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41. 发明授权

US5804411A Polypeptide of protein P140 and DNAS encoding it 失效
标题翻译：蛋白质P140的多肽和编码它的DNAS
公开(公告)号：US5804411A
公开(公告)日：1998-09-08
申请号：US571785
申请日：1995-12-13
申请人： Hisao Tajima , Koichiro Kitagawa , Hiroyuki Ohno
发明人： Hisao Tajima , Koichiro Kitagawa , Hiroyuki Ohno
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N15/12 , C12P21/08 , C12P21/02 , C07H21/04 , C12N15/63
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector derived the said DNA; host cells transformed the said vector; antibody of the said polypeptide; pharmaceutical composition containing the said peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the said protein p140; agent for the prevention and/or treatment of diabetes, agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylate of protein p140, as active ingredient and the screening methods of the said prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention is not only to improve the diabetes-derived hypoglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).
摘要翻译：本发明涉及胰岛素信号传递系统中涉及的关键蛋白质的新型蛋白质p140多肽，制备方法编码所述多肽的DNA; 载体衍生所述DNA; 宿主细胞转化所述载体; 所述多肽的抗体; 含有所述肽或抗体的药物组合物; 用于预防和/或治疗糖尿病的方法，其特征在于所述蛋白质p140的酪氨酸磷酸化; 用于预防和/或治疗糖尿病的药剂，用于预防和/或治疗糖尿病的药剂，其特征在于含有可以将蛋白质p140的酪氨酸磷酸化的化合物作为活性成分，以及所述预防和/ 或治疗剂。蛋白质p140的酪氨酸磷酸化是通过葡萄糖摄取诱导低血糖的关键步骤。基于本发明的蛋白质p140的酪氨酸磷酸化的预防和/或治疗方法和药剂不仅可改善糖尿病衍生的低血糖状况，而且可用于治疗和/或预防糖尿病，特别是非胰岛素依赖性糖尿病（NIDDM）。

42. 发明授权

US5795890A Sulfonamide derivatives 失效
标题翻译：磺酰胺衍生物
公开(公告)号：US5795890A
公开(公告)日：1998-08-18
申请号：US718722
申请日：1996-09-24
申请人： Takahiko Nakae , Masashi Kato , Takehito Fujita , Kazuhito Kawabata , Hiroyuki Ohno
发明人： Takahiko Nakae , Masashi Kato , Takehito Fujita , Kazuhito Kawabata , Hiroyuki Ohno
IPC分类号： C07C311/29 , C07C311/64 , C07D203/24 , C07D207/48 , C07D209/42 , C07D211/96 , C07D235/22 , C07D263/38 , C07D277/56 , C07D295/26 , C07D307/68 , C07D309/10 , C07D333/24 , C07D491/10 , C07D521/00 , C07H5/10 , C07K5/078 , A61K31/535 , C07D413/12
CPC分类号： C07D295/26 , C07C311/29 , C07C311/64 , C07D203/24 , C07D207/48 , C07D209/42 , C07D211/96 , C07D231/12 , C07D233/56 , C07D235/22 , C07D249/08 , C07D263/38 , C07D277/56 , C07D307/68 , C07D309/10 , C07D333/24 , C07D491/10 , C07H5/10 , C07K5/06139 , C07K5/06165 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14
摘要： A sulfonamide derivatives of formula (I) ##STR1## a non-toxic salts, an acid addition salts or a solvates thereof which has an inhibitory effect on elastase.
摘要翻译：式（I）的磺酰胺衍生物（I）具有对弹性蛋白酶具有抑制作用的无毒盐，其酸加成盐或溶剂合物。

43. 发明授权

US5262431A Prolinal derivatives and pharmaceutical compositions thereof 失效
标题翻译：脯氨酸衍生物及其药物组合物
公开(公告)号：US5262431A
公开(公告)日：1993-11-16
申请号：US836971
申请日：1992-02-19
申请人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
发明人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
IPC分类号： C07D207/08 , A61K31/40 , C07D213/24
CPC分类号： C07D207/08
摘要： A novel prolinal derivative of general formula: ##STR1## [wherein A represents a group of the general formula: ##STR2## (wherein one of R.sup.1 and R.sup.2 represents hydrogen atom and the other represents alkyl group of from 2 to 5 carbon atoms, alkoxy group of from 1 to 5 carbon atom(s), phenyl group, benzyl group, cycloalkyl group of from 4 to 6 carbon atoms or (cycloalkyl group of from 4 to 6 carbon atoms)--methyl group or R.sup.1 and R.sup.2 each represents, same or different, alkyl group of from 1 to 4 carbon atom(s).) or a group of the general formula: ##STR3## (wherein m represents an integer of from 3 to 6.) n represents an integer of from 3 to 10.D represents carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three of halogen atom, nitro group, trifluoromethyl group, alkyl or alkoxy group of from 1 to 4 carbon atom(s).]possess inhibitory activity on prolyl endopeptidase, and therefore be useful for treating and/or preventing agent for amnesia.
摘要翻译：一种新型的通式为：其中A表示通式为：IMA的基团（其中R 1和R 2中的一个表示氢原子，另一个表示2至5个碳原子的烷基）原子，1〜5个碳原子的烷氧基，苯基，苄基，4〜6个碳原子的环烷基或（4〜6个碳原子的环烷基） - 甲基或者R 1和R 2各自表示相同或不同的1至4个碳原子的烷基）或下列通式的基团：其中m表示3至6的整数。n表示从 D表示未被取代或被1至3个卤素原子，硝基，三氟甲基，1至4个碳原子的烷基或烷氧基取代的碳环或杂环]具有对脯氨酰内肽酶的抑制活性，因此可用于治疗和/或预防健忘症药物。

44. 发明授权

US5160740A Macromolecular endoplasmic reticulum 失效
标题翻译：大分子内生真菌
公开(公告)号：US5160740A
公开(公告)日：1992-11-03
申请号：US515955
申请日：1990-04-27
申请人： Etsuo Hasegawa , Shinji Takeoka , Hiroyuki Ohno , Hiroyuki Nishide , Eishun Tsuchida
发明人： Etsuo Hasegawa , Shinji Takeoka , Hiroyuki Ohno , Hiroyuki Nishide , Eishun Tsuchida
IPC分类号： A61K9/00 , A61K9/127
CPC分类号： A61K9/0026 , A61K9/1273
摘要： The present invention relates to a micromolecular endoplasmic reticulum which comprises a polymer obtained by polymerization of a mixture containing one or more polymerizable phospholipids, cholesterol and one or more polymerizable fatty acid. The macromolecular endoplasmic reticulum in which surface charge is fixed to negative can be used as a carrier of medicine, enzyme, hemoglobin, etc. in industrial fields or medical fields.

45. 发明授权

US5091406A Prolinal derivatives 失效
标题翻译：乳制品
公开(公告)号：US5091406A
公开(公告)日：1992-02-25
申请号：US479493
申请日：1990-02-07
申请人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
发明人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
IPC分类号： C07D207/08
CPC分类号： C07D207/08
摘要： A prolinal derivative of general formula: ##STR1## [wherein A represents alkylene group of from 1 to 4 carbon atom(s) or saturated hydrocarbon ring of from 3 to 7 carbon atoms,n represents a number 2, 3 or 4,D represents carbocyclic or heterocyclic ring unsubstituted orsubstituted by from one to three of halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), nitro group or trifluoromethyl group.]. possess inhibitory activity on prolyl endopeptidase, and therefore be useful for treating and/or preventing agent for amnesia.

46. 发明授权

US4977180A Novel prolinal derivatives 失效
标题翻译：新颖的流涎衍生物
公开(公告)号：US4977180A
公开(公告)日：1990-12-11
申请号：US151862
申请日：1988-02-03
申请人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
发明人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
IPC分类号： C07D207/08
CPC分类号： C07D207/08
摘要： A novel prolinal derivative of general formula: ##STR1## wherein A represents alkylene group of from 1 to 4 carbon atom(s) or saturated hydrocarbon ring of from 3 to 7 carbon atoms, n represents a number 2, 3 or 4, D represents carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three of halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), nitro group or trifluromethyl group posses inhibitory activity on prolyl endopeptidase, and therefore are useful for treating and/or preventing agent for amnesia.

47. 发明授权

US4956380A Prolinal compounds useful in treating amnesia 失效
标题翻译：可用于治疗遗忘症的肛门化合物
公开(公告)号：US4956380A
公开(公告)日：1990-09-11
申请号：US123410
申请日：1987-11-20
申请人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
发明人： Masaaki Toda , Shuichi Ohuchida , Hiroyuki Ohno
IPC分类号： A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61P25/28 , C07D207/08 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号： C07D207/08 , C07D405/12
摘要： Novel prolinal derivatives of the general formula: ##STR1## wherein A represents alkylene group of from 1 to 8 carbon atoms or alkenylene group of from 2 to 8 carbon atom(s) or a saturated hydrocarbon ring of from 3 to 7 carbon atoms, R represents hydrogen atom, phenyl group, benzyl group, alkyl group of from 1 to 8 carbon atom(s) or cycloalkyl group of from 3 to 7 carbon atoms,B represents alkylene group of from 1 to 8 atom(s) unsubstituted or substituted by phenyl group or benzyl group, or a single bond,D represents carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three of halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), nitro group or trifluoromethyl group which prolinal derivatives possess inhibitory activity on prolyl endopeptidase, and therefore are useful as a treating or preventing agent for amnesia.

48. 发明申请

US20130233505A1 CONTINUOUS CASTING METHOD FOR STEEL AND METHOD FOR MANUFACTURING STEEL SHEET 有权
标题翻译：钢的连续铸造方法和制造钢板的方法
公开(公告)号：US20130233505A1
公开(公告)日：2013-09-12
申请号：US13583487
申请日：2011-03-09
申请人： Yuji Miki , Takeshi Murai , Hiroyuki Ohno
发明人： Yuji Miki , Takeshi Murai , Hiroyuki Ohno
IPC分类号： B22D11/103
CPC分类号： B22D11/103 , B21B1/22 , B22D11/115 , B22D11/122 , C22C38/06 , C22C38/12 , C22C38/14
摘要： In a method for continuously casting an extremely low carbon steel using a continuous casting machine, by adjusting the chemical components of extremely low carbon steel within a specified range by taking into account an interface tension gradient in a concentration boundary layer on a front surface of a solidified shell, and also by optimizing intensities of the DC magnetic fields applied to the upper magnetic poles and the lower magnetic poles respectively corresponding to a slab width of a slab to be casted and a casting speed, it is possible to acquire the slab having high quality not only with the small number of defects caused by the entrainment of bubbles, non-metallic inclusion and a mold flux into the molten steel.
摘要翻译：在使用连续铸造机连续铸造极低碳钢的方法中，通过考虑到在特定范围内的浓度边界层的界面张力梯度，将极低碳钢的化学成分调整到规定范围内固化壳，并且通过优化分别对应于要铸造的板坯的板坯宽度和铸造速度的上磁极和下磁极施加的DC磁场的强度，可以获得具有高的质量不仅具有由于气泡夹带，非金属夹杂物和模具通量进入钢水引起的少量缺陷。

49. 发明授权

US07569608B2 Pentanoic acid derivatives 失效
标题翻译：戊酸衍生物
公开(公告)号：US07569608B2
公开(公告)日：2009-08-04
申请号：US11192002
申请日：2005-07-29
申请人： Shuichi Ohuchida , Kazuo Kishimoto , Narito Tateishi , Hiroyuki Ohno
发明人： Shuichi Ohuchida , Kazuo Kishimoto , Narito Tateishi , Hiroyuki Ohno
IPC分类号： A61K31/19 , A61K31/192 , A61K31/20
CPC分类号： C07D213/75 , A61K31/19 , C07C53/21 , C07C69/612 , C07C69/63 , C07C69/708 , C07C233/05 , C07C233/11 , C07C233/25 , C07C233/47 , C07C233/54 , C07C323/52 , C07D295/185
摘要： Formula (I) compounds: wherein R1 is alkyl substituted by fluorine(s); R2 is hydroxy, alkoxy, alkoxy substituted by phenyl, NR3R4, in which R3, R4 is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R3 and R4, taken together is a saturated heterocyclic ring or amino acid residue; and non-toxic salts and acid addition salts thereof. Also, Formula (X) compounds: wherein n is 0 or 1, R11 is hydrogen and chlorine, R5 is R7—CH2— or R8, or R5 and R11, taken together is alkylidene; R6 is hydroxy, alkoxy, alkoxy substituted by phenyl, NR9R10, in which R9, R10 is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl-substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R9 and R10, taken together is a saturated heterocyclic ring or amino acid residue, R7 is (i) F—(CH2)m- or F3C—CH2—, (ii) alkyl substituted by chlorine, (iii) alkyl substituted by alkoxy, cycloalkyl, phenyl, phenoxy; R8 is alkyl, alkenyl, alkoxy, alkylthio, cycloalkyl, phenyl, phenoxy. Non-toxic and acid addition salts thereof are useful to prevent and/or treat neurodegenerative disease (e.g., Alzheimer's) and neuronal dysfunction by stroke or traumatic injury (e.g., Multiple sclerosis).
摘要翻译：式（I）化合物：其中R1是被氟取代的烷基; R2是羟基，烷氧基，被苯基取代的烷氧基，NR3R4，其中R3，R4是（i）氢，（ii）烷基，（iii）苯基，（iv）被烷氧基或羧基取代的苯基，（v）氮原子，（vi）被苯基取代的烷基，被烷氧基或羧基取代的苯基，含氮原子的杂环，（vii）与R3和R4键合的氮原子一起是饱和杂环或氨基酸残基; 及其无毒盐及其酸加成盐。另外，式（X）化合物：其中n为0或1，R11为氢和氯，R5为R7-CH2-或R8，或R5和R11为亚烷基; R6是羟基，烷氧基，被苯基取代的烷氧基，NR9R10，其中R9，R10是（i）氢，（ii）烷基，（iii）苯基，（iv）被烷氧基或羧基取代的苯基，（v）氮原子，（vi）被苯基取代的烷基，被烷氧基或羧基取代的苯基，含氮原子的杂环，（vii）与R 9和R 10结合的氮一起是饱和的杂环或氨基酸残基，R7是（ⅰ）F-（CH2）m-或F3C-CH2-，（ⅱ）被氯取代的烷基，（ⅲ）被烷氧基，环烷基，苯基，苯氧基取代的烷基; R8是烷基，烯基，烷氧基，烷硫基，环烷基，苯基，苯氧基。其无毒和酸加成盐可用于预防和/或治疗神经变性疾病（例如阿尔茨海默氏症）和神经元功能障碍（卒中或创伤性损伤（例如多发性硬化））。

50. 发明申请

US20070191612A1 Novel imidazolium compound 失效
标题翻译：新型咪唑鎓化合物
公开(公告)号：US20070191612A1
公开(公告)日：2007-08-16
申请号：US10590549
申请日：2005-02-24
申请人： Hiroyuki Ohno , Tomonobu Mizumo , Masahiro Yoshida , Takayoshi Suga
发明人： Hiroyuki Ohno , Tomonobu Mizumo , Masahiro Yoshida , Takayoshi Suga
IPC分类号： C07D233/56 , C07D233/58
CPC分类号： H01M10/0569 , C07D233/56 , H01M10/052
摘要： A novel imidazolium compound represented by the following general formula (I), which has an allyl group incorporated in the 3-position of the imidazolium ring. It needs no complicated operations for dissolution and has excellent handleability and a high ionic conductivity.
摘要翻译：一种由以下通式（I）表示的咪唑鎓化合物，其具有并入咪唑鎓环的3位的烯丙基。不需要复杂的溶解操作，具有优异的操作性和高离子电导率。

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