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41. 发明申请

US20100049309A1 COATED MEDICAL DEVICE 有权
标题翻译：涂层医疗器械
公开(公告)号：US20100049309A1
公开(公告)日：2010-02-25
申请号：US12609521
申请日：2009-10-30
申请人： Brian L. Bates , Anthony O. Ragheb , Joseph M. Stewart, IV , William J. Bourdeau , Brian D. Choules , James D. Purdy , Neal E. Fearnot
发明人： Brian L. Bates , Anthony O. Ragheb , Joseph M. Stewart, IV , William J. Bourdeau , Brian D. Choules , James D. Purdy , Neal E. Fearnot
IPC分类号： A61F2/82
CPC分类号： A61M25/10 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/958 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0025 , A61F2250/0026 , A61F2250/0067 , A61F2250/0081 , A61F2250/0098 , A61F2310/00011 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2250/00
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
摘要翻译：一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

42. 发明申请

US20090285975A1 METHODS FOR MAKING IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：用于制造可植入医疗器械的方法
公开(公告)号：US20090285975A1
公开(公告)日：2009-11-19
申请号：US12490162
申请日：2009-06-23
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
IPC分类号： B05D7/00
CPC分类号： A61K51/1282 , A61F2/24 , A61F2/82 , A61F2/885 , A61F2/91 , A61F2210/0076 , A61F2250/0068 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

43. 发明授权

US07550005B2 Coated implantable medical device 失效
标题翻译：涂层可植入医疗器械
公开(公告)号：US07550005B2
公开(公告)日：2009-06-23
申请号：US10218305
申请日：2002-08-14
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
IPC分类号： A61F2/06
CPC分类号： A61K51/1282 , A61F2/24 , A61F2/82 , A61F2/885 , A61F2/91 , A61F2210/0076 , A61F2250/0068 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

44. 发明申请

US20080147166A1 COATED IMPLANTABLE MEDICAL DEVICE 失效
标题翻译：涂层可植入医疗器械
公开(公告)号：US20080147166A1
公开(公告)日：2008-06-19
申请号：US11931678
申请日：2007-10-31
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees , Thomas G. Kozma
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees , Thomas G. Kozma
IPC分类号： A61F2/86 , A61F2/06
CPC分类号： A61K51/1282 , A61F2/24 , A61F2/82 , A61F2/885 , A61F2/91 , A61F2210/0076 , A61F2250/0068 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

45. 发明申请

US20080145396A1 COATED IMPLANTABLE MEDICAL DEVICE 有权
公开(公告)号：US20080145396A1
公开(公告)日：2008-06-19
申请号：US11931603
申请日：2007-10-31
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees
IPC分类号： A61F2/04 , A61K38/13 , A61P37/06
CPC分类号： A61L33/022 , A61F2/0077 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/82 , A61F2/91 , A61F2210/0076 , A61F2250/0067 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

46. 发明授权

US06743252B1 Cannula stent 有权
标题翻译：插管支架
公开(公告)号：US06743252B1
公开(公告)日：2004-06-01
申请号：US09464895
申请日：1999-12-16
申请人： Brian L. Bates , Dale T. Berry , Neal E. Fearnot , Coy M. Herald , Palle M. Hansen , Jesper Thyregod
发明人： Brian L. Bates , Dale T. Berry , Neal E. Fearnot , Coy M. Herald , Palle M. Hansen , Jesper Thyregod
IPC分类号： A61F206
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0054
摘要： A stent (10) formed from cannula and having flexible segments (11) and high hoop strength segments (12) alternating therealong. Axial tie bars (21,22) interconnect the segments; minimal length reduction would occur upon expansion. In the high hoop strength segment (12), struts (16) are initially parallel in the unexpanded strut condition, while in the flexible segment (11), struts (14) extend from a respective bight (15) to converge at distal ends when unexpanded. In one embodiment, certain adjacent struts (16) of the hoop segment are spaced apart by a large gap (20) while others are spaced apart by a small gap (18). In another embodiment all the struts (16) of the hoop segment are spaced apart uniformly from each other (or from an axial tie bar) by a small gap (23), resulting in minimizing the occurrence of fatigue of high-stress sites upon expansion/contraction cycles from continuous pulsatile events.
摘要翻译：由套管形成并具有柔性段（11）和高环箍强度段（12）的支架（10）。轴向连杆（21,22）互连该段; 膨胀时会发生最小的长度减小。在高箍强度段（12）中，支柱（16）最初在未膨胀的支柱状态下平行，而在柔性段（11）中，支柱（14）从相应的弯曲部（15）延伸以在远端会聚，未膨胀在一个实施例中，环形节段的某些相邻的支柱（16）由较大的间隙（20）间隔开，而另一些间隔开一小间隙（18）。在另一个实施例中，环形节段的所有支柱（16）彼此均匀地（或从轴向连接杆）间隔开小间隙（23），从而最小化膨胀时高应力位点的疲劳的发生 /来自连续脉动事件的收缩周期。

47. 发明授权

US06730064B2 Coated implantable medical device 有权
公开(公告)号：US06730064B2
公开(公告)日：2004-05-04
申请号：US09850691
申请日：2001-05-07
申请人： Anthony O. Ragheb , Brian L. Bates , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma
发明人： Anthony O. Ragheb , Brian L. Bates , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma
IPC分类号： A61M532
CPC分类号： A61L29/085 , A61F2250/0068 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/608 , A61L2420/08 , H01L2924/3025 , C08L65/04 , H01L2924/00
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer is includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

48. 发明授权

US06530951B1 Silver implantable medical device 失效
标题翻译：银植入式医疗器械
公开(公告)号：US06530951B1
公开(公告)日：2003-03-11
申请号：US08956715
申请日：1997-10-23
申请人： Brian L. Bates , Neal E. Fearnot , Thomas G. Kozma , Thomas A. Osborne , Anthony O. Ragheb , Joseph W. Roberts , William D. Voorhees, III
发明人： Brian L. Bates , Neal E. Fearnot , Thomas G. Kozma , Thomas A. Osborne , Anthony O. Ragheb , Joseph W. Roberts , William D. Voorhees, III
IPC分类号： A61F206
CPC分类号： A61L29/16 , A61L27/306 , A61L27/54 , A61L29/106 , A61L31/088 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/416 , A61L2300/42 , A61L2300/61
摘要： A silver implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure 12 and the bioactive-material-free surface. Also included is a layer or impregnation of silver 45. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Silver is included as a base material, coating or included in a carrier, drug, medicament material utilized with the implantable stent.
摘要翻译：银可植入医疗装置10包括适于引入血管系统，食道，气管，结肠，胆道或尿道的结构12; 至少一层生物活性材料层18位于结构12的一个表面上; 并且位于结构12的一个表面上的生物活性材料层18上的至少一个多孔层20和不含生物活性材料的表面。还包括银层45或浸渍。优选地，结构12是冠状动脉支架。多孔层20由优选通过蒸气或等离子体沉积施加的聚合物组成，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，其仅通过单体蒸气的冷凝就不经溶剂，热或催化剂沉积。银包含作为基材，涂层或包含在与可植入支架一起使用的载体，药物，药物材料中。

49. 发明授权

US06494824B1 Medical, radiotherapy source vial 有权
标题翻译：医疗放射源小瓶
公开(公告)号：US06494824B1
公开(公告)日：2002-12-17
申请号：US09253310
申请日：1999-02-20
申请人： Marc G. Apple , Brian L. Bates , John A. DeFord , Neal E. Fearnot , James D. Purdy , Joseph P. Lane , Delbert C. Miller , Gregory A. Frankland
发明人： Marc G. Apple , Brian L. Bates , John A. DeFord , Neal E. Fearnot , James D. Purdy , Joseph P. Lane , Delbert C. Miller , Gregory A. Frankland
IPC分类号： A61N0500
CPC分类号： A61N5/1002 , A61M5/1785 , A61M5/31511 , A61M5/31515 , A61M25/10184 , A61M25/104 , A61N2005/1021
摘要： A catheter apparatus and radiation dosimetry unit indicator for delivery of a prescribed radiation dose to a patient. A radiotherapy source vial (700) includes a fluid container (701) of radioactive fluid with a seal (702,731) disposed about the container. Seal (702,731) is moveable with respect to container (701) to change the contained volume therein. A radioactive fluid transport site (703) is in communication with the contained volume and with an exterior (726) of the container (701), and may include a septum (707) or a valve (711). An engagement mechanism (704) is connectable to an external control mechanism (706) whereby the contained volume in the radioactive fluid container can be decreased and increased by actuation of the external control mechanism.
摘要翻译：导管装置和放射剂量测定单元指示器，用于向患者输送规定的辐射剂量。放射治疗源小瓶（700）包括具有围绕容器设置的密封件（702,731）的放射性流体的流体容器（701）。密封件（702,731）能够相对于容器（701）移动以改变其中的容纳体积。放射性流体输送部位（703）与所容纳的容积和容器（701）的外部（726）连通，并且可以包括隔膜（707）或阀（711）。接合机构（704）可连接到外部控制机构（706），由此可以通过外部控制机构的致动来减小和增加放射性液体容器中的容纳量。

50. 发明授权

US6096070A Coated implantable medical device 失效
标题翻译：涂层可植入医疗器械
公开(公告)号：US6096070A
公开(公告)日：2000-08-01
申请号：US645646
申请日：1996-05-16
申请人： Anthony O. Ragheb , Brian L. Bates , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
发明人： Anthony O. Ragheb , Brian L. Bates , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
IPC分类号： A61B17/00 , A61F2/00 , A61K9/00 , A61K51/12 , A61L27/30 , A61L27/54 , A61L29/08 , A61L29/10 , A61L29/16 , A61L31/00 , A61L31/08 , A61L31/10 , A61L31/16 , A61L33/02 , A61M37/00 , A61N5/10 , A61F2/06
CPC分类号： A61L31/088 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/022 , A61F2250/0068 , A61L2300/42 , A61L2300/602 , A61L2300/608 , A61N5/1002
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure (12) and the bioactive-material-free surface. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Also disclosed is the method of manufacture of the device 10, as well as a method of using it in medical treatments.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一层生物活性材料层18位于结构12的一个表面上; 和位于结构（12）的一个表面上的生物活性材料层18上的至少一个多孔层20和不含生物活性材料的表面。优选地，结构12是冠状动脉支架。多孔层20由优选通过蒸气或等离子体沉积施加的聚合物组成，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，其仅通过单体蒸气的冷凝就不经溶剂，热或催化剂沉积。还公开了装置10的制造方法，以及在医疗中使用该方法。

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