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41. 发明授权

US06370478B1 Methods for drug interaction prediction using biological response profiles 有权
标题翻译：使用生物反应曲线进行药物相互作用预测的方法
公开(公告)号：US06370478B1
公开(公告)日：2002-04-09
申请号：US09222595
申请日：1998-12-28
申请人： Roland Stoughton , Sergey Stepaniants
发明人： Roland Stoughton , Sergey Stepaniants
IPC分类号： G01N3348
CPC分类号： G06F19/20 , G06F19/00 , G06F19/18 , G06F19/24 , G16H50/50
摘要： This invention provides methods for detecting and predicting drug interaction. In one embodiment of the invention, a plurality of cellular constituents in a biological sample is monitored as the sample is subject to various drug treatments. The response of the cellular constituents are analyzed to detect interactions. This method is particularly useful for predicting drug interaction using a model organism. It is also useful for analyzing interaction between any perturbations to a biological system.
摘要翻译：本发明提供了检测和预测药物相互作用的方法。在本发明的一个实施方案中，当样品进行各种药物治疗时，监测生物样品中的多种细胞成分。分析细胞成分的反应以检测相互作用。该方法对于使用模型生物体预测药物相互作用特别有用。它也可用于分析与生物系统的任何扰动之间的相互作用。

42. 发明申请

US20130210644A1 FETAL ANEUPLOIDY DETECTION BY SEQUENCING 审中-公开
标题翻译：通过顺序检测器件进行异常检测
公开(公告)号：US20130210644A1
公开(公告)日：2013-08-15
申请号：US13863992
申请日：2013-04-16
申请人： Roland Stoughton , Ravi Kapur , Mehmet Toner , Ronald Davis , Barb Ariel Cohen
发明人： Roland Stoughton , Ravi Kapur , Mehmet Toner , Ronald Davis , Barb Ariel Cohen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6883 , C12Q2600/156
摘要： The present invention provides apparatus and methods for enriching components or cells from a sample and conducting genetic analysis, such as SNP genotyping to provide diagnostic results for fetal disorders or conditions.
摘要翻译：本发明提供了用于从样品中富集组分或细胞并进行遗传分析的装置和方法，例如SNP基因分型以提供胎儿障碍或病症的诊断结果。

43. 发明申请

US20120183963A1 DETERMINATION OF FETAL ANEUPLOIDY BY QUANTIFICATION OF GENOMIC DNA FROM MIXED SAMPLES 审中-公开
标题翻译：通过从混合样品中定量鉴定基因组DNA来确定天然异构体
公开(公告)号：US20120183963A1
公开(公告)日：2012-07-19
申请号：US13433232
申请日：2012-03-28
申请人： Roland Stoughton , Ravi Kapur , Mehmet Toner , Daniel Shoemaker , Ronald W. Davis , Barb Ariel Cohen
发明人： Roland Stoughton , Ravi Kapur , Mehmet Toner , Daniel Shoemaker , Ronald W. Davis , Barb Ariel Cohen
IPC分类号： C12Q1/68
CPC分类号： G01N1/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G16B20/00
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a determination and report a non-informative case. The present invention involves quantifying regions of genomic DNA from a mixed sample. More particularly the invention involves quantifying DNA polymorphisms from the mixed sample.
摘要翻译：本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常（即非整倍体）的系统，装置和方法。此外，本发明提供了确定何时胎儿细胞不足以确定并报告非信息性病例的方法。本发明涉及量化来自混合样品的基因组DNA的区域。更具体地，本发明涉及从混合样品中定量DNA多态性。

44. 发明申请

US20100233693A1 METHODS FOR DIAGNOSING, PROGNOSING, OR THERANOSING A CONDITION USING RARE CELLS 审中-公开
标题翻译：用于诊断，预处理或治疗使用稀有细胞的条件的方法
公开(公告)号：US20100233693A1
公开(公告)日：2010-09-16
申请号：US12595949
申请日：2008-04-16
申请人： Anne R. Kopf-Sill , Lena Wu , Roland Stoughton
发明人： Anne R. Kopf-Sill , Lena Wu , Roland Stoughton
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57488 , C12Q1/6883 , C12Q1/6886 , C12Q2600/118 , C12Q2600/156 , G01N1/31 , G01N33/5091 , G01N33/57484 , G01N33/57492 , G01N2333/705 , G01N2333/71 , G01N2333/912 , G01N2333/96433
摘要： The invention encompasses methods for diagnosing, theranosing, or prognosing a condition in a patient based on the results of one or more analysis methods. The methods can comprise enriching a sample obtained from the patient for one or more rare cells. The analysis methods can include performing enumeration of the one or more rare cells or cell subtypes, performing nucleic acid analysis, or detecting a serum marker.
摘要翻译：本发明包括基于一种或多种分析方法的结果来诊断，鉴别或预测患者病症的方法。所述方法可以包括富集从患者获得的一种或多种稀有细胞的样品。分析方法可以包括执行一个或多个稀有细胞或细胞亚型的计数，进行核酸分析或检测血清标记。

45. 发明申请

US20090291443A1 USE OF HIGHLY PARALLEL SNP GENOTYPING FOR FETAL DIAGNOSIS 审中-公开
标题翻译：使用高度并行SNP基因分析进行子宫诊断
公开(公告)号：US20090291443A1
公开(公告)日：2009-11-26
申请号：US12413467
申请日：2009-03-27
申请人： Roland Stoughton , Ravi Kapur , Barb Ariel Cohen
发明人： Roland Stoughton , Ravi Kapur , Barb Ariel Cohen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6883 , C12Q2600/156
摘要： The present invention provides apparatus and methods for enriching components or cells from a sample and conducting genetic analysis, such as SNP genotyping to provide diagnostic results for fetal disorders or conditions.
摘要翻译：本发明提供了用于从样品中富集组分或细胞并进行遗传分析的装置和方法，例如SNP基因分型以提供胎儿障碍或病症的诊断结果。

46. 发明授权

US07254487B2 Methods for determining therapeutic index from gene expression profiles 失效
标题翻译：从基因表达谱确定治疗指数的方法
公开(公告)号：US07254487B2
公开(公告)日：2007-08-07
申请号：US09823322
申请日：2001-04-02
申请人： Matthew Marton , Roland Stoughton
发明人： Matthew Marton , Roland Stoughton
IPC分类号： G01N33/48 , G01N31/00 , A01N37/18 , A01N43/04 , C12Q1/00 , C12Q1/68 , C12Q1/70 , C12P21/06
CPC分类号： C12Q1/6883 , C12Q1/025 , C12Q1/18 , C12Q2600/106 , C12Q2600/158 , G01N33/5005 , G01N33/5088 , G06F19/20 , G06F19/70
摘要： This invention provides methods for determining drug specificity, therapeutic index and effective doses for individual patients. According to the methods of the invention, graded levels of drug are applied to a biological sample or a patient. A plurality of cellular constituents are measured to determine the activity of the drug on a target pathway and at least one off-target pathway. A drug specificity is determined by comparing the target and off target activities of the drug. A therapeutic concentration (or dose) is defined as a concentration (or dose) of the drug that induces certain response in the target pathway. A toxic concentration (or dose) is defined as a concentration (or dose) of the drug that induces certain response in the off target pathway. Therapeutic index is the ratio of the toxic concentration over therapeutic concentration. Methods are also provided to determine an effective dose of a drug for a patient by measuring the activity of the drug on the particular patient.
摘要翻译：本发明提供用于确定个体患者的药物特异性，治疗指数和有效剂量的方法。根据本发明的方法，将分级药物施用于生物样品或患者。测量多个细胞成分以确定药物在靶途径和至少一个脱靶途径上的活性。通过比较药物的靶标和脱靶活性来确定药物特异性。治疗浓度（或剂量）被定义为在目标途径中诱导一定反应的药物的浓度（或剂量）。毒性浓度（或剂量）被定义为在脱靶途径中诱导某些反应的药物的浓度（或剂量）。治疗指标是毒性浓度与治疗浓度的比值。还提供了通过测量特定患者上的药物的活性来确定患者药物的有效剂量的方法。

47. 发明申请

US20050164273A1 Statistical combining of cell expression profiles 失效
标题翻译：细胞表达谱的统计学结合
公开(公告)号：US20050164273A1
公开(公告)日：2005-07-28
申请号：US11042654
申请日：2005-01-24
申请人： Roland Stoughton , Hongyue Dai
发明人： Roland Stoughton , Hongyue Dai
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N33/48 , G01N33/566 , G01N33/58 , G01N37/00 , G06F17/18 , G06F19/20 , G01N33/50 , G06F19/00
CPC分类号： G06F19/20 , C12Q1/6837 , Y10T436/10
摘要： A method for fluorophore bias removal in microarray experiments in which the fluorophores used in microarray experiment pairs are reversed. Further, a method for calculating the individual errors associated with each measurement made in nominally repeated microarray experiments. This error measurement is optionally coupled with rank based methods in order to determine a probability that a cellular constituent is up or down regulated in response to a perturbation. Finally, a method for determining the confidence in the weighted average of the expression level of a cellular constituent in nominally repeated microarray experiments.
摘要翻译：用于微阵列实验对中的荧光团的微阵列实验中的荧光团偏置去除方法是相反的。此外，一种用于计算与名义上重复的微阵列实验中进行的每个测量相关联的各个错误的方法。该误差测量可选地与基于秩的方法耦合，以便确定响应于扰动的细胞成分向上或向下调节的概率。最后，在名义上重复的微阵列实验中确定细胞成分的表达水平的加权平均的置信度的方法。

48. 发明授权

US06222093B1 Methods for determining therapeutic index from gene expression profiles 失效
标题翻译：从基因表达谱确定治疗指数的方法
公开(公告)号：US06222093B1
公开(公告)日：2001-04-24
申请号：US09222582
申请日：1998-12-28
申请人： Matthew Marton , Roland Stoughton
发明人： Matthew Marton , Roland Stoughton
IPC分类号： G01N3300
CPC分类号： C12Q1/6883 , C12Q1/025 , C12Q1/18 , C12Q2600/106 , C12Q2600/158 , G01N33/5005 , G01N33/5088 , G06F19/20 , G06F19/70
摘要： This invention provides methods for determining drug specificity, therapeutic index and effective doses for individual patients. According to the methods of the invention, graded levels of drug are applied to a biological sample or a patient. A plurality of cellular constituents are measured to determine the activity of the drug on a target pathway and at least one off-target pathway. A drug specificity is determined by comparing the target and off target activities of the drug. A therapeutic concentration (or dose) is defined as a concentration (or dose) of the drug that induces certain response in the target pathway. A toxic concentration (or dose) is defined as a concentration (or dose) of the drug that induces certain response in the off target pathway. Therapeutic index is the ratio of the toxic concentration over therapeutic concentration. Methods are also provided to determine an effective dose of a drug for a patient by measuring the activity of the drug on the particular patient.
摘要翻译：本发明提供用于确定个体患者的药物特异性，治疗指数和有效剂量的方法。根据本发明的方法，将分级药物施用于生物样品或患者。测量多个细胞成分以确定药物在靶途径和至少一个脱靶途径上的活性。通过比较药物的靶标和脱靶活性来确定药物特异性。治疗浓度（或剂量）被定义为在目标途径中诱导一定反应的药物的浓度（或剂量）。毒性浓度（或剂量）被定义为在脱靶途径中诱导某些反应的药物的浓度（或剂量）。治疗指标是毒性浓度与治疗浓度的比值。还提供了通过测量特定患者上的药物的活性来确定患者药物的有效剂量的方法。

49. 发明申请

US20130288242A1 DETERMINATION OF FETAL ANEUPLOIDY BY QUANTIFICATION OF GENOMIC DNA FROM MIXED SAMPLES 审中-公开
标题翻译：通过从混合样品中定量鉴定基因组DNA来确定天然异构体
公开(公告)号：US20130288242A1
公开(公告)日：2013-10-31
申请号：US13738268
申请日：2013-01-10
申请人： Roland Stoughton , Ravi Kapur , Mehmet Toner , Daniel Shoemaker , Ronald W. Davis
发明人： Roland Stoughton , Ravi Kapur , Mehmet Toner , Daniel Shoemaker , Ronald W. Davis
IPC分类号： C12Q1/68
CPC分类号： G01N1/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G16B20/00
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a determination and report a non-informative case. The present invention involves quantifying regions of genomic DNA from a mixed sample. More particularly the invention involves quantifying DNA polymorphisms from the mixed sample.
摘要翻译：本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常（即非整倍体）的系统，装置和方法。此外，本发明提供了确定何时胎儿细胞不足以确定并报告非信息性病例的方法。本发明涉及量化来自混合样品的基因组DNA的区域。更具体地，本发明涉及从混合样品中定量DNA多态性。

50. 发明申请

US20130189689A1 RARE CELL ANALYSIS USING SAMPLE SPLITTING AND DNA TAGS 有权
公开(公告)号：US20130189689A1
公开(公告)日：2013-07-25
申请号：US13837974
申请日：2013-03-15
申请人： Daniel Shoemaker , Ravi Kapur , Mehmet Toner , Roland Stoughton , Ronald W. Davis
发明人： Daniel Shoemaker , Ravi Kapur , Mehmet Toner , Roland Stoughton , Ronald W. Davis
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , B01L3/502761 , C12Q1/6809 , C12Q1/6869 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2015/1006 , G01N2015/1087 , Y10T436/143333
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.

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