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    • 41. 发明授权
    • Method and apparatus diagnosis and treatment of arrhythias
    • 方法和仪器诊断和治疗心律失常
    • US06567691B1
    • 2003-05-20
    • US09532478
    • 2000-03-22
    • Robert W. Stadler
    • Robert W. Stadler
    • A61B50468
    • A61N1/3622
    • Adaptive rules for a more accurate sinus tachycardia detection mechanism for implantable device (IMD) and other devices. In an embodiment, the rule is incorporated into a prioritized, rule-based arrhythmia classification system in an IMD. If the rule is met, anti-tachyarrhythmia therapy is withheld even if a lower priority rule determines presence of a treatable tachyarrhythmia. The rule includes adaptive onset criterion, where an expected range of R—R is calculated based on a trimmed mean and a metric of R—R variability derived over a preceding series of R—R intervals. Pattern codes indicative of gradual rate changes and normal sinus rhythm will be within a grammar defined by a continuous recognition machine and will if they persist, result in the ST rule being met. All other codes inconsistent with sinus tachycardia will not adhere to the associatd grammar and will result in the ST rule not being met.
    • 用于更准确的用于可植入装置(IMD)和其他装置的窦性心动过速检测机制的自适应规则。 在一个实施例中,该规则被并入IMD中的基于规则的基于心律失常的心律失常分类系统中。 如果规则得到满足,即使较低优先权规则确定存在可治疗的快速性心律失常,也可以禁止抗快速性心律失常治疗。 该规则包括自适应发起标准,其中基于在前一系列R-R间隔上导出的修整平均值和R-R可变性的度量来计算R-R的预期范围。 指示渐进率变化和正常窦性心律的模式代码将在由连续识别机定义的语法内,并且如果它们持续存在,则导致满足ST规则。 与窦性心动过速不一致的所有其他代码不会遵守相关语法,并且将导致ST规则不被满足。
    • 48. 发明授权
    • Ischemia detection and classification
    • 缺血检测和分类
    • US08688200B2
    • 2014-04-01
    • US12915925
    • 2010-10-29
    • Zhendong SongRobert W. Stadler
    • Zhendong SongRobert W. Stadler
    • A61B5/04
    • A61B5/0452A61B5/0245A61B5/1118
    • Techniques for detecting ischemia and classifying a type of ischemia are described. Electrograms of cardiac activity may be generated using implanted or external electrodes, e.g., electrodes carried on vascular leads within the heart and a housing electrode. In some examples, ischemia is detected and classified as benign or malignant based on whether a change an electrogram metric is detected, or first detected, in an endocardial electrogram or a non-endocardial electrogram. The relative timing of the change in the electrogram metric and a change in heart rate or patient activity may also be considered. In some examples, the system may create a stress test for detecting ischemia by instructing the patient to exercise or increasing the cardiac pacing rate.
    • 描述了用于检测缺血和分类一种缺血的技术。 可以使用植入或外部电极(例如,在心脏内的血管引线上承载的电极和外壳电极)产生心脏活动的电图。 在一些实例中,基于在心内膜电图或非心内膜电图中是否检测到或者首先检测到电描记图度量,检测到缺血并将其分类为良性或恶性。 也可以考虑电描记图度量的变化和心率或患者活动变化的相对时间。 在一些实例中,系统可以通过指示患者运动或增加心脏起搏速率来产生用于检测缺血的压力测试。
    • 50. 发明授权
    • Method and apparatus for detecting change in intrathoracic electrical impedance
    • 检测胸腔内电阻抗变化的方法和装置
    • US08428718B2
    • 2013-04-23
    • US13177912
    • 2011-07-07
    • Robert W. StadlerLi Wang
    • Robert W. StadlerLi Wang
    • A61B5/053
    • A61B5/0538A61B5/0537A61B5/4875A61B5/686A61B5/7275A61N1/362A61N1/3627A61N1/36521G06F12/0862G06F12/0877
    • A method and apparatus for detection of changes in impedance a patient that includes generating measured impedances, generating an adaptive baseline trend of the measured impedances corresponding to a first time period, generating a short term trend of the measured impedances corresponding to a second time period less than the first time period, determining changes in relative position of the short term trend and the baseline trend, the determined changes in relative position corresponding to determining intersecting of the baseline trend by the short term trend, determining differences between the baseline trend and calculated period average impedances, and accumulating, in response to determining no intersecting of the baseline trend by the short term trend, the determined differences between the baseline trend and the calculated period average impedances.
    • 一种用于检测患者阻抗变化的方法和装置,包括产生测量的阻抗,产生对应于第一时间段的所测量的阻抗的自适应基线趋势,产生对应于第二时间段的所测量的阻抗的短期趋势 确定短期趋势相对位置的变化和基准趋势,确定相对位置的变化对应于基线趋势与短期趋势的相交,确定基线趋势与计算周期之间的差异 平均阻力和累积,以确定基准趋势与短期趋势的相交,确定基线趋势与计算的周期平均阻抗之间的差异。