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41. 发明授权

US06487437B1 Device for high gain and uniformly localized magnetic resonance imaging 有权
标题翻译：用于高增益和均匀局部磁共振成像的装置
公开(公告)号：US06487437B1
公开(公告)日：2002-11-26
申请号：US09532145
申请日：2000-03-21
申请人： Raju R. Viswanathan , Raghu Raghavan
发明人： Raju R. Viswanathan , Raghu Raghavan
IPC分类号： A61B5055
CPC分类号： G01R33/34084 , G01R33/287 , G01R33/34053
摘要： A microcoil configuration, preferably on a medical device to be inserted into a patient, has an opposed pair of microcoils. At least one or each microcoil of the opposed pair of microcoils has at least a region where a diameter circumscribed by a first winding is greater than the diameter circumscribed by at least one complete second winding, especially an adjacent winding displaced from the first winding along an axis or core of the medical device or an axis of the microcoil. The second winding is nearer to or farther from an intermediate region between the microcoils that define the pair of microcoils. For example, it is common to have a connecting (usually straight or non-wound) lead between the two microcoils, and this lead may be used to define an intermediate region. The microcoil configuration with varying circumference between windings (especially adjacent windings) is generally referred to as a dumb-bell or horn configuration because of its general appearance and the individual microcoils are referred to as a horn microcoil, again because of the visual appearance of the microcoil. The configuration of the microcoils assists in defining the properties of an RF responsive field adjacent to the device.
摘要翻译：优选在待插入患者体内的医疗装置上的微线圈配置具有相对的一对微线圈。相对的一对微线圈的至少一个或每个微螺线具有至少一个区域，其中由第一绕组限定的直径大于由至少一个完整的第二绕组限定的直径，特别是沿着沿着第一绕组从第一绕组移位的相邻绕组医疗装置的轴线或芯部或微线圈的轴线。第二绕组更靠近或远离限定一对微型线圈的微型线圈之间的中间区域。例如，通常在两个微线圈之间具有连接（通常是直的或非缠绕的）引线，并且该引线可以用于限定中间区域。绕组（特别是相邻绕组）之间具有变化的周长的微线圈配置通常被称为哑铃或喇叭配置，因为它的一般外观，并且单独的微线圈被称为喇叭微线圈，再次由于视觉外观微线圈微线圈的配置有助于定义与设备相邻的RF响应场的属性。

42. 发明授权

US09265577B2 Methods and systems for providing planning and dispensation of research and/or treatment for brain disease 有权
标题翻译：提供脑部疾病的研究和/或治疗的规划和分配的方法和系统
公开(公告)号：US09265577B2
公开(公告)日：2016-02-23
申请号：US12116765
申请日：2008-05-07
申请人： Raghu Raghavan , Stuart A. Grossman
发明人： Raghu Raghavan , Stuart A. Grossman
IPC分类号： A61B19/00 , G06T7/00 , G06F19/00
CPC分类号： A61B34/10 , A61B6/461 , A61B6/481 , A61B6/501 , A61B90/00 , A61B2034/101 , A61B2034/252 , A61N2005/1021 , G06F19/00 , G06F19/321 , G06T7/0012 , G06T2207/30016 , G16H50/50 , Y02A90/24 , Y02A90/26
摘要： Methods and systems for providing planning and dispensation of research and/or treatment for brain disease. Radiological information is generated in a region of interest in an area of the a brain of an individual using a radiological imaging system. A physiological states model is constructed which assesses physiological states of the region of interest. Locations of sources of interstitial fluid flow, fluid conductivities of paths, and anatomical information in the region of interest are obtained using the radiological imaging information. Velocities of the interstitial fluid flow in the region of interest are computed using the physiological states model, the locations of sources of interstitial flow, the fluid conductivities, and the anatomic information. A model of the area of the brain is created, the model including the region of interest.
摘要翻译：提供脑部疾病的研究和/或治疗的规划和分配的方法和系统。使用放射线成像系统在个体的大脑的区域中的感兴趣区域中产生放射线信息。构建了一个生理状态模型，评估感兴趣区域的生理状态。使用放射成像信息获得组织液流的来源的位置，路径的流体电导率和感兴趣区域中的解剖信息。使用生理状态模型，间质流源，流体电导率和解剖信息来计算感兴趣区域中的间质液流的速度。创建大脑区域的模型，该模型包括感兴趣的区域。

43. 发明申请

US20140303593A1 DELIVERY OF MATERIALS INTO MARGINS OF TISSUE CAVITIES 审中-公开
标题翻译：将材料输送到组织中心
公开(公告)号：US20140303593A1
公开(公告)日：2014-10-09
申请号：US14229876
申请日：2014-03-29
申请人： Raghu Raghavan , Martin Brady
发明人： Raghu Raghavan , Martin Brady
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61M2025/105 , A61M2025/1086
摘要： Surgery is performed on a patient with a novel device by: excising tissue from tissue mass within a patient to create a cavity within the tissue mass; inserting a novel device of this invention into the cavity; shaping a flexible expandable component of the device to adjust dimensions on the flexible expandable component; providing a liquid into the component through the liquid input port; and controlling pressure or flow rate of the liquid in the component to move the liquid through the multiple openings and into the cavity. The device has a liquid inlet port, an exterior surface having length, width and depth, and multiple openings in the surface distributed throughout the length, width and depth to act as liquid delivery ports; the exterior surface of the liquid delivery device being shapeable by internal pneumatic pressure or hydraulic pressure to better fit inside dimensions of a surgical cavity; the multiple openings deliver the liquid through the multiple openings.
摘要翻译：通过以下方式对具有新颖装置的患者进行手术：从患者组织块切除组织以在组织块内形成空腔; 将本发明的新型装置插入空腔中; 使所述装置的柔性可膨胀部件成形以调整所述柔性可膨胀部件上的尺寸; 通过液体输入端口向组件提供液体; 并且控制所述部件中的液体的压力或流速以将所述液体移动通过所述多个开口并进入所述空腔。该装置具有液体入口，具有长度，宽度和深度的外表面，并且表面上的多个开口分布在整个长度，宽度和深度上以用作液体输送口; 液体输送装置的外表面可以通过内部气动压力或液压成形，以更好地适应手术腔的内部尺寸; 多个开口通过多个开口输送液体。

44. 发明申请

US20140243783A1 METHOD OF BACKFLOW REDUCTION DURING MATERIAL DELIVERY THROUGH A NEEDLE INTO TISSUE 审中-公开
标题翻译：通过将物体输送到组织中的回流减少方法
公开(公告)号：US20140243783A1
公开(公告)日：2014-08-28
申请号：US14046845
申请日：2013-10-04
申请人： Raghu Raghavan , Martin Brady
发明人： Raghu Raghavan , Martin Brady
IPC分类号： A61M25/10 , A61M25/01 , A61M5/158 , A61M25/00
CPC分类号： A61M5/158 , A61M25/02 , A61M25/04 , A61M25/10 , A61M2005/1588 , A61M2025/0002 , A61M2025/0293 , A61M2025/1047 , A61M2025/1093 , A61M2210/0693
摘要： Interstitial tissue structure is treated with a flowable liquid agent by: providing a delivery cannula having a proximal end and a distal end and an external surface with at least one expandable member located on the external surface of at least one catheter or needle. The delivery cannula is inserted into live tissue, creating a hole in the tissue surrounding the delivery cannula. Contact is made against an inner surface of the hole with contact pressure from the at least one expandable member, said contact pressure establishing a first level of stress in tissue surrounding the hole in the tissue. The expandable member is expanded to increase the contact pressure and provide a second level of stress in the tissue surrounding the hole in the tissue to a second level of stress that is greater than the first level of stress.
摘要翻译：用可流动的液体试剂处理间质组织结构，方法是：提供具有近端和远端的输送插管和具有位于至少一个导管或针的外表面上的至少一个可扩张构件的外表面。输送插管插入活组织中，在输送插管周围的组织中产生孔。接触是通过来自至少一个可膨胀构件的接触压力抵靠孔的内表面制成的，所述接触压力在围绕组织中的孔的组织中建立第一级应力。可膨胀构件被膨胀以增加接触压力，并且在围绕组织中的孔的组织中提供第二水平的应力至大于第一应力水平的第二水平的应力。

45. 发明授权

US08545405B2 Device, methods, and control for sonic guidance of molecules and other material utilizing time-reversal acoustics 有权
标题翻译：使用时间反转声学的分子和其他材料的声波引导的装置，方法和控制
公开(公告)号：US08545405B2
公开(公告)日：2013-10-01
申请号：US12319311
申请日：2009-01-06
申请人： Raghu Raghavan , Armen P. Sarvazyan
发明人： Raghu Raghavan , Armen P. Sarvazyan
IPC分类号： A61B8/00
CPC分类号： A61M37/00 , A61B8/0816 , A61B8/445
摘要： Acoustic waves exhibit force that pushes objects along the direction of sound propagation. Precise motions require well-focused beams. The technique of time-reversal acoustics (TRA) overcomes beam distortions introduced by propagation along irregular paths to focus sound without knowledge of the medium properties. TRA requires a small receiver to be placed at a point of desired focus. The invention disclosed refines TRA by introducing data matching schemes to extend the points of focus beyond the location points of the receivers. With as few as two receivers, a large region can be manipulated with well-focused acoustic beams and with no receiver at a desired point of focus. Applications are described in drug delivery in medicine; environmental fluid contaminant control; and in oil exploration, for retrieving oil stuck in underground pockets.
摘要翻译：声波表现出沿声音传播方向推动物体的力。精确的运动需要聚焦良好的光束。时间反射声学（TRA）的技术克服了通过不规则路径传播引起的波束失真，以聚焦声音而不知道介质属性。 TRA需要将小型接收器放置在所需焦点的位置。公开的发明通过引入数据匹配方案来提炼TRA，以将焦点扩展到接收器的位置点之外。使用少至两个接收器，可以使用良好聚焦的声束并且没有接收器在期望的焦点处操纵大的区域。药物中药物描述的应用; 环境流体污染物控制; 并在石油勘探中，用于检索卡在地下袋中的油。

46. 发明授权

US08406850B2 Method for estimating the physiological parameters defining the edema induced upon infusion of fluid from an intraparenchymally placed catheter 有权
标题翻译：用于估计限定在从实施静脉内放置的导管输注流体时引起的水肿的生理参数的方法
公开(公告)号：US08406850B2
公开(公告)日：2013-03-26
申请号：US13241936
申请日：2011-09-23
申请人： Raghu Raghavan , Martin Brady
发明人： Raghu Raghavan , Martin Brady
IPC分类号： A61B5/05
CPC分类号： A61K49/06 , A61M2005/14292 , G01R33/5601 , G01R33/56341
摘要： A method for estimating the physiological parameters defining the edema induced upon infusion of fluid from an intraparenchymally placed catheter including; a) acquisition of patient-specific medical data; b) estimation of pertinent tissue microstructure based on the patient-specific medical data and/or generalized information derived or drawn from one or more of the following: experience, literature, modeling, studies, research, analysis; c) acquisition of information about delivery parameters, and/or delivery device geometry, and/or fluid properties; and d) computing a field of values of predicted extracellular volume fraction over the tissue region using the information obtained in (b) and (c). According to a further aspect, a method of infusing or planning and/or monitoring an infusion of a contrast agent such that the distribution of such agent can be detected and observing and/or measuring the backflow length along the catheter track.
摘要翻译：一种估计生理参数的方法，所述生理参数限定了从实施静脉内放置的导管输注流体时引起的水肿，包括： a）获取患者特定的医疗数据; b）基于患者特定的医学数据和/或从以下一个或多个中得出或得出的一般化信息来估计相关的组织微结构：经验，文献，建模，研究，研究，分析; c）获取关于递送参数和/或递送装置几何形状和/或流体属性的信息; 以及d）使用（b）和（c）中获得的信息计算组织区域上预测的细胞外体积分数的值的场。根据另一方面，一种输注或规划和/或监测造影剂的输注的方法，使得可以检测这种药剂的分布，并观察和/或测量沿着导管轨迹的回流长度。

47. 发明授权

US08083753B2 Robotic trajectory guide 有权
标题翻译：机器人轨迹指南
公开(公告)号：US08083753B2
公开(公告)日：2011-12-27
申请号：US11873154
申请日：2007-10-16
申请人： Matthew S. Solar , Thomas I. Miller , John David , Raghu Raghavan , Martin Brady , Gerald W. Mills
发明人： Matthew S. Solar , Thomas I. Miller , John David , Raghu Raghavan , Martin Brady , Gerald W. Mills
IPC分类号： A61B19/00
CPC分类号： A61B90/11 , A61B34/20 , A61B34/30 , A61B34/70 , A61B2034/107 , A61B2034/2055 , A61B2034/301 , A61B2090/374
摘要： A surgical alignment device is disclosed that is controlled remotely through the use of an actuator, where the actuator in turn controls at least one local adjustment device. The alignment device is suited for neurosurgery, although it is not exclusively limited to neurosurgery. The alignment device includes an insertion guide that is coupled to the local adjustment device, the insertion guide being used to guide a device such as a catheter into a patient. The alignment device may also be coupled to a control module such as a microcomputer that controls the orientation of the insertion guide in response to inputs from the surgeon as to a location of interest within the patient.
摘要翻译：公开了通过使用致动器远程控制的外科对准装置，其中致动器依次控制至少一个局部调节装置。对准装置适用于神经外科手术，但并不限于神经外科手术。对准装置包括联接到局部调节装置的插入引导件，插入引导件用于将诸如导管的装置引导到患者体内。对准装置还可以耦合到诸如微型计算机的控制模块，微型计算机响应于来自外科医生的输入以及患者内感兴趣的位置来控制插入引导件的取向。

48. 发明授权

US07998128B2 Active delivery and flow redirection: novel devices and method of delivery of materials to patients 有权
标题翻译：主动输送和流向重定向：新型装置和向患者输送材料的方法
公开(公告)号：US07998128B2
公开(公告)日：2011-08-16
申请号：US11434080
申请日：2006-05-15
申请人： David Poston , Raghu Raghavan , Martin L. Brady
发明人： David Poston , Raghu Raghavan , Martin L. Brady
IPC分类号： A61M31/00
CPC分类号： A61M25/0026 , A61B17/3401 , A61B17/3421 , A61B2017/3419 , A61F2/82 , A61F2002/826 , A61M25/0021 , A61M25/0068 , A61M25/0069 , A61M25/0074 , A61M2025/0042 , A61M2025/0096 , A61M2025/0681
摘要： A medical device for delivering material through tissue into a defined area of a patient may comprise: a material delivery element through which the material may flow out of a delivery end; the delivery end having an opening that can be inserted through a surface of the tissue; and a sealing system proximal to the delivery end that can extend away from the material delivery element along the surface of the tissue and apply pressure to the tissue after the material delivery element has been inserted through the surface of the tissue. A physical barrier may be provided on the material delivery device to reduce back flow loss of delivered material.
摘要翻译：用于将材料通过组织输送到患者的限定区域中的医疗装置可以包括：材料递送元件，材料可以通过该材料输送元件从输送端流出; 所述输送端具有能够穿过所述组织的表面插入的开口; 以及靠近输送端的密封系统，其可以沿着组织的表面远离材料输送元件延伸，并且在材料输送元件已经穿过组织的表面插入之后对组织施加压力。可以在材料输送装置上提供物理屏障以减少输送材料的回流损失。

49. 发明申请

US20110106009A1 DEVICE AND METHOD FOR DELIVERING THERAPEUTIC AGENTS TO AN AREA OF THE BODY 审中-公开
标题翻译：将治疗药物递送到身体区域的装置和方法
公开(公告)号：US20110106009A1
公开(公告)日：2011-05-05
申请号：US12991756
申请日：2009-05-12
申请人： Matthew S. Solar , Chris Ross , Martin L. Brady , Raghu Raghavan
发明人： Matthew S. Solar , Chris Ross , Martin L. Brady , Raghu Raghavan
IPC分类号： A61M25/06
CPC分类号： A61B17/34 , A61B17/3478 , A61B2017/00247 , A61B2017/00331 , A61B2018/00392 , A61M37/00 , A61M37/0069
摘要： A device, system and method deliver an agent to a soft mass, such as an area of the body, and more specifically the brain. One aspect includes creation of one or more channels, tunnels or grooves in tissue using a relatively small diameter, minimally-invasive stylet and then removing the stylet prior to infusion. The stylet-created channels become paths of increased hydraulic conductivity, through which the infusate will tend to flow and produce a predictable infusion pattern. Infusate will be carried into these channels with relatively low resistance, and then infuse outward from these channels into the surrounding tissue. By carefully positioning these channels, one can control and modify the preferred paths and duration of distribution.
摘要翻译：装置，系统和方法将药剂递送到软质量体，例如身体的区域，更具体地是脑。一个方面包括使用相对小直径的微创管心针产生组织中的一个或多个通道，隧道或凹槽，然后在输注之前去除探针。探针创造的通道成为增加水力传导性的途径，通过该途径，输注物将倾向于流动并产生可预测的输注模式。输液将以相对较低的阻力进入这些通道，然后从这些通道向外注入周围组织。通过仔细定位这些通道，可以控制和修改分配的首选路径和持续时间。

50. 发明授权

US07366561B2 Robotic trajectory guide 有权
标题翻译：机器人轨迹指南
公开(公告)号：US07366561B2
公开(公告)日：2008-04-29
申请号：US09825786
申请日：2001-04-04
申请人： Gerald W. Mills , Martin Brady , Raghu Raghavan , John David , Thomas I. Miller , Matthew S. Solar
发明人： Gerald W. Mills , Martin Brady , Raghu Raghavan , John David , Thomas I. Miller , Matthew S. Solar
IPC分类号： A61B5/05
CPC分类号： A61B90/11 , A61B34/20 , A61B34/30 , A61B34/70 , A61B2034/107 , A61B2034/2055 , A61B2034/301 , A61B2090/374
摘要： A surgical alignment device is shown that is controlled remotely through the use of an actuator, where the actuator in turn controls at least one local adjustment device. The alignment device is suited for neurosurgery, although it is not exclusively limited to neurosurgery. The alignment device includes an insertion guide that is coupled to the local adjustment device, the insertion guide being used to guide a device such as a catheter into a patient. The alignment device may also be coupled to a control module such as a microcomputer that controls the orientation of the insertion guide in response to inputs from the surgeon as to a location of interest within the patient.
摘要翻译：示出了通过使用致动器远程控制的外科对准装置，其中致动器依次控制至少一个局部调节装置。对准装置适用于神经外科手术，但并不限于神经外科手术。对准装置包括联接到局部调节装置的插入引导件，插入引导件用于将诸如导管的装置引导到患者体内。对准装置还可以耦合到诸如微型计算机的控制模块，微型计算机响应于来自外科医生的输入以及患者内感兴趣的位置来控制插入引导件的取向。

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