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41. 发明授权

US08465692B2 Sodium/molybdenum composite metal articles and methods for producing metal articles 失效
标题翻译：钠/钼复合金属制品及其制造方法
公开(公告)号：US08465692B2
公开(公告)日：2013-06-18
申请号：US13038578
申请日：2011-03-02
申请人： Naresh Goel , Carl Cox , Dave Honecker , Eric Smith , Chris Michaluk , Adam DeBoskey , Sunil Chandra Jha
发明人： Naresh Goel , Carl Cox , Dave Honecker , Eric Smith , Chris Michaluk , Adam DeBoskey , Sunil Chandra Jha
IPC分类号： B22F3/16
CPC分类号： H01L31/02167 , B22F3/15 , B22F2998/10 , B22F2999/00 , C22C1/045 , C23C4/08 , C23C14/14 , C23C14/3414 , H01L31/022425 , H01L31/0322 , H01L31/03923 , H01L31/0749 , Y02E10/541 , Y02P70/521 , Y10T428/12 , Y10T428/31678 , B22F3/1007 , B22F2201/013 , B22F9/026 , B22F3/04
摘要： A method for producing a metal article may include: Producing a supply of a composite metal powder by: providing a supply of molybdenum metal powder; providing a supply of a sodium compound; combining the molybdenum metal powder and the sodium compound with a liquid to form a slurry; feeding the slurry into a stream of hot gas; and recovering the composite metal powder; and consolidating the composite metal powder to form the metal article, the metal article comprising a sodium/molybdenum metal matrix. Also disclosed is a metal article produced accordance with this method.
摘要翻译：金属制品的制造方法可以包括：通过以下方式制造复合金属粉末的供给：提供钼金属粉末的供给; 提供钠化合物的供应; 将钼金属粉末和钠化合物与液体结合以形成浆料; 将浆料送入热气流中; 并回收复合金属粉末; 并且将所述复合金属粉末固结以形成所述金属制品，所述金属制品包含钠/钼金属基体。还公开了根据该方法制造的金属制品。

42. 发明授权

US08183014B2 High affinity antibodies to human IL-6 receptor 有权
标题翻译：对人IL-6受体的高亲和力抗体
公开(公告)号：US08183014B2
公开(公告)日：2012-05-22
申请号：US13230081
申请日：2011-09-12
申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号： C12N5/10 , C12N15/13 , C12N15/63
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.
摘要翻译：提供了以约500pM以下的KD结合人IL-6受体（hIL-6R）的人抗体或抗原结合片段，并且以200pM以下的IC 50阻断IL-6活性。在优选的实施方案中，抗体抗体或抗原结合片段以相对于其结合猴IL-6R至少高2倍的亲和力结合hIL-6R。

43. 发明授权

US08048418B2 Therapeutic methods for inhibiting tumor growth with combination of Dll4 antagonists and VEGF antagonists 有权
标题翻译：通过组合Dll4拮抗剂和VEGF拮抗剂抑制肿瘤生长的治疗方法
公开(公告)号：US08048418B2
公开(公告)日：2011-11-01
申请号：US12435030
申请日：2009-05-04
申请人： Irene Noguera-Troise , Gavin Thurston , Nicholas Gale , Eric Smith
发明人： Irene Noguera-Troise , Gavin Thurston , Nicholas Gale , Eric Smith
IPC分类号： A61K39/395 , A61K38/16
CPC分类号： C07K14/705 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/28 , C07K2317/73 , C07K2319/30 , C12N2799/022 , C12N2799/027
摘要： Disclosed is a therapeutic method for inhibiting development or growth of tumors that are resistant to the blockade of delta-like ligand 4 (Dll4), or vascular endothelial growth factor (VEGF), or to other therapeutic agents, by administering the combination of Dll4 antagonist and VEGF antagonist. The combined administration of these two agents, concurrently or sequentially, exhibits synergistic effects on blood vessel development and growth, thereby more effectively inhibiting the tumor growth than an administration of either agent alone. The Dll4 antagonist can be an anti-Dll4 antibody or antibody fragment capable of inhibiting the binding of Dll4 to a Notch receptor, or a fusion protein comprising the extracellular domain of Dll4 or a soluble Notch receptor, or a fragment thereof, fused to a multimerizing component. The VEGF antagonist can be a VEGF trap, anti-VEGF antibody or antibody fragment capable of inhibiting the binding of VEGF to a VEGF receptor.
摘要翻译：公开了通过施用Dll4拮抗剂的组合来抑制对阻滞δ-样配体4（Dll4）或血管内皮生长因子（VEGF）或其它治疗剂的抗性的肿瘤的发展或生长的治疗方法和VEGF拮抗剂。这两种试剂同时或相继地组合施用对血管发育和生长表现出协同作用，从而比单独施用任一试剂更有效地抑制肿瘤生长。 Dll4拮抗剂可以是能够抑制Dll4与Notch受体结合的抗Dll4抗体或抗体片段，或包含融合到多聚化的Dll4的细胞外结构域或其可溶性Notch受体或其片段的融合蛋白零件。 VEGF拮抗剂可以是能够抑制VEGF与VEGF受体结合的VEGF陷阱，抗VEGF抗体或抗体片段。

44. 发明授权

US08043617B2 Human antibodies to human IL-6 receptor 有权
标题翻译：人类IL-6受体的抗体
公开(公告)号：US08043617B2
公开(公告)日：2011-10-25
申请号：US12501657
申请日：2009-07-13
申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.
摘要翻译：以约500pM以下的KD结合人IL-6受体（hIL-6R）的人抗体或抗原结合片段，并以200pM以下的IC 50阻断IL-6活性。在优选的实施方案中，抗体抗体或抗原结合片段以相对于其结合猴IL-6R至少高2倍的亲和力结合hIL-6R。

45. 发明申请

US20110252006A1 OFFLINE SHARING CAPABILITY FOR CLIENT APPLICATION 有权
标题翻译：客户应用的离线共享能力
公开(公告)号：US20110252006A1
公开(公告)日：2011-10-13
申请号：US13164408
申请日：2011-06-20
申请人： Eric Smith , Cameron Stillion , Andrew Ash
发明人： Eric Smith , Cameron Stillion , Andrew Ash
IPC分类号： G06F17/30 , G06F15/16
CPC分类号： G06Q10/107 , G06F17/30578 , H04L51/066 , H04L67/1097
摘要： Application Programming Interfaces (APIs) and UI modifications for existing applications are used to implement efficient methods for taking content offline with full synchronization, incremental synchronization, in the case of document libraries per-folder synchronization, and the like. The APIs provide support for synchronizing changes to attachments, the ability to download a document library's complete contents or only a list of the available documents, and read-only folder hierarchy replication in the case of document libraries. These abilities coupled with corresponding user interface features enable easier browsing and searching of large document library structures, making edits to those documents offline, being able to see an up-to-date version of those documents in a preview mode, and receiving reminders when offline edits remain on the local computer and need to be updated to a server.
摘要翻译：用于现有应用程序的应用程序编程接口（API）和UI修改用于实现高效的方法，用于在文件库每文件夹同步的情况下，完全同步，增量同步，脱机内容等。 API提供对同步更改附件，下载文档库完整内容或仅可用文档列表的能力以及文档库中只读文件夹层次结构复制的支持。这些功能与相应的用户界面功能相结合，可以更轻松地浏览和搜索大型文档库结构，对这些文档进行离线编辑，能够以预览模式查看这些文档的最新版本，并在离线时接收提醒编辑仍保留在本地计算机上，需要更新到服务器。

46. 发明申请

US20110179623A1 Tapered Spiral Welded Structure 有权
标题翻译：锥形螺旋焊接结构
公开(公告)号：US20110179623A1
公开(公告)日：2011-07-28
申请号：US12693369
申请日：2010-01-25
申请人： Eric Smith , Alexander Slocum
发明人： Eric Smith , Alexander Slocum
IPC分类号： B23P11/00
CPC分类号： E04H12/08 , B21C37/124 , B21C37/185 , B23K31/02 , E04H12/342 , Y02E10/728 , Y10T29/49318 , Y10T29/49826 , Y10T428/12
摘要： A method for creating a tapered spiral welded conical structure where the overall shape of the cone is first graphically slit axially and unwrapped, and then a series of construction arcs and lines are created to form the edge lines of a strip that can then be wrapped (rolled) to form a tapered conical structure. The edges of the spirally wound strip can be welded together, and a very large conical structure can thus be achieved. Various construction options are presented from a constant width strip to strip made from straight segments. Equations are given for the formation of the strips to enable those skilled in the art of spiral welded tubing to practice the invention.
摘要翻译：一种用于产生锥形螺旋焊接圆锥形结构的方法，其中锥体的整体形状首先以图形方式被轴向地切开和展开，然后创建一系列构造弧线和线以形成条带的边缘线，轧制）以形成锥形锥形结构。螺旋卷绕的条带的边缘可以焊接在一起，因此可以实现非常大的锥形结构。从固定宽度的条带到由直线段制成的带状物呈现出各种构造选项。给出条带形成的等式，以使得螺旋焊接管技术领域的技术人员能够实践本发明。

47. 发明申请

US20090246199A1 THERAPEUTIC METHODS FOR INHIBITING TUMOR GROWTH WITH DLL4 ANTAGONISTS 有权
标题翻译：用DLL4拮抗剂抑制肿瘤生长的治疗方法
公开(公告)号：US20090246199A1
公开(公告)日：2009-10-01
申请号：US12435030
申请日：2009-05-04
申请人： Irene Noguera-Troise , Gavin Thurston , Nicholas Gale , Eric Smith
发明人： Irene Noguera-Troise , Gavin Thurston , Nicholas Gale , Eric Smith
IPC分类号： A61K39/395 , A61K38/16
CPC分类号： C07K14/705 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/28 , C07K2317/73 , C07K2319/30 , C12N2799/022 , C12N2799/027
摘要： Disclosed is a therapeutic method for inhibiting development or growth of tumors that are resistant to the blockade of delta-like ligand 4 (Dll4), or vascular endothelial growth factor (VEGF), or to other therapeutic agents, by administering the combination of Dll4 antagonist and VEGF antagonist. The combined administration of these two agents, concurrently or sequentially, exhibits synergistic effects on blood vessel development and growth, thereby more effectively inhibiting the tumor growth than an administration of either agent alone. The Dll4 antagonist can be an anti-Dll4 antibody or antibody fragment capable of inhibiting the binding of Dll4 to a Notch receptor, or a fusion protein comprising the extracellular domain of Dll4 or a soluble Notch receptor, or a fragment thereof, fused to a multimerizing component. The VEGF antagonist can be a VEGF trap, anti-VEGF antibody or antibody fragment capable of inhibiting the binding of VEGF to a VEGF receptor.
摘要翻译：公开了通过施用Dll4拮抗剂的组合来抑制对阻滞δ-样配体4（Dll4）或血管内皮生长因子（VEGF）或其它治疗剂的抗性的肿瘤的发展或生长的治疗方法和VEGF拮抗剂。这两种试剂同时或相继地组合施用对血管发育和生长表现出协同作用，从而比单独施用任一试剂更有效地抑制肿瘤生长。 Dll4拮抗剂可以是能够抑制Dll4与Notch受体结合的抗Dll4抗体或抗体片段，或包含融合到多聚化的Dll4的细胞外结构域或其可溶性Notch受体或其片段的融合蛋白零件。 VEGF拮抗剂可以是能够抑制VEGF与VEGF受体结合的VEGF陷阱，抗VEGF抗体或抗体片段。

48. 发明授权

US07582298B2 High affinity antibodies to human IL-6 receptor 有权
标题翻译：对人IL-6受体的高亲和力抗体
公开(公告)号：US07582298B2
公开(公告)日：2009-09-01
申请号：US11809482
申请日：2007-06-01
申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.
摘要翻译：以约500pM以下的KD结合人IL-6受体（hIL-6R）的人抗体或抗原结合片段，并以200pM以下的IC 50阻断IL-6活性。在优选的实施方案中，抗体抗体或抗原结合片段以相对于其结合猴IL-6R至少高2倍的亲和力结合hIL-6R。

49. 发明申请

US20090181179A1 Sodium/Molybdenum Composite Metal Powders, Products Thereof, and Methods for Producing Photovoltaic Cells 审中-公开
标题翻译：钠/钼复合金属粉末，其产品和生产光伏电池的方法
公开(公告)号：US20090181179A1
公开(公告)日：2009-07-16
申请号：US12013263
申请日：2008-01-11
申请人： Naresh Goel , Carl Cox , Dave Honecker , Eric Smith , Chris Michaluk , Adam DeBoskey , Sunil Chandra Jha
发明人： Naresh Goel , Carl Cox , Dave Honecker , Eric Smith , Chris Michaluk , Adam DeBoskey , Sunil Chandra Jha
IPC分类号： C23C4/08 , B22F9/00 , B22F1/00 , C23C14/14 , B32B15/04 , B05D1/36
CPC分类号： H01L31/02167 , B22F3/15 , B22F2998/10 , B22F2999/00 , C22C1/045 , C23C4/08 , C23C14/14 , C23C14/3414 , H01L31/022425 , H01L31/0322 , H01L31/03923 , H01L31/0749 , Y02E10/541 , Y02P70/521 , Y10T428/12 , Y10T428/31678 , B22F3/1007 , B22F2201/013 , B22F9/026 , B22F3/04
摘要： A method for producing a composite metal powder according to one embodiment of the invention may comprise: Providing a supply of molybdenum metal powder; providing a supply of a sodium compound; combining the molybdenum metal powder and the sodium compound with a liquid to form a slurry; feeding the slurry into a stream of hot gas; and recovering the composite metal powder.
摘要翻译：根据本发明的一个实施方案的复合金属粉末的制造方法可以包括：提供钼金属粉末; 提供钠化合物的供应; 将钼金属粉末和钠化合物与液体结合以形成浆料; 将浆料送入热气流中; 并回收复合金属粉末。

50. 发明申请

US20090142354A1 HUMAN ANTIBODIES TO HUMAN DELTA LIKE LIGAND 4 有权
标题翻译：人类抗体与人类三角形配对4
公开(公告)号：US20090142354A1
公开(公告)日：2009-06-04
申请号：US12371159
申请日：2009-02-13
申请人： Nicholas J. Papadopoulos , Joel H. Martin , Eric Smith , Irene Noguera-Troise , Gavin Thurston
发明人： Nicholas J. Papadopoulos , Joel H. Martin , Eric Smith , Irene Noguera-Troise , Gavin Thurston
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDll4) and blocks hDll4 binding to a Notch receptor. The human anti-hDll4 antibody or antibody fragment binds dimeric hDll4 with an affinity of 75 pM or better, as measured by surface plasmon resonance.
摘要翻译：分离的人抗体或人抗体的片段，其特异性结合人类δ样配体4（hDll4）并阻断hDll4与Notch受体的结合。通过表面等离振子共振测量，人抗hDll4抗体或抗体片段以75pM或更好的亲和力结合二聚体hDll4。

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