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41. 发明申请

US20060097527A1 Bumper system with energy absorber 失效
标题翻译：具有能量吸收器的保险杠系统
公开(公告)号：US20060097527A1
公开(公告)日：2006-05-11
申请号：US11313325
申请日：2005-12-21
申请人： Mark Weissenborn , Darin Evans , Robert Weykamp , David Powell
发明人： Mark Weissenborn , Darin Evans , Robert Weykamp , David Powell
IPC分类号： B60R19/03
CPC分类号： B29C44/08 , B60R19/04 , B60R19/18 , B60R2019/1813 , B60R2019/1846 , B60R2019/186 , B60R2019/1866 , B60R2019/1873 , Y10T29/49622 , Y10T29/4998
摘要： A bumper system includes a bumper beam having a face and ends, and an energy absorber mounted on the face. The energy absorber has a one-piece injection-molded non-foam piece with box sections and interconnecting straps, and a one-piece or multi-piece foam component securely insert-molded onto the injection-molded non-foam piece. Different foam molds can be used to form differently shaped front surfaces on the foam component. By this arrangement, different energy absorbing systems are provided for vehicles, such as to satisfy the need for different styling and shapes, while still using the same non-foam piece. By this arrangement, the energy absorber is a single unit that can be handled and attached to the bumper beam. At the same time, capital investment in molding dies and tooling is reduced.
摘要翻译：保险杠系统包括具有面和端部的保险杠梁，以及安装在所述面上的能量吸收器。能量吸收器具有一体式注塑非泡沫件，其具有盒形部分和互连带，以及将一片或多片泡沫部件牢固地嵌入模制到注射成型的非泡沫件上。可以使用不同的泡沫模具来在泡沫组件上形成不同形状的前表面。通过这种布置，为车辆提供了不同的能量吸收系统，以便在仍然使用相同的非泡沫件的同时满足不同造型和形状的需要。通过这种布置，能量吸收器是可以被处理并附接到保险杠梁的单个单元。同时，模具和模具的资本投资也有所减少。

42. 发明申请

US20060025006A1 Cable retaining system 审中-公开
标题翻译：电缆固定系统
公开(公告)号：US20060025006A1
公开(公告)日：2006-02-02
申请号：US11184479
申请日：2005-07-19
申请人： David Powell , Alan Brown , William Mackenzie
发明人： David Powell , Alan Brown , William Mackenzie
IPC分类号： H01R13/58
CPC分类号： H01R13/5812
摘要： A retaining system (1) that retains the front portion of a cable (7) in a connector housing (3). A sleeve device (21) has a base (25) with a hole (34) through which the cable extends, and has a pair of arms (27) with part-cylindrical inner surfaces that press against the cable to grip it. The arms have rear ends with recess (31). When the sleeve device is pushed fully forward into the connector housing, a bridging device (23) is pushed through an opening (15) into the housing. Legs (37) of the bridging element are inserted into the arm recesses (31) and prevent pull-out of the sleeve device and cable.
摘要翻译：一种将电缆（7）的前部保持在连接器壳体（3）中的保持系统（1）。套筒装置（21）具有带孔（34）的基座（25），电缆延伸通过该基座（25），并具有一对具有部分圆柱形内表面的臂（27），该部分圆柱形内表面压靠电缆以夹持它。臂具有带凹部（31）的后端。当套筒装置完全向前推入连接器壳体中时，桥接装置（23）被推动通过开口（15）进入壳体。桥接元件的腿部（37）插入到臂凹部（31）中，并且防止套筒装置和电缆的拉出。

43. 外观设计

USD284988S Spray gun 失效
公开(公告)号：USD284988S
公开(公告)日：1986-08-05
申请号：US634359
申请日：1984-07-25
申请人： David Powell
设计人： David Powell

44. 外观设计

USD282959S Spray wand 失效
公开(公告)号：USD282959S
公开(公告)日：1986-03-11
申请号：US681626
申请日：1984-12-14
申请人： David Powell
设计人： David Powell

45. 发明授权

US08742075B2 Monoclonal antibodies against ANGPTL3 有权
标题翻译：针对ANGPTL3的单克隆抗体
公开(公告)号：US08742075B2
公开(公告)日：2014-06-03
申请号：US13073617
申请日：2011-03-28
申请人： E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
发明人： E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
IPC分类号： C07K16/26 , C07K16/00 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
摘要翻译：提供特异性结合ANGPTL3的单克隆抗体。提供中和至少一种ANGPTL3活性的单克隆抗体。提供了使用中和单克隆抗体治疗脂质代谢紊乱的方法。

46. 发明授权

US08662441B2 Unmanned aerial vehicle launch system 有权
标题翻译：无人机发射系统
公开(公告)号：US08662441B2
公开(公告)日：2014-03-04
申请号：US13367494
申请日：2012-02-07
申请人： David Powell , Earl Mark , John T. Houck , Keith Huber
发明人： David Powell , Earl Mark , John T. Houck , Keith Huber
IPC分类号： B64F1/10
CPC分类号： B64C39/024 , B63G8/30 , B64C2201/021 , B64C2201/102 , B64C2201/201 , B64C2201/205
摘要： A system for launching an unmanned aerial vehicle (UAV) payload includes a launch tube, liquid rocket, and launch control assembly. The rocket is positioned in the launch tube and contains the UAV payload. A booster assembly may include a canister partially filled with liquid. A gas cylinder is filled with compressed gas. The liquid is pre-pressurized by the gas or mixed with the gas right before launch such that, upon launch, liquid and gaseous thrust stages launch the rocket to a threshold altitude. The UAV payload deploys after reaching the threshold altitude. Optional stability tubes may be connected to the launch tube, which may be buoyant for water-based operations. An optional tether may be connected to the liquid rocket for arresting its flight prior to reaching apogee. The UAV payload is not launched directly by the gas/liquid mix. A method of launching the UAV payload is also disclosed.
摘要翻译：用于发射无人机（UAV）有效载荷的系统包括发射管，液体火箭和发射控制组件。火箭定位在发射管中，并包含无人机的有效载荷。增压组件可以包括部分地填充有液体的罐。气瓶内充满压缩气体。液体被气体预加压或在发射前与气体混合，使得在发射时，液体和气体推进阶段将火箭发射到阈值高度。无人机有效载荷在达到阈值高度后部署。可选的稳定管可以连接到发射管，其可以浮动用于水基操作。可选的系绳可以连接到液体火箭，以在达到远地点之前停止其飞行。无人机有效载荷不直接由气/液混合发射。还公开了一种启动无人机有效载荷的方法。

47. 发明授权

US08568316B2 Tracheal tube sensor disposed on permeable membrane 有权
公开(公告)号：US08568316B2
公开(公告)日：2013-10-29
申请号：US12726210
申请日：2010-03-17
申请人： Alan Finneran , Garret Coady , John Desmond , Mark Cleary , David Powell , Patrick Dowling
发明人： Alan Finneran , Garret Coady , John Desmond , Mark Cleary , David Powell , Patrick Dowling
IPC分类号： A61B5/00
CPC分类号： A61M16/0051 , A61B5/0002 , A61B5/0071 , A61B5/0075 , A61B5/0833 , A61B5/0836 , A61B5/14503 , A61B5/14539 , A61B5/14542 , A61B5/1459 , A61B5/1473 , A61B5/6853 , A61B5/6885 , A61B5/742 , A61M16/0057 , A61M16/021 , A61M16/04 , A61M16/0434 , A61M16/0443 , A61M16/0459 , A61M16/0484 , A61M2016/0413 , A61M2205/3523 , A61M2230/202 , A61M2230/205 , A61M2230/208
摘要： Various embodiments of an tracheal tube having a sensor coupled to a selectively permeable membrane are provided. In some embodiments, the membrane may be permeable to one or more blood gases and/or blood analytes. Certain embodiments of the endotracheal tube may be capable of deploying the sensor during intubation to sense one or more indicators of blood flow characteristics, such as a level of blood gases and/or blood analytes, in the respiratory tract. Embodiments of the present invention may include positioning of the sensor in a variety of suitable positions with respect to the permeable membrane, such as mounting the sensor to the underside of an inflatable permeable membrane.

48. 发明授权

US08436051B2 Mesalamine suppository 有权
标题翻译：美沙胺栓剂
公开(公告)号：US08436051B2
公开(公告)日：2013-05-07
申请号：US12639645
申请日：2009-12-16
申请人： Carl Gauthier , Yves Dumoulin , David Powell , Hugues Moreau
发明人： Carl Gauthier , Yves Dumoulin , David Powell , Hugues Moreau
IPC分类号： A01N33/02 , A01N37/36 , A01N37/12 , A01N37/44 , A61K31/135 , A61K31/60 , A61K31/195 , A61F13/00
CPC分类号： A61K9/14 , A61K9/0031 , A61K9/02 , A61K31/136 , A61K31/195 , A61K31/606 , A61K47/44
摘要： The present invention relates to a mesalamine rectal suppository designed to provide improved comfort of use. One embodiment of the invention is a mesalamine rectal suppository comprising mesalamine and one or more pharmaceutically acceptable excipients, wherein the drug load of the suppository ranges from 35% to 50%. Yet another embodiment of the invention is a mesalamine rectal suppository comprising mesalamine having a tap density ranging from about 600 to about 800 g/L (as measured by USP ) and a hard fat having an ascending melting point of 32 to 35.5° C. Yet another embodiment is a mesalamine rectal suppository comprising mesalamine particles and one or more pharmaceutically acceptable excipients, where the mesalamine particles have a surface area of from about 0.1 m2/g to about 2.8 m2/g (e.g., from about 0.1 m2/g to about 1.3 m2/g). Methods of preparing and methods of treatment with mesalamine suppositories are also provided. The invention further provides a method of determining a dissolution parameter (such as dissolution rate) of a mesalamine rectal suppository, such as a 1 g mesalamine suppository, by measuring its dissolution with USP Apparatus #2 at 40° C. and a paddle rotation speed of 125 rpm in 0.2 M phosphate buffer at a pH of 7.5.
摘要翻译：本发明涉及美沙拉坦直肠栓剂，其旨在提供改善的使用舒适性。本发明的一个实施方案是美沙拉坦直肠栓剂，其包含美沙拉嗪和一种或多种药学上可接受的赋形剂，其中栓剂的药物负载范围为35％至50％。本发明的另一个实施方案是美沙拉坦直肠栓剂，其包含振荡密度范围为约600至约800g / L的美沙拉嗪（通过USP <616>测量）和具有上升熔点为32至35.5°的硬脂肪 C.另一个实施方案是美沙拉坦直肠栓剂，其包含美沙拉嗪颗粒和一种或多种药学上可接受的赋形剂，其中美沙拉嗪颗粒的表面积为约0.1m 2 / g至约2.8m 2 / g（例如，约0.1m 2 / g至约1.3m 2 / g）。还提供了制备方法和美沙拉坦栓剂的治疗方法。本发明还提供了一种通过用USP装置＃2在40℃下测量溶解参数（例如溶解度）来测定美沙拉嗪直肠栓剂如1g美沙胺栓剂的溶出参数（如溶出速率），并且桨叶转速在pH 7.5的0.2M磷酸盐缓冲液中的125rpm。

49. 发明授权

US08407872B2 Rail fence retractor 有权
标题翻译：铁轨牵引器
公开(公告)号：US08407872B2
公开(公告)日：2013-04-02
申请号：US12263931
申请日：2008-11-03
申请人： David Powell , Steven R. Watts
发明人： David Powell , Steven R. Watts
IPC分类号： B25B27/00 , B23P19/04
CPC分类号： E04H17/26 , E04H17/1413 , E04H2017/1469 , Y10T29/53683 , Y10T29/53909 , Y10T29/53943
摘要： A rail fence retractor allowing removal of a fence rail engaged with a fence post comprising a blade having a first and second end. The first end of the blade is configured for insertion into a fence post slot having a rail inserted therein. The rail has self-locking tabs which must be depressed for removal of the rail from the fence post slot. The fence rail retractor also has a handle which is attached to the second end of the blade. The handle allows the application of force against handle to fix the position of the handle against the fence post during removal of the rail from the fence post slot. The handle is also useful in carrying the rail fence retractor when not in use. The handles may be also be configured to allow a pair of rail fence retractors to fit or snap together when not in use.
摘要翻译：轨道牵引器，其允许移除与栅栏柱接合的围栏栏杆，所述围栏栏杆包括具有第一端和第二端的叶片。叶片的第一端构造成用于插入具有插入其中的轨道的挡板柱槽中。导轨具有自锁片，必须按下以将轨从栅栏柱槽中取出。围栏轨道牵开器还具有附接到叶片第二端的把手。手柄允许在从栅栏柱槽中移除轨道时施加力以将手柄的位置固定在栅栏柱上。当不使用时，手柄也可用于承载轨道牵引器。手柄还可以被配置成允许一对轨道护栏卷收器在不使用时装配或卡扣在一起。

50. 发明申请

US20110243948A1 Monoclonal Antibodies Against ANGPTL3 有权
标题翻译：针对ANGPTL3的单克隆抗体
公开(公告)号：US20110243948A1
公开(公告)日：2011-10-06
申请号：US13073617
申请日：2011-03-28
申请人： E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
发明人： E-Chiang Lee , Gregory Landes , Seokjoo Hong , Urvi Desai , David Powell , Xiao Feng
IPC分类号： A61K39/395 , C07K16/18 , A61P3/10 , A61P3/06 , A61P9/10 , A61P3/00 , A61P3/04
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
摘要翻译：提供特异性结合ANGPTL3的单克隆抗体。提供中和至少一种ANGPTL3活性的单克隆抗体。提供了使用中和单克隆抗体治疗脂质代谢紊乱的方法。

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