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41. 发明申请

US20050096705A1 Multi-site ventricular pacing therapy with parasympathetic stimulation 有权
标题翻译：多部位心室起搏治疗与副交感神经刺激
公开(公告)号：US20050096705A1
公开(公告)日：2005-05-05
申请号：US10700368
申请日：2003-11-03
申请人： Joseph Pastore , Zoe Harris-Hajenga , Julio Spinelli
发明人： Joseph Pastore , Zoe Harris-Hajenga , Julio Spinelli
IPC分类号： A61N1/362 , A61N1/368 , A61N1/365
CPC分类号： A61N1/36114 , A61N1/3622 , A61N1/3627 , A61N1/368
摘要： A method and device for delivering multi-site ventricular pacing therapy in conjunction with parasympathetic stimulation for reducing ventricular wall stress. Such reduction in ventricular wall stress is useful in reversing or preventing the ventricular remodeling which can occur in heart failure patients.
摘要翻译：结合副交感神经刺激减少心室壁应力的方法和装置，用于多局部心室起搏治疗。心室壁应激的这种减少可用于逆转或预防心力衰竭患者发生的心室重塑。

42. 发明授权

US09221301B1 System and method for a removable wheel device for a field game goal 有权
标题翻译：用于野战游戏目标的可移动轮装置的系统和方法
公开(公告)号：US09221301B1
公开(公告)日：2015-12-29
申请号：US14262136
申请日：2014-04-25
申请人： Joseph Pastore
发明人： Joseph Pastore
IPC分类号： A63B63/00 , B60B33/02
CPC分类号： B60B33/02 , A63B63/004 , A63B2071/025 , A63B2102/14 , A63B2210/50 , B60B33/0005 , B60B33/001 , B60B33/0018 , B60B33/0023 , B60B33/0039 , B60B33/0049 , Y10T16/184 , Y10T29/49826
摘要： A removable wheel device which slides onto the base of a sports field goal. The wheel device allows one person to move a goal across a field without using excessive force by sliding one wheel device onto the base of each goalpost and using leverage to tilt the goal and push or pull it for a distance. When inserted onto the base of the goal, the wheel device does not require any type of fastening to remain in place, but rather uses its own unique shape to hold onto the goal. Because field goals vary in structure, so too do each of the embodiments of the removable wheel device. Some of these variances include the angle of the axle, the location and structure of the notch, the use of a protrusion, and the use of a removable pin to secure the goalpost in place.
摘要翻译：滑动到运动场目标基座上的可移动轮装置。车轮装置允许一个人通过将一个车轮装置滑动到每个门柱的基座上并且使用杠杆来倾斜目标并将其推或拉一段距离，而不用过度的力量移动目标。当插入到目标的底部时，轮装置不需要任何类型的紧固件保持在适当位置，而是使用其自己独特的形状来保持目标。因为场目标的结构不同，所以可拆卸轮装置的每个实施例也是如此。这些方差中的一些包括轴的角度，凹口的位置和结构，突起的使用，以及使用可移除的销将球柱固定到位。

43. 发明授权

US09221300B1 System and method for a removable wheel device for a field game goal 有权
标题翻译：用于野战游戏目标的可移动轮装置的系统和方法
公开(公告)号：US09221300B1
公开(公告)日：2015-12-29
申请号：US14026602
申请日：2013-09-13
申请人： Joseph Pastore
发明人： Joseph Pastore
IPC分类号： A63B63/00 , B60B33/00
CPC分类号： B60B33/00 , A63B63/004 , A63B2071/025 , A63B2102/14 , A63B2210/50 , B60B33/0005 , B60B33/001 , B60B33/0023 , B60B33/0026 , B60B33/0039 , B60B33/0049 , Y10T16/184 , Y10T29/49826
摘要： A removable wheel device which slides onto the base of a sports field goal. The wheel device allows one person to move a goal across a field without using excessive force by sliding one wheel device onto the base of each goalpost and using leverage to tilt the goal and push or pull it for a distance. When inserted onto the base of the goal, the wheel device does not require any type of fastening to remain in place, but rather uses its own unique shape to hold onto the goal. Because field goals vary in structure, so too do each of the embodiments of the removable wheel device. Some of these variances include the angle of the axle, the location and structure of the notch, and the use of a protrusion.
摘要翻译：滑动到运动场目标基座上的可移动轮装置。车轮装置允许一个人通过将一个车轮装置滑动到每个门柱的基座上并且使用杠杆来倾斜目标并将其推或拉一段距离，而不用过度的力量移动目标。当插入到目标的底部时，轮装置不需要任何类型的紧固件保持在适当位置，而是使用其自己独特的形状来保持目标。因为场目标的结构不同，所以可拆卸轮装置的每个实施例也是如此。这些方差中的一些包括轴的角度，凹口的位置和结构以及突起的使用。

44. 发明申请

US20080027495A1 INTERMITTENT STRESS AUGMENTATION PACING FOR CARDIOPROTECTIVE EFFECT 有权
标题翻译：间歇性应激补充剂对保护作用的影响
公开(公告)号：US20080027495A1
公开(公告)日：2008-01-31
申请号：US11868767
申请日：2007-10-08
申请人： Frits Prinzen , Richard Cornelussen , Ward Vanagt , Joseph Pastore , Julio Spinelli
发明人： Frits Prinzen , Richard Cornelussen , Ward Vanagt , Joseph Pastore , Julio Spinelli
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译：公开了一种用于以对随后的缺血提供保护作用的方式向心脏递送电刺激的装置和方法。通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。

45. 发明申请

US20060167511A1 Apparatus and method for temporary treatment of acute heart failure decompensation 有权
公开(公告)号：US20060167511A1
公开(公告)日：2006-07-27
申请号：US11044971
申请日：2005-01-27
申请人： Joseph Pastore , Qingsheng Zhu
发明人： Joseph Pastore , Qingsheng Zhu
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/368
摘要： A system for providing temporary therapy, such as cardiac resynchronization therapy, to a patient suffering a decompensation event. The system can include a device having an external module for generating electrical stimuli, a first lead coupled to the module and implanted into an atrial region of a patient's heart, and a second lead coupled to the module and implanted into a ventricular region of the patient's heart. The device can also include a storage module coupled to the external module to store data associated with physiological data measured by the device. The external module is configured to temporarily generate electrical stimuli that are delivered by at least one of the first and second leads to provide therapy cardiac resynchronization therapy to the heart. A network can be coupled to the device to allow data stored in the device to be downloaded through the network to a central repository.

46. 发明申请

US20060134079A1 Implantable medical devices comprising isolated extracellular matrix 有权
标题翻译：可植入医疗器械包括分离的细胞外基质
公开(公告)号：US20060134079A1
公开(公告)日：2006-06-22
申请号：US11017432
申请日：2004-12-20
申请人： Haris Sih , Joseph Pastore
发明人： Haris Sih , Joseph Pastore
IPC分类号： A61K48/00 , A61K38/19 , C12N5/08 , A61N1/00
CPC分类号： A61K38/30 , A61K35/545 , A61K38/18 , A61K38/1833 , A61K38/193 , A61K38/39 , A61K48/00 , A61N1/05 , A61N1/375
摘要： Implantable devices containing extracellular matrix and methods of using the devices are provided.
摘要翻译：提供了含有细胞外基质的植入式装置和使用该装置的方法。

47. 发明申请

US20050149129A1 Baropacing and cardiac pacing to control output 审中-公开
标题翻译：支架和心脏起搏来控制输出
公开(公告)号：US20050149129A1
公开(公告)日：2005-07-07
申请号：US10746135
申请日：2003-12-24
申请人： Imad Libbus , Joseph Pastore
发明人： Imad Libbus , Joseph Pastore
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/362 , A61N1/36114
摘要： One aspect of the present subject matter relates to an implantable medical system. An embodiment of the system includes a baroreflex stimulator and a cardiac stimulator. The baroreflex stimulator applies a baroreflex stimulation signal through an electrode and provides a signal indicating that the baroreflex signal is being applied. The cardiac stimulator applies a pacing therapy with a pacing rate, receives the signal from the baroreflex stimulator, and increases the pacing rate of the pacing therapy to compensate for cardiac output compromised by applying the baroreflex stimulation signal. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及可植入医疗系统。系统的一个实施例包括压力反射刺激器和心脏刺激器。压力反射刺激器通过电极施加压力反射刺激信号，并提供指示正在施加压力反射信号的信号。心脏刺激器应用起搏速率的起搏治疗，接收来自压力反射刺激器的信号，并增加起搏治疗的起搏速率，以补偿通过应用压力反射刺激信号而损害的心输出量。本文提供了其他方面。

48. 发明授权

US5228830A Wicket gate 失效
标题翻译：小门
公开(公告)号：US5228830A
公开(公告)日：1993-07-20
申请号：US627341
申请日：1990-12-14
申请人： Joseph Pastore
发明人： Joseph Pastore
IPC分类号： F03B3/18
CPC分类号： F03B3/183 , F05B2230/90 , F05B2280/4003 , Y02E10/223 , Y02P70/525 , Y10T29/49337
摘要： This invention relates to an improvement in an apparatus for directing the flow of water from the penstock to the vanes of a hydraulic turbine, generally referred to as a wicket gate, and a method for making the improved wicket gate. The improved wicket gate comprises a rotatable planar body made either of a high-strength plastic material or metal, onto which a viscoelastic material is affixed. The improvement lies in the application of the viscoelastic material to the rotatable planar body in such a way that the viscoelastic material becomes an integral component of the rotatable planar body. This improvement extends the maintenance life cycle by reducing marine growth, erosion and pitting caused by cavitation.
摘要翻译：本发明涉及用于将水从水管引导到水轮机的叶片（通常称为小门）的装置的改进以及用于制造改进的小门的方法。改进的门板门包括由高强度塑料材料或金属制成的可旋转平面体，粘合有粘弹性材料。改进在于将粘弹性材料应用于可旋转平面体，使得粘弹性材料成为可旋转平面体的整体部件。这种改进通过减少由气蚀导致的海洋生长，侵蚀和点蚀延长了维护生命周期。

49. 发明申请

US20130303597A1 SDF-1 DELIVERY FOR TREATING ISCHEMIC TISSUE 有权
标题翻译： SDF-1交付用于治疗组织组织
公开(公告)号：US20130303597A1
公开(公告)日：2013-11-14
申请号：US13912435
申请日：2013-06-07
申请人： Marc S. Penn , Rahul Aras , Joseph Pastore , Timothy J. Miller
发明人： Marc S. Penn , Rahul Aras , Joseph Pastore , Timothy J. Miller
IPC分类号： A61K48/00
CPC分类号： A61K38/19 , A61K9/0019 , A61K31/711 , A61K38/00 , A61K48/005 , C07K14/521 , C07K2319/02 , C07K2319/09
摘要： Provided herein are methods of treating a cardiomyopathy in a subject by administering directly to, or expressing locally in, a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification. Also provided are methods of treating critical limb ischemia in a subject by administering a DNA plasmid encoding human SDF-1 by direct injection into the affected limb.
摘要翻译：本文提供了通过直接施用或表达受试者心肌组织的弱化，缺血和/或梗死周围区域来治疗受试者的心肌病的方法，所述量的SDF-1有效引起功能改善在以下参数中的至少一个中：左心室容积，左心室面积，左心室尺寸，心脏功能，6分钟步行测试或纽约心脏协会（NYHA）功能分类。还提供了通过直接注射到受影响的肢体中来施用编码人SDF-1的DNA质粒来治疗受试者的关键性肢体缺血的方法。

50. 发明授权

US08535184B2 System and method for a removable wheel device 有权
标题翻译：可移动轮装置的系统和方法
公开(公告)号：US08535184B2
公开(公告)日：2013-09-17
申请号：US12950225
申请日：2010-11-19
申请人： Joseph Pastore
发明人： Joseph Pastore
IPC分类号： A63B63/00
CPC分类号： A63B63/004 , A63B2071/025 , A63B2102/14 , B60B33/0005 , B60B33/0023 , B60B33/0039 , B60B33/0049 , Y10T16/184 , Y10T29/49826
摘要： A removable wheel device which slides onto the base of a sports field goal. The wheel device allows one person to move a goal across a field without using excessive force by sliding one wheel device onto the base of each goalpost and using leverage to tilt the goal and push or pull it for a distance. When inserted onto the base of the goal, the wheel device does not require any type of fastening to remain in place, but rather uses its own unique shape to hold onto the goal. In one embodiment the removable wheel device comprises a wheel, a bracket, and a U-shaped sleeve which may slide onto the base of a lacrosse goalpost.
摘要翻译：滑动到运动场目标基座上的可移动轮装置。车轮装置允许一个人通过将一个车轮装置滑动到每个门柱的基座上并且使用杠杆来倾斜目标并将其推或拉一段距离，而不用过度的力量移动目标。当插入到目标的底部时，轮装置不需要任何类型的紧固件保持在适当位置，而是使用其自己独特的形状来保持目标。在一个实施例中，可拆卸车轮装置包括可滑动到曲棍球场门柱的底座上的车轮，支架和U形套筒。

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