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41. 发明授权

US08762318B2 Supplementing a trained model using incremental data in making item recommendations 有权
标题翻译：使用增量数据来补充训练有素的模型来提出项目建议
公开(公告)号：US08762318B2
公开(公告)日：2014-06-24
申请号：US13618647
申请日：2012-09-14
申请人： Qiong Zhang , Wei Du , Wei Yu , Biswadeep Nag , Jessi Dong
发明人： Qiong Zhang , Wei Du , Wei Yu , Biswadeep Nag , Jessi Dong
IPC分类号： G06N5/04 , G06N99/00
CPC分类号： G06N99/005 , G06N5/045
摘要： Incremental training data is used to supplement a trained model to provide personalized recommendations for a user. The personalized recommendations can be made by taking into account the user's behavior, such as, without limitation, the user's short and long term web page interactions, to identify item recommendations. A trained model is generated from training data indicative of the web page interaction data collected from a plurality of users. Incremental training data indicative of other web page interaction data can be used to supplement the trained model, or in place of the trained model. Incremental training data can be indicative of user behavior collected more recently than the data used to train the model, for example.
摘要翻译：增量训练数据用于补充训练有素的模型，为用户提供个性化的建议。可以通过考虑用户的行为（例如但不限于用户的短期和长期网页交互）来识别项目建议来进行个性化建议。从训练数据生成训练模型，指示从多个用户收集的网页交互数据。可以使用指示其他网页交互数据的增量训练数据来补充训练的模型，或代替训练的模型。例如，增量训练数据可以指示比用于训练模型的数据最近收集的用户行为。

42. 发明授权

US08735067B2 Asymmetric PCR amplification, its special primer and application 有权
标题翻译：不对称PCR扩增，其特殊引物及应用
公开(公告)号：US08735067B2
公开(公告)日：2014-05-27
申请号：US11661069
申请日：2004-11-22
申请人： Zhiwei Zhang , Can Wang , Lingxiang Zhu , Qiong Zhang , Jing Cheng
发明人： Zhiwei Zhang , Can Wang , Lingxiang Zhu , Qiong Zhang , Jing Cheng
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/686 , C12Q2531/107 , C12Q2525/155 , C12Q2525/15
摘要： The present invention discloses an asymmetric PCR amplification method, its special primer and application, aims to provide a simple, effective PCR amplification for preparation of single-stranded product. The asymmetric PCR primer of the invention comprises some PCR primer pairs, in which an unrelated nucleic acids sequence to target sequence to be detected is added onto 5′-terminal of one primer. The asymmetric PCR amplification provided includes the steps: 1) preparative denaturing; 2) repetitiously denaturing, primers annealing, extending cycles as the first stage of PCR amplification; 3) repetitiously denaturing, primer extending cycles as the second stage of PCR amplification, wherein an unrelated nucleic acids sequence to target sequence to be detected is added onto 5′-terminal of one PCR primer of each pair in extension. With the asymmetric PCR amplification of the invention, high throughput of single-stranded products can be obtained, single PCR amplification or multiple PCR amplification can be carried out. And the method can be widely used in detection of nucleic acids.
摘要翻译：本发明公开了一种不对称PCR扩增方法及其特异性引物及其应用，旨在为单链产物的制备提供简单有效的PCR扩增。本发明的不对称PCR引物包含一些PCR引物对，其中将待检测的靶序列的不相关核酸序列添加到一个引物的5'末端。提供的不对称PCR扩增包括以下步骤：1）制备型变性; 2）重复变性，引物退火，延伸循环作为PCR扩增的第一阶段; 3）重复变性，引物延伸循环作为PCR扩增的第二阶段，其中将待检测的靶序列的不相关核酸序列添加到每对扩增中的一个PCR引物的5'末端。利用本发明的不对称PCR扩增，可以获得高通量的单链产物，可进行单PCR扩增或多重PCR扩增。该方法可广泛用于检测核酸。

43. 发明申请

US20140005969A1 TRAJECTORY CORRECTION METHOD AND APPARATUS FOR K-SPACE DATA IN MAGNETIC RESONANCE IMAGING 有权
标题翻译：磁共振成像中K空间数据的轨迹校正方法和装置
公开(公告)号：US20140005969A1
公开(公告)日：2014-01-02
申请号：US13927376
申请日：2013-06-26
申请人： De He Weng , Qiong Zhang
发明人： De He Weng , Qiong Zhang
IPC分类号： G01R35/00 , G01R33/48
CPC分类号： G01R35/005 , G01R33/482 , G01R33/4822 , G01R33/4824 , G01R33/565
摘要： In a trajectory correction method and apparatus for k-space data points in magnetic resonance imaging, a magnetic resonance data acquisition unit is operated to execute a sampling sequence to obtain k-space to be corrected. Empirical points are selected used to divide k-space to be corrected into a central region and a peripheral region. The trajectories of the data points in the central region and the peripheral region are corrected and the sampling sequence is executed again, with the corrected trajectories, to obtain corrected k-space.
摘要翻译：在用于磁共振成像中的k空间数据点的轨迹校正方法和装置中，操作磁共振数据获取单元以执行采样序列以获得要校正的k空间。经验点被选择用于将要校正的k空间划分为中心区域和外围区域。校正中心区域和外围区域中的数据点的轨迹，并且利用校正的轨迹再次执行采样序列，以获得校正的k空间。

44. 发明申请

US20130143899A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 有权
标题翻译：作为蛋白激酶抑制剂的化合物和组合物
公开(公告)号：US20130143899A1
公开(公告)日：2013-06-06
申请号：US13577209
申请日：2011-02-04
申请人： Shifeng Pan , John E. Tellew , Yongqin Wan , Yongping Xie , Xing Wang , Xia Wang , Shenlin Huang , Zuosheng Liu , Qiong Zhang
发明人： Shifeng Pan , John E. Tellew , Yongqin Wan , Yongping Xie , Xing Wang , Xia Wang , Shenlin Huang , Zuosheng Liu , Qiong Zhang
IPC分类号： C07D471/04 , A61K45/06 , A61K31/444 , A61K31/519 , C07D401/14 , A61K31/506
CPC分类号： C07D471/04 , A61K31/444 , A61K31/506 , A61K31/519 , A61K45/06 , C07D401/14
摘要： The invention provides a novel class of compounds of Formula (I) (wherein A, Y, R2, R3, R4 and R5 are defined in the summary of the invention), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译：本发明提供了一类新颖的式（I）化合物（其中A，Y，R 2，R 3，R 4和R 5在本发明概述中定义），包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症，特别是涉及B-Raf异常活化的疾病或病症。

45. 发明授权

US08326777B2 Supplementing a trained model using incremental data in making item recommendations 有权
标题翻译：使用增量数据来补充训练有素的模型来提出项目建议
公开(公告)号：US08326777B2
公开(公告)日：2012-12-04
申请号：US12533632
申请日：2009-07-31
申请人： Qiong Zhang , Wei Du , Wei Yu , Biswadeep Nag , Jessi Dong
发明人： Qiong Zhang , Wei Du , Wei Yu , Biswadeep Nag , Jessi Dong
IPC分类号： G06F15/18 , G06N5/02
CPC分类号： G06N99/005 , G06N5/045
摘要： Incremental training data is used to supplement a trained model to provide personalized recommendations for a user. The personalized recommendations can be made by taking into account the user's behavior, such as, without limitation, the user's short and long term web page interactions, to identify item recommendations. A trained model is generated from training data indicative of the web page interaction data collected from a plurality of users. Incremental training data indicative of other web page interaction data can be used to supplement the trained model, or in place of the trained model. Incremental training data can be indicative of user behavior collected more recently than the data used to train the model, for example.
摘要翻译：增量训练数据用于补充训练有素的模型，为用户提供个性化的建议。可以通过考虑用户的行为（例如但不限于用户的短期和长期网页交互）来识别项目建议来进行个性化建议。从训练数据生成训练模型，指示从多个用户收集的网页交互数据。可以使用指示其他网页交互数据的增量训练数据来补充训练的模型，或代替训练的模型。例如，增量训练数据可以指示比用于训练模型的数据最近收集的用户行为。

46. 发明申请

US20120225899A1 Compounds and Compositions as Protein Kinase Inhibitors 有权
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US20120225899A1
公开(公告)日：2012-09-06
申请号：US13473230
申请日：2012-05-16
申请人： Abran Q. Costales , Shenlin Huang , Jeff (Xianming) Jin , Zhuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
发明人： Abran Q. Costales , Shenlin Huang , Jeff (Xianming) Jin , Zhuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
IPC分类号： A61K31/506 , A61P35/00
CPC分类号： C07D403/04 , A61K31/506 , A61K45/06
摘要： The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译：本发明提供式I或II的化合物：其中R1，R1b，R2，R3，R4，R5，R6和R7如本文所定义。式（I）或（II）的化合物及其药物组合物可用于治疗B-Raf相关疾病。

47. 发明授权

US08242260B2 Compounds and compositions as protein kinase inhibitors 有权
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US08242260B2
公开(公告)日：2012-08-14
申请号：US12862418
申请日：2010-08-24
申请人： Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
发明人： Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
IPC分类号： C07D345/00 , C07D239/00 , C07D233/00
CPC分类号： C07D403/04 , A61K31/506 , A61K45/06
摘要： The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译：本发明提供式I或II的化合物：其中R1，R1b，R2，R3，R4，R5，R6和R7如本文所定义。式（I）或（II）的化合物及其药物组合物可用于治疗B-Raf相关疾病。

48. 发明申请

US20120117269A1 SYSTEMS AND METHODS FOR MULTI-LAYER TRAFFIC GROOMING 有权
标题翻译：多层交通运输系统与方法
公开(公告)号：US20120117269A1
公开(公告)日：2012-05-10
申请号：US12942586
申请日：2010-11-09
申请人： Qiong Zhang , Paparao Palacharla , Qingya She , Xi Wang , Motoyoshi Sekiya
发明人： Qiong Zhang , Paparao Palacharla , Qingya She , Xi Wang , Motoyoshi Sekiya
IPC分类号： G06F15/173
CPC分类号： H04J14/0257 , H04J14/0212
摘要： A method may include constructing an auxiliary graph for a network comprising a plurality of network elements, the network elements having an Internet Protocol layer, a lower layer, and a wavelength layer, the auxiliary graph including a plurality of directed edges, the plurality of directed edges indicative of connectivity of components of the plurality of network elements. The method may further include: (i) deleting directed edges from the auxiliary graph whose available bandwidth is lower than the required bandwidth of a selected demand; (ii) finding a path for the demand on the auxiliary graph via remaining directed edges; (iii) deleting at least one directed edge of the auxiliary graph on the wavelength layer along the path; (iv) adding lower layer lightpath edges to the auxiliary graph for a lower layer lightpath for the path; and (v) converting lower layer lightpaths to Internet Protocol lightpaths if a conversion condition is satisfied.
摘要翻译：方法可以包括为包括多个网络元件的网络构建辅助图形，所述网络元件具有互联网协议层，下层和波长层，所述辅助图形包括多个有向边缘，所述多个定向指示多个网络元件的组件的连接性的边缘。该方法还可以包括：（i）从可用带宽低于所选择的需求的所需带宽的辅助图中删除有向边; （ii）通过剩余的有向边找到对辅助图的需求的路径; （iii）沿所述路径删除所述波长层上的辅助图形的至少一个有向边缘; （iv）将下层光路边缘添加到辅助图形，用于路径的下层光路; 和（v）如果满足转换条件，则将下层光路转换为因特网协议光路。

49. 发明申请

US20060294315A1 Object-based pre-fetching Mechanism for disc drives 审中-公开
标题翻译：基于对象的预取磁盘驱动器的机制
公开(公告)号：US20060294315A1
公开(公告)日：2006-12-28
申请号：US11167550
申请日：2005-06-27
申请人： Sami Iren , Wilson Fish , Qiong Zhang
发明人： Sami Iren , Wilson Fish , Qiong Zhang
IPC分类号： G06F13/00 , G06F12/00
CPC分类号： G06F12/0862 , G06F12/0866 , G06F2212/6028
摘要： A method comprises: storing data for a plurality of objects in a plurality of physical blocks on a storage medium, using information about the objects to identify logical addresses for the physical blocks used to store the data, pre-fetching the data from particular ones of the physical blocks based on the identified logical addresses, and storing the pre-fetched data in a memory. Apparatus that performs the method is also included.
摘要翻译：一种方法包括：使用关于对象的信息将多个对象中的多个物体的数据存储在存储介质上的多个物理块中，以识别用于存储数据的物理块的逻辑地址，从数据的特定位置预取数据基于所识别的逻辑地址的物理块，并将预取数据存储在存储器中。还包括执行该方法的装置。

50. 发明授权

US09763937B2 Aminoheteroaryl benzamides as kinase inhibitors 有权
公开(公告)号：US09763937B2
公开(公告)日：2017-09-19
申请号：US14964057
申请日：2015-12-09
申请人： Jeffrey T. Bagdanoff , Yu Ding , Wooseok Han , Zilin Huang , Qun Jiang , Xianming Jin , Xiang Kou , Patrick Lee , Mika Lindvall , Zhongcheng Min , Yue Pan , Sabina Pecchi , Keith Bruce Pfister , Daniel Poon , Vivek Rauniyar , Xiaojing Michael Wang , Qiong Zhang , Jianguang Zhou , Shejin Zhu
发明人： Jeffrey T. Bagdanoff , Yu Ding , Wooseok Han , Zilin Huang , Qun Jiang , Xianming Jin , Xiang Kou , Patrick Lee , Mika Lindvall , Zhongcheng Min , Yue Pan , Sabina Pecchi , Keith Bruce Pfister , Daniel Poon , Vivek Rauniyar , Xiaojing Michael Wang , Qiong Zhang , Jianguang Zhou , Shejin Zhu
IPC分类号： C07D241/02 , A61K31/4965 , A61K31/497 , A61K31/4433 , A61K31/44 , A61K31/4436 , A61K31/5355
CPC分类号： A61K31/497 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , A61K2121/00 , C07D213/73 , C07D241/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04
摘要： The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

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