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    • 44. 发明授权
    • Method for preparing sulphostin and analogue thereof or preparation intermediate thereof
    • 磺普钠及其类似物的制备方法或其制备方法
    • US07531657B2
    • 2009-05-12
    • US10498272
    • 2002-12-16
    • Masashi NagaiHiroko YamazakiKeiichirou YamamotoMasatoshi Abe
    • Masashi NagaiHiroko YamazakiKeiichirou YamamotoMasatoshi Abe
    • C07F9/00C07F9/02C07D205/08C07D223/12
    • C07C215/30C07B2200/07C07F9/5532C07F9/568C07F9/572C07F9/59Y02P20/55
    • A method for preparing a compound represented by the following general formula (5) where, n is an integer of 0 to 3; and Y represents a protecting group for an amino group, the method including the steps of reacting a compound represented by the following general formula (3) where n and Y are as described above, with a silylating agent, and subsequently reacting it with P (═O) T3, where T represents a halogen atom, and further with ammonia. A method for preparing an optically active intermediate of sulphostin or an analogue thereof, which is an optically active amine salt of an optically active compound represented by the following general formula (8) where n is integer of 0 to 3; Y represents protecting group for the amino group; and each configuration at C* and P* may be the same or different and indicates S or R, the method including reacting a compound represented by the following general formula (7) where n and Y are as described above; and the configuration of C* indicates either of S or R, with an optically active amine, and resolving the formed diastereomeric salt by fractional crystallization.
    • 一种制备由以下通式(5)表示的化合物的方法,其中n为0-3的整数; Y表示氨基的保护基,该方法包括使下述通式(3)表示的化合物(其中n和Y如上所述)与甲硅烷基化剂反应,然后使其与P( -O)T3,其中T表示卤素原子,并且还含有氨。 一种制备光学活性中间体磺酸钠或其类似物的方法,它是由以下通式(8)表示的光学活性化合物的光学活性胺盐,其中n为0-3的整数; Y表示氨基的保护基; 并且C *和P *的每个构型可以相同或不同,表示S或R,该方法包括使由以下通式(7)表示的化合物,其中n和Y如上所述; 并且C *的构型表示S或R中的任一个与光学活性胺,并且通过分级结晶拆分形成的非对映体盐。
    • 47. 发明申请
    • Test kit
    • 测试套件
    • US20060211047A1
    • 2006-09-21
    • US11304800
    • 2005-12-14
    • Minami MutsuhikoHiroko Yamazaki
    • Minami MutsuhikoHiroko Yamazaki
    • G01N33/53G01N33/00
    • G01N33/6863G01N2800/122
    • It is an object of the present invention to significantly improve the treatment efficiency of bronchial asthma by intervening with inhaled steroids or the like and discontinuing the intervention at the most appropriate times respectively on the basis of accurately and objectively grasping the pathologic condition of an asthma patient among others. To achieve the above object, the present invention provides a method for inspecting the condition of a disease derived from a test sample by measuring the amounts of cytokines (IL-5, IL-6, IL-8, IL-10, TNF-α, IL-1β, IFN-γ, etc.) and/or chemokines in the test sample, and also a test kit for inspecting the condition of the disease, the test kit comprising a checking means for measuring the amounts of the cytokines in the test sample based on the method, a means for placing the test sample, and a means for allowing the test sample to access the checking means.
    • 本发明的目的是通过干预吸入类固醇等来显着提高支气管哮喘的治疗效率,并且在准确和客观地掌握哮喘患者的病理状况的基础上分别停止最适合的时间的干预 等等 为了实现上述目的,本发明提供了一种通过测量细胞因子(IL-5,IL-6,IL-8,IL-10,TNF-α)的量来检测来自测试样品的疾病状况的方法 ,IL-1β,IFN-γ等)和/或趋化因子,以及用于检查疾病状况的测试试剂盒,该测试试剂盒包括用于测量所述疾病的细胞因子的量的检查装置 基于该方法的测试样本,放置测试样本的装置以及允许测试样本访问检查装置的装置。
    • 49. 发明申请
    • Method for preparation of sulphostin and its analogue or intermediates thereof
    • 磺普钠及其类似物或其中间体的制备方法
    • US20050020834A1
    • 2005-01-27
    • US10498272
    • 2002-12-16
    • Masashi NagaiHiroko YamazakiKeichirou YamamotoMasatoshi Abe
    • Masashi NagaiHiroko YamazakiKeichirou YamamotoMasatoshi Abe
    • C07C215/30C07F9/553C07F9/568C07F9/572C07F9/59C07F9/547
    • C07C215/30C07B2200/07C07F9/5532C07F9/568C07F9/572C07F9/59Y02P20/55
    • A method for preparing a compound represented by the following general formula (5) where, n is an integer of 0 to 3; and Y represents a protecting group for an amino group, the method including the steps of reacting a compound represented by the following general formula (3) where n and Y are as described above, with a silylating agent, and subsequently reacting it with P (═O) T3, where T represents a halogen atom, and further with ammonia. A method for preparing an optically active intermediate of sulphostin or an analogue thereof, which is an optically active amine salt of an optically active compound represented by the following general formula (8) where n is an integer of 0 to 3; Y represents a protecting group for the amino group; and each configuration at C* and P* may be the same or different and indicates S or R, the method including reacting a compound represented by the following general formula (7) where n and Y are as described above; and the configuration of C* indicates either of S or R, with an optically active amine, and resolving the formed diastereomeric salt by fractional crystallization.
    • 一种制备由以下通式(5)表示的化合物的方法,其中n为0-3的整数; Y表示氨基的保护基,该方法包括使下述通式(3)表示的化合物(其中n和Y如上所述)与甲硅烷基化剂反应,然后使其与P( = O)T3,其中T表示卤素原子,并且还含有氨。 一种制备磺普钠或其类似物的光学活性中间体的方法,其为由以下通式(8)表示的光学活性化合物的光学活性胺盐,其中n为0-3的整数; Y表示氨基的保护基; 并且C *和P *的每个构型可以相同或不同,表示S或R,该方法包括使由以下通式(7)表示的化合物,其中n和Y如上所述; 并且C *的构型表示S或R中的任一个与光学活性胺,并且通过分级结晶拆分形成的非对映体盐。