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41. 发明申请

US20060019256A1 Compositions and methods for treating and diagnosing cancer 审中-公开
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：US20060019256A1
公开(公告)日：2006-01-26
申请号：US10864207
申请日：2004-06-09
申请人： Michael Clarke , Rui Liu
发明人： Michael Clarke , Rui Liu
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/6893 , C12N5/0695 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/574 , G01N33/57496
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, and treatment of solid tumor stem cells.
摘要翻译：本发明涉及用于治疗，表征和诊断癌症的组合物和方法。特别地，本发明提供了与实体肿瘤干细胞相关的基因表达谱，以及用于诊断，表征和治疗实体瘤干细胞的新型干细胞癌标记。

42. 发明申请

US20060006838A1 Portable tool storage device with power supply unit 审中-公开
标题翻译：便携式工具存储设备，带电源单元
公开(公告)号：US20060006838A1
公开(公告)日：2006-01-12
申请号：US11176788
申请日：2005-07-07
申请人： Michael Clarke
发明人： Michael Clarke
IPC分类号： H02J7/00
CPC分类号： H02J7/0055 , B25H3/02 , H02J7/0042
摘要： A portable tool storage device 100 having a power supply unit that comprises a rechargeable battery, an electrical connector means 20 by means of which the rechargeable battery can be connected to an external source of electrical power for charging the rechargeable battery, charging circuitry operable to control the charging of said rechargeable battery when the power supply unit is connected to said source of electric power, and a power outlet means 24, 26 electrically connected to the rechargeable battery to permit power to be drawn from the rechargeable battery by an external device.
摘要翻译：具有包括可再充电电池的电源单元的便携式工具存储装置100，电连接器装置20，借助于该连接器装置20，可再充电电池可连接到用于对可再充电电池充电的外部电力源，充电电路可操作以控制当所述电源单元连接到所述电源时，对所述可再充电电池进行充电;以及电连接到所述可再充电电池的电源插座装置24,26，以允许通过外部装置从所述可再充电电池抽出电力。

43. 发明申请

US20050232927A1 Compositions and methods for characterizing, regulating, diagnosing, and treating cancer 审中-公开
标题翻译：表征，调节，诊断和治疗癌症的组成和方法
公开(公告)号：US20050232927A1
公开(公告)日：2005-10-20
申请号：US11050282
申请日：2005-02-03
申请人： Michael Clarke , Muhammad Al-Hajj
发明人： Michael Clarke , Muhammad Al-Hajj
IPC分类号： A61K38/00 , A61K38/54 , A61K39/395 , C07K16/28 , G01N33/574
CPC分类号： A61K39/39558 , A61K31/337 , A61K38/005 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2863 , C07K16/3015 , C07K2317/76 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N33/57415 , G01N33/57484
摘要： The present invention relates to compositions and methods for characterizing, regulating, diagnosing, and treating cancer. For example, the present invention provides compositions and methods for inhibiting tumorigenesis of certain classes of cancer cells, including breast cancer cells and preventing metastasis. The present invention also provides systems and methods for identifying compounds that regulate tumorigenesis.
摘要翻译：本发明涉及用于表征，调节，诊断和治疗癌症的组合物和方法。例如，本发明提供抑制某些类型的癌细胞（包括乳腺癌细胞）和预防转移的肿瘤发生的组合物和方法。本发明还提供用于鉴定调节肿瘤发生的化合物的系统和方法。

44. 发明申请

US20050145577A1 Liquid filtration device 失效
标题翻译：液体过滤装置
公开(公告)号：US20050145577A1
公开(公告)日：2005-07-07
申请号：US11019966
申请日：2004-12-21
申请人： Marc Laverdiere , Michael Clarke
发明人： Marc Laverdiere , Michael Clarke
IPC分类号： B01D19/00 , B01D29/00 , B01D29/15 , B01D35/01 , B01D36/00 , B01D61/20 , B01D63/02 , B01D63/06 , B01D63/10 , B01D65/00
CPC分类号： B01D65/00 , B01D19/0031 , B01D19/0042 , B01D29/15 , B01D29/902 , B01D36/001 , B01D61/20 , B01D63/02 , B01D63/067 , B01D63/10 , B01D2201/302 , B01D2313/08 , B01D2313/16
摘要： The present invention provides a liquid filtration device with internal flow paths that facilitate the purging of air bubbles from the device. The device includes internal channels that collect bubbles from fluid entering the filtration device and more efficiently direct fluid to sweep bubbles from the device during operation. The present invention also provides for an automatic means to minimize fluid loss during a vent process.
摘要翻译：本发明提供一种液体过滤装置，其具有便于从装置吹扫气泡的内部流动路径。该装置包括内部通道，其从进入过滤装置的流体中收集气泡，并且在操作期间更有效地引导流体从装置中吹扫气泡。本发明还提供了一种在排气过程中使流体损失最小化的自动装置。

45. 发明申请

US20050077386A1 Foamer 审中-公开
标题翻译：发泡机
公开(公告)号：US20050077386A1
公开(公告)日：2005-04-14
申请号：US10686448
申请日：2003-10-14
申请人： Michael Clarke
发明人： Michael Clarke
IPC分类号： B05B7/00 , B05B7/24 , B05B9/03
CPC分类号： B05B7/2418 , B05B7/0018
摘要： A sprayer comprising a sprayer container, a spraying gun, at least one fluid connection line and a fitting. The sprayer container is adapted to be filled with a liquid and a gas. The spraying gun is connected to the sprayer container, with the spraying gun including a trigger for selectively spraying a pressurized combination of liquid and gas onto a predetermined object. The at least one fluid connection line connects the spraying gun to the sprayer container, with the at least one fluid connection line configured to supply liquid and gas in the sprayer container to the spraying gun. The fitting connects the at least one fluid connection line to the sprayer container.
摘要翻译：一种喷雾器，包括喷雾器容器，喷枪，至少一个流体连接管线和配件。喷雾器容器适于充满液体和气体。喷枪连接到喷雾器容器，喷枪包括用于选择性地将加压的液体和气体组合喷射到预定物体上的扳机。所述至少一个流体连接线将所述喷枪连接到所述喷雾器容器，所述至少一个流体连接线被配置为将所述喷雾器容器中的液体和气体供应到所述喷枪。该配件将至少一个流体连接管线连接到喷雾器容器。

46. 发明申请

US20050073515A1 Processor module packaging for a portable electronic device display 有权
公开(公告)号：US20050073515A1
公开(公告)日：2005-04-07
申请号：US10874697
申请日：2004-06-22
申请人： Martin Kee , Michael Clarke , Rod Fleck , Chao-Chi Chen , Craig O'Connell , Stephen Perrin
发明人： Martin Kee , Michael Clarke , Rod Fleck , Chao-Chi Chen , Craig O'Connell , Stephen Perrin
IPC分类号： G06F20060101 , G06F1/16 , G09G5/00
CPC分类号： G06F1/1616 , G06F1/1637 , G06F1/1692 , Y10S248/919 , Y10S345/905
摘要： A processor module is packaged with a display for a portable electronic device. The display is designed to create a space within a display housing to allow a processor module to be included in the display housing. The processor module can be designed to be integral with the display housing. Additionally, the processor module can be designed to be detachable from the display housing to provide a removable processor module. The removable processor module can be replaced with another processor module having different functionality or have stand alone functionality, as well as system functionality when attached to a display lid or a portable electronic device.

47. 发明申请

US20110124032A1 Methods and Compositions for Treating Carcinoma Stem Cells 审中-公开
标题翻译：治疗癌细胞干细胞的方法和组合
公开(公告)号：US20110124032A1
公开(公告)日：2011-05-26
申请号：US12865092
申请日：2009-01-30
申请人： Maximilian Diehn , Michael Clarke , Irving L. Weissman
发明人： Maximilian Diehn , Michael Clarke , Irving L. Weissman
IPC分类号： C12Q1/02
CPC分类号： G01N33/57496 , G01N33/5011 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N2800/52
摘要： Cancer stem cells (CSCs) have been prospectively isolated or identified from primary tumor samples, and shown to possess the unique properties of self-renewal and differentiation, and can form unique histological microdomains useful in cancer diagnosis. Such cancer stem cells are shown herein to have the phenotype of containing decreased levels of reactive oxygen species (ROS) relative to non-tumorigenic (non-stem cell) cancer cells, as well as expression of other protective pathways. The CSCs are further shown to be more resistant to ionizing radiation (IR) and certain chemotherapies and to express high levels of ROS genes.
摘要翻译：已经从原发性肿瘤样品前瞻性分离或鉴定了癌干细胞（CSCs），并显示其具有自我更新和分化的独特性质，并且可以形成用于癌症诊断的独特的组织学微区域。这种癌干细胞在本文中显示为具有相对于非致瘤性（非干细胞）癌细胞降低的活性氧（ROS）水平以及其它保护途径的表达的表型。进一步证明CSCs对电离辐射（IR）和某些化学疗法更具抗性，并表达高水平的ROS基因。

48. 发明申请

US20110082112A1 ANTIVIRAL PHOSPHINATE COMPOUNDS 有权
标题翻译：抗磷酸化合物
公开(公告)号：US20110082112A1
公开(公告)日：2011-04-07
申请号：US12913704
申请日：2010-10-27
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： A61K31/675 , A61P31/14
CPC分类号： C07F9/65583
摘要： The invention is related to a method of treating disorders associated with hepatitis C by administering to an individual a pharmaceutical composition which comprises a therapeutically effective amount of an anti-viral phosphinate compound.
摘要翻译：本发明涉及通过向个体施用包含治疗有效量的抗病毒次膦酸盐化合物的药物组合物来治疗与丙型肝炎相关的疾病的方法。

49. 发明授权

US07893264B2 Antiviral phosphinate compounds 有权
标题翻译：抗病毒磷酸盐化合物
公开(公告)号：US07893264B2
公开(公告)日：2011-02-22
申请号：US11825606
申请日：2007-07-06
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： C07D221/18 , C07F9/02 , A61K38/12
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译：本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法，以及可用于制备这些化合物的方法和中间体。

50. 发明授权

US07572367B2 Liquid filtration device 失效
标题翻译：液体过滤装置
公开(公告)号：US07572367B2
公开(公告)日：2009-08-11
申请号：US12221309
申请日：2008-08-01
申请人： Marc Laverdiere , Michael Clarke
发明人： Marc Laverdiere , Michael Clarke
IPC分类号： B01D35/01 , B01D36/00 , B01D29/15 , B01D19/00
CPC分类号： B01D65/00 , B01D19/0031 , B01D19/0042 , B01D29/15 , B01D29/902 , B01D36/001 , B01D61/20 , B01D63/02 , B01D63/067 , B01D63/10 , B01D2201/302 , B01D2313/08 , B01D2313/16
摘要： The present invention provides a liquid filtration device with internal flow paths that facilitate the purging of air bubbles from the device. The device includes internal channels that collect bubbles from fluid entering the filtration device and more efficiently direct fluid to sweep bubbles from the device during operation. The present invention also provides for an automatic means to minimize fluid loss during a vent process.
摘要翻译：本发明提供一种液体过滤装置，其具有便于从装置吹扫气泡的内部流动路径。该装置包括内部通道，其从进入过滤装置的流体中收集气泡，并且在操作期间更有效地引导流体从装置中吹扫气泡。本发明还提供了一种在排气过程中使流体损失最小化的自动装置。

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