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41. 发明申请

US20120270809A1 HUMAN TRANSMEMBRANE PROTEINS 审中-公开
标题翻译：人类跨膜蛋白
公开(公告)号：US20120270809A1
公开(公告)日：2012-10-25
申请号：US13477843
申请日：2012-05-22
申请人： Y. Tom Tang , Preeti Lal , Jennifer L. Hillman , Henry Yue , Karl J. Guegler , Neil C. Corley , Olga Bandman , Chandra Patterson , Gina A. Gorgone , Matthew R. Kaser , Mariah R. Baughn , Janice Au-Young
发明人： Y. Tom Tang , Preeti Lal , Jennifer L. Hillman , Henry Yue , Karl J. Guegler , Neil C. Corley , Olga Bandman , Chandra Patterson , Gina A. Gorgone , Matthew R. Kaser , Mariah R. Baughn , Janice Au-Young
IPC分类号： C07K14/435 , G01N33/566 , C07K17/00 , A61K38/17 , C07K16/18
CPC分类号： C07K16/28 , A61K38/00 , C07K14/705 , C07K2317/24 , C07K2317/622 , C07K2317/76 , G01N33/68
摘要： The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN.
摘要翻译：本发明提供了人跨膜蛋白（HTMPN）和识别和编码HTMPN的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了用于诊断，治疗或预防与HTMPN表达相关的障碍的方法。

42. 发明授权

US5821086A Human glycoprotein 失效
公开(公告)号：US5821086A
公开(公告)日：1998-10-13
申请号：US695355
申请日：1996-08-09
申请人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , A61P25/00 , C07K14/705 , C12N1/21 , C12N15/12 , C12P21/06 , C12N15/00 , C07K1/00 , C07H21/04
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human glycoprotein (SC2H). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding SC2H. The invention also provides for the use of substantially purified SC2H and its agonists in the commercial production of recombinant proteins for the treatment of diseases associated with the expression of SC2H. Additionally, the invention provides for the use of antisense molecules to SC2H in the treatment of diseases associated with the expression of SC2H. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding SC2H and antibodies which specifically bind to the protein.

43. 发明授权

US06808895B1 DNA encoding oxidoreductase and polypeptide encoded thereby 失效
标题翻译：编码氧化还原酶的DNA和由此编码的多肽
公开(公告)号：US06808895B1
公开(公告)日：2004-10-26
申请号：US09806536
申请日：2001-03-28
申请人： Preeti Lal , Karl J. Guegler , Gina A. Gorgone , Neil C. Corley , Mariah R. Baughn , Y. Tom Tang , Jennifer L. Hillman , Olga Bandman , Yalda Azimzai , Janice Au-Young , Henry Yue , Dyung Aina M. Lu , Junming Yang
发明人： Preeti Lal , Karl J. Guegler , Gina A. Gorgone , Neil C. Corley , Mariah R. Baughn , Y. Tom Tang , Jennifer L. Hillman , Olga Bandman , Yalda Azimzai , Janice Au-Young , Henry Yue , Dyung Aina M. Lu , Junming Yang
IPC分类号： C12N510
CPC分类号： C12N9/0004 , A61K38/00
摘要： The invention provides human oxidoreductase molecules (OXRE) and polynucleotides which identify and encode OXRE. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of OXRE.
摘要翻译：本发明提供人氧化还原酶分子（OXRE）和识别和编码OXRE的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与OXRE表达相关的障碍的方法。

44. 发明授权

US6132973A Human regulatory molecules 失效
标题翻译：人体调节分子
公开(公告)号：US6132973A
公开(公告)日：2000-10-17
申请号：US234613
申请日：1999-01-20
申请人： Preeti Lal , Jennifer L. Hillman , Olga Bandman , Purvi Shah , Janice Au-Young , Henry Yue , Karl J. Guegler , Neil C. Corley
发明人： Preeti Lal , Jennifer L. Hillman , Olga Bandman , Purvi Shah , Janice Au-Young , Henry Yue , Karl J. Guegler , Neil C. Corley
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N37/00 , C07H21/04 , C12P19/34 , C12P21/06 , C01N33/50
CPC分类号： C12N9/93 , C07K14/4702 , A61K38/00 , Y10T436/143333
摘要： The invention provides human regulatory molecules and polynucleotides (collectively designated HRM) which identify and encode them. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention further provides methods for diagnosing, preventing, and treating disorders associated with expression of human regulatory molecules.
摘要翻译：本发明提供鉴定和编码它们的人类调节分子和多核苷酸（统称为HRM）。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了用于诊断，预防和治疗与人类调节分子的表达相关的疾病的方法。

45. 发明授权

US6113904A Human glycoprotein 失效
标题翻译：人类糖蛋白
公开(公告)号：US6113904A
公开(公告)日：2000-09-05
申请号：US63869
申请日：1998-04-20
申请人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , A61P25/00 , C07K14/705 , C12N1/21 , C12N15/12 , A61K39/00 , C07K1/00
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human glycoprotein (SC2H). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding SC2H. The invention also provides for the use of substantially purified SC2H and its agonists in the commercial production of recombinant proteins for the treatment of diseases associated with the expression of SC2H. Additionally, the invention provides for the use of antisense molecules to SC2H in the treatment of diseases associated with the expression of SC2H. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding SC2H and antibodies which specifically bind to the protein.
摘要翻译：本发明提供鉴定和编码新型人糖蛋白（SC2H）的多核苷酸。本发明提供了包含编码SC2H的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了在商业生产重组蛋白质中用于治疗与SC2H表达相关的疾病的基本纯化的SC2H及其激动剂的用途。另外，本发明提供了用于治疗与SC2H表达相关的疾病的SC2H反义分子的用途。本发明还描述了利用包含与编码SC2H的天然存在的序列和特异性结合蛋白质的抗体杂交的多核苷酸的诊断组合物的诊断测定法。

46. 发明授权

US6015788A Human nucleic acid binding protein 失效
标题翻译：人核酸结合蛋白
公开(公告)号：US6015788A
公开(公告)日：2000-01-18
申请号：US195855
申请日：1998-11-19
申请人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , C07K14/47
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human nucleic acid binding protein (NABP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NABP. The invention also provides for the use of substantially purified NABP or its antagonists, in pharmaceutical compositions for the treatment of diseases associated with the expression of NABP. Additionally, the invention provides for the use of antisense molecules to NABP in pharmaceutical compositions for treatment of diseases associated with the expression of NABP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding NABP or anti-NABP antibodies which specifically bind to NABP.
摘要翻译：本发明提供鉴定和编码新的人核酸结合蛋白（NABP）的多核苷酸。本发明提供了包含编码NABP的核酸序列的基因工程表达载体和宿主细胞。本发明还提供在药物组合物中用于治疗与NABP表达相关的疾病的基本纯化的NABP或其拮抗剂的用途。另外，本发明提供了用于治疗与NABP表达相关的疾病的药物组合物中NABP的反义分子的用途。本发明还描述了利用包含多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与编码特异性结合NABP的NABP或抗NABP抗体的多核苷酸的基因组序列或转录物杂交。

47. 发明授权

US5932442A Human regulatory molecules 失效
公开(公告)号：US5932442A
公开(公告)日：1999-08-03
申请号：US933750
申请日：1997-09-23
申请人： Preeti Lal , Jennifer L. Hillman , Olga Bandman , Purvi Shah , Janice Au-Young , Henry Yue , Karl J. Guegler , Neil C. Corley
发明人： Preeti Lal , Jennifer L. Hillman , Olga Bandman , Purvi Shah , Janice Au-Young , Henry Yue , Karl J. Guegler , Neil C. Corley
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N37/00 , C12P21/06 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/93 , C07K14/4702 , A61K38/00 , Y10T436/143333
摘要： The invention provides human regulatory molecules and polynucleotides (collectively designated HRM) which identify and encode them. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention further provides methods for diagnosing, preventing, and treating disorders associated with expression of human regulatory molecules.

48. 发明授权

US5856128A Human nucleic acid binding protein 失效
公开(公告)号：US5856128A
公开(公告)日：1999-01-05
申请号：US698407
申请日：1996-08-15
申请人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , C07K14/47 , C12N15/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human nucleic acid binding protein (NABP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NABP. The invention also provides for the use of substantially purified NABP or its antagonists, in pharmaceutical compositions for the treatment of diseases associated with the expression of NABP. Additionally, the invention provides for the use of antisense molecules to NABP in pharmaceutical compositions for treatment of diseases associated with the expression of NABP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding NABP or anti-NABP antibodies which specifically bind to NABP.

49. 发明授权

US6136314A Histone fusion protein 失效
标题翻译：组蛋白融合蛋白
公开(公告)号：US6136314A
公开(公告)日：2000-10-24
申请号：US353688
申请日：1999-07-14
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , C12P21/06 , C07H21/04 , C07K1/00 , C12N1/20 , C12N15/00
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00
摘要： The present invention provides a human histone fusion protein (HFP) and polynucleotides which identify and encode HFP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention also provides methods for producing HFP and for treating or preventing disorders associated with expression of HFP.
摘要翻译：本发明提供了人组蛋白融合蛋白（HFP）和识别和编码HFP的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。此外，本发明还提供了用于生产HFP和用于治疗或预防与HFP表达相关的病症的方法。

50. 发明授权

US6083704A Human cytochrome b5 失效
标题翻译：人细胞色素b5
公开(公告)号：US6083704A
公开(公告)日：2000-07-04
申请号：US178881
申请日：1998-10-26
申请人： Jennifer L. Hillman , Surya K. Goli , David Gray Streeter
发明人： Jennifer L. Hillman , Surya K. Goli , David Gray Streeter
IPC分类号： A61K38/00 , C07K14/80 , C12N1/21 , C12N15/12 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/80 , A61K38/00
摘要： The present invention provides a human cytochrome b5 (HCB5) and polynucleotides which encode HCB5. The invention also provides genetically engineered expression vectors and host cells and a method for producing HCBS. The invention also provides for agonists, antisense molecules, antibodies, or antagonists of HCB5, and their use in the prevention and treatment of diseases associated with expression of HCB5. The invention also provides a method for detecting polynucleotides which encode HCB5.
摘要翻译：本发明提供人细胞色素b5（HCB5）和编码HCB5的多核苷酸。本发明还提供基因工程表达载体和宿主细胞以及生产HCBS的方法。本发明还提供HCB5的激动剂，反义分子，抗体或拮抗剂及其在预防和治疗与HCB5表达有关的疾病中的用途。本发明还提供了一种检测编码HCB5的多核苷酸的方法。

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