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41. 发明申请

US20120100035A1 MAGNESIUM ALLOY SHEET 审中-公开
标题翻译：镁合金板
公开(公告)号：US20120100035A1
公开(公告)日：2012-04-26
申请号：US13381009
申请日：2010-06-08
申请人： Yukihiro Oishi , Takahiro Kitamura , Nozomu Kawabe
发明人： Yukihiro Oishi , Takahiro Kitamura , Nozomu Kawabe
IPC分类号： C22C23/02 , B22D11/00
CPC分类号： C22C23/02 , C22F1/00 , C22F1/06
摘要： A magnesium alloy sheet having high impact resistance at low temperature, a magnesium alloy structural member using this sheet, and a method for producing a magnesium alloy sheet are provided. The magnesium alloy sheet is composed of a magnesium alloy containing Al and Mn. When a region from a surface of the alloy sheet to 30% of the thickness of the alloy sheet in a thickness direction of the magnesium alloy sheet is defined as a surface region and when a 50 μm2 sub-region is arbitrarily selected from this surface region, the number of grains that are crystallized phases containing both Al and Mn is 15 or less. The maximum diameter of each of the crystallized phases is 0.1 to 1 μm and the mass ratio Al/Mn of Al to Mn is 2 to 5. This magnesium alloy sheet has high impact resistance since it contains crystallized phases that are small in size and in amount contained and cause breaking and the like, and exhibits good mechanical properties even in a low-temperature environment.
摘要翻译：提供了低温下耐冲击性高的镁合金板，使用该片的镁合金结构件以及镁合金板的制造方法。镁合金板由含有Al和Mn的镁合金构成。当从合金薄板的表面到合金薄板的厚度方向的合金薄板的厚度相对于镁合金薄板的厚度方向的区域被定义为表面区域时，当从该表面区域任意选择50μm2个子区域含有Al和Mn的结晶相的晶粒数为15个以下。结晶相的最大直径为0.1〜1μm，Al与Mn的质量比Al / Mn为2〜5。该镁合金板具有高耐冲击性，因为它含有尺寸小的结晶相，含量并引起断裂等，即使在低温环境下也显示出良好的机械性能。

42. 发明授权

US07414066B2 Amide compounds and medications containing the same technical field 失效
标题翻译：酰胺化合物和含有相同技术领域的药物
公开(公告)号：US07414066B2
公开(公告)日：2008-08-19
申请号：US10985915
申请日：2004-11-09
申请人： Kimiyuki Shibuya , Toru Miura , Katsumi Kawamine , Yukihiro Sato , Tadaaki Ohgiya , Takahiro Kitamura , Chiyoka Ozaki , Toshiyuki Edano , Mitsuteru Hirata
发明人： Kimiyuki Shibuya , Toru Miura , Katsumi Kawamine , Yukihiro Sato , Tadaaki Ohgiya , Takahiro Kitamura , Chiyoka Ozaki , Toshiyuki Edano , Mitsuteru Hirata
IPC分类号： A61K31/4439 , C07D401/12
CPC分类号： C07D403/12 , A61K31/4439 , C07D401/12 , C07D413/12 , C07D417/12 , C07D513/04
摘要： The present invention provides to a novel compound having an ACAT inhibiting activity.The present invention relates to compounds represented by formula (I) wherein represents an optionally substituted divalent residue such as benzene, pyridine, cyclohexane or naphthalene, or a group, Het represents a 5- to 8-membered, substituted or unsubstituted heterocyclic group containing at least one heteroatom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, such as a monocyclic group, a polycyclic group or a group of a fused ring, X represents —NH—, an oxygen atom or a sulfur atom, Y represents —NR4—, an oxygen atom, a sulfur atom, a sulfoxide or a sulfone, Z represents a single bond or —NR5—, R4 represents a hydrogen atom, a lower alkyl group, an aryl group or an optionally substituted silyl lower alkyl group, R5 represents a hydrogen atom, a lower alkyl group, an aryl group or an optionally substituted silyl lower alkyl group, and n is an integer of from 1 to 15, or salts or solvates thereof, and a pharmaceutical composition containing at least one of these compounds.
摘要翻译：本发明提供具有ACAT抑制活性的新型化合物。本发明涉及由式（I）表示的化合物，其中表示任选取代的二价残基例如苯，吡啶，环己烷或萘，或者基团，Het表示5至8元，取代或未取代的杂环基，至少一个选自氮原子，氧原子和硫原子的杂原子，如单环基团，多环基团或稠环基团，X表示-NH-，氧原子或硫原子原子，Y表示-NR 4 - ，氧原子，硫原子，亚砜或砜，Z表示单键或-NR 5 - ， - R 4表示氢原子，低级烷基，芳基或任选取代的甲硅烷基低级烷基，R 5表示氢原子，低级烷基，芳基基团或任选取代的甲硅烷基低级烷基，n为1至15的整数，或其盐或溶剂化物， d含有这些化合物中的至少一种的药物组合物。

43. 发明申请

US20050131002A1 Novel amide compounds and medications containing the same 失效
标题翻译：新颖的酰胺化合物和含有相同的药物
公开(公告)号：US20050131002A1
公开(公告)日：2005-06-16
申请号：US10985938
申请日：2004-11-09
申请人： Kimiyuki Shibuya , Toru Miura , Katsumi Kawamine , Yukihiro Sato , Tadaaki Ohgiya , Takahiro Kitamura , Chiyoka Ozaki , Toshiyuki Edano , Mitsuteru Hirata
发明人： Kimiyuki Shibuya , Toru Miura , Katsumi Kawamine , Yukihiro Sato , Tadaaki Ohgiya , Takahiro Kitamura , Chiyoka Ozaki , Toshiyuki Edano , Mitsuteru Hirata
IPC分类号： A61K31/4439 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D498/04 , C07D513/04 , A61K31/506 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号： C07D403/12 , A61K31/4439 , C07D401/12 , C07D413/12 , C07D417/12 , C07D513/04
摘要： The present invention provides to a novel compound having an ACAT inhibiting activity. The present invention relates to compounds represented by formula (I) wherein represents an optionally substituted divalent residue such as benzene, pyridine, cyclohexane or naphthalene, or a group, Het represents a 5- to 8-membered, substituted or unsubstituted heterocyclic group containing at least one heteroatom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, such as a monocyclic group, a polycyclic group or a group of a fused ring, X represents —NH—, an oxygen atom or a sulfur atom, Y represents —NR4—, an oxygen atom, a sulfur atom, a sulfoxide or a sulfone, Z represents a single bond or —NR5—, R4 represents a hydrogen atom, a lower alkyl group, an aryl group or an optionally substituted silyl lower alkyl group, R5 represents a hydrogen atom, a lower alkyl group, an aryl group or an optionally substituted silyl lower alkyl group, and n is an integer of from 1 to 15, or salts or solvates thereof, and a pharmaceutical composition containing at least one of these compounds.
摘要翻译：本发明提供具有ACAT抑制活性的新型化合物。本发明涉及由式（I）表示的化合物，其中表示任选取代的二价残基例如苯，吡啶，环己烷或萘，或者基团，Het表示5至8元，取代或未取代的杂环基，至少一个选自氮原子，氧原子和硫原子的杂原子，如单环基团，多环基团或稠环基团，X表示-NH-，氧原子或硫原子原子，Y表示-NR 4 - ，氧原子，硫原子，亚砜或砜，Z表示单键或-NR 5 - ， - R 4表示氢原子，低级烷基，芳基或任选取代的甲硅烷基低级烷基，R 5表示氢原子，低级烷基，芳基基团或任选取代的甲硅烷基低级烷基，n为1至15的整数，或其盐或溶剂化物， d含有这些化合物中的至少一种的药物组合物。

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