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41. 发明授权

US06889567B2 3D array integrated cells for the sampling and detection of air bound chemical and biological species 失效
标题翻译： 3D阵列综合细胞用于空气结合化学和生物物种的采样和检测
公开(公告)号：US06889567B2
公开(公告)日：2005-05-10
申请号：US10340231
申请日：2003-01-10
申请人： Cleopatra Cabuz
发明人： Cleopatra Cabuz
IPC分类号： G01N21/64 , B81B3/00 , F04B43/04 , G01N1/24 , G01N27/02 , G01N27/04 , G01N27/12 , G01N33/00 , G01N35/08 , G01N37/00 , G01N1/26 , G01N1/14 , G01N1/20
CPC分类号： F04B43/043 , G01N1/24 , G01N33/0011 , G01N33/0031 , G01N33/0032
摘要： An integrated mesopump-sensor suitable for disposition in two- and three-dimensional arrays having small dimensions is disclosed. One mesopump is formed of an electrostatically attractable flexible diaphragm disposed through cavities or pumping chambers formed between two opposing electrostatically chargeable material layers. Fluid is pumped through the chambers by sequentially moving the diaphragm toward the first chargeable layer, then towards the second chargeable layer, which can pull and push the fluid through a series of chambers, and past the sensor. One group of sensors utilizes multiple and varied chemoresistive sensors which can vary in resistance differently in response to the presence of various analytes. Another group of sensors utilizes chemo-fluorescent sensors that fluoresce in the presence of particular analytes. Some mesopump-sensor systems can be manufactured using MEMS technology and can be coupled to controllers for sequencing the pumps and analyzing sensor outputs using methods including Principle Component Analysis.
摘要翻译：公开了一种适用于具有小尺寸的二维和三维阵列中的集成介质传感器传感器。一个介质泵由静电吸引的柔性隔膜形成，通过形成在两个相对的可静电带电材料层之间的空腔或泵送室。流体通过将隔膜朝向第一可充电层依次移动，然后朝向第二可充电层泵送，该第二可充电层可以拉动和推动流体通过一系列的室并且经过传感器。一组传感器利用多种不同的化学电阻传感器，其可以响应于各种分析物的存在而不同地改变电阻。另一组传感器使用在特定分析物存在下荧光的化学荧光传感器。一些介质传感器系统可以使用MEMS技术制造，并且可以耦合到控制器，用于对泵进行排序，并使用包括原理分量分析的方法分析传感器输出。

42. 发明授权

US06582985B2 SOI/glass process for forming thin silicon micromachined structures 失效
公开(公告)号：US06582985B2
公开(公告)日：2003-06-24
申请号：US09748488
申请日：2000-12-27
申请人： Cleopatra Cabuz , Jeffrey Alan Ridley
发明人： Cleopatra Cabuz , Jeffrey Alan Ridley
IPC分类号： H01L2100
CPC分类号： B81C1/0015 , B81B2201/0228 , B81C2201/019 , H01L27/12 , H01L27/1203
摘要： Methods for making thin silicon layers suspended over recesses in glass wafers. One method includes providing a thin silicon-on-insulator (SOI) wafer, and a glass wafer. The SOI wafer can include a silicon oxide layer disposed between a first undoped or substantially undoped silicon layer and a second silicon layer. Recesses can be formed in the glass wafer surface and electrodes may be formed on the glass wafer surface. The first silicon layer of the SOI wafer is then bonded to the glass wafer surface having the recesses, and the second silicon layer is subsequently removed using the silicon oxide layer as an etch stop. Next, the silicon oxide layer is removed. The first silicon layer can then be etched to form the desired structure. In another illustrative embodiment, the first silicon layer has a patterned metal layer thereon. The SOI wafer is bonded to the glass wafer, with the patterned metal layer positioned adjacent the recesses in the glass wafer. Then, the second silicon layer is removed using the silicon oxide layer as an etch stop, and the silicon oxide layer is subsequently removed. The first silicon layer is then etched using the patterned metal layer as an etch stop. The patterned metal layer is then removed.

43. 发明授权

US06184607B2 Driving strategy for non-parallel arrays of electrostatic actuators sharing a common electrode 有权
标题翻译：非平行阵列静电致动器共享公共电极的驱动策略
公开(公告)号：US06184607B2
公开(公告)日：2001-02-06
申请号：US09223082
申请日：1998-12-29
申请人： Cleopatra Cabuz , Eugen I. Cabuz
发明人： Cleopatra Cabuz , Eugen I. Cabuz
IPC分类号： H02N100
CPC分类号： H02N1/006
摘要： An electrostatic actuator array having at least one cell, in which the individual cells share a common electrode. Each cell includes first and second electrodes separated by a distance and having a moveable diaphragm mounted there between for conducting a voltage potential thereto. One of the pair is movable with respect to the other, and the pair are positioned to move upon application of a voltage potential thereto by electrodes attached thereto. A voltage potential producing an alternate polarity field generated from a single DC power supply is selectively provided to the electrodes to cause the movement. The preferred signals from the power supply are uni-polar square wave signals, preferably deriving the alternate polarity field from a DC current having time allocation of signals to present alternating fields to each actuator. The individual cells are configured in an actuator array wherein some cells operate out of phase with adjoining cells. The plurality of actuation cells equals n, having 2n electrodes, where n is an integer of at least 2. A preferred actuator array comprises n actuation cells working out of phase with 2n electrodes driven with n+1 unipolar signals.
摘要翻译：具有至少一个单元的静电致动器阵列，其中各个单元共享公共电极。每个单元包括分开一定距离的第一和第二电极，并且具有安装在其上的可移动隔膜，用于对其施加电压电位。该对中的一个可相对于另一个移动，并且该对被定位成通过附接到其上的电极施加电位而移动。产生从单个DC电源产生的交替极性场的电压电势被选择性地提供给电极以引起运动。来自电源的优选信号是单极方波信号，优选地从具有时间分配信号的直流电流导出交替极性场，以向每个致动器呈现交变场。各个单元被配置在致动器阵列中，其中一些单元与相邻的单元异步操作。多个致动单元等于n，其具有2n个电极，其中n是至少为2的整数。优选的致动器阵列包括与由n + 1个单极信号驱动的2n个电极异相工作的n个致动单元。

44. 发明授权

US08828320B2 Portable sample analyzer cartridge 有权
标题翻译：便携式样品分析仪盒
公开(公告)号：US08828320B2
公开(公告)日：2014-09-09
申请号：US11615927
申请日：2006-12-22
申请人： Ron L. Bardell , Aravind Padmanabhan , Peter L. Reutiman , Tom M. Rezachek , James A. Cox , Bernard S. Fritz , Cleopatra Cabuz
发明人： Ron L. Bardell , Aravind Padmanabhan , Peter L. Reutiman , Tom M. Rezachek , James A. Cox , Bernard S. Fritz , Cleopatra Cabuz
IPC分类号： G01N33/00
CPC分类号： G01N35/085 , G01N15/1056 , G01N15/12 , G01N15/1459 , G01N15/1484 , G01N35/00603 , G01N35/00663 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1062 , G01N2015/1486 , G06F19/00
摘要： A system relating to sample analyzers, and more particular, to sample analyzers that are simple to operate and have a reduced risk of providing an erroneous result to a user. In some cases, the sample analyzer may be a portable sample analyzer that includes a disposable fluidic cartridge. The operators of the analyzers need not be trained.
摘要翻译：与样品分析仪有关的系统，更具体地说，涉及操作简单且降低向用户提供错误结果的风险的样品分析仪。在一些情况下，样品分析仪可以是便携式样品分析仪，其包括一次性流体盒。不需要对分析仪的操作员进行培训。

45. 发明授权

US07978329B2 Portable scattering and fluorescence cytometer 有权
标题翻译：便携式散射和荧光细胞仪
公开(公告)号：US07978329B2
公开(公告)日：2011-07-12
申请号：US10304773
申请日：2002-11-26
申请人： Aravind Padmanabhan , Cleopatra Cabuz , Bernard S. Fritz
发明人： Aravind Padmanabhan , Cleopatra Cabuz , Bernard S. Fritz
IPC分类号： G01N21/00
CPC分类号： G01N15/147 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150343 , A61B5/150351 , A61B5/157 , A61B5/417 , B01L3/5027 , G01N15/1404 , G01N15/1484 , G01N2015/0088 , G01N2015/1075 , G01N2015/1486 , G01N2035/00891
摘要： An apparatus having scattering and multi-color fluorescence detecting, analyzing and identification capabilities of blood or other fluids of interest. The sample to be tested may be entered in a disposable microfluidic cartridge which in turn is insertable in a hand-holdable or implantable miniaturized and portable cytometer instrument. This cytometer has significant application in biological warfare agent detection, hematology and other clinical and research fields.
摘要翻译：一种具有散射和多色荧光检测，分析和识别血液或其他感兴趣液体的能力的装置。要测试的样品可以输入一次性微流控盒中，该滤芯又可插入手持式或可植入式的小型化便携式血细胞仪器中。该细胞仪在生物战剂检测，血液学等临床和研究领域具有重要应用。

46. 发明授权

US07420659B1 Flow control system of a cartridge 有权
标题翻译：墨盒的流量控制系统
公开(公告)号：US07420659B1
公开(公告)日：2008-09-02
申请号：US10908014
申请日：2005-04-25
申请人： Cleopatra Cabuz , Eugen Cabuz
发明人： Cleopatra Cabuz , Eugen Cabuz
IPC分类号： G01N33/49 , F04B17/00
CPC分类号： B01L9/527 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150343 , A61B5/150755 , A61B5/150969 , B01L3/5027 , B01L2200/0636 , B01L2300/0816 , B01L2400/0481 , B01L2400/0487 , B01L2400/0633 , B01L2400/0655 , F16K99/0015 , F16K99/0051 , G01F1/7086 , G01N15/1056 , G01N15/1404 , G01N15/1484 , G01N2015/1486
摘要： An apparatus having a disposable cytometer cartridge containing pumps, pressure chambers, reservoirs, flow sensors, flow channels, and microfluidic circuits with fluid operations on the cartridge. The circuits may include mesopumps and mesovalves embedded in the chip, card or cartridge. The apparatus may have multiple detecting, analyzing and identification capabilities of blood or other fluids of interest. The sample to be tested may be entered in the disposable microfluidic cartridge which in turn is insertable in a hand-holdable or portable cytometer instrument. This apparatus may have significant application in biological warfare agent detection, water analyses, environmental checks, hematology, and other clinical and research fields.
摘要翻译：一种装置，其具有一个包含泵，压力室，储存器，流量传感器，流动通道和在墨盒上具有流体操作的微流体电路的一次性血细胞计数器盒。这些电路可以包括嵌入在芯片，卡或盒中的中间泵和中间阀。该装置可以具有对感兴趣的血液或其它流体的多个检测，分析和识别能力。待测试的样品可以进入一次性微流控盒，其又可插入手持式或便携式的血液计仪器中。该装置可能在生物战剂检测，水分析，环境检查，血液学等临床和研究领域具有重要应用。

47. 发明授权

US07277166B2 Cytometer analysis cartridge optical configuration 有权
标题翻译： Cytometer分析盒光学配置
公开(公告)号：US07277166B2
公开(公告)日：2007-10-02
申请号：US10908543
申请日：2005-05-16
申请人： Aravind Padmanabhan , Jay G. Schwichtenberg , Bernard S. Fritz , Cleopatra Cabuz , Ernest A. Satren
发明人： Aravind Padmanabhan , Jay G. Schwichtenberg , Bernard S. Fritz , Cleopatra Cabuz , Ernest A. Satren
IPC分类号： G01N21/01 , G01N33/48 , G01N1/10 , G01N15/02
CPC分类号： G01N15/1459 , B01L3/502715 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0636 , B01L2200/0689 , B01L2300/0645 , B01L2300/0654 , B01L2400/0487 , B01L2400/0633 , G01N15/1456 , G01N15/1484 , G01N2015/008 , G01N2015/1452 , G01N2015/1486
摘要： A medium having microfluidic circuitry for sampling and analyses. The medium may be a cartridge having a window countersunk into it and containing a flow channel. The flow channel may have items of interest flowing through it. Analyses of these items may be optical involving one or more light sources emanating light to and one or more light detectors receiving light from the channel. There are various configurations so that source and detector light cones may reach the flow channel without obscuration or interference of the light to and from the flow channel in the window.
摘要翻译：具有用于取样和分析的微流体电路的介质。该介质可以是具有一个窗口沉入其中并包含流动通道的盒。流动通道可以具有流过其的兴趣物品。这些项目的分析可以是光学的，涉及发射光的一个或多个光源和从该通道接收光的一个或多个光检测器。存在各种配置，使得源和检测器光锥可以到达流动通道而不会使光在窗口中的流动通道的光线不受干扰或干扰。

48. 发明申请

US20070146974A1 Electrical circuit pattern design by injection mold 审中-公开
标题翻译：注塑模具电路图案设计
公开(公告)号：US20070146974A1
公开(公告)日：2007-06-28
申请号：US11318033
申请日：2005-12-23
申请人： Cleopatra Cabuz , Eugen Cabuz , Tzu-Yu Wang
发明人： Cleopatra Cabuz , Eugen Cabuz , Tzu-Yu Wang
IPC分类号： H05K5/00
CPC分类号： H05K3/107 , H05K1/0284 , H05K3/046 , H05K3/146 , H05K3/16 , H05K2201/09036 , H05K2201/09045 , H05K2201/09118 , H05K2201/09127 , H05K2201/09836 , H05K2201/09863
摘要： A method of forming an electronic part having a circuit pattern, by forming a cavity mold having trench lines in the cavity mold with a first area perpendicular to an axis and a second area having a negative slope with respect to the axis. The part is molded and removed, and a conductive material is deposited to form conductive and nonconductive areas thereon. The preferred deposit step is by blanket metallization which coats all surfaces except the sides of the trench lines and the second area of the part. The method may include the additional step of molding vertical flash portions on the part instead of or in addition to the trench lines that are removed after the conductive material is deposited thereon to form the circuit pattern.
摘要翻译：一种形成具有电路图形的电子部件的方法，通过在空腔模具中形成具有沟槽线的空腔模具，其具有垂直于轴线的第一区域和相对于该轴线具有负斜率的第二区域。该部件被模制和去除，并且沉积导电材料以在其上形成导电和非导电区域。优选的沉积步骤是通过覆盖金属化，其涂覆除了沟槽线的侧面和部分的第二区域之外的所有表面。该方法可以包括在导电材料沉积在其上以形成电路图案之后，在部分上成型垂直闪光部分的附加步骤，而不是或除了沟槽线之外去除的导电材料。

49. 发明申请

US20060169326A1 MESOVALVE MODULATOR 失效
标题翻译： MESOVALVE调制器
公开(公告)号：US20060169326A1
公开(公告)日：2006-08-03
申请号：US10905995
申请日：2005-01-28
申请人： Eugen Cabuz , Cleopatra Cabuz , Claudiu Banu
发明人： Eugen Cabuz , Cleopatra Cabuz , Claudiu Banu
IPC分类号： G05D7/06
CPC分类号： F16K31/02 , F16K7/14 , Y10T137/0396 , Y10T137/7759 , Y10T137/7761 , Y10T137/785
摘要： A mesovalve having a diaphragm situated between a first chamber and a second chamber. There may be an inlet and an outlet in the first chamber. The diaphragm may provide an orifice between the first and second chambers. There may be a first electrode on the diaphragm and a second electrode on an inside surface of the second chamber. The diaphragm may have first and second positions, or numerous variable positions. Applying a voltage across the electrodes may electrostatically move the diaphragm to the second position during which the outlet is at least partially opened for fluid communication with the inlet, the orifice is closed and the diaphragm is stopped in the second position by a cushioning fluid pressure in the second cavity to prevent pull-in. Removing the voltage from the electrodes may let the diaphragm return to the first position, open the orifice and close the outlet.
摘要翻译：具有位于第一室和第二室之间的隔膜的中间阀。在第一室中可以有入口和出口。隔膜可以在第一和第二室之间提供孔口。隔膜上可以有第一电极，在第二室的内表面上可以有第二电极。隔膜可以具有第一和第二位置或多个可变位置。在电极两端施加电压可以将隔膜静电移动到第二位置，在该位置，出口至少部分打开以与入口流体连通，孔口关闭，隔膜通过缓冲流体压力在第二位置停止第二个腔防止拉入。从电极去除电压可能会使膜片返回到第一位置，打开孔口并关闭出口。

50. 发明申请

US20060161364A1 Calibrated pressure sensor 失效
标题翻译：校准压力传感器
公开(公告)号：US20060161364A1
公开(公告)日：2006-07-20
申请号：US11027289
申请日：2004-12-30
申请人： Tzu-Yu Wang , Cleopatra Cabuz , Eugen Cabuz , Stephen Shiffer , David Zook
发明人： Tzu-Yu Wang , Cleopatra Cabuz , Eugen Cabuz , Stephen Shiffer , David Zook
IPC分类号： G01L27/00 , G06F19/00
CPC分类号： G01L9/0072 , G01L27/002
摘要： A control system coupled to a pressure sensor calibrates the pressure sensor. The control system may measure a plurality of capacitance values at a plurality of corresponding applied voltages to compare the values with a first calibration mechanism generated by sample pressure sensors in a comparison. A final calibration mechanism may be generated by adjusting the first calibration mechanism in response to the comparison. The unknown differential pressure may be applied to a diaphragm of the pressure sensor. A capacitance value at the unknown differential pressure may then be measured. Using the final calibration mechanism, the differential pressure at the measured capacitance value may be retrieved.
摘要翻译：耦合到压力传感器的控制系统校准压力传感器。控制系统可以在多个对应的施加电压下测量多个电容值，以便在比较中将该值与由样品压力传感器产生的第一校准机构进行比较。可以通过响应于比较来调整第一校准机构来产生最终校准机构。未知的压差可以应用于压力传感器的隔膜。然后可以测量未知压差下的电容值。使用最终校准机构，可以检索测量的电容值的压差。

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