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41. 发明授权

US06777539B2 Soluble zalpha11 cytokine receptors 有权
标题翻译：可溶性zalpha11细胞因子受体
公开(公告)号：US06777539B2
公开(公告)日：2004-08-17
申请号：US09825561
申请日：2001-04-03
申请人： Cindy A. Sprecher , Julia E. Novak , James W. West , Scott R. Presnell , Richard D. Holly , Andrew J. Nelson
发明人： Cindy A. Sprecher , Julia E. Novak , James W. West , Scott R. Presnell , Richard D. Holly , Andrew J. Nelson
IPC分类号： C07K14435
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2317/73 , C07K2319/00
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zlapha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译：公开了可用作新型细胞因子拮抗剂的可溶性zalpha11受体的新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，以及用于检测刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法体外和体内。配体结合受体多肽也可用于在体外和体内阻断zlapha11配体活性，并可与zalpha11配体和其他细胞因子结合使用以选择性刺激免疫系统。本发明还包括生产蛋白质的方法，用途及其抗体。

42. 发明授权

US6136964A Mammalian lysophosphatidic acid acyltransferase 失效
标题翻译：哺乳动物溶血磷脂酸酰基转移酶
公开(公告)号：US6136964A
公开(公告)日：2000-10-24
申请号：US618651
申请日：1996-03-19
申请人： David W. Leung , James W. West , Christopher K. Tompkins
发明人： David W. Leung , James W. West , Christopher K. Tompkins
IPC分类号： C12N9/10 , C12N15/54 , C07H21/04 , C12N9/12
CPC分类号： C12N9/1029
摘要： There is disclosed cDNA sequences and polypeptides having the enzyme lysophosphatidic acid acyltransferase (LPAAT) activity. LPAAT is also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.
摘要翻译：公开了具有酶溶血磷脂酸酰基转移酶（LPAAT）活性的cDNA序列和多肽。 LPAAT也称为1-酰基sn-甘油-3-磷酸酰基转移酶。

43. 发明授权

US6060263A Mammalian lysophosphatidic acid acyltransferase 失效
公开(公告)号：US6060263A
公开(公告)日：2000-05-09
申请号：US400742
申请日：1999-09-21
申请人： David W. Leung , James W. West , Christopher K. Tompkins
发明人： David W. Leung , James W. West , Christopher K. Tompkins
IPC分类号： C12N9/10 , C12N15/54 , C12Q1/48
CPC分类号： C12N9/1029
摘要： There is disclosed cDNA sequences and polypeptides having the enzyme lysophosphatidic acid acyltransferase (LPAAT) activity. LPAAT is also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.

44. 发明申请

US20120219540A1 COMPOSITIONS AND METHODS FOR MODULATING IMMUNE RESPONSES 审中-公开
标题翻译：用于调节免疫应答的组合物和方法
公开(公告)号：US20120219540A1
公开(公告)日：2012-08-30
申请号：US13417587
申请日：2012-03-12
申请人： Zeren Gao , Steven D. Levin , Janine Bilsborough , James W. West , Cameron S. Brandt , Eric M. Chadwick
发明人： Zeren Gao , Steven D. Levin , Janine Bilsborough , James W. West , Cameron S. Brandt , Eric M. Chadwick
IPC分类号： A61K38/17 , G01N33/566 , A61K31/7105 , A61P37/00 , A61K39/395 , A61K31/713
CPC分类号： C07K16/2827 , A61K38/00 , A61K2039/507 , C07K14/47 , C07K14/70532 , C07K16/2803 , C07K16/2818 , C07K2317/34 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C12Q1/66 , G01N33/505 , G01N33/56972 , G01N2333/70532
摘要： The present invention provides a newly identified B7 receptor, zB7R1 that functions as lymphocyte inhibitory receptor, which is a PD-1-like molecule and is expressed on T cells. The present invention also provides the discovery of zB7R1's ability to bind to CD155. Methods and compositions for modulating zB7R1-mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic and research purposes are also provided.
摘要翻译：本发明提供新鉴定的B7受体，作为淋巴细胞抑制性受体的zB7R1，其是PD-1样分子，并在T细胞上表达。本发明还提供了zB7R1与CD155结合的能力的发现。还提供了用于调节zB7R1介导的负信号并干扰其反受体相互作用用于治疗，诊断和研究目的的方法和组合物。

45. 发明申请

US20110059087A1 IL-17 AND IL-23 ANTAGONISTS AND METHODS OF USING THE SAME 有权
标题翻译： IL-17和IL-23拮抗剂及其使用方法
公开(公告)号：US20110059087A1
公开(公告)日：2011-03-10
申请号：US12870199
申请日：2010-08-27
申请人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Brent Meengs , Steven D. Levin
发明人： Katherine E. Lewis , Scott R. Presnell , James W. West , Robert Mabry , Brent Meengs , Steven D. Levin
IPC分类号： A61K39/395 , C07K16/24 , C12N5/0783 , A61P25/28 , A61P1/00
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/507 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.
摘要翻译：本发明涉及通过其p19亚基或IL-17和IL-23（通过p19）阻断，抑制，降低，拮抗或中和IL-17，IL-23的活性。 IL-17和IL-23是涉及炎症过程和人类疾病的细胞因子。

46. 发明申请

US20100074905A1 METHODS FOR SOLUBLE ZALPHA11 CYTOKINE RECEPTORS 审中-公开
标题翻译：可溶性ZALPHA11细胞因子受体的方法
公开(公告)号：US20100074905A1
公开(公告)日：2010-03-25
申请号：US12560637
申请日：2009-09-16
申请人： Cindy A. Sprecher , Julie E. Novak , James W. West , Scott R. Presnet , Richard D. Holly , Andrew J. Nelson
发明人： Cindy A. Sprecher , Julie E. Novak , James W. West , Scott R. Presnet , Richard D. Holly , Andrew J. Nelson
IPC分类号： A61K39/395 , A61K38/16 , A61P37/06
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2317/73 , C07K2319/00
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zalpha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译：公开了可用作新型细胞因子拮抗剂的可溶性zalpha11受体的新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，以及用于检测刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法体外和体内。配体结合受体多肽也可用于在体外和体内阻断zalpha11配体活性，并可与zalpha11配体和其他细胞因子结合使用以选择性刺激免疫系统。本发明还包括生产蛋白质的方法，用途及其抗体。

47. 发明申请

US20090192291A1 PRODUCTION OF HOMOTRIMERIC FUSION PROTEINS 审中-公开
标题翻译：共培养融合蛋白的生产
公开(公告)号：US20090192291A1
公开(公告)日：2009-07-30
申请号：US12353713
申请日：2009-01-14
申请人： James W. West , Cameron S. Brandt , Stephen R. Jaspers
发明人： James W. West , Cameron S. Brandt , Stephen R. Jaspers
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K14/78 , C07K2319/00 , C07K2319/03 , C12N15/62
摘要： The present invention provides method for producing trimeric tumor necrosis factor receptors that are potent inhibitors of their cognate ligands. More particularly, the present invention provides polypeptides that comprise: (1) an extracellular domain of the transmembrane activator and CAML (calcium-signal modulating cyclophilin ligand) interactor (TACI), and (2) a trimerizing polypeptide. Suitable TACI extracellular domains include: (1) amino acid residues 30 to 110 of SEQ ID NO:4, (2) amino acid residues 1 to 110 of SEQ ID NO:4, (3) amino acid residues 30 to 154 of SEQ ID NO:4, and (4) amino acid residues 1 to 154 of SEQ ID NO:4. Illustrative trimerizing polypeptides include a trimerizing fragment of Heat Shock Binding Protein-1. The present invention further provides homotrimeric complexes of fusion proteins comprising a TACI extracellular domain and a trimerizing polypeptide.
摘要翻译：本发明提供了产生三聚体肿瘤坏死因子受体的方法，所述三聚体肿瘤坏死因子受体是其相关配体的有效抑制剂。更具体地，本发明提供多肽，其包含：（1）跨膜激活剂的胞外结构域和CAML（钙信号调节亲环蛋白配体）相互作用体（TACI），和（2）三聚体多肽。合适的TACI细胞外结构域包括：（1）SEQ ID NO：4的氨基酸残基30至110，（2）SEQ ID NO：4的氨基酸残基1至110，（3）SEQ ID NO：4的氨基酸残基30至154 NO.4和（4）SEQ ID NO：4的氨基酸残基1至154。示例性的三聚化多肽包括热休克结合蛋白-1的三聚体片段。本发明还提供了包含TACI胞外域和三聚多肽的融合蛋白的同源三聚体。

48. 发明授权

US07223564B2 Four-helical bundle protein zsig81 失效
标题翻译：四螺旋束蛋白zsig81
公开(公告)号：US07223564B2
公开(公告)日：2007-05-29
申请号：US10315379
申请日：2002-12-09
申请人： Christopher S. Piddington , James W. West , Richard D. Holly , Steven K. Burkhead
发明人： Christopher S. Piddington , James W. West , Richard D. Holly , Steven K. Burkhead
IPC分类号： C12N15/16 , C12N15/63 , C12N5/00 , C07K14/475 , C07K4/12
CPC分类号： C07K14/47 , C07K14/475
摘要： This present invention is directed to polypeptide and polynucleotide molecules that encode a four-helical bundle cytokine. The cytokine has been designated zsig81, and has restricted expression in primarily heart, lung and liver. zsig81 has been shown to stimulate proliferation of hematopoietic cells and will be useful expansion of these cells, as well as conditions associated with hematopoietic cells. The invention is directed to antibodies and methods of making zsig81 polypeptides, as well.
摘要翻译：本发明涉及编码四螺旋束细胞因子的多肽和多核苷酸分子。细胞因子被指定为zsig81，并且主要限制在心脏，肺和肝中的表达。已经显示zsig81刺激造血细胞的增殖，并且这些细胞的有用扩张以及与造血细胞相关的病症。本发明还涉及制备zsig81多肽的抗体和方法。

49. 发明授权

US06432673B1 Growth factor homolog ZVEGF3 有权
标题翻译：生长因子同源物ZVEGF3
公开(公告)号：US06432673B1
公开(公告)日：2002-08-13
申请号：US09457066
申请日：1999-12-07
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号： C12N1500
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译：公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体及其使用方法。多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。还公开了多肽的多聚体。多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。

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