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41. 发明授权

US5608069A 1-substituted, 3-carboxylic acid piperidine derivatives 失效
标题翻译： 1-取代的3-羧酸哌啶衍生物
公开(公告)号：US5608069A
公开(公告)日：1997-03-04
申请号：US263635
申请日：1994-06-22
申请人： Hans Petersen , Knud E. Andersen , Per O. S.o slashed.rensen , Jesper Lau , Henning B. Petersen , Behrend F. Lundt
发明人： Hans Petersen , Knud E. Andersen , Per O. S.o slashed.rensen , Jesper Lau , Henning B. Petersen , Behrend F. Lundt
IPC分类号： A61K31/445 , A61P25/00 , C07D211/60 , C07D211/78 , C07D211/68 , C07D211/80
CPC分类号： C07D211/78 , C07D211/60
摘要： The present invention relates to therapeutically active azaheterocyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a central nervous system ailment related to the GABA uptake.
摘要翻译：本发明涉及治疗活性的氮杂杂环化合物，其制备方法和包含该化合物的药物组合物。新化合物可用于治疗与GABA摄取相关的中枢神经系统疾病。

42. 发明授权

US4426697A Bus system with address and status conductors 失效
标题翻译：具有地址和状态导体的总线系统
公开(公告)号：US4426697A
公开(公告)日：1984-01-17
申请号：US276915
申请日：1981-06-24
申请人： Hans Petersen , Kurt Stegmann
发明人： Hans Petersen , Kurt Stegmann
IPC分类号： H04M9/02 , H04J6/00
CPC分类号： H04M9/025
摘要： A bus system with an address conductor and a status conductor onto which there are connected mutually parallel stations with programmable address decoders and with status decoders and/or status encoders, whereby the address conductor carries a sequence of address informations and the status conductor status informations timewise associated therewith. The bus system is essentially so constructed whereby the address conductor carries mutually spaced serially binary coded bit patterns of presently m address bits (address-bit pattern m), and the status conductor which is displaced relative to the address-bit pattern carries a serial bit pattern of r status bits (status-bit pattern r).
摘要翻译：具有地址导体和状态导体的总线系统，其上连接有可编程地址解码器和状态解码器和/或状态编码器的相互平行的站，由此地址导体随时携带一系列地址信息和状态导体状态信息相关联。总线系统基本上是这样构造的，由此地址导体承载当前m个地址位（地址位模式m）的相互间隔的串行二进制编码位模式，并且相对于地址位模式移位的状态导体承载串行位 r状态位的模式（状态位模式r）。

43. 发明申请

US20130211107A1 PROCESS FOR THE PURIFICATION OF PHARMACEUTICALLY ACCEPTABLE SALTS 有权
标题翻译：药物可接受的盐的净化过程
公开(公告)号：US20130211107A1
公开(公告)日：2013-08-15
申请号：US13810959
申请日：2011-07-12
申请人： Hans Petersen , Martin Markvard Knudsen
发明人： Hans Petersen , Martin Markvard Knudsen
IPC分类号： C07D307/87
CPC分类号： C07D307/87
摘要： The present invention is concerned with a process in connection with the purification of a pharmaceutically acceptable salt of escitalopram or citalopram.
摘要翻译：本发明涉及与依他普仑或西酞普兰的药学上可接受的盐的纯化相关的方法。

44. 发明授权

US07867113B2 Goal detector for detection of an object passing a goal plane 有权
标题翻译：用于检测通过目标平面的物体的目标检测器
公开(公告)号：US07867113B2
公开(公告)日：2011-01-11
申请号：US10547115
申请日：2004-03-01
申请人： Hans Petersen
发明人： Hans Petersen
IPC分类号： A63B63/00
CPC分类号： A63B24/0021 , A63B43/00 , A63B63/00 , A63B63/004 , A63B71/0605 , A63B2024/0037 , A63B2071/0611 , A63B2102/24 , A63B2220/83 , A63B2220/89 , A63B2225/50 , A63B2243/0025
摘要： A system is disclosed for detection of whether a movable object, such as a sports object, e.g. a football or an ice hockey puck, has passed a flat plane in space, such as a goal plane defined e.g. as a vertical plane extending from a goal line or a horizontal plane defined by the upper rim of the basketball basket. The system comprises a plurality of pairs of antennas arranged along the periphery of the flat target plane, the two antennas of each of said pairs being arranged with a mutual displacement in the direction perpendicularly to the flat target plane, radio wave emitter means arranged in the movable object and/or each antenna, and means for receiving the radio waves from the radio wave emitter means and provide an output accordingly arranged in each antenna and/or in the movable object, the system further comprising processing means to receive and process said output together with a predetermined set of conditions and providing a resulting output if the set of conditions are fulfilled so as to determine whether the movable object passes the flat target plane.
摘要翻译：公开了一种用于检测诸如运动物体之类的可移动物体的系统。一个足球或一个冰球冰球已经在太空中经过一个平面飞机，比如一个定位的目标飞机。作为从篮球篮的上边缘限定的球门线或水平面延伸的垂直平面。该系统包括沿着平面目标平面的周边布置的多对天线，每个所述对的两个天线在与平面目标平面垂直的方向上相互位移地布置，布置在可移动物体和/或每个天线，以及用于从无线电波发射器装置接收无线电波并提供相应地布置在每个天线和/或可移动物体中的输出的装置，该系统还包括处理装置，用于接收和处理所述输出连同预定的一组条件，并且如果满足条件集合以提供结果输出，以便确定可移动物体是否通过平面目标平面。

45. 发明授权

US07560576B2 Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base 有权
标题翻译：依他普仑和包含依他普仑碱的分散片的结晶基
公开(公告)号：US07560576B2
公开(公告)日：2009-07-14
申请号：US12046984
申请日：2008-03-12
申请人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
发明人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
IPC分类号： C07D307/00 , A61K31/34
CPC分类号： C07D307/81
摘要： The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-furancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.
摘要翻译：本发明涉及众所周知的抗抑郁药物依他普仑S-1- [3-（二甲基氨基）丙基] -1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃腈的结晶碱，其制剂的所述碱的方法，使用碱，通过所述方法获得的盐以及含有这些盐的制剂来制备依他普仑的纯化盐如草酸盐的方法，以及制备纯化的依他普仑游离碱或其盐的方法使用氢溴酸盐，通过所述方法获得的盐和含有这些盐的制剂，例如草酸盐。最后，本发明涉及硬度至少为22N，口服崩解时间小于120秒的可分散片剂，其包含吸附在水溶性填料上的活性药物成分，其中活性药物成分的熔点为 40-100℃的范围，以及制造这种可分散片剂的方法。

46. 发明申请

US20080161584A1 CRYSTALLINE BASE OF ESCITALOPRAM AND ORODISPERSIBLE TABLETS COMPRISING ESCITALOPRAM BASE 有权
公开(公告)号：US20080161584A1
公开(公告)日：2008-07-03
申请号：US12046999
申请日：2008-03-12
申请人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
发明人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
IPC分类号： C07D307/87
CPC分类号： C07D307/81
摘要： The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-furancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.

47. 发明授权

US07390913B2 Process for the preparation of racemic citalopram diol and/or S- or R-citalopram diols and the use of such diols for the preparation of racemic citalopram, R-citalopram and/or S-citalopram 失效
标题翻译：用于制备外消旋西酞普兰二醇和/或S-或R-西酞普兰二醇的方法以及用于制备外消旋西酞普兰，西酞普兰和/或西酞普兰的这些二醇的用途
公开(公告)号：US07390913B2
公开(公告)日：2008-06-24
申请号：US10540300
申请日：2003-12-18
申请人： Hans Petersen , Brian Christiansen , Robert Dancer , Rikke E. Humble
发明人： Hans Petersen , Brian Christiansen , Robert Dancer , Rikke E. Humble
IPC分类号： C07D307/78 , C07D307/87 , C07D307/93
CPC分类号： C07D307/87 , C07C253/34
摘要： In the following, citalopram diol means 4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)-benzonitrile, as free base and/or acid addition salt. The invention relates to a process for the preparation of racemic citalopram diol and/or R- or S-citalopram diol, comprising the separation of a non-racemic mixture of R- and S-citalopram diol with more than 50% of one of the enantiomers into a fraction being enriched with S- or R-citalopram diol and a fraction comprising RS-citalopram diol wherein the ratio of R-citalopram diol:S-citalopram diol is equal to 1:1 or closer to 1:1 than in the initial mixture. The method is characterized in that (i) RS-citalopram diol is precipitated from a solution of the initial non-racemic mixture, or R- or S-citalopram diol is dissolved into a solvent from the initial non-racemic mixture, leaving a residue of RS-citalopram diol, and in that (ii) the residue/precipitate formed is separated from the final solution phase, followed by optional steps of repetition, recrystallisation, purification, isolation and conversion between free base and salts. The invention also relates to a process for the preparation of RS-citalopram, S-citalopram or R-citalopram (all as free base and/or acid addition salt) comprising the method described above followed by ring closure.
摘要翻译：在下文中，西酞普兰二醇是指作为游离碱和/或酸加成盐的4-（4-（二甲基氨基）-1-（4-氟苯基）-1-羟基丁基）-3-（羟甲基） - 苄腈。本发明涉及一种制备外消旋西酞普兰二醇和/或R-或S-西酞普兰二醇的方法，包括将R-和S-西酞普兰二醇的非外消旋混合物与50％以上的对映异构体转化成富含S-或R-西酞普兰二醇的级分和包含RS-西酞普兰二醇的级分，其中R-西酞普兰二醇：西西酞普兰二醇的比例等于1:1比或接近1比1 初始混合物。该方法的特征在于（i）RS-西酞普兰二醇从初始非外消旋混合物的溶液中沉淀，或将R-或S-西酞普兰二醇从初始非外消旋混合物中溶解到溶剂中，留下残余物的RS-西酞普兰二醇，并且（ii）所形成的残余物/沉淀物与最终溶液相分离，随后重复，重结晶，纯化，分离和转化游离碱和盐之间的任选步骤。本发明还涉及一种制备RS-西酞普兰，西酞普兰或R-西酞普兰（均为游离碱和/或酸加成盐）的方法，包括上述方法，然后闭环。

48. 发明申请

US20080054207A1 Valve Actuator 失效
标题翻译：阀门执行器
公开(公告)号：US20080054207A1
公开(公告)日：2008-03-06
申请号：US11577896
申请日：2005-10-27
申请人： Hans Petersen , Henning Muller
发明人： Hans Petersen , Henning Muller
IPC分类号： F16K31/52
CPC分类号： F16K41/103 , F16K31/52408
摘要： The present invention relates to a valve actuator comprising a support member for supporting a rotatable positioning element operatively connected to a valve rod. The valve actuator further comprises a track follower adapted to follow at least part of a track provided in the positioning element. The track follower is biased against at least part of the track by a resilient member. The rotatable positioning element comprises a curved outer portion arranged in an associated bearing formed in the support member.
摘要翻译：本发明涉及一种阀致动器，其包括用于支撑可操作地连接到阀杆的可旋转定位元件的支撑构件。阀致动器还包括适于跟随设置在定位元件中的轨道的至少一部分的轨道跟随器。轨道跟随器通过弹性构件偏压到轨道的至少一部分。可旋转定位元件包括设置在形成在支撑构件中的相关联的轴承中的弯曲外部。

49. 发明授权

US07271273B2 Method for the preparation of citalopram 失效
标题翻译：西酞普兰制备方法
公开(公告)号：US07271273B2
公开(公告)日：2007-09-18
申请号：US11285922
申请日：2005-11-23
申请人： Hans Petersen , Michael Harold Rock
发明人： Hans Petersen , Michael Harold Rock
IPC分类号： C07D307/54
CPC分类号： C07D307/88
摘要： The invention provides a new and improved method for the preparation of 5-cyano-phtalid, which is a key intermediate in the preparation of the antidepressant compound citalopram.
摘要翻译：本发明提供了一种新的改进的制备5-氰基 - 邻苯二甲酸的方法，该方法是制备抗抑郁化合物西酞普兰的关键中间体。

50. 发明申请

US20060079700A1 Method for the preparation of citalopram 失效
标题翻译：西酞普兰制备方法
公开(公告)号：US20060079700A1
公开(公告)日：2006-04-13
申请号：US11285922
申请日：2005-11-23
申请人： Hans Petersen , Michael Rock
发明人： Hans Petersen , Michael Rock
IPC分类号： C07D305/12
CPC分类号： C07D307/88
摘要： The invention provides a new and improved method for the preparation of 5-cyano-phtalid, which is a key intermediate in the preparation of the antidepressant compound citalopram.
摘要翻译：本发明提供了一种新的改进的制备5-氰基 - 邻苯二甲酸的方法，该方法是制备抗抑郁化合物西酞普兰的关键中间体。

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