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41. 发明授权

US08968709B2 Therapeutic dental composition and related methods 有权
标题翻译：治疗牙科成分及相关方法
公开(公告)号：US08968709B2
公开(公告)日：2015-03-03
申请号：US12594994
申请日：2008-07-10
申请人： Jie Yang , Bhaskar V. Velamakanni , Sumita B Mitra , Alphonsus V. Pocius , John J. Stofko, Jr. , Jeremy M. Yarwood
发明人： Jie Yang , Bhaskar V. Velamakanni , Sumita B Mitra , Alphonsus V. Pocius , John J. Stofko, Jr. , Jeremy M. Yarwood
IPC分类号： A61K8/41 , A61K8/42 , A61K8/85 , A61K8/89 , A61Q11/00 , C07C215/10 , C07C233/18
CPC分类号： A61K8/41 , A61Q11/00
摘要： Dental compositions are provided comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein n is an integer from about 2 to about 5.
摘要翻译：提供牙科组合物，其包含式（I）的化合物或其药学上可接受的盐：其中n为约2至约5的整数。

42. 发明授权

US08766720B2 Hybrid load differential amplifier operable in a high temperature environment of a turbine engine 有权
标题翻译：混合负载差动放大器可在涡轮发动机的高温环境中操作
公开(公告)号：US08766720B2
公开(公告)日：2014-07-01
申请号：US13537572
申请日：2012-06-29
申请人： David J. Mitchell , John R. Fraley , Jie Yang , Cora Schillig , Roberto Marcelo Schupbach , Bryon Western
发明人： David J. Mitchell , John R. Fraley , Jie Yang , Cora Schillig , Roberto Marcelo Schupbach , Bryon Western
IPC分类号： H03F3/45
CPC分类号： H03F3/45 , F01D5/14 , F01D5/3007 , F01D17/085 , F05D2270/54 , G01L1/225
摘要： A circuitry (120) adapted to operate in a high-temperature environment of a turbine engine is provided. The circuitry may include a differential amplifier (122) having an input terminal (124) coupled to a sensing element to receive a voltage indicative of a sensed parameter. A hybrid load circuitry (125) may be AC-coupled to the differential amplifier. The hybrid load circuitry may include a resistor-capacitor circuit (134) arranged to provide a path to an AC signal component with respect to the drain terminal of the switch (e.g., 126) of a differential pair of semiconductor switches 126, 128, which receives the voltage indicative of the sensed parameter.
摘要翻译：提供适于在涡轮发动机的高温环境中操作的电路（120）。电路可以包括具有耦合到感测元件的输入端子（124）的差分放大器（122），以接收指示感测参数的电压。混合负载电路（125）可以被AC耦合到差分放大器。混合负载电路可以包括电阻器 - 电容器电路（134），其被布置成提供相对于差分对半导体开关126,128的开关（例如126）的漏极端子的AC信号分量的路径，接收指示感测参数的电压。

43. 发明授权

US08697648B2 Protein agent for diabetes treatment and β cell imaging 有权
标题翻译：糖尿病治疗用蛋白剂细胞成像
公开(公告)号：US08697648B2
公开(公告)日：2014-04-15
申请号：US13503194
申请日：2010-10-20
申请人： Zhi-Ren Liu , Jie Yang , Bing Xu , Wangda Zhou , Shenghui Xue
发明人： Zhi-Ren Liu , Jie Yang , Bing Xu , Wangda Zhou , Shenghui Xue
IPC分类号： A61K38/26 , A61K38/00 , C07K14/605 , C07K19/00 , A61K47/48 , A61K49/08
CPC分类号： A61K38/26 , A61K38/00 , A61K47/60 , A61K49/085 , C07K14/605 , C07K2319/00
摘要： The 30 amino acid peptide GLP-1 has been integrated into the stable host protein human calbindin D9k. The fusion protein binds to GLP-1R. The fusion protein agents can be useful for both diabetes treatment and GLP-1R receptor targeting MR imaging. The fusion protein comprises a first peptide that selectively binds to a site of a target cell and linked to a second peptide, where the fusion protein is more stable than the first peptide alone and may further comprise a detectable label. The first peptide of the fusion protein may be glucagon-like peptide-1 (GLP-1), glucagon-like peptide-1 (GLP-1)(7-36), or glucagon-like peptide-1 (GLP-1) (9-36), or a conservative variant thereof.
摘要翻译：已将30个氨基酸的肽GLP-1整合到稳定的宿主蛋白人卡金登丁D9k中。融合蛋白与GLP-1R结合。融合蛋白剂可用于糖尿病治疗和靶向MR成像的GLP-1R受体。融合蛋白包含选择性结合靶细胞位点并与第二肽连接的第一肽，其中融合蛋白比单独的第一肽更稳定，并且还可以包含可检测标记。融合蛋白的第一个肽可以是胰高血糖素样肽-1（GLP-1），胰高血糖素样肽-1（GLP-1）（7-36）或胰高血糖素样肽-1（GLP-1）（9-36）或其保守变体。

44. 发明申请

US20140009222A1 CHOPPER CIRCUITRY OPERABLE IN A HIGH TEMPERATURE ENVIRONMENT OF A TURBINE ENGINE 有权
标题翻译：在涡轮发动机的高温环境中操作的切割电路
公开(公告)号：US20140009222A1
公开(公告)日：2014-01-09
申请号：US13544159
申请日：2012-07-09
申请人： David J. Mitchell , Jie Yang , Roberto Marcelo Schupbach , John R. Fraley , Cora Schillig , Bryon Western
发明人： David J. Mitchell , Jie Yang , Roberto Marcelo Schupbach , John R. Fraley , Cora Schillig , Bryon Western
IPC分类号： H03F3/45
CPC分类号： G01K7/021 , G01K13/08 , H04Q9/00 , H04Q2209/40
摘要： Chopper circuitry may be adapted to operate in a high-temperature environment of a turbine. A first semiconductor switch (122) may have a first terminal coupled to receive a first output signal from a first leg (148) of a differential amplifier (150). A second switch (128) may have a first terminal coupled thru a first resistive element (R1) to a second terminal of the first semiconductor switch. The first terminal of the second semiconductor switch may be coupled to receive thru a second resistive element (R2) a second output signal from a second leg (152) of the amplifier. Switches (122,128) may be responsive to a switching control signal to respective gate terminals of the switches to supply an output signal, which alternates in correspondence with a frequency of the switching control signal from a first amplitude level to a second amplitude level, which effectively provides a doubling amplification factor.
摘要翻译：斩波器电路可以适于在涡轮机的高温环境中操作。第一半导体开关（122）可以具有耦合以从差分放大器（150）的第一支路（148）接收第一输出信号的第一端子。第二开关（128）可以具有通过第一电阻元件（R1）耦合到第一半导体开关的第二端子的第一端子。第二半导体开关的第一端子可以被耦合以通过第二电阻元件（R2）接收来自放大器的第二支路（152）的第二输出信号。开关（122,128）可以响应于开关的相应栅极端子的开关控制信号，以提供输出信号，该输出信号与切换控制信号的频率相对应，从第一幅度电平到第二幅度电平，这有效地提供了倍增放大系数。

45. 发明授权

US08595174B2 Answer support system and method 有权
标题翻译：回答支持系统和方法
公开(公告)号：US08595174B2
公开(公告)日：2013-11-26
申请号：US12955772
申请日：2010-11-29
申请人： Peng Gao , Jie Yang , Wei Zhou , Qing Zou
发明人： Peng Gao , Jie Yang , Wei Zhou , Qing Zou
IPC分类号： G06N5/02
CPC分类号： G06N5/022 , G06F17/30525 , G06Q10/10
摘要： An answer support system generates a target cause to aid in solving a current problem. Upon receiving known problem symptoms of the current problem from the customer, a search of problem causes is conducted in a knowledge database to find potential causes corresponding to the known problem symptoms. If conventional techniques cannot determine the target cause of the current problem, an attribute is selected which is not among the attributes associated with the known problem symptoms in the database. The attribute selection is based on the attribute deemed most likely to identify the target cause of the current problem from among the potential causes found in the knowledge database.
摘要翻译：答案支持系统产生目标原因来帮助解决当前的问题。在从客户那里收到当前问题的已知问题症状时，在知识数据库中进行问题原因的搜索，以找出与已知问题症状相对应的潜在原因。如果常规技术不能确定当前问题的目标原因，则选择不在数据库中与已知问题症状相关联的属性之中的属性。属性选择是基于认知最有可能从知识数据库中发现的潜在原因中识别当前问题的目标原因的属性。

46. 发明授权

US08557893B2 Substituted saccharide compounds and dental compositions 有权
标题翻译：取代的糖类化合物和牙齿组合物
公开(公告)号：US08557893B2
公开(公告)日：2013-10-15
申请号：US13813673
申请日：2011-08-19
申请人： Jie Yang , Sumita B. Mitra , Yi He , Brian A. Shukla , Naimul Karim , Afshin Falsafi , Richard B. Ross , Paul R. Klaiber , George W. Griesgraber
发明人： Jie Yang , Sumita B. Mitra , Yi He , Brian A. Shukla , Naimul Karim , Afshin Falsafi , Richard B. Ross , Paul R. Klaiber , George W. Griesgraber
IPC分类号： A61K6/083 , C07C233/20
CPC分类号： A61K6/0029 , A61K6/0023 , A61K6/083 , C07H13/12 , C08L33/24 , C08L33/10
摘要： Substituted saccharide compounds, dental compositions comprising substituted saccharide compounds, and methods of using dental compositions are described. In one embodiment, the substituted saccharide amide compound comprises a hydrophobic group and at least one free-radically polymerizable group with the proviso that the hydrophobic group is not bonded to the ethylenically unsaturated carbon atom of the free-radically polymerizable group. The hydrophobic group is typically bonded to a nitrogen atom of a saccharide amine residue or a carbonyl moiety of saccharide amide residue.
摘要翻译：描述了取代的糖类化合物，包含取代的糖类化合物的牙科组合物和使用牙科用组合物的方法。在一个实施方案中，取代的糖酰胺化合物包含疏水基团和至少一个可自由基聚合的基团，条件是疏水基团不与可自由基聚合基团的烯属不饱和碳原子键合。疏水基团通常键合到糖胺残基的氮原子或糖酰胺残基的羰基部分。

47. 发明授权

US08484748B2 Method and device for classifying and processing data in instant messaging system 有权
标题翻译：在即时通讯系统中对数据进行分类和处理的方法和设备
公开(公告)号：US08484748B2
公开(公告)日：2013-07-09
申请号：US12637253
申请日：2009-12-14
申请人： Ran Wei , Jie Yang
发明人： Ran Wei , Jie Yang
IPC分类号： H04L29/06
CPC分类号： H04L51/04 , H04L63/08
摘要： The embodiment of this invention provides a method for classifying and processing data in an instant messaging system, which includes: classifying the data of every service included in the instant messaging system into confidential data and non-confidential data; obtaining and processing the non-confidential data of every service after a first authentication is passed successfully; and obtaining and processing the confidential data of every service after a second authentication is passed successfully. The embodiment of this invention also provides a device for classifying and processing data in an instant messaging system. According to the embodiment of the present invention, the security requirements of the instant messaging system are met, and the user is facilitated to use various services provided by the instant messaging system.
摘要翻译：本发明的实施例提供了一种用于在即时消息收发系统中分类和处理数据的方法，其包括：将包括在即时消息系统中的每个服务的数据分类为机密数据和非机密数据; 在第一次认证成功通过后，获取和处理每个业务的非机密数据; 并且在第二认证之后获得和处理每个服务的机密数据成功通过。本发明的实施例还提供了一种用于在即时消息系统中分类和处理数据的设备。根据本发明的实施例，满足了即时消息系统的安全性要求，并且便于用户使用由即时消息系统提供的各种服务。

48. 发明申请

US20130052713A1 GH61 GLYCOSIDE HYDROLASE PROTEIN VARIANTS AND COFACTORS THAT ENHANCE GH61 ACTIVITY 有权
公开(公告)号：US20130052713A1
公开(公告)日：2013-02-28
申请号：US13592024
申请日：2012-08-22
申请人： Jie Yang , Xiyun Zhang , Jungjoo Yoon , Kripa Rao , John H. Grate , David Elgart , Dipnath Baidyaroy
发明人： Jie Yang , Xiyun Zhang , Jungjoo Yoon , Kripa Rao , John H. Grate , David Elgart , Dipnath Baidyaroy
IPC分类号： C12N9/42 , C12N15/80 , C12N1/15 , C12N9/96 , C12N9/26 , C12N9/34 , C12N9/16 , C12N9/20 , C12N15/56 , C12N1/19
CPC分类号： C12N9/2434 , C12N9/242 , C12N9/2437 , C12N9/2445 , C12P7/10 , C12P19/14 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16
摘要： The present invention provides various GH61 protein variants comprising various amino acid substitutions. The GH61 protein variants have an improved ability to synergize with cellulase enzymes, thereby increasing the yield of fermentable sugars obtained by saccharification of biomass. In some embodiments, sugars obtained from saccharification are fermented to produce numerous end-products, including but not limited to alcohol.

49. 发明申请

US20120306511A1 PARTIAL DISCHARGE EXPERIMENT POWER SUPPLY SYSTEM FOR EXTRA-HIGH VOLTAGE TRANSFORMER AND METHOD THEREOF 有权
标题翻译：用于超高压变压器的部分放电实验电源系统及其方法
公开(公告)号：US20120306511A1
公开(公告)日：2012-12-06
申请号：US13513491
申请日：2010-11-12
申请人： Guangfan Li , Jie Yang , Jinzhong Li , Xiaocen Hu , Shuqi Zhang , Yuewen Qi , Xiaoning Wang , Ninghua Wang
发明人： Guangfan Li , Jie Yang , Jinzhong Li , Xiaocen Hu , Shuqi Zhang , Yuewen Qi , Xiaoning Wang , Ninghua Wang
IPC分类号： H02N99/00
CPC分类号： G01R31/1227 , G01R31/027
摘要： A partial discharge test power supply system for an extra high voltage transformer comprises: an electric motor (1); an intermediate frequency generator (2) driven by the electric motor and outputting an intermediate frequency voltage; a middle transformer (9) receiving the intermediate frequency voltage and outputting a test voltage to be applied to a test sample (11) by a generator outlet (5); a low-voltage compensating reactor (8) connected between the intermediate frequency generator and the middle transformer; a high-voltage compensating reactor (10) connected between the middle transformer and the sample; wherein the electric motor and the intermediate frequency generator are arranged in a metal housing (100). The system also includes the following filters: a filter (a) arranged in the excitation circuit of the intermediate frequency generator, a filter (h) arranged between the high-voltage compensating reactor and the sample and a filter (c) arranged between the generator outlet and the low-voltage compensating reactor. The system provides a simple and reliable power source system with little background interference for the extra high voltage partial discharge tests.
摘要翻译：一种用于超高压变压器的局部放电测试电源系统包括：电动机（1）; 由电动机驱动并输出中频电压的中频发生器（2）; 接收中频电压的中间变压器（9），并通过发电机出口（5）输出要施加到测试样品（11）的测试电压; 连接在中频发生器和中间变压器之间的低压补偿电抗器（8）; 连接在中间变压器和样品之间的高压补偿电抗器（10）其中所述电动机和所述中频发生器布置在金属壳体（100）中。该系统还包括以下滤波器：布置在中频发生器的激励电路中的滤波器（a），布置在高压补偿反应器和样品之间的滤波器（h）和布置在发电机之间的滤波器（c）出口和低压补偿电抗器。该系统提供了一个简单可靠的电源系统，对于额外的高压部分放电测试，具有很小的背景干扰。

50. 发明申请

US20120295892A1 GABAERGIC RECEPTOR SUBTYPE SELECTIVE LIGANDS AND THEIR USES 有权
标题翻译：化合物受体亚型选择性配体及其用途
公开(公告)号：US20120295892A1
公开(公告)日：2012-11-22
申请号：US13458168
申请日：2012-04-27
申请人： James M. Cook , Terry S. Clayton , Hiteshkumar D. Jain , Sundari K. Rallipalli , Yun Teng Johnson , Jie Yang , Michael Ming-Jin Poe , Ojas A. Namjoshi , Zhi-jian Wang
发明人： James M. Cook , Terry S. Clayton , Hiteshkumar D. Jain , Sundari K. Rallipalli , Yun Teng Johnson , Jie Yang , Michael Ming-Jin Poe , Ojas A. Namjoshi , Zhi-jian Wang
IPC分类号： A61K31/5517 , A61P25/18 , A61P25/22 , A61P25/08 , C07D487/04 , C07D487/14
CPC分类号： A61K31/695 , A61K31/551 , C07D487/04 , C07D487/14 , C07D519/00
摘要： Described herein are α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.
摘要翻译：本文描述的是α3或α2或α2/α3GABA能受体亚型选择性配体，药物组合物，以及这些配体和组合物在治疗焦虑症，癫痫和精神分裂症以及降低镇静和共济失调副作用中的应用的方法。在实施方案中，诸如α3或α2或α2/α3GABA能受体亚型选择性配体缺少酯键，因此可能因酯酶水解而相对不敏感。

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