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41. 发明申请

US20090023755A1 USE OF ISTRADEFYLLINE FOR TREATING BEHAVIORAL DISORDERS 审中-公开
标题翻译：用于治疗行为障碍的ISTRADEFLLLINE的使用
公开(公告)号：US20090023755A1
公开(公告)日：2009-01-22
申请号：US12239955
申请日：2008-09-29
申请人： Shizuo Shiozaki , Junichi Shimada , Hiroshi Kase , Mayumi Shindo
发明人： Shizuo Shiozaki , Junichi Shimada , Hiroshi Kase , Mayumi Shindo
IPC分类号： A61K31/522 , A61P25/20 , A61P25/14
CPC分类号： A61K31/52 , A61K31/522
摘要： The present invention provides a method of treating behavioral disorders such as attention deficit hyperactivity disorder, comprising administering an effective amount of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methylxanthine or a pharmaceutically acceptable salt thereof to a patient in need thereof and the like.
摘要翻译：本发明提供治疗诸如注意缺陷多动障碍的行为障碍的方法，其包括给予有效量的（E）-8-（3,4-二甲氧基苯乙烯基）-1,3-二乙基-7-甲基黄嘌呤或其药学上可接受的其盐给有需要的患者等。

42. 发明申请

US20060241102A1 Medicinal compositions 有权
标题翻译：药用成分
公开(公告)号：US20060241102A1
公开(公告)日：2006-10-26
申请号：US10565239
申请日：2004-07-22
申请人： Hiroshi Kase , Minoru Kobayashi , Shizuo Shiozaki , Akihisa Mori , Naoki Seno
发明人： Hiroshi Kase , Minoru Kobayashi , Shizuo Shiozaki , Akihisa Mori , Naoki Seno
IPC分类号： A61K31/551 , A61K31/5415 , A61K31/496 , A61K31/522
CPC分类号： A61K31/522 , A61K31/137 , A61K31/138 , A61K31/16 , A61K31/335 , A61K31/343 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/435 , A61K31/4525 , A61K31/496 , A61K31/52 , A61K31/5375 , A61K31/55 , A61K31/553 , A61K45/06 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions, which are useful for treatment of depression and the like, and which comprises a compound having an adenosine A2A receptor antagonistic activity such as (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione or a pharmaceutically acceptable salt thereof and an antidepressant drug (for example, a tricyclic antidepressant, a tetracyclic antidepressant, a selective serotonin reuptake inhibitor, a selective noradrenalin reuptake inhibitor, a dopamine reuptake inhibitor, a serotonin-noradrenalin reuptake inhibitor, a monoamine oxidase inhibitor, a 5-HT2 antagonist or the like), and the like.
摘要翻译：本发明提供了可用于治疗抑郁症等的药物组合物，其包含具有腺苷A 2A受体拮抗活性的化合物，例如（E）-8-（3,4 - 二甲氧基苯乙烯基）-1,3-二乙基-7-甲基-3,7-二氢-1H-嘌呤-2,6-二酮或其药学上可接受的盐和抗抑郁药（例如，三环抗抑郁药，四环抗抑郁药，选择性5-羟色胺再摄取抑制剂，选择性去甲肾上腺素再摄取抑制剂，多巴胺再摄取抑制剂，5-羟色胺去甲肾上腺素再摄取抑制剂，单胺氧化酶抑制剂，5-HT 2拮抗剂等），以及喜欢。

43. 发明申请

US20060148827A1 Methods of treating patients suffering from movement disorders 有权
标题翻译：治疗运动障碍患者的方法
公开(公告)号：US20060148827A1
公开(公告)日：2006-07-06
申请号：US11326516
申请日：2006-01-06
申请人： Hiroshi Kase , Akihisa Mori , Yutaka Waki , Yutaka Ohsawa , Akira Karasawa , Yoshihisa Kuwana
发明人： Hiroshi Kase , Akihisa Mori , Yutaka Waki , Yutaka Ohsawa , Akira Karasawa , Yoshihisa Kuwana
IPC分类号： A61K31/522 , A61K31/198 , A61K31/137
CPC分类号： A61K31/522 , A61K9/0019 , A61K9/20 , A61K9/48 , A61K31/198 , A61K45/06
摘要： The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A2A receptor antagonists to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of L-DOPA in patients receiving L-DOPA therapy in the treatment of Parkinson's disease. The present invention further provides methods and compositions for treating Parkinson's disease patients with sub-clinically effective doses of L-DOPA by combining L-DOPA treatment with an effective amount of one or more adenosine A2A receptor antagonists (i.e., L-DOPA sparing effect). The present invention further provides methods of effective treatment of Parkinson's disease by co-administering at least one adenosine A2A receptor antagonist, L-DOPA and a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor. The present invention further provides methods of prolonging effective treatment of Parkinson's disease by administering an adenosine A2A receptor antagonist singly or together with a dopamine agonist, and/or a COMT inhibitor, and/or a MAO inhibitor without prior or subsequent administration of L-DOPA, delaying or removing on-set of L-DOPA motor complication.
摘要翻译：本发明涉及通过向有需要的患者施用有效量的一种或多种腺苷A 2A 2受体拮抗剂来治疗运动障碍的方法。本发明还提供降低L-DOPA在接受L-DOPA治疗的帕金森病治疗中的不良反应的方法。本发明进一步提供了通过将L-DOPA治疗与有效量的一种或多种腺苷A 2A受体拮抗剂组合（用于治疗患有亚临床有效剂量的L-DOPA）的帕金森病患者的方法和组合物即L-DOPA保护作用）。本发明还提供了通过共同施用至少一种腺苷A 2A受体拮抗剂，L-DOPA和多巴胺激动剂和/或COMT抑制剂和/或MAO来有效治疗帕金森病的方法抑制剂。本发明还提供了通过单独或与多巴胺激动剂和/或COMT抑制剂和/或MAO抑制剂一起施用腺苷A 2A受体拮抗剂而延长帕金森病有效治疗的方法，而没有之前或之后的L-DOPA给药，延迟或去除L-DOPA运动并发症。

44. 发明申请

US20050219980A1 Data recording and reproducing apparatus, data recording and reproducing method and recording medium 审中-公开
标题翻译：数据记录和再现装置，数据记录和再现方法以及记录介质
公开(公告)号：US20050219980A1
公开(公告)日：2005-10-06
申请号：US11083266
申请日：2005-03-17
申请人： Hiroshi Kase , Yoshiho Gotoh , Harutoshi Miyamoto
发明人： Hiroshi Kase , Yoshiho Gotoh , Harutoshi Miyamoto
IPC分类号： G11B20/12 , G11B20/18 , G11B27/36 , G11B5/09
CPC分类号： G11B20/18 , G11B20/12 , G11B27/36
摘要： To record video data or audio data on an optical disc on which a defective area exists, there is a method of determining an allowable number of defects in proportion to a recording size and skipping the defective area to use an adjacent area thereto. This method has a problem that the size of the recording area becomes larger by an equivalent of the skipped defective area so as to take a longer time for recording a file, and so convenience for a user is damaged. The size of the defective area allowed in a recording area is limited regardless of the size of the recording area.
摘要翻译：为了在存在缺陷区域的光盘上记录视频数据或音频数据，存在与记录尺寸成比例地确定允许的缺陷数量并跳过缺陷区域以使用相邻区域的方法。这种方法存在的问题是记录区域的尺寸变得相当于跳过的缺陷区域，从而需要更长的时间来记录文件，因此用户的便利被损坏。记录区域允许的缺陷区域的大小受限于记录区域的大小。

45. 发明授权

US5342841A Xanthine derivatives 失效
标题翻译：黄嘌呤衍生物
公开(公告)号：US5342841A
公开(公告)日：1994-08-30
申请号：US29069
申请日：1993-03-10
申请人： Fumio Suzuki , Junichi Shimada , Akira Karasawa , Hideaki Mizumoto , Hiroshi Kase , Hiromi Nonaka
发明人： Fumio Suzuki , Junichi Shimada , Akira Karasawa , Hideaki Mizumoto , Hiroshi Kase , Hiromi Nonaka
IPC分类号： C07D473/06 , A61K31/52 , C07D473/02
CPC分类号： C07D473/06
摘要： A xanthine derivative of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are substituted or unsubstituted alicyclic alkyl; m1 and m2 are the same or different and represent an integer of 0 to 2; and Q represents ##STR2## (in which R.sup.3 and R.sup.4 are the same or different and are substituted or unsubstituted alicyclic alkyl) or ##STR3## (in which n is 0 or 1, and Y is a single bond or alkylene); or a pharmaceutically acceptable salt thereof is disclosed.This derivative has diuretic activity and renal protecting activity.
摘要翻译：式（I）的黄嘌呤衍生物：其中R1和R2相同或不同，为取代或未取代的脂环族烷基; m1和m2相同或不同，表示0〜2的整数。和Q表示（其中R 3和R 4相同或不同，是取代或未取代的脂环族烷基）或（其中n为0或1，Y为单键或亚烷基）。或其药学上可接受的盐。该衍生物具有利尿活性和肾脏保护活性。

46. 发明授权

US5011854A Hydroxamic acid derivatives and use thereof in combatting lipoxygenase-mediated diseases 失效
标题翻译：羟肟酸衍生物及其在抗氧化酶介导的疾病中的应用
公开(公告)号：US5011854A
公开(公告)日：1991-04-30
申请号：US281050
申请日：1989-12-07
申请人： Mitsuru Takahashi , Shigeto Kitamura , Hiroshi Kase , Masaji Kasai , Isao Kawamoto , Takao Iida , Hiroshi Sano , Hiromitsu Saito , Koji Yamada , Chikara Murakata
发明人： Mitsuru Takahashi , Shigeto Kitamura , Hiroshi Kase , Masaji Kasai , Isao Kawamoto , Takao Iida , Hiroshi Sano , Hiromitsu Saito , Koji Yamada , Chikara Murakata
IPC分类号： C07C239/16 , C07C259/06
CPC分类号： C07C239/16 , C07C259/06
摘要： A hydroxamic acid compound represented by the general formula (I) or a salt thereof; ##STR1## wherein R.sup.1 represents a hydrogen atom, or a substituted or unsubstituted alkanoyl group, R.sup.2 represents an unsubstituted alkanoyl, substituted lower alkanoyl or substituted lower alkyl group, and m represents an integer of 3 to 7, which are useful for the prevention and/or treatment of diseases caused by lipoxygenase-mediated metablites.

47. 发明申请

US20110310308A1 VIDEO/AUDIO OUTPUT DEVICE AND EXTERNAL SPEAKER CONTROL APPARATUS 审中-公开
标题翻译：视频/音频输出设备和外部扬声器控制设备
公开(公告)号：US20110310308A1
公开(公告)日：2011-12-22
申请号：US13216488
申请日：2011-08-24
申请人： Sako ASAYAMA , Hiroshi Kase , Mitsuteru Kataoka
发明人： Sako ASAYAMA , Hiroshi Kase , Mitsuteru Kataoka
IPC分类号： H04N5/60
CPC分类号： H04R3/12 , H04N5/60 , H04N5/63 , H04N21/436 , H04N21/4396 , H04N21/44227 , H04N21/44231 , H04R27/00 , H04R2499/15
摘要： An external speaker control apparatus causes only one of an internal speaker and an external speaker to output audio when a power supply of the external speaker control apparatus which controls the external speaker changes from an off state to an on state, the external speaker being a speaker outside a video and audio output apparatus. The external speaker control apparatus includes a microcomputer for detecting the change of the power supply of an amplifier from an off state to an on state and a HDMI/CEC communication unit or outputting an instruction requesting output of information which indicates the audio output mode to the video and audio output apparatus while at the same time receiving the information indicating the audio detects the change of the power supply from an off state to an on state, wherein the microcomputer controls the output of the audio from the external speaker according to the information indicating the audio output mode.
摘要翻译：当控制外部扬声器的外部扬声器控制装置的电源从关闭状态变为接通状态时，外部扬声器控制装置仅使内部扬声器和外部扬声器中的一个输出音频，外部扬声器是扬声器在视频和音频输出设备之外。外部扬声器控制装置包括：微型计算机，用于检测放大器从关闭状态到接通状态的电源的变化;以及HDMI / CEC通信单元，或者将指示音频输出模式的信息的输出的指示输出到视频和音频输出设备，同时接收指示音频的信息检测电源从关闭状态到接通状态的变化，其中微计算机根据指示的信息来控制来自外部扬声器的音频的输出音频输出模式。

48. 发明授权

US08034820B2 Pharmaceutical composition 有权
标题翻译：药物组成
公开(公告)号：US08034820B2
公开(公告)日：2011-10-11
申请号：US10565239
申请日：2004-07-22
申请人： Hiroshi Kase , Minoru Kobayashi , Shizuo Shiozaki , Akihisa Mori , Naoki Seno
发明人： Hiroshi Kase , Minoru Kobayashi , Shizuo Shiozaki , Akihisa Mori , Naoki Seno
IPC分类号： A01N43/90 , A01N43/52 , A61K31/522 , A61K31/415 , C07D473/00 , C07D403/02 , C07D317/44 , C07C211/00 , C07C213/00 , C07C215/00 , C07C217/00
CPC分类号： A61K31/522 , A61K31/137 , A61K31/138 , A61K31/16 , A61K31/335 , A61K31/343 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/435 , A61K31/4525 , A61K31/496 , A61K31/52 , A61K31/5375 , A61K31/55 , A61K31/553 , A61K45/06 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions, which are useful for treatment of depression and the like, and which comprises a compound having an adenosine A2A receptor antagonistic activity such as (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione or a pharmaceutically acceptable salt thereof and an antidepressant drug (for example, a tricyclic antidepressant, a tetracyclic antidepressant, a selective serotonin reuptake inhibitor, a selective noradrenalin reuptake inhibitor, a dopamine reuptake inhibitor, a serotonin-noradrenalin reuptake inhibitor, a monoamine oxidase inhibitor, a 5-HT2 antagonist or the like), and the like.
摘要翻译：本发明提供了可用于治疗抑郁症等的药物组合物，其包含具有腺苷A2A受体拮抗活性的化合物，例如（E）-8-（3,4-二甲氧基苯乙烯基）二乙基-7-甲基-3,7-二氢-1H-嘌呤-2,6-二酮或其药学上可接受的盐和抗抑郁药（例如，三环抗抑郁药，四环抗抑郁药，选择性5-羟色胺再摄取抑制剂，选择性去甲肾上腺素再摄取抑制剂，多巴胺再摄取抑制剂，5-羟色胺去甲肾上腺素再摄取抑制剂，单胺氧化酶抑制剂，5-HT2拮抗剂等）等。

49. 发明授权

US07727994B2 Methods of treating patients suffering from movement disorders 有权
标题翻译：治疗运动障碍患者的方法
公开(公告)号：US07727994B2
公开(公告)日：2010-06-01
申请号：US11326516
申请日：2006-01-06
申请人： Hiroshi Kase , Akihisa Mori , Yutaka Waki , Yutaka Ohsawa , Akira Karasawa , Yoshihisa Kuwana
发明人： Hiroshi Kase , Akihisa Mori , Yutaka Waki , Yutaka Ohsawa , Akira Karasawa , Yoshihisa Kuwana
IPC分类号： A61K31/522 , A61K31/505
CPC分类号： A61K31/522 , A61K9/0019 , A61K9/20 , A61K9/48 , A61K31/198 , A61K45/06
摘要： The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A2A receptor antagonists to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of L-DOPA in patients receiving L-DOPA therapy in the treatment of Parkinson's disease. The present invention further provides methods and compositions for treating Parkinson's disease patients with sub-clinically effective doses of L-DOPA by combining L-DOPA treatment with an effective amount of one or more adenosine A2A receptor antagonists (i.e., L-DOPA sparing effect). The present invention further provides methods of effective treatment of Parkinson's disease by co-administering at least one adenosine A2A receptor antagonist, L-DOPA and a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor. The present invention further provides methods of prolonging effective treatment of Parkinson's disease by administering an adenosine A2A receptor antagonist singly or together with a dopamine agonist, and/or a COMT inhibitor, and/or a MAO inhibitor without prior or subsequent administration of L-DOPA, delaying or removing on-set of L-DOPA motor complication.
摘要翻译：本发明涉及通过向有需要的患者施用有效量的一种或多种腺苷A 2A受体拮抗剂来治疗运动障碍的方法。本发明还提供降低L-DOPA在接受L-DOPA治疗的帕金森病治疗中的不良反应的方法。本发明进一步提供了通过将L-DOPA治疗与有效量的一种或多种腺苷A 2A受体拮抗剂组合（即L-DOPA备用效应）来治疗具有亚临床有效剂量的L-DOPA的帕金森病患者的方法和组合物，。本发明还提供了通过共同施用至少一种腺苷A 2A受体拮抗剂，L-DOPA和多巴胺激动剂和/或COMT抑制剂和/或MAO抑制剂来有效治疗帕金森病的方法。本发明还提供了延长帕金森病有效治疗的方法，通过单独或与多巴胺激动剂和/或COMT抑制剂和/或MAO抑制剂一起施用腺苷A2A受体拮抗剂，而无需先前或随后给予L-DOPA ，延迟或消除L-DOPA电机并发症。

50. 发明授权

US07707231B2 Creating standardized playlists and maintaining coherency 有权
标题翻译：创建标准化播放列表并维护一致性
公开(公告)号：US07707231B2
公开(公告)日：2010-04-27
申请号：US11167963
申请日：2005-06-28
申请人： Kevin Leigh LaChapelle , Brian James Walker , Ian Cameron Mercer , Hiroshi Kase , Keisuke Matsuo , Sako Asayama
发明人： Kevin Leigh LaChapelle , Brian James Walker , Ian Cameron Mercer , Hiroshi Kase , Keisuke Matsuo , Sako Asayama
IPC分类号： G06F17/30
CPC分类号： G11B27/034 , G11B19/025 , G11B27/105 , G11B27/329 , G11B27/34 , G11B2220/218 , G11B2220/2545 , G11B2220/2562 , G11B2220/61 , G11B2220/90
摘要： Updating automatically generated playlists in response to media content being edited. Aspects of the invention associate a playlist type or other code with each playlist to define the structure of the playlist. When media content is added to or deleted from a collection of media files, one or more playlist types corresponding to the media content are identified. The playlists with the identified playlist types are updated to reflect the addition or deletion of the media content.
摘要翻译：根据正在编辑的媒体内容更新自动生成的播放列表。本发明的方面将播放列表类型或其他代码与每个播放列表相关联以定义播放列表的结构。当媒体内容被添加到媒体文件的集合或从媒体文件的集合中删除时，识别与媒体内容对应的一个或多个播放列表类型。具有所识别的播放列表类型的播放列表被更新以反映媒体内容的添加或删除。

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