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41. 发明授权

US08329722B2 Inhibitors of janus kinases and/or 3-phosphoinositide-dependent protein kinase-1 有权
标题翻译：甘油激酶和/或3-磷酸肌醇依赖性蛋白激酶-1的抑制剂
公开(公告)号：US08329722B2
公开(公告)日：2012-12-11
申请号：US12530648
申请日：2008-03-10
申请人： Tony Siu , Jonathan Young , Michael Altman , Alan Northrup , Ekaterina Kozina , Christopher Dinsmore , David J. Guerin , Kevin A. Keenan , Joon O. Jung , Solomon Kattar , Rachel N. MacCoss
发明人： Tony Siu , Jonathan Young , Michael Altman , Alan Northrup , Ekaterina Kozina , Christopher Dinsmore , David J. Guerin , Kevin A. Keenan , Joon O. Jung , Solomon Kattar , Rachel N. MacCoss
IPC分类号： C07D487/14 , A61K31/4375
CPC分类号： C07D471/04 , C07D471/14
摘要： The instant invention provides for compounds that inhibit JAK2 tyrosine kinase and/or PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting JAK2 tyrosine kinase activity and/or PDK1 kinase inhibitory activity by administering the compound to a patient in need of treatment or prevention of myeloproliferative disorders or cancer.
摘要翻译：本发明提供抑制JAK2酪氨酸激酶和/或PDK1的化合物。本发明还提供了包含这种抑制化合物的组合物以及通过将该化合物给予需要治疗或预防骨髓增生性疾病或癌症的患者来抑制JAK2酪氨酸激酶活性和/或PDK1激酶抑制活性的方法。

42. 发明授权

US08326108B2 Modular network connection equipment 有权
标题翻译：模块化网络连接设备
公开(公告)号：US08326108B2
公开(公告)日：2012-12-04
申请号：US12517728
申请日：2007-12-06
申请人： Peter Ejvinsson , Jakob Bioje , Viktor Holmqvist , Hans Nyström , Jonathan Young , Rickard Gustavsson , Ola Skogsfors , Niclas Sonesson , Stefan Tegenfalk
发明人： Peter Ejvinsson , Jakob Bioje , Viktor Holmqvist , Hans Nyström , Jonathan Young , Rickard Gustavsson , Ola Skogsfors , Niclas Sonesson , Stefan Tegenfalk
IPC分类号： G02B6/00 , H05K13/00
CPC分类号： H04L12/2805 , H05K5/0021 , Y10T29/49117
摘要： An apparatus for connecting user equipment to a broadband network includes a chassis having attachment points for connection to a supporting surface and a guide that permits entry of a communication cable. A cable termination unit may be mounted on the chassis such that a cable that is led through the guide can be connected and provided with a termination to which functional connections can be made. A cover may be mounted on the chassis in such a way as to be removable and reattachable to allow access to the chassis. The chassis may include mounting points for connecting at least one functional module to the communication cable and for allowing different communication functions to be provided to user equipment that is connected to the network via the apparatus.
摘要翻译：用于将用户设备连接到宽带网络的装置包括具有用于连接到支撑表面的附接点的底盘和允许通信电缆进入的引导件。电缆终端单元可以安装在底盘上，使得通过引导件引导的电缆可以被连接并且设置有能够进行功能连接的终端。盖子可以以可拆卸的方式安装在底盘上，并且可重新连接以允许进入底盘。底盘可以包括用于将至少一个功能模块连接到通信电缆的安装点，并且用于允许将不同的通信功能提供给经由设备连接到网络的用户设备。

43. 发明申请

US20120147002A1 VIRTUAL CELLULAR STAINING 有权
标题翻译：虚拟细胞染色
公开(公告)号：US20120147002A1
公开(公告)日：2012-06-14
申请号：US13314001
申请日：2011-12-07
申请人： Jonathan Young , Kathleen Free , Elizabeth Browne
发明人： Jonathan Young , Kathleen Free , Elizabeth Browne
IPC分类号： G09G5/02 , G06Q30/00 , G06T15/00
CPC分类号： G06T11/001 , G01N1/30 , G06K9/00127 , G06K9/0014 , G06K9/00201 , G06T7/0012 , G06T15/04 , G06T19/20 , G06T2207/10024 , G06T2207/10056 , G06T2207/30024 , G06T2219/2012
摘要： Systems and methods are used to display cell structures of a biological cell. A plurality of cell structures of a biological cell is stored and for each cell structure of the plurality of cell structures one or more stain colors are stored. A selected cell structure is received from an input device. One or more stain colors of the selected cell structure are retrieved. The one or more stain colors of the selected cell structure are displayed. A selected stain color is received from the input device. The selected cell structure is displayed in the selected stain color in an exemplary cell image. Further, a three-dimensional image of a biological cell is stored. The three-dimensional image is displayed on a display that includes a touch screen. A movement selection is received from the touch screen. The three-dimensional image is displayed on the display according to the movement selection.
摘要翻译：系统和方法用于显示生物细胞的细胞结构。存储生物细胞的多个细胞结构，并且对于多个细胞结构的每个细胞结构，存储一种或多种染色。从输入设备接收所选择的单元结构。检索所选择的细胞结构的一种或多种染色。显示所选单元结构的一个或多个染色。从输入装置接收选定的染色。所选细胞结构以示例性细胞图像中所选择的染色显示。此外，存储生物细胞的三维图像。三维图像显示在包括触摸屏的显示器上。从触摸屏接收移动选择。根据移动选择，三维图像显示在显示器上。

44. 发明申请

US20110099270A1 Communications Device and Method of Operation Thereof 审中-公开
标题翻译：通信设备及其操作方法
公开(公告)号：US20110099270A1
公开(公告)日：2011-04-28
申请号：US12740916
申请日：2008-09-10
申请人： Peter Hartman , Jonathan Young
发明人： Peter Hartman , Jonathan Young
IPC分类号： G06F15/173
CPC分类号： H04M1/677 , H04M1/2745 , H04M1/56 , H04M1/663 , H04M1/72572 , H04W8/10
摘要： A communications device, such as a mobile telephone, fixed line telephone, computer with network access, or any other similar device which is equipped to communicate using network and/or telephony protocols, is provided, wherein before a call or other communications sessions is set up and made, a determination of the present time at the intended recipient of the call or session is made. In some embodiments, this determination of the time at the intended recipient's location is displayed to a user of the calling device to allow the user to decide whether to proceed with a call to the intended recipient. In other embodiments the determined time is compared with a set of one or more predetermined time bands during which calls to a recipient should not be made. Depending on the results of the comparison, the operation of the communications device is altered, for example, in one embodiment the call is not made, and the user preferably informed. In another embodiment, the user (caller) is advised that the call is being made at an inappropriate time for the intended recipient, and prompted to indicate whether the call should proceed. With such techniques, the problems noted above of unwanted calls being set up unnecessarily can be addressed.
摘要翻译：提供了诸如移动电话，固定电话电话，具有网络接入的计算机的通信设备或者被配备为使用网络和/或电话协议进行通信的任何其它类似设备，其中在设置呼叫或其它通信会话之前确定当前在通话或会话的接收方的当前时间。在一些实施例中，向目标接收者的位置的时间的这种确定被显示给主叫设备的用户，以允许用户决定是否继续对预期接收者进行呼叫。在其他实施例中，将确定的时间与一个或多个预定时间段的集合进行比较，在此期间不应该对接收者进行呼叫。根据比较的结果，改变了通信设备的操作，例如，在一个实施例中，不进行呼叫，并且优选地通知用户。在另一个实施例中，建议用户（呼叫者）在预期接收者的不适当时间进行呼叫，并且提示用户指示呼叫是否应当继续进行。利用这样的技术，可以解决上述不必要的呼叫建立不必要的问题。

45. 发明申请

US20100170954A1 VEHICLE HEATERS AND CONTROLS THEREFOR 有权
标题翻译：车辆加热器及其控制
公开(公告)号：US20100170954A1
公开(公告)日：2010-07-08
申请号：US12554967
申请日：2009-09-07
申请人： Jonathan Young , Douglas Thompson Paul , Angelo Faccone
发明人： Jonathan Young , Douglas Thompson Paul , Angelo Faccone
IPC分类号： B60H1/22 , F23M9/06 , F23N1/02
CPC分类号： B60H1/2209 , B60H1/2206 , F23N3/082 , F23N5/203 , F23N2023/04 , F23N2023/08 , F23N2027/10 , F23N2031/10 , F23N2033/08 , F23N2041/14
摘要： A heater for a liquid has a combustion chamber, a jacket for the liquid extending about the combustion chamber and a burner head assembly connected to the combustion chamber. The burner head assembly includes a housing having a burner mounted thereon and a hollow interior. A control module and a fan are mounted in the hollow interior, the fan being connected to an electric motor. A compressor and a fuel pump are mounted on the housing and are operatively connected to the electric motor. The control module may include controls for exercising components of the heater prior to combustion, thereby verifying operation of these components. Preferably there is a speed control for the motor, such as a closed loop speed control which regulates motor speed and accordingly output of the heater. Preferably there is a backup system using a lookup table in the event that the closed loop speed control fails. Also preferably there is provision for monitoring flame sensor functionality by providing an indicator light which mirrors operation of the flame sensor. The heater may have a selective soft start for the coolant pump which operates only when required so as to reduce unnecessary chatter on the motor relay. A system is also provided for distinguishing true overcurrent faults from overcurrents arising from voltage changes during starting of the vehicle engine. Reignition algorithms are provided to restart the burner in the event of flame sputters caused, for example, by fuel bubbles, but shut off the heater in the event that the fuel is truly cut off.
摘要翻译：用于液体的加热器具有燃烧室，用于围绕燃烧室延伸的液体的护套和连接到燃烧室的燃烧器头组件。燃烧器头组件包括具有安装在其上的燃烧器和中空内部的壳体。控制模块和风扇安装在中空内部，风扇连接到电动机。压缩机和燃料泵安装在壳体上并且可操作地连接到电动机。控制模块可以包括用于在燃烧之前锻炼加热器的部件的控制，从而验证这些部件的操作。优选地，存在用于电动机的速度控制，例如调节电动机速度并因此输出加热器的闭环速度控制。优选地，在闭环速度控制失败的情况下，存在使用查找表的备份系统。还优选地，通过提供反映火焰传感器的操作的指示灯来监视火焰传感器功能。加热器可以具有用于仅在需要时操作的冷却剂泵的选择性软启动，以便减少马达继电器上的不必要的颤动。还提供一种系统，用于区分真实的过电流故障与车辆发动机启动期间电压变化引起的过电流。提供重燃算法以在例如由燃料气泡导致的火焰喷溅器的情况下重新启动燃烧器，但是在燃料被真正切断的情况下关闭加热器。

46. 发明授权

US07529373B2 Laser autocalibration for QKD systems 有权
标题翻译： QKD系统的激光自动校准
公开(公告)号：US07529373B2
公开(公告)日：2009-05-05
申请号：US10589419
申请日：2005-03-03
申请人： Jonathan Young , Harry Vig , Michael J. Lagasse
发明人： Jonathan Young , Harry Vig , Michael J. Lagasse
IPC分类号： H04L9/00 , H04L9/08
CPC分类号： H04B10/70 , H04L9/0852
摘要： A method of autocalibrating a quantum key distribution (QKD) system (200) is disclosed. The QKD system includes a laser ((202) that generates photon signals in response to a laser gating signal (S0) from a controller (248). The method includes first performing a laser gate scan (304) to establish the optimum arrival time (TMAX) of the laser gating signal corresponding to an optimum—e.g., a maximum number of photon counts (NMAX)—from a single-photon detector (SPD) unit (216) in the QKD system when exchanging photon signals between encoding stations (Alice and Bob) of the QKD system. Once the optimal laser gating signal arrival time (TMAX) is determined, the laser gate scan is terminated and a laser gate dither process (308) is initiated. The laser dither involves varying the arrival time (T) of the laser gating signal around the optimum value of the arrival time TMAX. The laser gate dither provides minor adjustments to the laser gating signal arrival time to ensure that the SPD unit produces an optimum (e.g., maximum) number of photon counts.
摘要翻译：公开了一种自动校准量子密钥分发（QKD）系统（200）的方法。 QKD系统包括激光器（202），其响应于来自控制器（248）的激光门控信号（S0）产生光子信号，该方法包括首先执行激光门扫描（304）以建立最佳到达时间（当在编码站之间交换光子信号时，QKD系统中的单光子检测器（SPD）单元（216）中的最佳光子计数（NMAX）的最佳数量对应于激光门控信号（TMAX）和Bob），一旦确定了最佳激光门控信号到达时间（TMAX），终止激光门扫描，开始激光门抖动处理（308），激光抖动涉及改变到达时间（T ）激光门控信号绕到达到时间TMAX的最佳值。激光门抖动对激光门控信号到达时间进行微调，以确保SPD单元产生最佳（例如，最大）数量的光子计数。

47. 发明申请

US20080076783A1 Cycloalkyl Keto Piperidine Tachykinin Receptor Antagonists 审中-公开
标题翻译：环烷基酮基哌啶速激肽受体拮抗剂
公开(公告)号：US20080076783A1
公开(公告)日：2008-03-27
申请号：US11667284
申请日：2005-11-18
申请人： Robert DeVita , Sander Mills , Ronsar Eid , Jonathan Young
发明人： Robert DeVita , Sander Mills , Ronsar Eid , Jonathan Young
IPC分类号： A61K31/445 , A61K31/454 , A61K31/506 , A61P13/00 , A61P25/04 , A61P25/24 , A61P29/00 , C07D211/22 , C07D239/26 , C07D401/04
CPC分类号： C07D401/06 , C07D211/46 , C07D401/08
摘要： The present invention is directed to certain piperidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
摘要翻译：本发明涉及某些可用作神经激肽-1（NK-1）受体拮抗剂的哌啶化合物和速激肽抑制剂，特别是物质P。本发明还涉及包含这些化合物作为活性成分的药物制剂和使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。

48. 发明授权

US07270098B2 Vehicle heater and controls therefor 有权
标题翻译：车辆加热器及其控制
公开(公告)号：US07270098B2
公开(公告)日：2007-09-18
申请号：US10195150
申请日：2002-07-15
申请人： Jonathan Young , Douglas Thompson Paul , Angelo Faccone
发明人： Jonathan Young , Douglas Thompson Paul , Angelo Faccone
IPC分类号： F27D23/00
CPC分类号： B60H1/2209 , B60H1/2206 , F23N3/082 , F23N5/203 , F23N2023/04 , F23N2023/08 , F23N2027/10 , F23N2031/10 , F23N2033/08 , F23N2041/14
摘要： A heater for a liquid has a combustion chamber, a jacket for the liquid extending about the combustion chamber and a burner head assembly connected to the combustion chamber. The burner head assembly includes a housing having a burner mounted thereon and a hollow interior. A control module and a fan are mounted in the hollow interior, the fan being connected to an electric motor. A compressor and a fuel pump are mounted on the housing and are operatively connected to the electric motor. The control module may include controls for exercising components of the heater prior to combustion, thereby verifying operation of these components. Preferably there is a speed control for the motor, such as a closed loop speed control which regulates motor speed and accordingly output of the heater. Preferably there is a backup system using a lookup table in the event that the closed loop speed control fails. Also preferably there is provision for monitoring flame sensor functionality by providing an indicator light which mirrors operation of the flame sensor. The heater may have a selective soft start for the coolant pump which operates only when required so as to reduce unnecessary chatter on the motor relay. A system is also provided for distinguishing true overcurrent faults from overcurrents arising from voltage changes during starting of the vehicle engine. Reignition algorithms are provided to restart the burner in the event of flame sputters caused, for example, by fuel bubbles, but shut off the heater in the event that the fuel is truly cut off.
摘要翻译：用于液体的加热器具有燃烧室，用于围绕燃烧室延伸的液体的护套和连接到燃烧室的燃烧器头组件。燃烧器头组件包括具有安装在其上的燃烧器和中空内部的壳体。控制模块和风扇安装在中空内部，风扇连接到电动机。压缩机和燃料泵安装在壳体上并且可操作地连接到电动机。控制模块可以包括用于在燃烧之前锻炼加热器的部件的控制，从而验证这些部件的操作。优选地，存在用于电动机的速度控制，例如调节电动机速度并因此输出加热器的闭环速度控制。优选地，在闭环速度控制失败的情况下，存在使用查找表的备份系统。还优选地，通过提供反映火焰传感器的操作的指示灯来监视火焰传感器功能。加热器可以具有用于仅在需要时操作的冷却剂泵的选择性软启动，以便减少马达继电器上的不必要的颤动。还提供一种系统，用于区分真实的过电流故障与车辆发动机启动期间电压变化引起的过电流。提供重燃算法以在例如由燃料气泡导致的火焰喷溅器的情况下重新启动燃烧器，但是在燃料被真正切断的情况下关闭加热器。

49. 发明申请

US20060239463A1 QKD system laser autocalibration based on bit-error rate 有权
标题翻译：基于误码率的QKD系统激光自动校准
公开(公告)号：US20060239463A1
公开(公告)日：2006-10-26
申请号：US11110031
申请日：2005-04-20
申请人： Jonathan Young
发明人： Jonathan Young
IPC分类号： H04L9/00
CPC分类号： H04B10/70 , H04L9/0852
摘要： A method of autocalibrating the timing of the laser (202) in a quantum key distribution (QKD) system (200) is disclosed. Laser (202) generates photon signals (204) in response to a laser gating signal (S0) from a controller (248). The method includes first performing a laser gate scan (304) to establish the optimum arrival time (TMIN) of the laser gating signal corresponding to an optimum (e.g., minimum) bit-error rate BER (e.g., BERMIN) when exchanging photon signals between encoding stations (Alice and Bob) of the QKD system. Once the optimum laser gating signal arrival time (TMIN) is determined, the laser gate scan is terminated (306) and a laser gate dither process (308) is initiated. The laser gate dither involves varying the arrival time (T) of the laser gating signal around the optimum value of the arrival time TMIN. The laser gate dither provides minor adjustments to the laser gating signal arrival time to ensure that the system operates at or near the optimum BER.
摘要翻译：公开了一种在量子密钥分配（QKD）系统（200）中自动校准激光器（202）的定时的方法。响应于来自控制器（248）的激光门控信号（S0），激光器（202）产生光子信号（204）。该方法包括首先执行激光门扫描（304）以建立对应于最佳（例如最小）比特误码率BER的激光门控信号的最佳到达时间（T MIN）。当在QKD系统的编码站（Alice和Bob）之间交换光子信号时，BER BER最小。一旦确定了最佳的激光门控信号到达时间（T MIN），终止激光门扫描（306），并启动激光门抖动处理（308）。激光门抖动涉及将激光门控信号的到达时间（T）变化到达到达时间T MIN MIN的最佳值。激光门抖动对激光门控信号到达时间进行了微小调整，以确保系统在最佳BER或接近最佳BER时工作。

50. 发明申请

US20060239460A1 QKD system detector autocalibration based on bit-error rate 有权
标题翻译：基于误码率的QKD系统检测器自动校准
公开(公告)号：US20060239460A1
公开(公告)日：2006-10-26
申请号：US11110227
申请日：2005-04-20
申请人： Jonathan Young
发明人： Jonathan Young
IPC分类号： H04K1/00
CPC分类号： H04L9/0852
摘要： In a quantum key distribution (QKD) system, a method of autocalibrating the gating of a single-photon detector (SPD) unit is disclosed. The method includes exchanging photon signals (P1, P2) to establish a bit-error rate (BER). The method also includes performing a detector gate signal timing scan (314) that varies the signal arrival time (T) to establish an optimum arrival time (TMIN) corresponding to an optimum (e.g., minimum) BER. Detector gate signal timing dithering is then performed (318). This involves varying the detector gate signal arrival times about the optimum arrival time to ensure that the QKD system operates at or near an optimum BER.
摘要翻译：在量子密钥分配（QKD）系统中，公开了一种自动校准单光子检测器（SPD）单元门控的方法。该方法包括交换光子信号（P 1，P 2）以建立误码率（BER）。该方法还包括执行检测器门信号定时扫描（314），其改变信号到达时间（T）以建立对应于最佳（例如最小）BER的最佳到达时间（T MIN）。然后执行检测器门信号定时抖动（318）。这涉及到关于最佳到达时间的检测器门信号到达时间的变化，以确保QKD系统在最佳BER或接近最佳BER时工作。

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