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41. 发明授权

US09408556B2 Integrated analysis device for simultaneously detecting EBCs and VOCs in human exhaled breath 有权
标题翻译：用于同时检测人呼气中的EBC和VOC的综合分析装置
公开(公告)号：US09408556B2
公开(公告)日：2016-08-09
申请号：US13990007
申请日：2010-12-01
申请人： Ping Wang , Di Wang , Le Wang , Jin Yu , Kai Yu , Yishan Wang , Lin Wang , Cong Zhao
发明人： Ping Wang , Di Wang , Le Wang , Jin Yu , Kai Yu , Yishan Wang , Lin Wang , Cong Zhao
IPC分类号： A61B5/08 , G01N33/00 , G01N33/497 , A61B5/097
CPC分类号： A61B5/082 , A61B5/097 , G01N33/0047 , G01N33/497
摘要： The present embodiments disclose a device including a module for sampling, separating and enriching a detected object, an exhaled breath condensates (EBCs) detection module and a combined volatile organic compounds (VOCs) detection module. The sampling module is connected with the EBCs detection module via a syringe pump for sample injection and is connected with the combined VOCs detection module by a capillary separation column. EBCs and VOCs in human exhaled breath are simultaneously sampled, separated and condensed; the heavy metal ions, cell factors, etc. in the collected EBCs are detected with a light addressable potentiometric sensor (LAPS); the condensed VOCs can be quantitatively detected by the combined VOCs detection module with a high sensitivity; and a heating rod and a platinum resistor can be conveniently replaced because a separated outlet heating piece is designed in the combined VOCs detection module.
摘要翻译：本实施例公开了一种包括用于对检测到的物体进行取样，分离和富集的模块，呼出呼吸冷凝物（EBC）检测模块和组合的挥发性有机化合物（VOC））检测模块的装置。采样模块通过注射泵与EBC检测模块连接，用于注射样品，并通过毛细管分离柱与组合的VOC检测模块连接。人呼吸中的EBC和VOCs被同时取样，分离和浓缩; 用光寻址电位传感器（LAPS）检测收集的EBC中的重金属离子，细胞因子等; 可以通过组合的VOC检测模块以高灵敏度定量检测浓缩的VOC; 并且可以方便地更换加热棒和铂电阻器，因为在组合的VOC检测模块中设计了分离的出口加热片。

42. 发明授权

US08445679B2 7-substituted indole MCL-1 inhibitors 有权
标题翻译： 7-取代吲哚MCL-1抑制剂
公开(公告)号：US08445679B2
公开(公告)日：2013-05-21
申请号：US12104294
申请日：2008-04-16
申请人： Xilu Wang , Xiaohong Song , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Lisa A. Hasvold , Le Wang , Zhi-Fu Tao , Aaron K. Kunzer
发明人： Xilu Wang , Xiaohong Song , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Lisa A. Hasvold , Le Wang , Zhi-Fu Tao , Aaron K. Kunzer
IPC分类号： C07D403/04 , A61K31/497
CPC分类号： C07D209/42 , A61K31/5377 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D491/113
摘要： Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
摘要翻译：公开了抑制抗凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物，以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。

43. 发明申请

US20130109146A1 METHOD FOR FABRICATING SMALL-SCALE MOS DEVICE 有权
标题翻译：用于制作小尺寸MOS器件的方法
公开(公告)号：US20130109146A1
公开(公告)日：2013-05-02
申请号：US13807306
申请日：2011-10-09
申请人： Le Wang
发明人： Le Wang
IPC分类号： H01L29/66
CPC分类号： H01L29/66492 , H01L29/665 , H01L29/6659 , H01L29/66636 , H01L29/7833
摘要： A method for fabricating a small-scale MOS device, including: preparing a substrate; forming a first trench in the substrate along a first side of the gate region and forming a second trench in the substrate along a second side of the gate region, the first side of the gate region opposite the second side of the gate region; forming a first lightly doped drain region and a second lightly doped drain region in the first trench and the second trench, respectively; forming a third trench in the substrate overlapping at least a first portion of the first lightly doped drain region and a fourth trench in the substrate overlapping at least a first portion of the second lightly doped drain region; and forming a source region and a drain region in the third trench and the fourth trench, respectively.
摘要翻译：一种制造小型MOS器件的方法，包括：制备衬底; 在所述栅极区域的第一侧沿所述衬底中形成第一沟槽，并且沿所述栅极区域的第二侧在所述衬底中形成第二沟槽，所述栅极区域的所述第一侧与所述栅极区域的第二侧相对; 在所述第一沟槽和所述第二沟槽中分别形成第一轻掺杂漏极区和第二轻掺杂漏极区; 在所述衬底中形成与所述第一轻掺杂漏极区域的至少第一部分重叠的第三沟槽和所述衬底中的与所述第二轻掺杂漏极区域的至少第一部分重叠的第四沟槽; 以及在第三沟槽和第四沟槽中分别形成源区和漏区。

44. 发明授权

US08148384B2 Substituted thieno[3,2-d]pyrimidine PIM kinase inhibitors as cancer chemotherapeutics 有权
标题翻译：取代的噻吩并[3,2-d]嘧啶PIM激酶抑制剂作为癌症化学治疗剂
公开(公告)号：US08148384B2
公开(公告)日：2012-04-03
申请号：US11951546
申请日：2007-12-06
申请人： Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
发明人： Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
IPC分类号： C07D495/04 , A61K31/519 , A61P35/00 , C07D495/14
CPC分类号： C07D495/04
摘要： Compounds of formula I wherein A1, A2, and A3 are as defined herein are inhibitors of PIM kinase. The compounds of formula I are useful for the treatment of diseases such as cancer.
摘要翻译：其中A1，A2和A3如本文所定义的式I化合物是PIM激酶的抑制剂。式I化合物可用于治疗诸如癌症的疾病。

45. 发明申请

US20100152183A1 BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES 有权
标题翻译：用于治疗癌症和免疫疾病的BCL-2-选择性病毒诱导剂
公开(公告)号：US20100152183A1
公开(公告)日：2010-06-17
申请号：US12631404
申请日：2009-12-04
申请人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
发明人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
IPC分类号： A61K31/5377 , A61P35/04 , A61K31/497 , A61K31/4439 , A61K31/415 , A61K31/405 , A61K31/18 , C07D413/02 , C07D413/12 , C07D413/14 , C07D401/12 , C07D235/04 , C07D209/04 , C07C311/00
CPC分类号： C07D401/12 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D209/32 , C07D211/58 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D241/04 , C07D249/04 , C07D295/125 , C07D295/14 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
摘要翻译：公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。

46. 发明申请

US20090054402A1 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS 有权
标题翻译： 7-取代的MCL-1抑制剂
公开(公告)号：US20090054402A1
公开(公告)日：2009-02-26
申请号：US12104294
申请日：2008-04-16
申请人： Xilu Wang , Xiaohong Song , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Lisa A. Hasvold , Le Wang , Zhi-Fu Tao , Aaron R. Kunzer
发明人： Xilu Wang , Xiaohong Song , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Lisa A. Hasvold , Le Wang , Zhi-Fu Tao , Aaron R. Kunzer
IPC分类号： A61K31/55 , C07D209/04 , A61K31/404 , C07D413/02 , A61K31/5377 , C07D401/02 , A61K31/4439 , C07D215/00 , A61K31/4709 , C07D403/02 , A61K31/496 , C07D413/14 , C07D265/36 , A61K31/538 , A61K31/517 , C07D417/02 , A61K31/541 , C07D223/16 , A61P43/00
CPC分类号： C07D209/42 , A61K31/5377 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D491/113
摘要： Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
摘要翻译：公开了抑制抗凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物，以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。

47. 发明申请

US20080161559A1 PIM KINASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS 有权
公开(公告)号：US20080161559A1
公开(公告)日：2008-07-03
申请号：US11951546
申请日：2007-12-06
申请人： Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
发明人： Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： Inhibitors of Pim kinases, ways to make them and methods of treating patients using them are disclosed.

48. 发明申请

US20080015192A1 INHIBITORS OF POLO-LIKE KINASES 有权
标题翻译： POLO-LIKE KINASES的抑制剂
公开(公告)号：US20080015192A1
公开(公告)日：2008-01-17
申请号：US11753279
申请日：2007-05-24
申请人： Robert Diebold , Stevan Djuric , Vincent Giranda , Laura Hexamer , Nan-Horng Lin , Julie Miyashiro , Thomas Penning , Magdalena Przytulinska , Thomas Sowin , Gerard Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith Woods , Zhiren Xia , Henry Zhang
发明人： Robert Diebold , Stevan Djuric , Vincent Giranda , Laura Hexamer , Nan-Horng Lin , Julie Miyashiro , Thomas Penning , Magdalena Przytulinska , Thomas Sowin , Gerard Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith Woods , Zhiren Xia , Henry Zhang
IPC分类号： A61K31/50 , A61K31/34 , A61K31/40 , A61K31/505 , A61P35/00 , C07D233/61 , C07D239/24 , C07D307/04 , C07D413/02 , C07D277/08 , C07D239/20 , C07D207/30 , A61K31/5377 , A61K31/4164 , A61K31/425
CPC分类号： C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20
摘要： Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
摘要翻译：公开了抑制Plk1的化合物，含有该化合物的组合物和使用该化合物治疗疾病的方法。

49. 发明申请

US20060264476A1 Farnesyltransferase Inhibitors 有权
标题翻译：法呢基转移酶抑制剂
公开(公告)号：US20060264476A1
公开(公告)日：2006-11-23
申请号：US11459745
申请日：2006-07-25
申请人： Akiyo Claiborne , Stephen Gwaltney , Lisa Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert Mantei , Todd Rockway , Hing Sham , Gerard Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
发明人： Akiyo Claiborne , Stephen Gwaltney , Lisa Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert Mantei , Todd Rockway , Hing Sham , Gerard Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
摘要翻译：具有下式的取代的咪唑和噻唑可用于抑制法呢基转移酶。还公开了法呢基转移酶抑制组合物和在患者体内抑制法尼基转移酶的方法。

50. 发明申请

US20050096324A1 Macrocyclic kinase inhibitors 审中-公开
公开(公告)号：US20050096324A1
公开(公告)日：2005-05-05
申请号：US10702140
申请日：2003-11-05
申请人： Zhi-Fu Tao , Nan-Horng Lin , Le Wang , Thomas Sowin
发明人： Zhi-Fu Tao , Nan-Horng Lin , Le Wang , Thomas Sowin
IPC分类号： C07D498/08 , C07D498/18 , A61K31/498 , C07D491/14
CPC分类号： C07D498/08 , C07D498/18
摘要： Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

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