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41. 发明授权

US07659968B2 System with extended range of molecular sensing through integrated multi-modal data acquisition 有权
标题翻译：通过综合多模态数据采集扩展分子感测范围的系统
公开(公告)号：US07659968B2
公开(公告)日：2010-02-09
申请号：US12018108
申请日：2008-01-22
申请人： Xuefeng Wang , David D. Nolte , Manoj Varma , Brian Weichel , Timothy Norwood , Fouad Sayegh , Ming Zhao
发明人： Xuefeng Wang , David D. Nolte , Manoj Varma , Brian Weichel , Timothy Norwood , Fouad Sayegh , Ming Zhao
IPC分类号： G01N21/00 , G01N21/64
CPC分类号： G01N21/6452 , G01N21/253
摘要： A multi-modal data acquisition system for detecting target material on a biological reaction surface, the system comprising a radiation source for generating an incoming beam that impinges on the biological reaction surface at an oblique incidence angle and produces a reflected beam, an interferometric detector for detecting an interferometric signal from the illuminated surface, the reflected beam being directed to the interferometric detector, a fluorescence detector for detecting a fluorescence signal from the illuminated surface; the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam; and a processing system for receiving the interferometric and fluorescence signals and determining the presence or absence of target material on the biological reaction surface. A reaction surface conditioned for the simultaneous collection of fluorescence, interferometric and other signals. A multi-modal data acquisition system for collecting and processing additional modes, including multiple interferometric, fluorescence and scattering channels.
摘要翻译：一种多模式数据采集系统，用于检测生物反应表面上的目标材料，所述系统包括用于产生入射光束的辐射源，该入射光束以倾斜入射角度撞击在生物反应表面上并产生反射光束，干涉检测器检测来自所述照射表面的干涉信号，所述反射光束被引导到所述干涉检测器;荧光检测器，用于检测来自被照射表面的荧光信号; 荧光检测器被定位成基本上最小化反射光束的入射; 以及用于接收干涉测量和荧光信号并确定生物反应表面上目标材料的存在或不存在的处理系统。用于同时收集荧光，干涉仪和其他信号的反应表面。一种多模式数据采集系统，用于收集和处理其他模式，包括多个干涉仪，荧光和散射通道。

42. 发明申请

US20090300779A1 Cancer selective auxotrophs 有权
标题翻译：癌症选择性营养缺陷型
公开(公告)号：US20090300779A1
公开(公告)日：2009-12-03
申请号：US11631247
申请日：2005-06-29
申请人： Ming Zhao , Meng Yang
发明人： Ming Zhao , Meng Yang
IPC分类号： A01K67/00 , C12N1/21 , A61K35/74 , A61K39/40 , C12N9/00
CPC分类号： A61K35/74 , A61K38/2013 , A61K38/51
摘要： Bacteria that are auxotrophic for at least two amino acids found in at least one tumor are effective anti tumor treatments, labeling agents, and vaccines against infection. Improved antitumor effects can also be provided such strains by passage through an appropriate tumor model.
摘要翻译：在至少一种肿瘤中发现的至少两种氨基酸营养缺陷型细菌是有效的抗肿瘤治疗，标记试剂和针对感染的疫苗。也可以通过适当的肿瘤模型通过这些菌株提供改善的抗肿瘤作用。

43. 发明授权

US07493688B1 Method of manufacturing a magnetic recording transducer 失效
标题翻译：制造磁记录传感器的方法
公开(公告)号：US07493688B1
公开(公告)日：2009-02-24
申请号：US11352536
申请日：2006-02-13
申请人： Lei Wang , Liping Ren , Yingjian Chen , Christopher T. Ngo , Ming Zhao
发明人： Lei Wang , Liping Ren , Yingjian Chen , Christopher T. Ngo , Ming Zhao
IPC分类号： G11B5/127 , H04R31/00
CPC分类号： G11B5/3163 , G11B5/3116 , Y10T29/49041 , Y10T29/49043 , Y10T29/49046 , Y10T29/49048 , Y10T29/49052
摘要： A method for providing a magnetic recording transducer is disclosed. The method includes providing a first pole having front and rear portions and a back gap on the rear portion. The method also includes providing an insulator on the first pole. The method includes providing a write gap and providing a portion of a second pole on at least the write gap. A portion of the write gap resides on the front portion of the first pole. A portion of the insulator covers a portion of the first pole between the portion of the second pole and the back gap. The method also includes providing a mask that covers the back gap and exposes the portion of the second pole and the insulator. The method also includes performing a pole trim that can substantially remove the portion of the insulator covering the remaining portion of the first pole.
摘要翻译：公开了一种用于提供磁记录换能器的方法。该方法包括提供具有前部和后部的第一极和后部上的后部间隙。该方法还包括在第一极上提供绝缘体。所述方法包括提供写入间隙并且在至少所述写入间隙上提供第二极点的一部分。写入间隙的一部分位于第一极的前部。绝缘体的一部分覆盖第二极的部分和后间隙之间的第一极的一部分。该方法还包括提供覆盖后隙并且暴露第二极和绝缘体的部分的掩模。该方法还包括执行极性修剪，其可以基本上去除覆盖第一极的剩余部分的绝缘体的部分。

44. 发明申请

US20080198808A1 SYSTEM AND METHOD FOR PERFORMING HANDOVER IN WiMAX MOBILE COMMUNICATION SYSTEM 有权
标题翻译：用于在WiMAX移动通信系统中执行切换的系统和方法
公开(公告)号：US20080198808A1
公开(公告)日：2008-08-21
申请号：US12034706
申请日：2008-02-21
申请人： Seong-Taek HWANG , Shuangfeng Han , Chunhui Zhou , Jing Wang , Ming Zhao , Zheng Xu
发明人： Seong-Taek HWANG , Shuangfeng Han , Chunhui Zhou , Jing Wang , Ming Zhao , Zheng Xu
IPC分类号： H04Q7/00
CPC分类号： H04W36/06 , H04W88/085
摘要： Disclosed is a system and a method for performing handover in a Worldwide interoperability for Microwave Access (WiMAX) mobile communication system supporting broadband wireless access. The system includes a plurality of Mobile Stations (MSs); at least one distributed antenna having the ability to perform simultaneous communications with the plurality of MSs; and a base station connected to the at least one distributed antenna through optical fibers for performing communications and handovers with the multiple MSs.
摘要翻译：公开了一种在支持宽带无线接入的全球微波接入（WiMAX）移动通信系统互操作性中进行切换的系统和方法。该系统包括多个移动站（MS）; 至少一个具有与所述多个MS同时通信的能力的分布式天线; 以及通过光纤连接到所述至少一个分布式天线的基站，用于执行与所述多个MS的通信和切换。

45. 发明申请

US20070212257A1 IN-LINE QUADRATURE AND ANTI-REFLECTION ENHANCED PHASE QUADRATURE INTERFEROMETRIC DETECTION 审中-公开
标题翻译：在线渐近和抗反射增强相位差分干涉检测
公开(公告)号：US20070212257A1
公开(公告)日：2007-09-13
申请号：US11675359
申请日：2007-02-15
申请人： David Nolte , Manoj Varma , Ming Zhao
发明人： David Nolte , Manoj Varma , Ming Zhao
IPC分类号： G01N21/00
CPC分类号： G01N21/45 , G01N21/253 , G01N21/47 , G01N21/75 , G01N21/77 , G01N33/54373 , G01N2021/4707 , G01N2021/7773 , G01N2021/7779
摘要： Method and apparatus for use with a probe beam and detector for detecting the presence of a target analyte in a sample. The apparatus includes a substrate; and a biolayer located on the substrate designed to react to target analyte when the sample is deposited on the biolayer. The substrate can be selected to substantially minimize reflectance by the substrate while substantially maintaining scattering by the target analyte. The substrate can be designed so waves reflected by the substrate are substantially in quadrature with waves scattered by target analyte; or so waves reflected by the substrate and scattered by target analyte interfere in the far field and directly create intensity modulation detectable by the detector. The biolayer can include a plurality of spots, and the spots can be grouped into unit cells having specific antibodies and non-specific antibodies for reacting with target analyte.
摘要翻译：用于探测束和检测器的用于检测样品中目标分析物的存在的方法和装置。该装置包括基板; 以及位于衬底上的生物层，设计成当样品沉积在生物层上时与靶分析物反应。可以选择衬底以基本上最小化衬底的反射率，同时基本上保持靶分析物的散射。可以设计衬底，使得由衬底反射的波基本上与被靶分析物散射的波正交; 由基板反射并被目标分析物散射的波浪会在远场干扰，并直接产生由检测器可检测的强度调制。生物层可以包括多个斑点，并且斑点可以分组成具有特异性抗体的单位细胞和用于与靶分析物反应的非特异性抗体。

46. 发明申请

US20060233439A1 Method and apparatus for processing a Bayer-pattern color digital image signal 审中-公开
标题翻译：用于处理拜耳图案彩色数字图像信号的方法和装置
公开(公告)号：US20060233439A1
公开(公告)日：2006-10-19
申请号：US11349046
申请日：2006-02-07
申请人： Ming Zhao
发明人： Ming Zhao
IPC分类号： G06K9/00
CPC分类号： H04N9/045 , G06T5/005 , G06T5/20 , G06T2207/10024 , H04N2209/045
摘要： A method and apparatus for processing a Bayer-pattern color digital image signal are provided. The apparatus includes: a first defect detector generating first defect information of a first pixel to be processed from input image data; a second defect detector generating second defect information and horizontal and vertical gradients of the first pixel from the input image data; and a corrector compensating for a center-point defect, a thin line defect, or an edge defect in the first pixel according to the horizontal and vertical gradients using the first and second defect information to output corrected image data.
摘要翻译：提供了一种处理拜耳图案彩色数字图像信号的方法和装置。该装置包括：第一缺陷检测器，从输入图像数据生成要处理的第一像素的第一缺陷信息; 第二缺陷检测器，从输入图像数据生成第一缺陷信息和第一像素的水平和垂直梯度; 以及校正器，使用第一和第二缺陷信息根据水平和垂直梯度补偿第一像素中的中心点缺陷，细线缺陷或边缘缺陷，以输出校正图像数据。

47. 发明授权

US07078580B2 Process for separating aromatics by extractive distillation and a composite solvent used therein 有权
标题翻译：通过萃取蒸馏分离芳烃的方法和其中使用的复合溶剂
公开(公告)号：US07078580B2
公开(公告)日：2006-07-18
申请号：US10184751
申请日：2002-06-28
申请人： Longsheng Tian , Wencheng Tang , Ming Zhao , Yunming Zhang , Zhifeng Bian , Huixia Sun , Shijin Wu
发明人： Longsheng Tian , Wencheng Tang , Ming Zhao , Yunming Zhang , Zhifeng Bian , Huixia Sun , Shijin Wu
IPC分类号： C10C7/10 , C10C7/17
CPC分类号： B01D3/40 , C10G7/08 , C10G21/27
摘要： This application relates to a composite solvent for separating aromatics by extractive distillation, comprising a main solvent, a solutizer and a modifier. Said solutizer is selected from any one or mixtures of any two of C8–C11 aromatics having different number of carbon atoms, the content of which is 3–39 wt %, and the number of carbon atoms of the lowest aromatic in the solutizer should be greater than that of the highest aromatic in the aromatics to be separated. When the solutizer is selected from any one of C8–C11 aromatics, the composite solvent contains 0.01–10.0 wt % of the modifier; when the solutizer is selected from mixtures of any two of C8–C11 aromatics having different number of carbon atoms, the composite solvent contains 0–10.0 wt % of the modifier. Said main solvent and modifier are independently selected from sulfolane derivatives, N-formyl morpholine, and N-methyl pyrrolidone, provided that the acidity and basicity of the modifier are opposite to those of the main solvent. When the composite solvent is used to recover aromatics by extractive distillation, it is possible to moderate the operation conditions of solvent recovery, increase the yield of aromatics, and make the separated aromatics to be neutral.
摘要翻译：本申请涉及通过萃取蒸馏分离芳族化合物的复合溶剂，其包括主要溶剂，溶剂和改性剂。所述溶剂选自具有不同碳原子数的C 8 -C 11 -C 11芳族化合物的任何一种或其混合物，其含量为3-39重量％，并且溶剂中最低芳族化合物的碳原子数应大于待分离芳烃中最高芳族化合物的碳原子数。当溶剂选自C 8 -C 12芳族化合物中的任何一种时，复合溶剂含有0.01-10.0重量％的改性剂; 当溶剂选自具有不同碳原子数的C 2 -C 11 -C 11芳族化合物的任何两种的混合物时，复合溶剂含有0-10.0重量％的改性剂。所述主要溶剂和改性剂独立地选自环丁砜衍生物，N-甲酰基吗啉和N-甲基吡咯烷酮，条件是改性剂的酸度和碱度与主要溶剂的酸度和碱度相反。当通过萃取蒸馏将复合溶剂用于回收芳族化合物时，可以调节溶剂回收的操作条件，提高芳族化合物的产率，并使分离的芳族化合物成为中性。

48. 发明授权

US07053047B2 Cyclic pentapeptides and their preparation 有权
标题翻译：循环五肽及其制备方法
公开(公告)号：US07053047B2
公开(公告)日：2006-05-30
申请号：US10404124
申请日：2003-04-02
申请人： Shigi Peng , Ming Zhao , Chao Wang , Lin Na
发明人： Shigi Peng , Ming Zhao , Chao Wang , Lin Na
IPC分类号： A61K38/00 , A61K38/12
CPC分类号： C07K7/64 , A61K38/00
摘要： This invention relates to cyclic peptides, with the following formula (I) (SEQ ID NO: 1), cyclo(Xaa-Arg-Pro-Ala-Lys) (I) where Xaa is Ala, Gly, Glu, Gln, Asp, Asn, Arg or Lys. The cyclic peptides have thrombolytic effects. This invention also relates to cyclic peptide preparations.
摘要翻译：本发明涉及具有下式（I）（SEQ ID NO：1），<？在线公式描述=“在线公式”中的环状肽end =“lead”→>环（Xaa-Arg- Pro-Ala-Lys）（I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中Xaa是Ala，Gly，Glu，Gln，Asp，Asn，Arg或Lys。环肽具有溶栓作用。本发明还涉及环肽制剂。

49. 发明申请

US20050043396A1 5-Benzoylamino-1,3-dioxacyclanes, the method for preparing the same and their use as PKC inhibitor 审中-公开
标题翻译： 5-苯甲酰氨基-1,3-二氧环己烷，其制备方法及其作为PKC抑制剂的用途
公开(公告)号：US20050043396A1
公开(公告)日：2005-02-24
申请号：US10674148
申请日：2003-09-29
申请人： Hayley Zen , Shiqi Peng , Lanrong Bi , Ming Zhao , Chao Wang
发明人： Hayley Zen , Shiqi Peng , Lanrong Bi , Ming Zhao , Chao Wang
IPC分类号： C07D273/06 , C07D319/06 , C07D321/12 , A61K31/335
CPC分类号： C07D319/06 , C07D273/06 , C07D321/12
摘要： The present invention discloses a series of benzoylamino-1,3-dioxacyclane compounds, of which compounds 1-21 were prepared via transacetalisation reaction between N-benzoylaminoglycol and 1,1,3,3-tetramethoxypropane; while compounds 22-48 were prepared via stereospecific acetalisation reaction between N-benzoylamino glycol and aromatic aldehyde, and if necessary, the nitro groups were reduced and further be salified with propane diacid and L-Arg or L-Lys. These compounds possess the structural type of PKC inhibitor and positive anti-inflammatory effect, and can be applied in medical fields as PKC inhibitor for corresponding therapy.
摘要翻译：本发明公开了一系列苯甲酰基氨基-1,3-二氧杂环烷化合物，其中化合物1-21是通过N-苯甲酰氨基甘氨酸与1,1,3,3-四甲氧基丙烷之间的转化反应制备的; 而化合物22-48通过N-苯甲酰氨基二醇和芳族醛之间的立体特异性缩醛化反应制备，并且如果需要，硝基还原，并进一步用丙烷二酸和L-Arg或L-Lys进行成盐。这些化合物具有PKC抑制剂的结构型和阳性消炎作用，可作为PKC抑制剂用于医学领域，用于相应的治疗。

50. 发明授权

US06306837B1 Heavy metal chelating agent for oral administration, its synthesis and its uses in medicine and health protection 有权
标题翻译：一种用于口服给药的新型重金属螯合剂，其合成及其在医药和保健中的应用
公开(公告)号：US06306837B1
公开(公告)日：2001-10-23
申请号：US09473737
申请日：1999-12-28
申请人： Shiqi Peng , Chao Wang , Ming Zhao , Xingwei Li , Yancheng Wu , Taigang Mo
发明人： Shiqi Peng , Chao Wang , Ming Zhao , Xingwei Li , Yancheng Wu , Taigang Mo
IPC分类号： A61K3170
CPC分类号： C07H15/12 , Y10S514/836
摘要： The present invention relates to a new kind of heavy metal chelating agents and a preparation process and uses thereof. The said heavy metal chelating agents are expressed in &agr;-[D(+)glucose-1-yl-amino]-&bgr;3-mercapto-(S)-propanoic acid (abbreviated to NGP,I) and/or N,N′-di[D(+)glucose-1-yl]-L-cystine (abbreviated to NGCD,II). In the process of preparation, glucose and cysteine are reacted with a base, with a reducing agent, and the obtained products are acidified to give NGP,I, which can be used in and/or as drugs, health foods and food additives for accelerating the excretion of heavy metals including Pb, Cd, Hg, Al, Sb, As, etc. The structural feature of the compounds of the present invention is that they contain glucose and cysteirie in their molecules. Compared with the heavy metal-excreting drugs of prior art, the compounds of the present invention have four advantages, namely suitability for oral administration, high ability to accelerate the excretion of heavy metals, high selectivity and less toxicity.
摘要翻译：本发明涉及一种新型的重金属螯合剂及其制备方法和用途。所述重金属螯合剂在α-[D（+）葡萄糖-1-基 - 氨基]-β-巯基 - （S） - 丙酸（缩写为NGP，I）和/或N，二[D（+）葡萄糖-1-基] -L-胱氨酸（缩写为NGCD，II）。在制备过程中，葡萄糖和半胱氨酸与碱反应，还原剂，将所得产物酸化，得到NGP，I，可用于和/或作为药物的保健食品和食品添加剂加速重金属的排泄，包括Pb，Cd，Hg，Al，Sb，As等。本发明化合物的结构特征是它们在其分子中含有葡萄糖和半胱氨酸。与现有技术的重金属排泄物相比，本发明的化合物具有四个优点，即口服适用性，加速重金属排泄能力高，选择性低，毒性小。

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