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41. 发明授权

US09267179B2 Methods and compositions for detecting and identifying species of Candida 有权
标题翻译：用于检测和鉴定假丝酵母菌种的方法和组合物
公开(公告)号：US09267179B2
公开(公告)日：2016-02-23
申请号：US13935599
申请日：2013-07-05
申请人： Jason Trama , Martin E. Adelson , Eli Mordechai
发明人： Jason Trama , Martin E. Adelson , Eli Mordechai
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895 , C12Q1/689
摘要： Methods and compositions useful in the detection and identification of species of Candida are disclosed. The compositions are combinations of oligonucleotides, where the forward primers of the primer pairs have identical sequences, while each reverse primer of the primer pairs has a unique sequence relative to all of the other reverse primers; or the reverse primers of the primer pairs have identical sequences, while each forward primer of the primer pairs has a unique sequence relative to all of the other forward primers. The oligonucleotides also include probes capable of detecting these amplicons, and sequencing primers for determining, in primer extension reactions, the nucleotide sequences contained within the amplicons. The detection of an amplicon indicated that the sample contains at least one isolate of Candida ablicans, Candida glabrata, Candida parapsilosis, or Candida tropicalis, and the nucleotide sequence data is used to determine which of these four Candida species is present.
摘要翻译：公开了用于检测和鉴定假丝酵母菌种的方法和组合物。组合物是寡核苷酸的组合，其中引物对的正向引物具有相同的序列，而引物对的每个反向引物相对于所有其它反向引物具有唯一的序列; 或引物对的反向引物具有相同的序列，而引物对的每个正向引物相对于所有其它正向引物具有唯一的序列。寡核苷酸还包括能够检测这些扩增子的探针和测序引物，用于在引物延伸反应中测定扩增子中包含的核苷酸序列。扩增子的检测表明样品含有至少一种假丝酵母，光滑念珠菌，热带假丝酵母或热带假丝酵母的分离物，核苷酸序列数据用于确定这四种假丝酵母属中存在哪一种。

42. 发明申请

US20140377749A1 METRONIDAZOLE RESISTANCE IN TRICHOMONAS VAGINALIS AND SINGLE NUCLEOTIDE POLYMORPHISMS 有权
标题翻译：三氯胞嘧啶和单核苷酸多态性中的地塞米松耐药性
公开(公告)号：US20140377749A1
公开(公告)日：2014-12-25
申请号：US14258339
申请日：2014-04-22
申请人： David W. Hilbert , Scott E. Gygax , Martin E. Adelson , Eli Mordechai , Jessica Schuyler , Teresa Paulish-Miller
发明人： David W. Hilbert , Scott E. Gygax , Martin E. Adelson , Eli Mordechai , Jessica Schuyler , Teresa Paulish-Miller
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895 , C12Q1/6869 , C12Q1/689 , C12Q2600/156
摘要： The present invention is directed to the discovery of single nucleotide polymorphisms (SNPs) in the presence of metronidazole-resistant Trichomonas vaginalis. The presence of G76C, C213G, or C318A (SNP) in tvntr 4 or the presence of A238T, G427C, or T476C (SNP) in tvntr6 provides a reliable biomarker for the presence of metronidazole-resistant Trichomonas vaginalis. The present invention further provides reagents used for detecting the SNPs to screen subjects for metronidazole resistance in Trichomonas vaginalis.
摘要翻译：本发明涉及在存在甲硝唑抗性阴道毛滴虫的情况下发现单核苷酸多态性（SNPs）。在tvntr6中存在G76C，C213G或C318A（SNP）或tvntr6中存在A238T，G427C或T476C（SNP））为阴道毛滴虫阴道滴虫的存在提供了可靠的生物标志物。本发明还提供了用于检测SNP以筛选阴道毛滴虫中甲硝唑耐药性的试剂。

43. 发明申请

US20140141457A1 DETECTION KIT CONTAINING A NOVEL RECOMBINANT 15-kDA POLYPEPTIDE USEFUL FOR DETECTING HUMAN INFECTION WITH BARTONELLA HENSELAE 审中-公开
标题翻译：检测包含新型重组体15-kDA多肽用于检测人体感染BARTONELLA HENSELAE
公开(公告)号：US20140141457A1
公开(公告)日：2014-05-22
申请号：US14048548
申请日：2013-10-08
申请人： John G. Hoey , Lisa P. Huang , Martin E. Adelson , Eli Mordechai
发明人： John G. Hoey , Lisa P. Huang , Martin E. Adelson , Eli Mordechai
IPC分类号： C07K14/195 , G01N33/68
CPC分类号： C07K14/195 , G01N33/56911 , G01N33/6893 , G01N2469/20
摘要： Disclosed are the cloning and expression of a novel antigen of Bartonella henselae. The recombinant polypeptide is found to be highly immunogenic and is useful as a diagnostic test antigen. The polypeptide of the present invention provides the basis of a diagnostic assay that is sensitive, rapid and accurate diagnosis of infection with Bartonella henselae using patient's sera. Disclosed also are the ELISA for both IgG and IgM and allows diagnosis of early and late infection.
摘要翻译：披露了巴氏杆菌的新型抗原的克隆和表达。发现重组多肽是高度免疫原性的，并且可用作诊断测试抗原。本发明的多肽提供了使用患者血清敏感，快速和准确诊断感染巴氏杆菌的诊断测定的基础。还公开了IgG和IgM的ELISA，并且可以诊断早期和晚期感染。

44. 发明授权

US08715936B2 Method of determining types I, II, III, IV or V or methicillin-resistant Staphylococcus aureus (MRSA) in a biological sample 有权
标题翻译：在生物样品中测定I，II，III，IV或V型或耐甲氧西林金黄色葡萄球菌（MRSA）的方法
公开(公告)号：US08715936B2
公开(公告)日：2014-05-06
申请号：US12930663
申请日：2011-01-13
申请人： Scott E. Gygax , Christina Lim Overmyer , Lisa A. DeSalvia , Martin E. Adelson , Eli Mordechai
发明人： Scott E. Gygax , Christina Lim Overmyer , Lisa A. DeSalvia , Martin E. Adelson , Eli Mordechai
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/689 , A61K31/5377 , A61K38/12 , A61K38/14 , C12Q1/6844 , C12Q2600/16
摘要： Disclosed are diagnostic methods for determining a subtype of methicillin-resistant Staphylococcus aureus (MRSA) in a biological sample of a mammal. Methods include providing a biological sample of the mammal, performing a PCR analysis of the biological sample, and analyzing the PCR amplicons with respect to their sizes so as to determine for type I, type II, type III, type IV or type V MRSA that may be present in the biological sample. Further example embodiments include using at least one mecA primer pair and/or using at least one Staphylococcus aureus nuc primer pair in the PCR analysis. Further disclosed are methods for screening populations for MRSA, and methods of treating a mammal testing positive for Type IV MRSA. Also disclosed are kits for determining a MRSA subtype in a mammal and isolated primers that may be used in the present methods and kits.
摘要翻译：公开了用于确定哺乳动物生物样品中耐甲氧西林金黄色葡萄球菌（MRSA）亚型的诊断方法。方法包括提供哺乳动物的生物样品，对生物样品进行PCR分析，并根据其大小对PCR扩增子进行分析，以确定I型，II型，III型，IV型或V型MRSA，可能存在于生物样品中。另外的实施例包括在PCR分析中使用至少一个mecA引物对和/或使用至少一种金黄色葡萄球菌引物对。进一步披露的是用于筛选MRSA群体的方法以及治疗IV型MRSA阳性的哺乳动物的方法。还公开了用于测定哺乳动物中MRSA亚型的试剂盒和可用于本发明方法和试剂盒的分离的引物。

45. 发明申请

US20130230848A1 Oligonucleotides Useful in Methods for Detecting and Characterizing Aspergillus fumigatus 有权
标题翻译：用于检测和表征烟曲霉的方法中的寡核苷酸
公开(公告)号：US20130230848A1
公开(公告)日：2013-09-05
申请号：US13461122
申请日：2012-09-17
申请人： Jason Trama , Martin E. Adelson , Eli Mordechai
发明人： Jason Trama , Martin E. Adelson , Eli Mordechai
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895 , C12Q1/689 , C12Q2561/113 , C12Q2565/301 , C12Q2600/156
摘要： Methods for using oligonucleotides in the detection of Aspergillus fumigatus are disclosed. The oligonucleotides of the invention have nucleotide sequences derived from the gene encoding the cytochrome P450 14 alpha-sterol demethylase (the cyp51A protein) of Aspergillus fumigatus. The oligonucleotides include primers capable of producing amplicons specific to cyp51A in polymerase chain reactions using nucleic acids isolated from Aspergillus fumigatus as templates. The oligonucleotides also include probes capable of detecting these cyp51A-specific amplicons. The oligonucleotides of the invention also include primers for nucleotide sequencing reactions to determine whether an isolate of Aspergillus fumigatus is more tolerant than wild-type Aspergillus fumigatus to a triazole.
摘要翻译：公开了在检测烟曲霉中使用寡核苷酸的方法。本发明的寡核苷酸具有衍生自编码烟曲霉的细胞色素P45014α-固醇脱甲基酶（cyp51A蛋白）的基因的核苷酸序列。寡核苷酸包括能够使用从烟曲霉分离的核酸作为模板在聚合酶链反应中产生cyp51A特异性扩增子的引物。寡核苷酸还包括能够检测这些cyp51A特异性扩增子的探针。本发明的寡核苷酸还包括用于核苷酸测序反应的引物，以确定烟曲霉分离物是否比野生型烟曲霉对三唑的耐受性更高。

46. 发明申请

US20130189715A1 Hemolysin and its Protein Fragments in Sero-Detection of Anaplasma Phagocytophilum 有权
标题翻译：溶血素及其蛋白质片段在血清中检测不育巨噬细胞
公开(公告)号：US20130189715A1
公开(公告)日：2013-07-25
申请号：US13561624
申请日：2012-07-30
申请人： John G. Hoey , Denise P. Dimitrov , Lisa P. Huang , Martin E. Adelson , Eli Mordechai
发明人： John G. Hoey , Denise P. Dimitrov , Lisa P. Huang , Martin E. Adelson , Eli Mordechai
IPC分类号： C07K14/29 , G01N33/569
CPC分类号： C07K14/29 , C07K14/195 , G01N33/56911 , G01N2469/20
摘要： Disclosed is the cloning, expression and purification of a hemolysin protein and its protein fragments in Anaplasma phagocytophilum. The recombinant hemolysin and its protein fragments are useful in the ELISA detection of anaplasma pathogen. The use of same as a kit for ELISA is also disclosed.
摘要翻译：披露了解淀粉蛋白及其蛋白质片段在噬菌体噬菌体中的克隆，表达和纯化。重组溶血素及其蛋白质片段可用于阿片样病原体的ELISA检测。还公开了与ELISA试剂盒相同的用途。

47. 发明授权

US08283439B2 Recombinant fragments and synthetic peptides of 17-kDa polypeptide useful in detecting Bartonella henselae 有权
标题翻译： 17-kDa多肽的重组片段和合成肽，可用于检测白僵菌（Bartonella henselae）
公开(公告)号：US08283439B2
公开(公告)日：2012-10-09
申请号：US12462602
申请日：2009-08-06
申请人： Lisa P. Huang , John G. Hoey , Martin E. Adelson , Eli Mordechai
发明人： Lisa P. Huang , John G. Hoey , Martin E. Adelson , Eli Mordechai
IPC分类号： C07K14/195 , G01N33/53
CPC分类号： G01N33/56911 , C07K14/195 , G01N33/6854
摘要： The present disclosure describes recombinant and synthetic polypeptides of Bartonella henselae and related methods and kits for the detection of antibodies specific for Bartonella henselae. The 17-kDa polypeptides, methods and kits are useful in the detection of recent and/or ongoing infections with Bartonella henselae, which can be useful in the diagnosis of Cat Scratch Disease (CSD).
摘要翻译：本公开描述了贝氏杆菌的重组和合成多肽以及用于检测针对巴氏杆菌的抗体的相关方法和试剂盒。 17-kDa多肽，方法和试剂盒可用于检测近来和/或持续感染巴氏杆菌，其可用于猫抓痕病（CSD）的诊断。

48. 发明授权

US08257938B2 Hemolysin and its protein fragments in sero-detection of Anaplasma phagocytophilum 有权
标题翻译：溶血素及其蛋白质片段在血清反应中检测Anaplasma phagocytophilum
公开(公告)号：US08257938B2
公开(公告)日：2012-09-04
申请号：US12658537
申请日：2010-02-09
申请人： John G. Hoey , Denise P. Dimitrov , Lisa P. Huang , Martin E. Adelson , Eli Mordechai
发明人： John G. Hoey , Denise P. Dimitrov , Lisa P. Huang , Martin E. Adelson , Eli Mordechai
IPC分类号： G01N33/569 , C07H21/00
CPC分类号： C07K14/29 , C07K14/195 , G01N33/56911 , G01N2469/20
摘要： Disclosed is the cloning, expression and purification of a hemolysin protein and its protein fragments in Anaplasma phagocytophilum. The recombinant hemolysin and its protein fragments are useful in the ELISA detection of anaplasma pathogen. The use of same as a kit for ELISA is also disclosed.
摘要翻译：披露了解淀粉蛋白及其蛋白质片段在噬菌体噬菌体中的克隆，表达和纯化。重组溶血素及其蛋白质片段可用于阿片样病原体的ELISA检测。还公开了与ELISA试剂盒相同的用途。

49. 发明申请

US20120058495A1 Recombinant fragments and synthetic peptides of 17-kDa polypeptide useful in detecting Bartonella henselae 有权
公开(公告)号：US20120058495A1
公开(公告)日：2012-03-08
申请号：US12462602
申请日：2009-08-06
申请人： Lisa P. Huang , John G. Hoey , Martin E. Adelson , Eli Mordechai
发明人： Lisa P. Huang , John G. Hoey , Martin E. Adelson , Eli Mordechai
IPC分类号： G01N33/569 , C12P21/02 , C12N15/70 , C12N1/21 , C07K7/08 , C07K14/195
CPC分类号： G01N33/56911 , C07K14/195 , G01N33/6854
摘要： The present disclosure describes recombinant and synthetic polypeptides of Bartonella henselae and related methods and kits for the detection of antibodies specific for Bartonella henselae. The 17-kDa polypeptides, methods and kits are useful in the detection of recent and/or ongoing infections with Bartonella henselae, which can be useful in the diagnosis of Cat Scratch Disease (CSD).

50. 发明申请

US20110076699A1 Hemolysin and its protein fragments in sero-detection of anaplasma phagocytophilum 有权
标题翻译：溶血素及其蛋白质片段在血清检测不育细胞噬菌体中的应用
公开(公告)号：US20110076699A1
公开(公告)日：2011-03-31
申请号：US12658537
申请日：2010-02-09
申请人： John G. Hoey , Denise P. Dimitrov , Lisa P. Huang , Martin E. Adelson , Eli Mordechai
发明人： John G. Hoey , Denise P. Dimitrov , Lisa P. Huang , Martin E. Adelson , Eli Mordechai
IPC分类号： G01N33/569 , C07K14/29 , C07H21/00 , C12N15/63 , C12N1/21 , C12P21/02 , G01N33/53
CPC分类号： C07K14/29 , C07K14/195 , G01N33/56911 , G01N2469/20
摘要： Disclosed is the cloning, expression and purification of a hemolysin protein and its protein fragments in Anaplasma phagocytophilum. The recombinant hemolysin and its protein fragments are useful in the ELISA detection of anaplasma pathogen. The use of same as a kit for ELISA is also disclosed.
摘要翻译：披露了解淀粉蛋白及其蛋白质片段在噬菌体噬菌体中的克隆，表达和纯化。重组溶血素及其蛋白质片段可用于阿片样病原体的ELISA检测。还公开了与ELISA试剂盒相同的用途。

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