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41. 发明授权

US09316450B2 Heat exchanger and method for manufacturing a heat exchanger 有权
标题翻译：热交换器和制造热交换器的方法
公开(公告)号：US09316450B2
公开(公告)日：2016-04-19
申请号：US13528490
申请日：2012-06-20
申请人： Martin Engelhardt , Stefan Hirsch , Lars Ludwig , Florin Moldovan
发明人： Martin Engelhardt , Stefan Hirsch , Lars Ludwig , Florin Moldovan
IPC分类号： H01M10/613 , H01M10/625 , H01M10/66 , F28F9/02 , F28F9/14 , F28D1/053 , F28F1/00 , F28F1/22
CPC分类号： F28F9/02 , F28D1/05366 , F28F1/00 , F28F1/22 , F28F9/14 , F28F2255/16 , H01M10/613 , H01M10/625 , H01M10/66 , Y10T29/4935
摘要： A heat exchanger is provided having a tube block having a plurality of essentially parallel tubes for carrying a temperature control fluid, wherein at least the ends of the tubes are connected to one another. In addition, the heat exchanger comprises at least one header box that is designed to receive a temperature control fluid from the tubes, wherein the at least one header box has an inside height that corresponds within a tolerance range to the height of the ends of the tubes and wherein the header box is placed over the ends of the tubes and is joined thereto in a material-to-material fashion.
摘要翻译：提供一种热交换器，其具有管块，该管块具有用于承载温度控制流体的多个基本上平行的管，其中至少管的端部彼此连接。另外，热交换器包括至少一个集管箱，其被设计成从管接收温度控制流体，其中至少一个集管箱具有内部高度，所述内部高度在与所述管的端部的高度相对应的公差范围内管，并且其中集管箱被放置在管的端部上并且以材料对材料方式与其连接。

42. 发明授权

US08985193B2 Heat exchanger 有权
标题翻译：热交换器
公开(公告)号：US08985193B2
公开(公告)日：2015-03-24
申请号：US13401482
申请日：2012-02-21
申请人： Stefan Hirsch , Kurt Molt , Uwe Foerster
发明人： Stefan Hirsch , Kurt Molt , Uwe Foerster
IPC分类号： F28F9/02
CPC分类号： F28F9/0224 , F28F2275/12 , Y10T29/49389
摘要： A heat exchanger having at least one collecting tank which extends in a longitudinal direction and which comprises a plate and a cover, wherein the plate has, at least one of its edge regions running in the longitudinal direction, a rim by means of which the plate engages at the outside over an edge region, which runs in the longitudinal direction, of the cover, or wherein the cover has, at least one of its edge regions running in the longitudinal direction, a rim by means of which the cover engages at the outside over an edge region, which runs in the longitudinal direction, of the plate. The respective rim have, in the longitudinal direction, a multiplicity of calked portions by means of which said rim, in the region of each individual calked portion, is deformed in the plate and the cover to one another.
摘要翻译：一种热交换器，具有至少一个沿纵向方向延伸并且包括板和盖的收集罐，其中所述板具有沿着纵向方向延伸的边缘区域中的至少一个边缘，借助于该边缘板，在外侧上在盖的纵向方向上延伸的边缘区域上接合，或者其中盖子具有沿纵向方向延伸的边缘区域中的至少一个，边缘通过盖子接合在该边缘区域在板的纵向方向上延伸的边缘区域外侧。相应的边缘在纵向方向上具有多个凹口部分，通过该部分，所述边缘在每个单独的凹口部分的区域中在板和盖彼此变形。

43. 发明授权

US08034929B2 Continuous method for producing highly methylolated melamine and etherified melamine formaldehyde resins 有权
标题翻译：用于生产高度羟甲基化的三聚氰胺和醚化的三聚氰胺甲醛树脂的连续方法
公开(公告)号：US08034929B2
公开(公告)日：2011-10-11
申请号：US10586580
申请日：2005-01-13
申请人： Jörg Schneider , Günter Scherr , Rainer Erhardt , Andreas Eichfelder , Martin Reif , Stefan Hirsch , Hans Schupp , Christel Hittinger , Alain Robert
发明人： Jörg Schneider , Günter Scherr , Rainer Erhardt , Andreas Eichfelder , Martin Reif , Stefan Hirsch , Hans Schupp , Christel Hittinger , Alain Robert
IPC分类号： C07D251/64
CPC分类号： C07D251/64
摘要： The invention relates to a process for preparing polymethylolated melamine and polymethylolated melamine compounds polyetherified with alkanol, wherein the methylolation reaction is carried out in a kneading reactor.
摘要翻译：本发明涉及一种制备多羟基化三聚氰胺和用链烷醇多醚化的多羟甲基化三聚氰胺化合物的方法，其中甲基化反应在捏合反应器中进行。

44. 发明申请

US20100197804A1 PHARMACEUTICAL COMPOSITIONS COMPRISING TERBINAFINE 审中-公开
标题翻译：包含酪氨酸蛋白酶的药物组合物
公开(公告)号：US20100197804A1
公开(公告)日：2010-08-05
申请号：US12758145
申请日：2010-04-12
申请人： Stefan Hirsch , Dieter Becker , Patrice Guitard , Andreas Carl Eugster
发明人： Stefan Hirsch , Dieter Becker , Patrice Guitard , Andreas Carl Eugster
IPC分类号： A61K31/137 , C07C211/30 , A61P31/10
CPC分类号： A61K9/2009 , A61K31/137
摘要： Pharmaceutical compositions for oral administration comprising terbinafine, a buffering component and a disintegrant. The compositions show rapid disintegration and having taste-masking properties.
摘要翻译：用于口服给药的药物组合物，包括特比萘芬，缓冲组分和崩解剂。组合物显示快速崩解并具有掩味性质。

45. 发明申请

US20100113693A1 Continuous method for producing highly methylolated melamine and etherified melamine formaldehyde resins 有权
标题翻译：用于生产高度羟甲基化的三聚氰胺和醚化的三聚氰胺甲醛树脂的连续方法
公开(公告)号：US20100113693A1
公开(公告)日：2010-05-06
申请号：US10586580
申请日：2005-01-13
申请人： Jörg Schneider , Günter Scherr , Rainer Erhardt , Andreas Eichfelder , Martin Reif , Stefan Hirsch , Hans Schupp , Christel Hittinger , Alain Robert
发明人： Jörg Schneider , Günter Scherr , Rainer Erhardt , Andreas Eichfelder , Martin Reif , Stefan Hirsch , Hans Schupp , Christel Hittinger , Alain Robert
IPC分类号： C08G8/28 , C08G12/32 , C08G63/91
CPC分类号： C07D251/64
摘要： The invention relates to a process for preparing polymethylolated melamine and polymethylolated melamine compounds polyetherified with alkanol, wherein the methylolation reaction is carried out in a kneading reactor.
摘要翻译：本发明涉及一种制备多羟基化三聚氰胺和用链烷醇多醚化的多羟甲基化三聚氰胺化合物的方法，其中甲基化反应在捏合反应器中进行。

46. 发明申请

US20080306261A1 Process For Treating a Reaction Mixture Comprising Alkoxycarbonylaminotriazine 审中-公开
标题翻译：用于处理包含烷氧基氨基三嗪的反应混合物的方法
公开(公告)号：US20080306261A1
公开(公告)日：2008-12-11
申请号：US11916626
申请日：2006-06-02
申请人： Jörg Schneider , Gunter Scherr , Rainer Erhardt , Andreas Eichfelder , Martin Reif , Stefan Hirsch , Georg Sieder , Thomas Holtmann , Jurgen Ciprian , Hermann Ascherl
发明人： Jörg Schneider , Gunter Scherr , Rainer Erhardt , Andreas Eichfelder , Martin Reif , Stefan Hirsch , Georg Sieder , Thomas Holtmann , Jurgen Ciprian , Hermann Ascherl
IPC分类号： C07D251/48
CPC分类号： C07D251/70
摘要： Processes comprising: providing an alkanolic reaction mixture, the alkanolic reaction mixture comprising: at least one alkoxycarbonylaminotriazine; at least one carbonic ester; at least one C1-C13-alkanol, which alkanol may further comprise up to two ether-bound oxygen atoms and may further comprise a substituent selected from the group consisting of C1-C4-alkyls and hydroxyls; and at least one alkali metal alkoxide or alkaline earth metal alkoxide; and subjecting the alkanolic reaction mixture to extraction with a polar extractant such that at least a portion of polar/ionic components present in the reaction mixture are removed, wherein the polar extractant is less than entirely miscible with an organic phase of the reaction mixture, to form an alkanolic phase comprising the at least one alkoxycarbonylaminotriazine and a polar phase comprising the polar extractant and the portion of polar/ionic components; and wherein the extraction is carried out with one or more selected from the group consisting of mixer/settler units, columns, centrifugal field separation extractors, and combinations thereof.
摘要翻译：方法包括：提供烷醇反应混合物，所述链烷醇反应混合物包含：至少一种烷氧基羰基氨基三嗪; 至少一个碳酸酯; 至少一种C1-C13-链烷醇，该链烷醇还可包含至多两个醚结合的氧原子，并且还可包含选自C 1 -C 4 - 烷基和羟基的取代基; 和至少一种碱金属醇盐或碱土金属醇盐; 并用极性萃取剂对链烷醇反应混合物进行萃取，使得除去反应混合物中存在的至少一部分极性/离子组分，其中极性萃取剂与反应混合物的有机相完全混溶，至形成包含至少一种烷氧基羰基氨基三嗪和极性相的链烷醇相，所述极性相包含极性萃取剂和部分极性/离子组分; 并且其中所述萃取用选自混合器/沉降器单元，塔，离心场分离提取器及其组合的一种或多种进行。

47. 发明申请

US20080107613A1 Pharmaceutical composition comprising a macrolide t-cell immunomodulator and anti-photoaging agent 审中-公开
标题翻译：药物组合物，其包含大环内酯类T细胞免疫调节剂和抗光老化剂
公开(公告)号：US20080107613A1
公开(公告)日：2008-05-08
申请号：US11666793
申请日：2005-11-14
申请人： Thomas Hultsch , Carle Paul , Nablia Sekkat , Stefan Hirsch
发明人： Thomas Hultsch , Carle Paul , Nablia Sekkat , Stefan Hirsch
IPC分类号： A61K31/4745 , A61K38/46 , A61K8/64
CPC分类号： A61K8/49 , A61K31/125 , A61K31/355 , A61K31/436 , A61K33/24 , A61Q19/08 , A61K2300/00
摘要： Compositions are provided comprising a macrolide T-cell immunomodulator or immunosuppressant agent, e.g. pimecrolimus, and at least one anti-photoaging agent such as a sunscreen, an anti-oxidant or a DNA-repair enzyme.They are useful in particular in the curative treatment or prevention of dermatological diseases and of conditions where it is desired to inhibit the skin aging effects of light radiation such as UV-A and UV-B light, e.g. development of skin cancer.
摘要翻译：提供了包含大环内酯T细胞免疫调节剂或免疫抑制剂的组合物，例如。吡美莫司和至少一种抗光老化剂如防晒剂，抗氧化剂或DNA修复酶。它们特别可用于治疗或预防皮肤病和期望抑制诸如UV-A和UV-B光等光辐射的皮肤老化作用的条件，例如，皮肤癌的发展。

48. 发明申请

US20070276004A1 Pharmaceutical Composition Comprising an Immunosuppressant for Use in the Treatment of Skin Diseases 审中-公开
标题翻译：包含用于治疗皮肤疾病的免疫抑制剂的药物组合物
公开(公告)号：US20070276004A1
公开(公告)日：2007-11-29
申请号：US10550357
申请日：2004-04-02
申请人： Stefan Hirsch , Friedrich Mayer , Carle Paul , Nabila Sekkat , Carl-Martin Weiss
发明人： Stefan Hirsch , Friedrich Mayer , Carle Paul , Nabila Sekkat , Carl-Martin Weiss
IPC分类号： A61K31/445 , A61P17/00
CPC分类号： A61K9/0014 , A61K31/435 , A61K31/436 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/44 , A61K2300/00
摘要： Synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and an emollient such as dimethicone, glycerol or isostearyl isostearate are provided, which are useful in particular in the treatment of dermatological or mucosal diseases such as dry skin or atopic or contact dermatitis.
摘要翻译：提供大环内酯T细胞免疫调节剂或免疫抑制剂如33-表氯-3-脱氧菌丝霉素和软化剂如二甲聚硅氧烷，甘油或异硬脂基异硬脂酸酯的协同组合，其特别用于治疗皮肤病学或粘膜疾病如干皮肤或特应性或接触性皮炎。

49. 发明申请

US20070021377A1 Pharmaceutical composition comprising a macrolide immunomodulator 审中-公开
标题翻译：包含大环内酯类免疫调节剂的药物组合物
公开(公告)号：US20070021377A1
公开(公告)日：2007-01-25
申请号：US10550356
申请日：2004-04-02
申请人： Maximilian Grassberger , Stefan Hirsch , Friedrich Mayer , Nabila Sekkat , Anton Stutz
发明人： Maximilian Grassberger , Stefan Hirsch , Friedrich Mayer , Nabila Sekkat , Anton Stutz
IPC分类号： A61K31/739 , A61K31/395 , A61K31/202
CPC分类号： A61K31/164 , A61K39/39 , A61K2300/00
摘要： Snyergistic combination of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and a ceramide such as ceramide 3, LPC-9S or linoleic acid are provided, which are useful in particular in the treatment of dermatological or mucosal diseases such as atopic or contact dermatitis or dry skin, asteatotic eczema or xerosis.
摘要翻译：提供大环内酯类T细胞免疫调节剂或免疫抑制剂如33-表氯-3-脱氧菌丝霉素和神经酰胺如神经酰胺3，LPC-9S或亚油酸的综合组合，其特别用于治疗皮肤病学或粘膜疾病如特应性或接触性皮炎或干性皮肤，硬皮病湿疹或干性病。

50. 外观设计

USD530814S1 Combined capsule and tablets 有权
标题翻译：胶囊和片剂组合
公开(公告)号：USD530814S1
公开(公告)日：2006-10-24
申请号：US29252244
申请日：2006-01-20
申请人： Jean-Daniel Bonny , Stefan Hirsch , Oskar Kalb , Peter Pietzonka
设计人： Jean-Daniel Bonny , Stefan Hirsch , Oskar Kalb , Peter Pietzonka

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