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41. 发明授权

US4106168A Method and apparatus for assembling a ball cage of the type utilized in a motion transmitting remote control assembly 失效
标题翻译：用于组装运动发射遥控组件中使用的类型的球笼的方法和装置
公开(公告)号：US4106168A
公开(公告)日：1978-08-15
申请号：US670750
申请日：1976-03-26
申请人： William H. Parsons
发明人： William H. Parsons
IPC分类号： B23P15/00 , F16C1/20 , F16C1/28 , B21D53/12 , B21H1/12 , B23P21/00
CPC分类号： F16C1/20 , B23P15/003 , F16C1/28 , Y10T29/49691 , Y10T29/5137 , Y10T29/5191 , Y10T29/5198 , Y10T29/53104 , Y10T74/20444
摘要： A ball cage retainer of the type including a pair of coextensive strips having annular pocket portions defined by truncated angular flanges to define ball retaining pockets for rotatably retaining balls between the strips with the strips spot welded together and a method and apparatus for assembling such a ball cage. The ball cage is utilized in a conduit of a motion transmitting remote control assembly for facilitating the movement of a motion transmitting core element within the conduit. The cage is assembled by indexing a pair of metal ribbon-like strips successively through a plurality of stations by two sets of fixed and movable clamping assemblies. The pocket portions, and alignment notches adjacent the pocket portions, are simultaneously formed in each of the strips at a first station as the strips pass through the first station in parallel relationship to one another. One of the strips passes through a second station and balls are placed in each of the pocket portions of that strip. Thereafter the two strips are guided into coextensive abutting relationship with the coacting pocket portions defining the ball retaining pockets surrounding the balls. With the strips in abutting relationship with one another they pass through a third station where an aligning member engages the alignment notches in the two strips for longitudinally aligning the strips along the length of the strips having the ball retaining pocket therein adjacent which the strips are to be secured together by a welder which engages the strips for spot welding the strips together while the strips are maintained aligned with one another by the aligning member.
摘要翻译：一种球笼保持器，包括一对共同延伸条，其具有由截头角法兰限定的环形袋部分，以限定用于可旋转地保持条之间的球的球保持袋，其中带有点焊接在一起的条带以及用于组装这样的球的方法和装置笼。球笼用于运动传递遥控组件的导管中，以促进运动传递芯元件在导管内的移动。通过两组固定和可移动的夹紧组件，通过多个工位连续地分配一对金属带状条来组装笼。随着条带彼此平行的关系通过第一站时，在第一站处，每个条带中同时形成袋状部分和邻近袋部分的对准槽口。其中一条穿过第二站，球放置在该条的每个口袋部分中。此后，两个条带被引导与限定围绕球的球保持袋的共同作用袋部分的共同邻接关系。当条带彼此邻接关系时，它们穿过第三工位，其中对准构件与两个条带中的对准凹口接合，用于沿着具有球保持袋的条带的长度纵向对准条带，所述条带邻近于条带通过焊接机固定在一起，焊接机将条带接合在一起，同时通过对准部件保持条彼此对准。

42. 发明授权

US4062251A Motion transmitting remote control assembly 失效
标题翻译：运动遥控装置
公开(公告)号：US4062251A
公开(公告)日：1977-12-13
申请号：US670749
申请日：1976-03-26
申请人： William H. Parsons
发明人： William H. Parsons
IPC分类号： F16C1/20 , F16C1/10 , F16C31/00
CPC分类号： F16C1/28 , F16C1/20 , Y10T29/49691 , Y10T74/20444
摘要： A ball cage retainer of the type including a pair of coextensive strips having annular pocket portions defined by truncated angular flanges to define ball retaining pockets for rotatably retaining balls between the strips with the strips spot welded together and a method and apparatus for assembling such a ball cage. The ball cage is utilized in a conduit of a motion transmitting remote control assembly for facilitating the movement of a motion transmitting core element within the conduit. The cage is assembled by indexing a pair of metal ribbon-like strips successively through a plurality of stations by two sets of fixed and movable clamping assemblies. The pocket portions, and alignment notches adjacent the pocket portions, are simultaneously formed in each of the strips at a first station as the strips pass through the first station in parallel relationship to one another. One of the strips passes through a second station and balls are placed in each of the pocket portions of that strip. Thereafter the two strips are guided into coextensive abutting relationship with the coacting pocket portions defining the ball retaining pockets surrounding the balls. With the strips in abutting relationship with one another they pass through a third station where an aligning member engages the alignment notches in the two strips for longitudinally aligning the strips along the length of the strips having the ball retaining pocket therein adjacent which the strips are to be secured together by a welder which engages the strips for spot welding the strips together while the strips are maintained aligned with one another by the aligning member.
摘要翻译：一种球笼保持器，包括一对共同延伸条，其具有由截头角法兰限定的环形袋部分，以限定用于可旋转地保持条之间的球的球保持袋，其中带有点焊接在一起的条带以及用于组装这样的球的方法和装置笼。球笼用于运动传递遥控组件的导管中，以促进运动传递芯元件在导管内的移动。通过两组固定和可移动的夹紧组件，通过多个工位连续地分配一对金属带状条来组装笼。随着条带彼此平行的关系通过第一站时，在第一站处，每个条带中同时形成袋状部分和邻近袋部分的对准槽口。其中一条穿过第二站，球放置在该条的每个口袋部分中。此后，两个条带被引导与限定围绕球的球保持袋的共同作用袋部分的共同邻接关系。当条带彼此邻接关系时，它们穿过第三工位，其中对准构件与两个条带中的对准凹口接合，用于沿着具有球保持袋的条带的长度纵向对准条带，所述条带邻近于条带通过焊接机固定在一起，焊接机将条带接合在一起，同时通过对准部件保持条彼此对准。

43. 发明申请

US20110190364A1 BENZIMIDAZOLE MODULATORS OF VR1 审中-公开
标题翻译： VR1的苯并咪唑调节剂
公开(公告)号：US20110190364A1
公开(公告)日：2011-08-04
申请号：US13084718
申请日：2011-04-12
申请人： Mark R. Player , Scott L. Dax , William H. Parsons , Michael Richard Brandt , Raul R. Calvo , Sharmila Patel , Jian Liu , Wing S. Cheung , Michele C. Jetter , Yu-Kai Lee , Mark A. Youngman , Wenxi Pan , Kenneth M. Wells , Derek A. Beauchamp
发明人： Mark R. Player , Scott L. Dax , William H. Parsons , Michael Richard Brandt , Raul R. Calvo , Sharmila Patel , Jian Liu , Wing S. Cheung , Michele C. Jetter , Yu-Kai Lee , Mark A. Youngman , Wenxi Pan , Kenneth M. Wells , Derek A. Beauchamp
IPC分类号： A61K31/4184 , A61P29/00
CPC分类号： C07D401/06 , C07D235/08 , C07D403/06
摘要： The invention is directed to compounds of Formula (I): to pharmaceutical compositions containing such compounds and to methods of treatment using them.
摘要翻译：本发明涉及式（I）的化合物：含有这些化合物的药物组合物和使用它们的治疗方法。

44. 发明申请

US20080280873A1 Biaryl Substituted Pyrazinones as Sodium Channel Blockers 审中-公开
标题翻译：二芳基取代的吡嗪酮作为钠通道阻断剂
公开(公告)号：US20080280873A1
公开(公告)日：2008-11-13
申请号：US10594367
申请日：2005-03-25
申请人： Jun Liang , Prasun K. Chakravarty , Deborah E. Pan , William H. Parsons , Pengcheng P. Shao , Feng Yee , Bishan Zhou
发明人： Jun Liang , Prasun K. Chakravarty , Deborah E. Pan , William H. Parsons , Pengcheng P. Shao , Feng Yee , Bishan Zhou
IPC分类号： A61K31/4965 , C07D241/24
CPC分类号： C07D241/24 , B05B1/02 , B05B1/14 , B05B1/34 , B65D83/20 , C07D241/18 , C07D403/06 , C07D405/04 , C07D413/06
摘要： Biaryl substituted pyrazinone compounds represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, urinary incontinence, itchiness, allergic dermatitis, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.
摘要翻译：由式I表示的二芳基取代的吡嗪酮化合物或其药学上可接受的盐。药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，尿失禁，瘙痒，过敏性皮炎，癫痫，肠易激综合征，抑郁症，焦虑，多发性硬化和双相性精神障碍，包括单独或与一种或多种其它治疗活性化合物组合施用有效量的本发明化合物。施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。

45. 发明授权

US07414067B2 Ophthalmic compositions for treating ocular hypertension 失效
标题翻译：用于治疗高眼压症的眼用组合物
公开(公告)号：US07414067B2
公开(公告)日：2008-08-19
申请号：US10542169
申请日：2004-03-24
申请人： Edward Andrew Boyd , Michael H. Fisher , Maria L. Garcia , Gregory J. Kaczorowski , Peter T. Meinke , William H. Parsons , Stephen Price , John Stibbard
发明人： Edward Andrew Boyd , Michael H. Fisher , Maria L. Garcia , Gregory J. Kaczorowski , Peter T. Meinke , William H. Parsons , Stephen Price , John Stibbard
IPC分类号： A61K31/427 , A61K31/5377 , C07D277/20 , C07D403/02 , C07D413/02
CPC分类号： C07D405/12 , C07D209/28 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译：本发明涉及有效的钾通道阻滞剂或其制剂在治疗青光眼和导致患者眼睛中眼内压升高的其它病症中的用途。本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。

46. 发明授权

US07348348B2 Aryl-link-aryl substituted thiazolidine-dione and oxazolidine-dione as sodium channel blockers 失效
标题翻译：芳基 - 芳基取代的噻唑烷二酮和恶唑烷二酮作为钠通道阻断剂
公开(公告)号：US07348348B2
公开(公告)日：2008-03-25
申请号：US10512924
申请日：2003-04-25
申请人： Howard C. H. Kuo , Michelle B. Ayer , Prasun K. Chakravarty , Peter T. Meinke , William H. Parsons , Sriram Tyagarajan
发明人： Howard C. H. Kuo , Michelle B. Ayer , Prasun K. Chakravarty , Peter T. Meinke , William H. Parsons , Sriram Tyagarajan
IPC分类号： A61K31/425 , C07D277/00
CPC分类号： A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , C07D263/44 , C07D277/20 , C07D277/34 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14
摘要： Aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds are sodium channel blockers; pharmaceutical compositions that include an effective amount of the aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds and a pharmaceutically acceptable carrier, and a method of treatment of acute pain, chronic pain, visceral pain, inflammatory pain, or neuropathic pain, as well as initable bowel syndrome, Cnohns disease, epilepsy, partial and generalized tonic seizures, multiple sclerosis, bipolar depression, and tachy-arrhythmias by the administration of an effective amount of aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds are described.
摘要翻译：芳基 - 链接 - 芳基噻唑烷二酮和芳基 - 芳基恶唑烷二酮化合物是钠通道阻断剂; 包括有效量的芳基 - 芳基噻唑烷二酮和芳基链接 - 芳基恶唑烷二酮化合物和药学上可接受的载体的药物组合物，以及治疗急性疼痛，慢性疼痛，内脏痛，炎性疼痛的方法，或神经性疼痛，以及起始肠综合征，鼻咽疾病，癫痫，部分和全身性强直性癫痫发作，多发性硬化症，双相抑郁症和快速心律不齐，通过施用有效量的芳基链接 - 芳基噻唑烷二酮和芳基 - 链烯基 - 恶唑烷二酮化合物。

47. 发明申请

US20070259936A1 Benzimidazole Modulators of VR1 有权
标题翻译： VR1的苯并咪唑调节剂
公开(公告)号：US20070259936A1
公开(公告)日：2007-11-08
申请号：US11734984
申请日：2007-04-13
申请人： Mark R. Player , Scott L. Dax , William H. Parsons , Michael Richard Brandt , Raul R. Calvo , Sharmila Patel , Jian Liu , Wing S. Cheung , Michele C. Jetter , Yu-Kai Lee , Mark A. Youngman , Wenxi Pan , Kenneth M. Weils , Derek A. Beauchamp
发明人： Mark R. Player , Scott L. Dax , William H. Parsons , Michael Richard Brandt , Raul R. Calvo , Sharmila Patel , Jian Liu , Wing S. Cheung , Michele C. Jetter , Yu-Kai Lee , Mark A. Youngman , Wenxi Pan , Kenneth M. Weils , Derek A. Beauchamp
IPC分类号： A61K31/4184
CPC分类号： C07D401/06 , C07D235/08 , C07D403/06
摘要： The invention is directed to compounds of Formula (I): to pharmaceutical compositions containing such compounds and to methods of treatment using them.
摘要翻译：本发明涉及式（I）的化合物：含有这些化合物的药物组合物和使用它们的治疗方法。

48. 发明授权

US06498165B1 Src kinase inhibitor compounds 失效
标题翻译： Src激酶抑制剂化合物
公开(公告)号：US06498165B1
公开(公告)日：2002-12-24
申请号：US09604305
申请日：2000-06-26
申请人： Helen M. Armstrong , Richard Beresis , Joung L. Goulet , Mark A. Holmes , Xingfang Hong , Sander G. Mills , William H. Parsons , Peter J. Sinclair , Mark G. Steiner , Frederick Wong , Dennis M. Zaller
发明人： Helen M. Armstrong , Richard Beresis , Joung L. Goulet , Mark A. Holmes , Xingfang Hong , Sander G. Mills , William H. Parsons , Peter J. Sinclair , Mark G. Steiner , Frederick Wong , Dennis M. Zaller
IPC分类号： A61K31505
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of protein tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.
摘要翻译：嘧啶化合物（式I）或其药学上可接受的盐，水合物，溶剂合物，晶体形式和单独的非对映异构体，以及包含其的药物组合物，其是酪氨酸激酶的抑制剂，因此可用于预防和治疗蛋白质酪氨酸激酶相关疾病，例如免疫疾病，过度增殖性疾病和其中认为不适当的蛋白激酶作用发挥作用的其它疾病，例如癌症，血管生成素，动脉粥样硬化症，移植排斥反应，类风湿性关节炎和牛皮癣。

49. 发明授权

US06455548B2 4-alkyl piperidinyl pyrrolidine modulators of chemokine receptor activity 失效
标题翻译：趋化因子受体活性的4-烷基哌啶基吡咯烷调节剂
公开(公告)号：US06455548B2
公开(公告)日：2002-09-24
申请号：US09795030
申请日：2001-02-27
申请人： Jennifer Chee , Jill N. Johanson , Frank Kayser , William H. Parsons , Kathleen M. Rupprecht
发明人： Jennifer Chee , Jill N. Johanson , Frank Kayser , William H. Parsons , Kathleen M. Rupprecht
IPC分类号： A61K31454
CPC分类号： C07D409/04 , A61K31/445 , A61K31/4535 , A61K31/454 , C07D409/14 , C07D413/06 , C07D413/14
摘要： The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4c, R4d, and R4f are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.
摘要翻译：本发明涉及可用作趋化因子受体活性调节剂的式I的吡咯烷化合物（其中R1，R2，R3，R4c，R4d和R4f如本文所定义）。特别地，这些化合物可用作趋化因子受体CCR-3和/或CCR-5的调节剂。

50. 发明授权

US06329380B1 SRC kinase inhibitor compounds 失效
标题翻译： SRC激酶抑制剂化合物
公开(公告)号：US06329380B1
公开(公告)日：2001-12-11
申请号：US09603688
申请日：2000-06-26
申请人： Joung L. Goulet , Mark A. Holmes , Julianne A. Hunt , Sander G. Mills , William H. Parsons , Peter J. Sinclair , Dennis M. Zaller
发明人： Joung L. Goulet , Mark A. Holmes , Julianne A. Hunt , Sander G. Mills , William H. Parsons , Peter J. Sinclair , Dennis M. Zaller
IPC分类号： C07D40114
CPC分类号： C07D401/14 , C07D403/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07F9/59 , C07F9/65583
摘要： Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of proteins tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.
摘要翻译：嘧啶化合物（式I）或其药学上可接受的盐，水合物，溶剂合物，晶体形式和单独的非对映异构体，以及包含其的药物组合物，其是酪氨酸激酶的抑制剂，因此可用于预防和治疗蛋白质酪氨酸激酶相关疾病，例如免疫疾病，过度增殖性疾病和其中认为不适当的蛋白激酶作用发挥作用的其它疾病，例如癌症，血管生成素，动脉粥样硬化症，移植排斥反应，类风湿性关节炎和牛皮癣。

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