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41. 发明申请

US20070293474A1 Combination of a DPP IV inhibitor and a cardiovascular compound 审中-公开
标题翻译： DPP IV抑制剂与心血管化合物的组合
公开(公告)号：US20070293474A1
公开(公告)日：2007-12-20
申请号：US11815536
申请日：2007-08-03
申请人： David Holmes , Suraj Shetty , Thomas Hughes
发明人： David Holmes , Suraj Shetty , Thomas Hughes
IPC分类号： A61K31/4439 , A61K31/135 , A61K31/40 , A61K31/403 , A61K31/496 , A61K31/549 , A61P17/00 , A61P3/00 , A61P3/10 , A61P9/12 , A61P3/04 , A61P27/06 , A61K31/55 , A61K31/513 , A61K31/407 , A61K31/41 , A61K31/44
CPC分类号： A61K31/454 , A61K31/16 , A61K31/40 , A61K31/41
摘要： The present invention relates to a combination, such as a combined preparation or pharmaceutical composition, respectively, comprising of a DPP IV inhibitor or a pharmaceutically acceptable salt thereof and a cardiovascular compound (being different from statin) or a pharmaceutically acceptable salt thereof. The present invention furthermore relates to the use of such a combination for the prevention, delay of progression or treatment of diseases and disorders.
摘要翻译：本发明涉及分别包含DPP IV抑制剂或其药学上可接受的盐和心血管化合物（不同于他汀类）或其药学上可接受的盐的组合制剂或药物组合物的组合。本发明还涉及这种组合用于预防，延缓进展或治疗疾病和病症的用途。

42. 发明申请

US20070009993A1 metRS2 失效
公开(公告)号：US20070009993A1
公开(公告)日：2007-01-11
申请号：US11424836
申请日：2006-06-16
申请人： Daniel Gentry , David Holmes , Karen Ingraham
发明人： Daniel Gentry , David Holmes , Karen Ingraham
IPC分类号： C07K14/315 , C07H21/04 , C12N1/21 , C12N15/74
CPC分类号： C12N9/93 , C07K14/3156 , C12Q1/689
摘要： The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infections in materials.

43. 发明申请

US20060034608A1 Method and system for providing a signature signal in an optical network in the event of loss of a client 失效
标题翻译：在客户端丢失的情况下，在光网络中提供签名信号的方法和系统
公开(公告)号：US20060034608A1
公开(公告)日：2006-02-16
申请号：US11184966
申请日：2005-07-20
申请人： David Holmes , Paul Reepschlager
发明人： David Holmes , Paul Reepschlager
IPC分类号： G02F1/00
CPC分类号： H04B10/00 , H04L41/06
摘要： An optical network including multiple nodes is subject to intermittent faults that may raise alarms in the system. The invention focuses on an optical network based on the Any rate architecture. A single fault such as a client failure at a node in such a network can give rise to a loss of client signal leading to multiple alarms detected at multiple points. To alleviate this problem this invention provides switching in a special Signature signal in place of the lost client signal. By detecting the Signature signal containing a specific code, the fault on the any rate-based architecture can be uniquely identified. In addition to fault identification, the Signature signal on the network makes it possible to maintain Clock and Data Recovery Locks at downstream nodes. The Signature signal serves also as a vehicle for carrying a special optical tag called Wavekey provided by the Wavelength Tracker technology developed by the Applicant. This optical tag includes a low frequency modulation of one or more dither tones onto an optical channel, which is uniquely identified by the tag. Maintaining the Wavekey is important for tracing the end-to-end path and power level of the signal on each wavelength. A method and a Field Programmable Gate Array-based system for the generation and identification of such a Signature signal that not only identifies the fault that has occurred on the optical network but also provides for the maintenance of the Wavekey, are described.
摘要翻译：包括多个节点的光网络经受间歇性故障，可能会引起系统中的报警。本发明专注于基于Any Rate架构的光网络。诸如这种网络中的节点处的客户端故障的单个故障可能导致客户端信号的丢失，导致在多个点处检测到的多个警报。为了减轻这个问题，本发明提供了一种特殊的Signature信号来代替丢失的客户端信号。通过检测包含特定代码的签名信号，可以唯一地识别任何基于速率的架构上的故障。除了故障识别之外，网络上的Signature信号还可以在下游节点保持Clock和Data Recovery Lock。签名信号还用作携带由本申请人开发的波长跟踪技术提供的称为Wavekey的特殊光学标签的载体。该光学标签包括一个或多个抖动音调到光信道上的低频调制，其由标签唯一地标识。维护Wavekey对于跟踪每个波长上的信号的端到端路径和功率电平非常重要。描述了一种用于生成和识别这样的签名信号的方法和基于现场可编程门阵列的系统，其不仅识别出在光网络上发生的故障，而且提供波形的维护。

44. 发明申请

US20050274778A1 Method and apparatus for packaging various products 审中-公开
标题翻译：用于包装各种产品的方法和装置
公开(公告)号：US20050274778A1
公开(公告)日：2005-12-15
申请号：US11151917
申请日：2005-06-14
申请人： Deborah Rubyan , David Holmes
发明人： Deborah Rubyan , David Holmes
IPC分类号： B65D5/02 , B65D5/10 , B65D5/36 , B65D5/42
CPC分类号： B65D5/4229 , B65D5/3621 , B65D5/4208
摘要： A method and apparatus for packaging various products. The present invention provides a collapsible container having a plurality of side walls successively connected at fold lines there between. The side walls have a bottom end, whereby the side walls may fold into a collapsed position, wherein the side walls are substantially flat with respect to one another for ease of storage and shipping, and an erect position, wherein the side walls form an enclosure. A pair of interconnecting flaps and a bottom flap are integrally connected to the bottom end of at least one of the side walls along a fold line. The interconnecting flaps and bottom flap are foldable between the collapsed position, wherein the interconnecting flaps and bottom flap disengage one another to become substantially flat with the side walls, and the erect position, wherein the interconnecting flaps and bottom flap engage one another to form an enclosed end of the enclosure. Advertisements and promotional materials may be printed on the collapsible container for raising charitable donations.
摘要翻译：一种用于包装各种产品的方法和装置。本发明提供了一种可折叠容器，其具有在其之间的折叠线处连续连接的多个侧壁。侧壁具有底端，由此侧壁可以折叠成折叠位置，其中侧壁相对于彼此基本上是平的，以便于存储和运输，以及直立位置，其中侧壁形成外壳。一对互连翼片和底部翼片沿着折叠线一体地连接到至少一个侧壁的底端。互连翼片和底部翼片可在折叠位置之间折叠，其中互连翼片和底部翼片彼此脱开以与侧壁基本平齐，并且具有直立位置，其中互连翼片和底部翼片彼此接合以形成封闭的封闭端。广告和促销材料可能印在可折叠的集装箱上，用于募集慈善捐款。

45. 发明申请

US20050197168A1 System and method for providing an adapter module 审中-公开
标题翻译：用于提供适配器模块的系统和方法
公开(公告)号：US20050197168A1
公开(公告)日：2005-09-08
申请号：US11058103
申请日：2005-02-14
申请人： David Holmes , Edward Schmitt , Ibrahim Mohamed , Thomas Nelson
发明人： David Holmes , Edward Schmitt , Ibrahim Mohamed , Thomas Nelson
IPC分类号： H04B1/38 , H04M1/00
CPC分类号： H04M1/6091 , H04B1/3883 , H04M2250/02
摘要： Disclosed embodiments include a system and method for adapting a wireless device, such as a Bluetooth-enabled mobile device or other Bluetooth-enabled device to a hands-free car kit or similar system. The adapter module is physically configured so that it can be inserted directly into the cradle in place of the phone. Once inserted into the cradle, the adapter module makes electrical contact with the connector in the cradle with a matching connector on one side of the adapter module. The mated connectors provide power to the adapter module and bi-directional communications between the adapter module and the hands-free car kit. The adapter module includes circuitry for communicating with the Bluetooth-enabled mobile device and the hands-free car kit in order to exchange communications signals between the Bluetooth-enabled mobile device and the hands-free car kit.
摘要翻译：公开的实施例包括用于将无线设备（诸如启用蓝牙的移动设备或其他支持蓝牙的设备）适配到免提车载套件或类似系统的系统和方法。适配器模块的物理配置使其可以直接插入到支架中代替手机。一旦插入到支架中，适配器模块就使用与适配器模块一侧的匹配连接器的托架中的连接器进行电气接触。配对连接器为适配器模块提供电源，并在适配器模块和免提车载套件之间进行双向通信。适配器模块包括用于与启用蓝牙的移动设备和免提车载套件进行通信的电路，以便在支持蓝牙的移动设备和免提车载套件之间交换通信信号。

46. 发明申请

US20050066336A1 Method and apparatus for software-based allocation and scheduling of hardware resources in an electronic device 失效
标题翻译：用于电子设备中的硬件资源的基于软件的分配和调度的方法和装置
公开(公告)号：US20050066336A1
公开(公告)日：2005-03-24
申请号：US10750532
申请日：2003-12-30
申请人： Chakki Kavoori , Keith Reiken , David Holmes
发明人： Chakki Kavoori , Keith Reiken , David Holmes
IPC分类号： H04B1/04 , H04B1/38 , H04B1/40 , H04B7/06 , H04L12/28 , H04L12/56 , H04L27/00 , H04W72/00 , H04W72/12 , H04W88/02 , G06F9/46 , G06F13/00
CPC分类号： H04B1/04 , H04B1/38 , H04B1/406 , H04B7/06 , H04W72/1215 , H04W88/02 , H04W88/06 , Y10S707/99953 , Y10S707/99955
摘要： An architecture and method for dynamic resource allocation and scheduling in a communication device is disclosed herein. The method of controlling hardware resources in a communication device having a processor, a computer readable memory, and at least one hardware resource coupled to each other includes several steps. The first step locates a memory address in the computer readable memory that is associated with a first hardware resource. In the next step, control information associated with the first memory address is transmitted to the first hardware resource for it to be operated. In the last step, a pointer associated with the first address that locates a subsequent address for a subsequent hardware resource, is read.
摘要翻译：本文公开了一种用于通信设备中的动态资源分配和调度的架构和方法。在具有处理器，计算机可读存储器和至少一个彼此耦合的硬件资源的通信设备中控制硬件资源的方法包括几个步骤。第一步找到与第一硬件资源相关联的计算机可读存储器中的存储器地址。在下一步骤中，将与第一存储器地址相关联的控制信息发送到第一硬件资源以供操作。在最后一步中，读取与定位后续硬件资源的后续地址的第一地址相关联的指针。

47. 发明申请

US20050009567A1 One button access to network services from a remote control device 有权
标题翻译：从遥控设备一键访问网络服务
公开(公告)号：US20050009567A1
公开(公告)日：2005-01-13
申请号：US10612970
申请日：2003-07-07
申请人： David Holmes
发明人： David Holmes
IPC分类号： H04M1/247 , H04M1/27 , H04M1/725 , H04M3/42 , H04M3/493 , H04B7/00
CPC分类号： H04W4/16 , H04M1/271 , H04M1/7253 , H04M3/42204 , H04M3/493 , H04M2207/18 , H04W12/06 , H04W12/08
摘要： Systems and methods of accessing a network-based communication service provide for generating a dialing request at a remote control device based on user input. A dialing signal is transmitted toward a mobile communication device based on the request, where the dialing signal instructs the mobile communication device to access the network-based communication service. Communication services can enable a user to use information retrieval at a network server as well as use number dialing at the network server. In one example, the dialing signal is transmitted according to a Bluetooth standard.
摘要翻译：基于网络的通信服务的系统和方法提供用于基于用户输入在远程控制设备处生成拨号请求。基于请求，向移动通信设备发送拨号信号，其中拨号信号指示移动通信设备接入基于网络的通信服务。通信服务可以使用户能够在网络服务器上使用信息检索，以及在网络服务器上使用号码拨号。在一个示例中，根据蓝牙标准发送拨号信号。

48. 发明授权

US5497451A Computerized method for decomposing a geometric model of surface or volume into finite elements 失效
标题翻译：将表面或体积的几何模型分解为有限元的计算机化方法
公开(公告)号：US5497451A
公开(公告)日：1996-03-05
申请号：US823109
申请日：1992-01-22
申请人： David Holmes
发明人： David Holmes
IPC分类号： G06T17/20
CPC分类号： G06T17/20
摘要： A computerized process for defining finite elements in a surface or volume for ultimately predicting a physical characteristic of the surface or volume. For the surface, for example, the process includes a first step of inputting surface boundary point coordinates of a geometric model of the surface to a computer system, the computer system including an image display screen displaying the geometric model. The process further includes preparing the boundary edges of surface by generating piecewise geometrically smooth bezier curves between boundary points and converting the bezier curves to cubic interpolation polynomials and defining evenly spaced points on each cubic interpolation polynomial and decomposing the surface with divider curves, if the surface is not already 3, 4, or 5 sided, into 3, 4, and 5 sided primitives. Thereafter, a determination is made of the largest acceptable element size and the number of elements disposed along each edge of each primitive. The next steps are readjusting one of the divider curves to match a closest even element vertices and mapping in 3 and 5 sided clusters and then preparing remaining 4 sided primitives for decomposition into 4 sided elements and mapping in elements and element patches. Thereafter, method includes the steps of optimising the elements in the mesh and writing the resulting mesh to a storage file.
摘要翻译：用于定义表面或体积中的有限元素以最终预测表面或体积的物理特性的计算机化过程。对于表面，例如，该处理包括将表面的几何模型的表面边界点坐标输入到计算机系统的第一步骤，该计算机系统包括显示几何模型的图像显示屏幕。该过程还包括通过在边界点之间产生分段几何平滑的贝塞尔曲线并将贝塞尔曲线转换为三次插值多项式并且在每个三次插值多项式上定义均匀间隔的点并且用分割器曲线分解表面来准备表面的边界边缘，如果表面已经没有3，4或5面，分成3，4和5面的原语。此后，确定最大可接受元件尺寸和沿着每个图元的每个边缘设置的元件的数量。接下来的步骤是重新调整其中一个分割曲线以匹配最接近的偶数元素顶点，并在3和5个边集合中进行映射，然后准备剩余的4面基元以便分解成4面元素，并在元素和元素贴图中进行映射。此后，方法包括优化网格中的元素并将所得到的网格写入存储文件的步骤。

49. 发明授权

US5150896A Game racket with incurvate contact surfaces 失效
标题翻译：游戏球拍与接触面接触
公开(公告)号：US5150896A
公开(公告)日：1992-09-29
申请号：US845393
申请日：1992-03-03
申请人： David Holmes
发明人： David Holmes
IPC分类号： A63B59/00
CPC分类号： A63B59/80 , A63B2060/006 , A63B60/50
摘要： A game racket (20) having rigid, incurvate contact surfaces (29) with apertures (52) for the passage of air rather than the conventional network of stringing, both contact surfaces (29) having a continuous, smooth corrective curvature able to automatically compensate for the lateral and longitudinal torsional forces that are exerted by an incoming ball (56) onto the racket (20), when a player fails to hit the ball dead center on the racket face. Having no stringing, the racket of the present invention is completely maintenance-free and provides numerous other advantages over conventional racket designs, including: texturable contact surfaces (38); a variety of aperture (52) shapes and patterns with aerodynamic fairing (53); contact surfaces (29) whose playable area extends to their extreme periphery (31 and 33); means for employing vibration-dampening and shock absorbant materials in the racket's construction; and a curvature which aids in the execution of "slice" shots. An alternative design allows the two contact surfaces (43 and 44) to have differentiated curvatures and textures (39, 40, 41, 42, 54 and 55) for forehand and backhand shots. Insofar as the racket (20) itself compensates for all torsional forces, it can be gripped more loosely in the hand, and should reduce the incidence of "tennis elbow."
摘要翻译：一种游戏球拍（20），其具有刚性的具有孔（52）的接触表面（29），所述接触表面具有用于空气通过的孔（52），而不是常规的穿线网络，两个接触表面（29）具有连续的平滑校正曲率，能够自动补偿对于当球员不能击中球拍面上的死球中心时，由进球（56）施加到球拍（20）上的横向和纵向扭转力。本发明的球拍没有绳索，是完全免维护的，并且与传统球拍设计相比具有许多其它优点，包括：可纹理的接触表面（38）; 各种孔径（52）形状和图案与气动整流罩（53）; 其可播放区域延伸到其最外围（31和33）的接触表面（29）; 在球拍结构中采用减震和减震材料的方法; 以及有助于执行“切片”镜头的曲率。替代设计允许两个接触表面（43和44）具有不同的曲率和纹理（39,40,41,42,54和55），用于正手和反手镜头。只要球拍（20）本身能够补偿所有的扭转力，就可以在手中松动握紧，并且应该减少“网球肘”的发生。

50. 发明申请

US20160078422A1 SYSTEM AND METHOD FOR ENHANCING RFID TAGGED PRODUCTS IN PACKAGES WITH MULTIPLE PRODUCTS 审中-公开
标题翻译：使用多种产品提供包装中的RFID标签产品的系统和方法
公开(公告)号：US20160078422A1
公开(公告)日：2016-03-17
申请号：US14849906
申请日：2015-09-10
申请人： David Holmes , Mathew Smith
发明人： David Holmes , Mathew Smith
IPC分类号： G06Q20/20 , G06Q30/04 , G06Q20/10 , G07G1/00
CPC分类号： G06Q30/04 , G07G1/0045 , G07G1/009
摘要： A multi-product-package POS (point of sale) enhancement system for enhancing software features in products at the POS. The system comprising a register and a multi-product contactless POS read/write terminal at a retail location and a central server at a remote location. The register configured for identifying one or more products in a package, indicating one or more enhancements available for the product(s), and receiving indication of a selected enhancement(s) from the customer. The multi-product contactless POS read/write terminal is in communication with the register and configured for receiving one or more PEA (product enhancement authorization) tokens for the selected enhancement(s), validating the PEA token(s) and executing the enhancement(s) of each product via an RFID tag coupled to the product, generating an audit record of the enhancement(s) of the product(s), and sending the audit record from the contactless POS terminal to the central server.
摘要翻译：多产品包POS（Point of sale）增强系统，用于增强POS产品中的软件功能。该系统包括在零售位置处的寄存器和多产品非接触POS读/写终端以及在远程位置的中央服务器。所述寄存器被配置用于识别包中的一个或多个产品，指示可用于所述产品的一个或多个增强，以及从所述客户接收所选增强的指示。多产品非接触POS读/写终端与寄存器通信，并配置为接收所选增强的一个或多个PEA（产品增强授权）令牌，验证PEA令牌并执行增强（通过耦合到产品的RFID标签，产生每个产品的增强的审计记录，以及将审计记录从非接触POS终端发送到中央服务器。

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