q11/04 , G06F13/00
CPC分类号： H04Q11/0478 , G06F15/17375 , H04L49/253 , H04L49/101 , H04L49/3018 , H04L49/40
摘要： A self-routing crossbar switch interconnects a plurality of processors with a plurality of memory modules. In a self-routing crossbar switch connecting N processors and N memory modules, a processor is connected to each input port and a memory module is connected to each output port; each of the N processors can transmit a memory request simultaneously provided that there is no port contention and no bank contention. Port contention occurs if two or more processors attempt to access the same output port of the self-routing crossbar switch at the same time. The memory module consists of several memory banks that are connected in an interleaved manner. If the memory bank is accessed before it is ready to accept a new request, bank contention is said to have occurred. In the self-routing crossbar switch the requests directed to a port are first passed through an aligner and a conflict resolution logic. There is one aligner associated with each output port. The aligner inputs the requests directed at an output port and aligns them so that, at the output of the aligner, all the active requests appear in a consecutive fashion. The conflict resolution logic resolves the port and bank contention.
摘要翻译：自路由交叉开关将多个处理器与多个存储器模块互连。在连接N个处理器和N个存储器模块的自路由交叉开关中，处理器连接到每个输入端口，并且存储器模块连接到每个输出端口; N个处理器中的每一个可以同时发送存储器请求，只要没有端口争用并且没有银行争用。如果两个或多个处理器同时尝试访问自路由交叉开关的相同输出端口，则会发生端口争用。存储器模块由以交错方式连接的多个存储体组成。如果在准备好接受新请求之前存储存储器被访问，则认为银行争用已经发生。在自路由交叉开关中，引导到端口的请求首先通过对齐器和冲突解决逻辑。每个输出端口都有一个对齐器。对准器输入针对输出端口的请求并对齐它们，使得在对齐器的输出处，所有活动请求以连续的方式出现。冲突解决逻辑解决了港口和银行的争论。

47. 发明申请

US20190050692A1 CONTEXT-BASED DIGITAL SIGNAL PROCESSING 审中-公开
公开(公告)号：US20190050692A1
公开(公告)日：2019-02-14
申请号：US15855763
申请日：2017-12-27
申请人： Vinod Sharma , Monica Martinez-Canales , Peggy Jo Irelan , Malini Krishnan Bhandaru , Rita Chattopadhyay , Soila Pertet Kavulya
发明人： Vinod Sharma , Monica Martinez-Canales , Peggy Jo Irelan , Malini Krishnan Bhandaru , Rita Chattopadhyay , Soila Pertet Kavulya
IPC分类号： G06K9/62 , G06K9/00 , G06K9/66 , G06K9/20
CPC分类号： G06K9/6292 , G06K9/00805 , G06K9/00825 , G06K9/00845 , G06K9/209 , G06K9/66
摘要： Various systems and methods for implementing context-based digital signal processing are described herein. An object detection system includes a processor to: access sensor data from a first sensor and a second sensor integrated in a vehicle; access an operating context of the vehicle; assign a first weight to a first object detection result from sensor data of the first sensor, the first weight adjusted based on the operating context; assign a second weight to a second object detection result from sensor data of the second sensor, the second weight adjusted based on the operating context; and perform a combined object detection technique by combining the first object detection result weighted by the first weight and the second object detection result weighted by the second weight.

48. 发明申请

US20120130303A1 RATE CONTROL DURING AF USING CELLULAR INTERVENTION TO MODULATE AV NODE 审中-公开
标题翻译：在使用细胞干扰调节AV节点的AF期间的速率控制
公开(公告)号：US20120130303A1
公开(公告)日：2012-05-24
申请号：US13359949
申请日：2012-01-27
申请人： Vinod Sharma , Daniel C. Sigg
发明人： Vinod Sharma , Daniel C. Sigg
IPC分类号： A61K31/7052 , A61P9/00 , A61N1/362 , A61K35/00
CPC分类号： A61N1/362 , A61K9/0019 , A61K31/221 , A61K38/177 , A61N1/0568
摘要： A biologic intervention method and apparatus generates a persistent modification to an AV node that is physiologically stable after the agent has matured but is alterable with subsequent application of an agent. Specifically, the generic agent is used to modulate a node in a cardiac conduction system including rate control using one and a combination of a family of K+ channel or equivalent. Specifically, the channel is implemented to slow conduction by generating an outward current during optimization of action potential and repolarization phase thus decreasing the current that is available to excite downstream cells. A Kv 1.3 channel, for example, may be used as the biologic channel. The invention enables reversal of the modulation or adjustment for various heart rates (BPM) based on medical and patient-specific needs.
摘要翻译：生物干预方法和装置对于在该药剂已经成熟但随后随后施用药剂而可变化的生理稳定的AV节点产生持久性修饰。具体地，通用代理用于调制心脏传导系统中的节点，包括使用一个K +通道或等效物系的组合的速率控制。具体地，通过在动作电位和复极相优化期间产生向外的电流来实现缓慢传导，从而减少可用于激发下游单元的电流。例如，可以使用Kv1.3通道作为生物通道。本发明能够根据医疗和患者特定的需要逆转各种心率（BPM）的调节或调整。

49. 发明授权

US08170663B2 Method and apparatus to control delivery of high-voltage and anti-tachy pacing therapy in an implantable medical device 有权
标题翻译：用于控制可植入医疗装置中的高电压和抗速度起搏治疗递送的方法和装置
公开(公告)号：US08170663B2
公开(公告)日：2012-05-01
申请号：US11687282
申请日：2007-03-16
申请人： Paul J. DeGroot , Kevin T. Ousdigian , Vasant Padmanabhan , Paul Krause , Vinod Sharma
发明人： Paul J. DeGroot , Kevin T. Ousdigian , Vasant Padmanabhan , Paul Krause , Vinod Sharma
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3688 , A61N1/3925 , A61N1/3956 , A61N1/3962 , A61N1/3987
摘要： A system and method for delivering both anti-tachy pacing (ATP) therapy and high-voltage shock therapy in response to detection of abnormal cardiac rhythms is disclosed. The system controls the time between delivering ATP therapy and the charging of high-voltage capacitors in preparation for shock delivery based on a predetermined set of criteria. In one embodiment, the inventive system operates in an ATP During Capacitor Charging (ATP-DCC) mode wherein all, or substantially all, of the ATP therapy is delivered during charging of the high-voltage capacitors. Based on evaluation of the predetermined set of criteria, the system may switch to an additional ATP Before Capacitor Charging (ATP-BCC) mode, wherein substantially all of the ATP therapy is delivered prior to charging of the high-voltage capacitor. According to one aspect of the invention, the predetermined set of criteria is based, at least in part, on the effectiveness of previously-delivered ATP therapy.
摘要翻译：公开了一种用于响应于异常心律的检测而提供抗起搏起搏（ATP）治疗和高压休克疗法的系统和方法。该系统基于预定的一组标准来控制ATP治疗与高压电容器的充电之间的时间，以准备冲击输送。在一个实施例中，本发明的系统在ATP电容器充电（ATP-DCC）模式下工作，其中在高压电容器充电期间全部或基本上全部ATP治疗被递送。基于对预定标准集合的评估，系统可以切换到在电容器充电（ATP-BCC）模式之外的另外的ATP，其中在高压电容器充电之前基本上全部ATP治疗被递送。根据本发明的一个方面，预定的一组标准至少部分地基于先前传递的ATP治疗的有效性。

50. 发明授权

US08076305B2 Biological pacemakers including mutated hyperpolarization-activated cyclic nucleotide-gated (HCN) channels 有权
标题翻译：生物起搏器包括突变的超极化激活的环核苷酸门控（HCN）通道
公开(公告)号：US08076305B2
公开(公告)日：2011-12-13
申请号：US11565433
申请日：2006-11-30
申请人： Daniel C. Sigg , Vinod Sharma , Yong-Fu Xiao
发明人： Daniel C. Sigg , Vinod Sharma , Yong-Fu Xiao
IPC分类号： A61K48/00 , A01N63/00 , C12N15/74 , C07H21/04
CPC分类号： A61K48/005 , A61K38/00 , C07K14/705
摘要： A composition for implantation into cardiac tissue includes a biological pacemaker that, when implanted, expresses an effective amount of a mutated hyperpolarization-activated and cyclic nucleotide-gated (HCN) isoform to modify Ih when compared with wild-type HCN. Methods for implementing each of the biologocal pacemakers include implanting each of biologocal pacemakers into cardiac tissue.
摘要翻译：用于植入心脏组织的组合物包括生物起搏器，当植入时，与野生型HCN相比，表达有效量的突变超极化激活和环核苷酸门控（HCN）同种型以修饰Ih。实现每个生物定位心脏起搏器的方法包括将每个生物定位心脏起搏器植入心脏组织。

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