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41. 发明授权

US4612283A Method for purification of HBs antigen 失效
标题翻译： HBs抗原纯化方法
公开(公告)号：US4612283A
公开(公告)日：1986-09-16
申请号：US656315
申请日：1984-10-01
申请人： Keishin Sugahara , Chikateru Nozaki , Fukusaburo Hamada , Fumio Miake , Nobuya Ohtomo
发明人： Keishin Sugahara , Chikateru Nozaki , Fukusaburo Hamada , Fumio Miake , Nobuya Ohtomo
IPC分类号： C12N15/09 , A61K39/00 , C07K1/22 , C07K14/005 , C07K14/02 , C07K14/10 , C07K14/18 , C07K14/195 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/865 , A61K39/29
CPC分类号： C07K14/005 , A61K39/00 , C12N2730/10122
摘要： A method for purification of HBs antigen, which comprises treating an HBs tigen-containing material with an acid, optionally subjecting to salting out with ammonium sulfate, and subjecting the material to a chromatography with hydroxyapatite, by which a highly purified HBs antigen suitable for the preparation of HBV vaccine or diagnostic agent can be obtained in an industrial scale. This method is particularly useful for the purification of HBs antigen-containing material produced by recombinants obtained by DNA recombination technique.
摘要翻译：一种用于纯化HBs抗原的方法，其包括用酸处理含HBs抗原的材料，任选地用硫酸铵进行盐析，并用羟基磷灰石进行色谱分离，通过该色谱法，适用于可以以工业规模获得HBV疫苗或诊断剂的制备。该方法对于通过DNA重组技术获得的重组体产生的含HBs抗原的材料的纯化特别有用。

42. 发明授权

US09381242B2 Adjuvant composition containing citrulline 有权
标题翻译：含有瓜氨酸的佐剂组合物
公开(公告)号：US09381242B2
公开(公告)日：2016-07-05
申请号：US14004308
申请日：2012-03-09
申请人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda
发明人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda
IPC分类号： A61K45/00 , A61K39/145 , A61K39/39 , A61K39/12 , A61K39/00
CPC分类号： A61K39/39 , A61K39/0007 , A61K39/12 , A61K39/145 , A61K2039/55511 , A61K2039/55516 , A61K2039/575 , C12N2760/16134 , C12N2760/16171
摘要： A novel adjuvant composition is provided that is excellent in safety and convenience as compared to the conventional adjuvant such as Alum. An adjuvant composition comprising citrullines, which are water soluble substance present in the living body, and/or a salt thereof; a vaccine composition comprising said adjuvant composition and an antigen; a process for preparing said adjuvant composition and said vaccine composition; and a method for administering said adjuvant composition and said vaccine composition are provided.
摘要翻译：提供与常规佐剂如Alum相比，安全性和便利性优异的新型佐剂组合物。包含作为存在于生物体中的水溶性物质的瓜氨酸的佐剂组合物和/或其盐; 包含所述佐剂组合物和抗原的疫苗组合物; 一种制备所述佐剂组合物和所述疫苗组合物的方法; 并提供了用于施用所述佐剂组合物和所述疫苗组合物的方法。

43. 发明授权

US09028463B2 Microneedle device, and method for enhancing the efficacy of influenza vaccine by using microneedle device 有权
标题翻译：微针装置以及通过使用微针装置增强流感疫苗的功效的方法
公开(公告)号：US09028463B2
公开(公告)日：2015-05-12
申请号：US13001995
申请日：2009-05-22
申请人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda , Takaaki Terahara , Tetsuji Kuwahara , Seiji Tokumoto
发明人： Chikateru Nozaki , Kazuyoshi Kaminaka , Junichi Matsuda , Takaaki Terahara , Tetsuji Kuwahara , Seiji Tokumoto
IPC分类号： A61M31/00 , A61K39/145 , A61B17/20 , A61M37/00 , A61K39/00
CPC分类号： A61K39/145 , A61B17/205 , A61K39/12 , A61K2039/5252 , A61K2039/541 , A61K2039/545 , A61K2039/55511 , A61K2039/70 , A61M37/0015 , A61M2037/0046 , A61M2037/0061 , C12N2760/16134 , C12N2760/16234
摘要： The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.
摘要翻译：本发明提供使用能够增强流感疫苗的免疫原性的微针装置增强免疫原性的方法。根据使用本发明的微针装置的增强免疫原性的方法，将具有由聚乳酸制成的微针的微针装置涂敷于A型菌株（H1N1），A型菌株（H3N2）和A型菌株作为活性成分的B菌株与皮肤直接接触，以便经皮施用上述流感疫苗。在经皮给药之后，将月桂醇施用于已经与微针装置直接接触的皮肤部位。

44. 发明申请

US20120107334A1 METHOD FOR ENHANCING IMMUNE RESPONSE WITH PEPTIDE 有权
标题翻译：用于增强与肽的免疫应答的方法
公开(公告)号：US20120107334A1
公开(公告)日：2012-05-03
申请号：US13220452
申请日：2011-08-29
申请人： Junichi Matsuda , Kazuyoshi Kaminaka , Chikateru Nozaki
发明人： Junichi Matsuda , Kazuyoshi Kaminaka , Chikateru Nozaki
IPC分类号： A61K39/00 , A61P25/28 , A61P37/04 , C07K14/435
CPC分类号： A61K39/0007 , A61K31/711 , C07K14/4711
摘要： An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.
摘要翻译：本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默氏病的药物，其包括淀粉样蛋白诱导增强的免疫应答的肽。淀粉样蛋白肽或其部分，其中加入或插入半胱氨酸，以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。一种用于预防或治疗阿尔茨海默病的药物，其包含淀粉样蛋白肽或其部分诱导增强的免疫应答。可以具有相同效果的DNA疫苗，其包含编码淀粉样肽或其部分的基因，其通过加入或插入半胱氨酸诱导增强的免疫应答。

45. 发明申请

US20110268756A1 MODIFIED AMYLOID BETA PEPTIDE 有权
标题翻译：改性AMYLOID BETA肽
公开(公告)号：US20110268756A1
公开(公告)日：2011-11-03
申请号：US13124260
申请日：2009-10-16
申请人： Junichi Matsuda , Kazuyoshi Kaminaka , Chikateru Nozaki
发明人： Junichi Matsuda , Kazuyoshi Kaminaka , Chikateru Nozaki
IPC分类号： A61K39/00 , A61P37/04 , A61P25/28 , C07K14/47 , C07K7/08
CPC分类号： C07K14/4711 , A61K39/0007 , A61K2039/53
摘要： An object of the invention is to provide a peptide based on a sequence of an amyloid β peptide that may allow for induction of enhanced immune response and is safe and efficacious for prophylaxis and treatment of Alzheimer disease. An amyloid β peptide or a portion thereof with addition or insertion of cysteine or a cysteine analogue, and a method for enhancing immune response to amyloid β using said peptide, a medicament for prophylaxis and treatment of Alzheimer disease using said amyloid β peptide that induces an enhanced immune response, and a DNA vaccine comprising a gene coding for an amyloid β peptide or a sequence derived from an amyloid β peptide with addition or insertion of cysteine or a cysteine analogue, as expected to be similarly efficacious.
摘要翻译：本发明的目的是提供一种基于淀粉样蛋白和bgr的序列的肽; 肽，其可以诱导增强的免疫应答，并且对阿尔茨海默病的预防和治疗是安全有效的。淀粉样蛋白肽或其部分加入或插入半胱氨酸或半胱氨酸类似物，以及增强对淀粉样蛋白的免疫应答的方法; 使用所述肽，使用所述淀粉样蛋白来预防和治疗阿尔茨海默病的药物; 诱导增强的免疫应答的肽，以及包含编码淀粉样蛋白的基因的DNA疫苗; 肽或衍生自淀粉样蛋白的序列; 具有加入或插入半胱氨酸或半胱氨酸类似物的肽，如预期类似地有效。

46. 发明授权

US06995146B2 Compositions and methods for treatment of hepatitis C virus-associated diseases 失效
公开(公告)号：US06995146B2
公开(公告)日：2006-02-07
申请号：US09853409
申请日：2001-05-11
申请人： Kevin P. Anderson , Ronnie C. Hanecak , Chikateru Nozaki , F. Andrew Dorr , T. Jesse Kwoh
发明人： Kevin P. Anderson , Ronnie C. Hanecak , Chikateru Nozaki , F. Andrew Dorr , T. Jesse Kwoh
IPC分类号： A61K31/711 , A61K31/7105 , C07H21/04 , C07H21/02
CPC分类号： C12N15/1131 , A61K38/00 , C07H21/00 , C07K14/005 , C12N2310/315 , C12N2310/318 , C12N2310/3181 , C12N2310/321 , C12N2310/322 , C12N2310/3233 , C12N2310/33 , C12N2310/334 , C12N2310/341 , C12N2310/346 , C12N2310/3521 , C12N2310/3527 , C12N2770/24222 , C12Q1/707 , C12N2310/3525
摘要： Antisense oligonucleotides are provided which are complementary to and hybridizable with at least a portion of HCV RNA and which are capable of inhibiting the function of the HCV RNA. These oligonucleotides can be administered to inhibit the activity of Hepatitis C virus in vivo or in vitro. These compounds can be used either prophylactically or therapeutically to reduce the severity of diseases associated with Hepatitis C virus, and for diagnosis and detection of HCV and HCV-associated diseases. Methods of using these compounds are also disclosed.

47. 发明授权

US5770400A Exogenous gene expression vector containing chick .beta.-actin gene promoter 失效
公开(公告)号：US5770400A
公开(公告)日：1998-06-23
申请号：US814468
申请日：1997-03-10
申请人： Junichi Miyazaki , Ken-ichi Yamamura , Masatake Araki , Hiroshi Yonemura , Chikateru Nozaki
发明人： Junichi Miyazaki , Ken-ichi Yamamura , Masatake Araki , Hiroshi Yonemura , Chikateru Nozaki
IPC分类号： C07K14/02 , C12N9/38 , C12N15/85 , C12N15/70 , C12P21/02
CPC分类号： C07K14/005 , C12N15/85 , C12N9/2471 , C12Y302/01023 , C12N2730/10122 , C12N2800/108 , C12N2830/00 , C12N2830/005 , C12N2830/15 , C12N2830/60 , C12N2830/90 , C12N2840/44
摘要： An expression vector for the expression of an exogenous gene in an animal cell, which contains a chick .beta.-actin gene promoter and a restriction enzyme site for incorporating an exogenous gene at the downstream of said promoter and a process for expressing an exogenous gene, which comprises incorporating said exogenous gene into the expression vector at the restriction enzyme site for incorporating the exogenous gene, introducing said vector into an animal cell and culturing the obtained transformed animal cell. The expression system of the present invention can be applied to an expression of any exogenous gene and has an extremely high expression efficiency and is applicable to a wide range of host cells, and hence can sufficiently be utilized for industrial-scale production of a useful material.

48. 发明授权

US4997767A Yeast shuttle vector 失效
标题翻译：酵母穿梭载体
公开(公告)号：US4997767A
公开(公告)日：1991-03-05
申请号：US946329
申请日：1986-12-23
申请人： Chikateru Nozaki , Fukusaburo Hamada , Nobuya Ohtomo
发明人： Chikateru Nozaki , Fukusaburo Hamada , Nobuya Ohtomo
IPC分类号： C12N15/09 , A61K39/29 , C12N15/00 , C12N15/64 , C12N15/70 , C12N15/81 , C12R1/19 , C12R1/865
CPC分类号： C12N15/81 , C12N15/64 , C12N15/70 , Y10S435/911 , Y10S435/94 , Y10S435/942
摘要： Shuttle vectors including a DNA sequence of the yeast Saccharomyces cerevisiae including ars 1.2 micron ori and a marker gene for transformed yeast permitting synthesis of leucine by the transformant; adjacent to said ars 1 a DNA sequence of Escherichia coli which is either in EcoR1--PvuII or EcoR1--TthIII--I fragment of plasmid pBR322; and adjacent to the yeast marker gene the expression control region of the repressible acid phosphatase gene of yeast.
摘要翻译：穿梭载体包括酵母酿酒酵母的DNA序列，包括1.2微米的穗，以及转化酵母允许转化体合成亮氨酸的标记基因; 与所述ars1相邻的是质粒pBR322的EcoRⅠ-PvuII或EcoR1-TthIII-I片段中的大肠杆菌的DNA序列; 并与酵母标记基因相邻，是酵母抑制性酸性磷酸酶基因的表达控制区。

49. 发明授权

US08883165B2 Modified peptide vaccine derived from influenza M2 有权
标题翻译：来自流感M2的改良肽疫苗
公开(公告)号：US08883165B2
公开(公告)日：2014-11-11
申请号：US13392994
申请日：2010-08-23
申请人： Kazuyoshi Kaminaka , Chikateru Nozaki , Junichi Matsuda , Kiyoto Nishiyama
发明人： Kazuyoshi Kaminaka , Chikateru Nozaki , Junichi Matsuda , Kiyoto Nishiyama
IPC分类号： A61K39/12 , A61K39/00 , A61K39/385 , A61K39/145 , A61K38/00 , C07K17/00 , C07K14/005
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/55505 , C07K14/005 , C12N2760/16122 , C12N2760/16134
摘要： A modified peptide derived from matrix protein 2 (hereinafter also referred to as “M2”), one of surface layer proteins of influenza virus, and a method for utilization of the modified peptide are provided. A peptide (hereinafter also referred to as “M2eC peptide”) that is made up by inserting cysteine residue(s) into a peptide (hereinafter also referred to as “M2e”) consisting of 23 amino acid residues of from positions No. 2 to No. 24 of M2 in influenza virus type A, a fusion protein consisting of said modified peptide and a polypeptide, an influenza vaccine comprising said modified peptide or said fusion protein as an active ingredient, a device which can be delivered into the body comprising said influenza vaccine, a nucleic acid fragment consisting of a nucleotide sequence encoding the amino acid sequence of said modified peptide or said fusion protein, an expression vector in which said nucleic acid fragment is incorporated, a host in which said expression vector is introduced, and an antibody that has a protective effect against influenza virus.
摘要翻译：提供了衍生自基质蛋白2的修饰肽（以下也称为“M2”），流感病毒的表层蛋白之一和使用修饰肽的方法。通过将半胱氨酸残基插入由位置2〜23的23个氨基酸残基组成的肽（以下也称为“M2e”）而构成的肽（以下也称为“M2eC肽” 流感病毒A型M2的第24号，由所述修饰肽和多肽组成的融合蛋白，包含所述修饰肽或所述融合蛋白作为活性成分的流感疫苗，可以递送到身体的装置，包括所述流感疫苗，由编码所述修饰肽或所述融合蛋白质的氨基酸序列的核苷酸序列组成的核酸片段，其中加入所述核酸片段的表达载体，导入所述表达载体的宿主和对流感病毒具有保护作用的抗体。

50. 发明授权

US08623374B2 Method for enhancing immune response with peptide 有权
标题翻译：用肽增强免疫应答的方法
公开(公告)号：US08623374B2
公开(公告)日：2014-01-07
申请号：US13220452
申请日：2011-08-29
申请人： Junichi Matsuda , Kazuyoshi Kaminaka , Chikateru Nozaki
发明人： Junichi Matsuda , Kazuyoshi Kaminaka , Chikateru Nozaki
IPC分类号： A61K38/17 , A61K39/00 , A61P37/04 , A61P25/00 , C07K14/435
CPC分类号： A61K39/0007 , A61K31/711 , C07K14/4711
摘要： An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid β peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.
摘要翻译：本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默病的药物，其包含诱导增强的免疫应答的淀粉样蛋白β肽。具有添加或插入半胱氨酸的淀粉样蛋白β肽或其部分，以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。一种用于预防或治疗阿尔茨海默病的药物，其包含诱导增强的免疫应答的淀粉样蛋白β肽或其部分。可以具有相同效果的DNA疫苗，其包含编码淀粉样蛋白β肽或其部分的基因，其通过加入或插入半胱氨酸诱导增强的免疫应答。

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