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41. 发明授权

US06280703B1 Simultaneous multimodal measurement of physiological function 失效
标题翻译：同时多功能测量生理功能
公开(公告)号：US06280703B1
公开(公告)日：2001-08-28
申请号：US09519455
申请日：2000-03-06
申请人： Arthur H. Combs , Richard B. Dorshow , Joseph E. Bugaj , Raghavan Rajagopalan , Samuel I. Achilefu
发明人： Arthur H. Combs , Richard B. Dorshow , Joseph E. Bugaj , Raghavan Rajagopalan , Samuel I. Achilefu
IPC分类号： A61K4900
CPC分类号： A61B5/14546 , A61B5/0071 , A61B5/0084 , A61B5/0086 , A61B5/0275 , A61B5/412 , A61K49/0002 , A61K49/0017 , A61K49/0034 , A61K49/0043 , A61K49/0056 , A61K51/0474
摘要： A method of measuring physiological function of a group of body cells, includes the step of selecting a detectable agent capable of absorbing or emitting a measurable electromagnetic emission. The agent is introduced into body fluid which contacts the group of body cells. The absorbance or emission is measured, and physiological function is determined based on measurement of the absorbance or emission. Measurements may be made noninvasively or with the use of a modified pulmonary artery catheter. Multiple agents which can be distinguished from each other can be utilized simultaneously to measure multiple physiological functions at the same time.
摘要翻译：测量一组身体细胞的生理功能的方法包括选择能够吸收或发射可测量电磁辐射的可检测剂的步骤。该药剂被引入与身体细胞组接触的体液中。测量吸光度或发射，并且基于吸光度或发射的测量来确定生理功能。测量可以非侵入性地或使用改进的肺动脉导管进行。可以彼此区分的多个试剂可以同时使用以同时测量多种生理功能。

42. 发明授权

US07566444B2 Versatile hydrophilic dyes 失效
标题翻译：多用途亲水染料
公开(公告)号：US07566444B2
公开(公告)日：2009-07-28
申请号：US11126137
申请日：2005-05-10
申请人： Samuel I. Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj
发明人： Samuel I. Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00
CPC分类号： A61K49/0032 , A61K41/0033 , A61K41/0057 , A61K49/0056
摘要： Dye-peptide conjugates useful for diagnostic imaging and therapy are disclosed. The dye-peptide conjugates include several cyanine dyes with a variety of bis- and tetrakis(carboxylic acid) homologues. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350-1300 nm, the exact range being dependent upon the particular dye. Use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The molecules of the invention are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities and for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.
摘要翻译：公开了用于诊断成像和治疗的染料 - 肽缀合物。染料 - 肽缀合物包括具有多种双和四（羧酸）同系物的几种花青染料。与较大的分子量成像剂相比，化合物的小尺寸允许更有利于肿瘤细胞的递送。各种染料在350-1300nm的范围内是有用的，精确的范围取决于特定的染料。使用二甲基亚砜有助于维持化合物的荧光。本发明的分子可用于诊断成像和治疗，用于检测肿瘤和其他异常以及用于局部治疗，用于光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗的内窥镜应用中。

43. 发明授权

US07514069B2 Tumor-targeted optical contrast agents 失效
标题翻译：肿瘤靶向光学造影剂
公开(公告)号：US07514069B2
公开(公告)日：2009-04-07
申请号：US11682032
申请日：2007-03-05
申请人： Samuel I. Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj , Muthunadar P. Periasamy
发明人： Samuel I. Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj , Muthunadar P. Periasamy
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00
CPC分类号： A61K49/0032 , A61K41/0033 , A61K49/0056 , C07D209/14 , C07D405/06 , C07K1/13 , C07K14/655
摘要： Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologs. The compounds may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350 to 1300 nm, the exact range being dependent upon the particular dye. The use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluoresence tumor imaging, detection and therapy.
摘要翻译：公开了可用于诊断成像和治疗的花青染料生物缀合物。缀合物包括几种具有多种双和四（羧酸）同系物的花青染料。化合物可以与生物活性肽，碳水化合物，激素，药物或其他生物活性剂缀合。与较大的分子量成像剂相比，化合物的小尺寸允许更有利于肿瘤细胞的递送。各种染料在350至1300nm的范围内是有用的，精确的范围取决于特定的染料。使用二甲基亚砜有助于维持化合物的荧光。本发明化合物可用于诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声波荧光肿瘤成像，检测和治疗。

44. 发明授权

US07230088B2 Compounds for dual photodiagnosis and therapy 失效
标题翻译：用于双重光诊断和治疗的化合物
公开(公告)号：US07230088B2
公开(公告)日：2007-06-12
申请号：US10685172
申请日：2003-10-14
申请人： Raghavan Rajagopalan , Samuel I. Achilefu , Joseph E. Bugaj , Richard B. Dorshow , Muthunadar P. Periasamy
发明人： Raghavan Rajagopalan , Samuel I. Achilefu , Joseph E. Bugaj , Richard B. Dorshow , Muthunadar P. Periasamy
IPC分类号： C07K1/13 , G01N33/531 , G01N33/533
CPC分类号： C09B23/083 , A61K41/0057 , A61K41/0061 , A61K41/0071 , A61K47/546 , A61K47/66 , B82Y5/00 , C09B47/045 , C09B47/30 , Y10S436/80 , Y10T436/13
摘要： The invention discloses compounds and compositions for dual phototherapy and combined therapy and diagnosis of tumors and other lesions. The compounds have a Dye that, when photoactivated, operates via Type I and/or Type II mechanisms. Other Dye or azide components may operate by the same or different mechanisms. Selection of particular components in a compound, and formulation of the compound(s) in a composition permit different activation wavelengths to be used for different therapies. A targeting moiety may be added to the compound or composition so that the Dye locates at a particular site, such as a hormone-sensitive tumor, for diagnosis and/or treatment. The compounds and compositions may be incorporated within liposomes.
摘要翻译：本发明公开了用于双光疗法和组合治疗和诊断肿瘤和其他病变的化合物和组合物。化合物具有染料，当光活化时，它们通过I型和/或II型机制进行操作。其他染料或叠氮化物组分可以通过相同或不同的机理操作。选择化合物中的特定组分以及组合物中化合物的配制允许不同的激活波长用于不同疗法。可以将靶向部分加入到化合物或组合物中，使得染料位于特定部位，例如激素敏感性肿瘤，用于诊断和/或治疗。化合物和组合物可以掺入脂质体中。

45. 发明授权

US07198778B2 Tumor-targeted optical contrast agents 失效
标题翻译：肿瘤靶向光学造影剂
公开(公告)号：US07198778B2
公开(公告)日：2007-04-03
申请号：US10654033
申请日：2003-09-03
申请人： Samuel I. Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj , Muthunadar P. Periasamy
发明人： Samuel I. Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj , Muthunadar P. Periasamy
IPC分类号： A61B10/00 , A61B8/00
CPC分类号： A61K49/0032 , A61K41/0033 , A61K49/0056 , C07D209/14 , C07D405/06 , C07K1/13 , C07K14/655
摘要： Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologs. The compounds may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350 to 1300 nm, the exact range being dependent upon the particular dye. The use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluoresence tumor imaging, detection and therapy.
摘要翻译：公开了可用于诊断成像和治疗的花青染料生物缀合物。缀合物包括几种具有多种双和四（羧酸）同系物的花青染料。化合物可以与生物活性肽，碳水化合物，激素，药物或其他生物活性剂缀合。与较大的分子量成像剂相比，化合物的小尺寸允许更有利于肿瘤细胞的递送。各种染料在350至1300nm的范围内是有用的，精确的范围取决于特定的染料。使用二甲基亚砜有助于维持化合物的荧光。本发明化合物可用于诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声波荧光肿瘤成像，检测和治疗。

46. 发明授权

US06747151B2 Azo compounds for type I phototherapy 失效
标题翻译：用于I型光疗法的偶氮化合物
公开(公告)号：US06747151B2
公开(公告)日：2004-06-08
申请号：US10272123
申请日：2002-10-15
申请人： Raghavan Rajagopalan , Gary L. Cantrell , Joseph E. Bugaj , Samuel I. Achilefu , Richard B. Dorshow
发明人： Raghavan Rajagopalan , Gary L. Cantrell , Joseph E. Bugaj , Samuel I. Achilefu , Richard B. Dorshow
IPC分类号： C07D23726
CPC分类号： A61K31/5025 , A61K41/0057 , A61K47/64 , A61K49/0026 , A61K49/0039 , A61K49/0041 , A61K49/0056 , C07D471/06 , C07D491/06
摘要： Novel azo compounds and their bioconjugates for phototherapy and/or photodiagnosis of tumors and other lesions. The azo derivatives of the present invention are designed to absorb at the low-energy ultraviolet, visible, or near-infrared (NIR) region of the electromagnetic spectrum. The phototherapeutic effect is caused by direct interaction of free radicals, the reactive intermediate produced upon photoexcitation of the azo compound, with the tissue of interest.
摘要翻译：新型偶氮化合物及其生物缀合物用于光疗和/或光化学诊断肿瘤和其他病变。本发明的偶氮衍生物被设计成在电磁光谱的低能量紫外线，可见光或近红外（NIR）区域吸收。光疗效果是由自由基（通过偶氮化合物的光激发产生的反应性中间体）与感兴趣的组织的直接相互作用引起的。

47. 发明授权

US06485704B1 Azo compound for type I pototherapy 失效
标题翻译：用于I型光疗法的偶氮化合物
公开(公告)号：US06485704B1
公开(公告)日：2002-11-26
申请号：US09849163
申请日：2001-05-04
申请人： Raghavan Rajagopalan , Gary L. Cantrell , Joseph E. Bugaj , Samuel I. Achilefu , Richard B. Dorshow
发明人： Raghavan Rajagopalan , Gary L. Cantrell , Joseph E. Bugaj , Samuel I. Achilefu , Richard B. Dorshow
IPC分类号： A61K4900
CPC分类号： A61K49/0026 , A61K41/0057 , A61K47/64 , A61K49/0039 , A61K49/0041 , A61K49/0056 , C07D471/06
摘要： Novel azo compounds and their bioconjugates for phototherapy and/or photodiagnosis of tumors and other lesions. The azo derivatives of the present invention are designed to absorb at the low-energy ultraviolet, visible, or near-infrared (NIR) region of the electromagnetic spectrum. The phototherapeutic effect is caused by direct interaction of free radicals, the reactive intermediate produced upon photoexcitation of the azo compound, with the tissue of interest.
摘要翻译：新型偶氮化合物及其生物缀合物用于光疗和/或光化学诊断肿瘤和其他病变。本发明的偶氮衍生物被设计成在电磁光谱的低能量紫外线，可见光或近红外（NIR）区域吸收。光疗效果是由自由基（通过偶氮化合物的光激发产生的反应性中间体）与感兴趣的组织的直接相互作用引起的。

48. 发明授权

US06277841B1 Quinoline ligands and metal complexes for diagnosis and therapy 失效
标题翻译：喹啉配体和金属配合物用于诊断和治疗
公开(公告)号：US06277841B1
公开(公告)日：2001-08-21
申请号：US09517252
申请日：2000-03-02
申请人： Raghavan Rajagopalan , Samuel I. Achilefu , Joseph E. Bugaj , Richard B. Dorshow
发明人： Raghavan Rajagopalan , Samuel I. Achilefu , Joseph E. Bugaj , Richard B. Dorshow
IPC分类号： C07F700
CPC分类号： C07F13/005 , C07D215/26
摘要： The present invention relates to novel ligands for forming metal complexes that absorb or fluoresce in the visible or near-infrared (NIR) region of the electromagnetic spectrum, new complexes incorporating such ligands, process for preparing such complexes, and methods of imaging or therapy using such agents. More particularly, the present invention specifically pertains to novel metal complexes derived from quinoline based heterocyclic N2O3, N3O3, N3O4, N3O5 and N2OS ligands, and are useful as general imaging, diagnostic, or therapeutic agents employing optical, nuclear medicine, or magnetic resonance procedures.
摘要翻译：本发明涉及用于形成在电磁光谱的可见光或近红外（NIR）区域中吸收或发出荧光的金属络合物的新配体，包含这种配体的新配合物，制备这种配体的方法，以及使用这样的代理。更具体地说，本发明具体涉及衍生自喹啉类杂环N 2 O 3，N 3 O 3，N 3 O 4，N 3 O 5和N 2 OS配体的新型金属络合物，并且可用作使用光学，核医学或磁共振程序的一般成像，诊断或治疗剂。

49. 发明授权

US07510700B2 Pathological tissue detection and treatment employing targeted benzoindole optical agents 失效
标题翻译：使用靶向苯并吲哚光学剂的病理组织检测和治疗
公开(公告)号：US07510700B2
公开(公告)日：2009-03-31
申请号：US11388382
申请日：2006-03-24
申请人： Samuel Achilefu , Richard B. Dorshow , Raghavan Rajagopalan , Joseph B. Bugaj
发明人： Samuel Achilefu , Richard B. Dorshow , Raghavan Rajagopalan , Joseph B. Bugaj
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00
CPC分类号： C07D417/04 , A61K41/0057 , A61K47/62 , A61K49/0032 , A61K49/0034 , A61K49/0052 , A61K49/0056 , C07D209/60 , C07D417/14 , C09B23/086 , C09B47/00
摘要： Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and phototoxic agent to diseased tissues. A combination of these elements takes full advantage of the unique and efficient properties of each component for an effective patient care management.
摘要翻译：公开了新型肿瘤特异性光疗法和光诊断剂。该化合物包括用于可视化的碳菁染料，用于光动力学治疗的光敏剂和用于将位点特异性递送探针和光毒性剂到患病组织的肿瘤受体 - 鸟苷肽。这些元素的组合充分利用了每个组件的独特而有效的特性来进行有效的患者护理管理。

50. 发明授权

US06887854B2 Compounds as dynamic organ function monitoring agents 失效
标题翻译：化合物作为动态器官功能监测剂
公开(公告)号：US06887854B2
公开(公告)日：2005-05-03
申请号：US10436759
申请日：2003-05-13
申请人： Samuel Achilefu , Hermo N. Jimenez , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugai
发明人： Samuel Achilefu , Hermo N. Jimenez , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugai
IPC分类号： C07H15/26 , A61K49/00 , C07D209/08 , C07D209/12 , C07D209/60 , C07D405/14 , A01N43/04 , A61K31/70 , C07D277/04 , C07H15/00
CPC分类号： C07D405/14 , C07D209/08 , C07D209/12 , C07D209/60
摘要： Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
摘要翻译：公开了在可见光区域吸收和发出荧光的高度亲水的吲哚和苯并吲哚衍生物。这些化合物可用于生理和器官功能监测。特别地，本发明的分子可用于肾脏和心脏疾病的光学诊断以及体内血液体积估计。

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